MutL_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA repair protein Rad9, putative

Species:

Leishmania major

UniProt:

Q4QF86_LEIMA

TriTrypDb:

LmjF.15.0980 , LMJLV39_150016800 , LMJSD75_150016800

Length:

821

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0030896	checkpoint clamp complex	3	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

Q4QF86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF86

Function

Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	7
GO:0000076	DNA replication checkpoint signaling	6	2
GO:0000077	DNA damage checkpoint signaling	5	7
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0007093	mitotic cell cycle checkpoint signaling	4	2
GO:0007165	signal transduction	2	7
GO:0007346	regulation of mitotic cell cycle	5	2
GO:0008152	metabolic process	1	2
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	7
GO:0010212	response to ionizing radiation	4	2
GO:0010564	regulation of cell cycle process	5	7
GO:0010948	negative regulation of cell cycle process	6	7
GO:0022402	cell cycle process	2	2
GO:0031570	DNA integrity checkpoint signaling	5	7
GO:0031573	mitotic intra-S DNA damage checkpoint signaling	7	2
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0035556	intracellular signal transduction	3	7
GO:0042770	signal transduction in response to DNA damage	4	7
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044773	mitotic DNA damage checkpoint signaling	6	2
GO:0044774	mitotic DNA integrity checkpoint signaling	5	2
GO:0045786	negative regulation of cell cycle	5	7
GO:0045930	negative regulation of mitotic cell cycle	6	2
GO:0046483	heterocycle metabolic process	3	2
GO:0048519	negative regulation of biological process	3	7
GO:0048523	negative regulation of cellular process	4	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0051726	regulation of cell cycle	4	7
GO:0065007	biological regulation	1	7
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071478	cellular response to radiation	4	2
GO:0071479	cellular response to ionizing radiation	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0104004	cellular response to environmental stimulus	3	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901987	regulation of cell cycle phase transition	6	7
GO:1901988	negative regulation of cell cycle phase transition	7	7
GO:1903047	mitotic cell cycle process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.524
CLV_C14_Caspase3-7	253	257	PF00656	0.662
CLV_C14_Caspase3-7	408	412	PF00656	0.667
CLV_C14_Caspase3-7	797	801	PF00656	0.632
CLV_NRD_NRD_1	173	175	PF00675	0.658
CLV_NRD_NRD_1	449	451	PF00675	0.780
CLV_NRD_NRD_1	520	522	PF00675	0.588
CLV_NRD_NRD_1	63	65	PF00675	0.521
CLV_NRD_NRD_1	66	68	PF00675	0.514
CLV_NRD_NRD_1	726	728	PF00675	0.734
CLV_PCSK_FUR_1	64	68	PF00082	0.502
CLV_PCSK_KEX2_1	160	162	PF00082	0.361
CLV_PCSK_KEX2_1	173	175	PF00082	0.658
CLV_PCSK_KEX2_1	449	451	PF00082	0.780
CLV_PCSK_KEX2_1	519	521	PF00082	0.536
CLV_PCSK_KEX2_1	63	65	PF00082	0.519
CLV_PCSK_KEX2_1	66	68	PF00082	0.518
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.361
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.536
CLV_PCSK_PC7_1	59	65	PF00082	0.496
CLV_PCSK_SKI1_1	116	120	PF00082	0.472
CLV_PCSK_SKI1_1	165	169	PF00082	0.605
CLV_PCSK_SKI1_1	279	283	PF00082	0.493
CLV_PCSK_SKI1_1	480	484	PF00082	0.492
CLV_PCSK_SKI1_1	54	58	PF00082	0.520
CLV_PCSK_SKI1_1	544	548	PF00082	0.719
CLV_PCSK_SKI1_1	612	616	PF00082	0.793
CLV_PCSK_SKI1_1	67	71	PF00082	0.490
CLV_PCSK_SKI1_1	804	808	PF00082	0.578
DEG_APCC_DBOX_1	115	123	PF00400	0.460
DEG_Kelch_Keap1_1	634	639	PF01344	0.763
DEG_Nend_UBRbox_4	1	3	PF02207	0.450
DEG_SCF_FBW7_1	602	608	PF00400	0.710
DEG_SCF_FBW7_1	763	770	PF00400	0.699
DEG_SPOP_SBC_1	347	351	PF00917	0.656
DOC_CKS1_1	427	432	PF01111	0.695
DOC_CKS1_1	602	607	PF01111	0.708
DOC_CKS1_1	691	696	PF01111	0.726
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.518
DOC_MAPK_gen_1	83	91	PF00069	0.496
DOC_MAPK_MEF2A_6	150	158	PF00069	0.479
DOC_MAPK_RevD_3	507	521	PF00069	0.543
DOC_PP1_RVXF_1	726	733	PF00149	0.727
DOC_PP2B_LxvP_1	168	171	PF13499	0.627
DOC_PP2B_LxvP_1	331	334	PF13499	0.608
DOC_PP2B_LxvP_1	454	457	PF13499	0.721
DOC_PP2B_PxIxI_1	112	118	PF00149	0.590
DOC_PP4_FxxP_1	400	403	PF00568	0.531
DOC_SPAK_OSR1_1	305	309	PF12202	0.549
DOC_USP7_MATH_1	235	239	PF00917	0.706
DOC_USP7_MATH_1	245	249	PF00917	0.630
DOC_USP7_MATH_1	314	318	PF00917	0.504
DOC_USP7_MATH_1	347	351	PF00917	0.664
DOC_USP7_MATH_1	361	365	PF00917	0.718
DOC_USP7_MATH_1	372	376	PF00917	0.674
DOC_USP7_MATH_1	381	385	PF00917	0.413
DOC_USP7_MATH_1	390	394	PF00917	0.412
DOC_USP7_MATH_1	405	409	PF00917	0.672
DOC_USP7_MATH_1	459	463	PF00917	0.566
DOC_USP7_MATH_1	569	573	PF00917	0.553
DOC_USP7_MATH_1	579	583	PF00917	0.812
DOC_USP7_MATH_1	590	594	PF00917	0.679
DOC_USP7_MATH_1	597	601	PF00917	0.555
DOC_USP7_MATH_1	605	609	PF00917	0.658
DOC_USP7_MATH_1	644	648	PF00917	0.796
DOC_USP7_MATH_1	698	702	PF00917	0.766
DOC_USP7_MATH_1	71	75	PF00917	0.506
DOC_USP7_MATH_1	726	730	PF00917	0.724
DOC_USP7_MATH_1	742	746	PF00917	0.600
DOC_USP7_MATH_1	755	759	PF00917	0.769
DOC_USP7_MATH_1	761	765	PF00917	0.662
DOC_USP7_MATH_1	771	775	PF00917	0.552
DOC_USP7_MATH_1	812	816	PF00917	0.529
DOC_WW_Pin1_4	144	149	PF00397	0.498
DOC_WW_Pin1_4	403	408	PF00397	0.678
DOC_WW_Pin1_4	426	431	PF00397	0.721
DOC_WW_Pin1_4	444	449	PF00397	0.768
DOC_WW_Pin1_4	48	53	PF00397	0.486
DOC_WW_Pin1_4	510	515	PF00397	0.521
DOC_WW_Pin1_4	601	606	PF00397	0.732
DOC_WW_Pin1_4	624	629	PF00397	0.833
DOC_WW_Pin1_4	690	695	PF00397	0.729
DOC_WW_Pin1_4	696	701	PF00397	0.710
DOC_WW_Pin1_4	709	714	PF00397	0.500
DOC_WW_Pin1_4	759	764	PF00397	0.803
LIG_14-3-3_CanoR_1	103	107	PF00244	0.516
LIG_14-3-3_CanoR_1	272	278	PF00244	0.475
LIG_14-3-3_CanoR_1	520	529	PF00244	0.475
LIG_14-3-3_CanoR_1	606	614	PF00244	0.840
LIG_14-3-3_CanoR_1	727	731	PF00244	0.776
LIG_14-3-3_CanoR_1	785	793	PF00244	0.566
LIG_APCC_ABBA_1	90	95	PF00400	0.513
LIG_BIR_III_4	411	415	PF00653	0.731
LIG_BIR_III_4	719	723	PF00653	0.717
LIG_BRCT_BRCA1_1	104	108	PF00533	0.490
LIG_BRCT_BRCA1_1	226	230	PF00533	0.494
LIG_BRCT_BRCA1_1	728	732	PF00533	0.727
LIG_FHA_1	208	214	PF00498	0.578
LIG_FHA_1	282	288	PF00498	0.472
LIG_FHA_1	392	398	PF00498	0.599
LIG_FHA_1	474	480	PF00498	0.536
LIG_FHA_2	264	270	PF00498	0.514
LIG_FHA_2	330	336	PF00498	0.531
LIG_FHA_2	387	393	PF00498	0.620
LIG_FHA_2	408	414	PF00498	0.717
LIG_FHA_2	498	504	PF00498	0.568
LIG_FHA_2	511	517	PF00498	0.416
LIG_FHA_2	706	712	PF00498	0.714
LIG_GBD_Chelix_1	488	496	PF00786	0.490
LIG_LIR_Apic_2	689	694	PF02991	0.779
LIG_LIR_Gen_1	295	306	PF02991	0.597
LIG_LIR_Gen_1	392	403	PF02991	0.616
LIG_LIR_Gen_1	779	787	PF02991	0.565
LIG_LIR_Nem_3	295	301	PF02991	0.619
LIG_LIR_Nem_3	392	398	PF02991	0.599
LIG_LIR_Nem_3	466	472	PF02991	0.722
LIG_LIR_Nem_3	562	566	PF02991	0.572
LIG_LIR_Nem_3	779	783	PF02991	0.508
LIG_MYND_1	88	92	PF01753	0.509
LIG_Pex14_1	273	277	PF04695	0.464
LIG_Pex14_2	391	395	PF04695	0.518
LIG_PROFILIN_1	435	441	PF00235	0.560
LIG_SH2_CRK	315	319	PF00017	0.469
LIG_SH2_CRK	691	695	PF00017	0.718
LIG_SH2_NCK_1	787	791	PF00017	0.634
LIG_SH2_STAP1	277	281	PF00017	0.471
LIG_SH2_STAT5	133	136	PF00017	0.433
LIG_SH2_STAT5	205	208	PF00017	0.481
LIG_SH2_STAT5	566	569	PF00017	0.557
LIG_SH2_STAT5	787	790	PF00017	0.553
LIG_SH3_3	107	113	PF00018	0.592
LIG_SH3_3	424	430	PF00018	0.752
LIG_SH3_3	432	438	PF00018	0.647
LIG_SH3_3	550	556	PF00018	0.720
LIG_SH3_3	599	605	PF00018	0.707
LIG_SH3_3	65	71	PF00018	0.518
LIG_SH3_3	757	763	PF00018	0.696
LIG_SH3_3	86	92	PF00018	0.493
LIG_SUMO_SIM_anti_2	701	708	PF11976	0.830
LIG_SUMO_SIM_par_1	117	123	PF11976	0.516
LIG_SUMO_SIM_par_1	166	172	PF11976	0.551
LIG_SUMO_SIM_par_1	505	511	PF11976	0.482
LIG_SUMO_SIM_par_1	701	708	PF11976	0.732
LIG_TRAF2_1	500	503	PF00917	0.570
LIG_TRAF2_1	513	516	PF00917	0.446
MOD_CDC14_SPxK_1	147	150	PF00782	0.633
MOD_CDC14_SPxK_1	447	450	PF00782	0.771
MOD_CDK_SPK_2	444	449	PF00069	0.769
MOD_CDK_SPK_2	601	606	PF00069	0.732
MOD_CDK_SPK_2	690	695	PF00069	0.729
MOD_CDK_SPxK_1	144	150	PF00069	0.506
MOD_CDK_SPxK_1	444	450	PF00069	0.772
MOD_CDK_SPxK_1	48	54	PF00069	0.488
MOD_CDK_SPxxK_3	709	716	PF00069	0.718
MOD_CK1_1	120	126	PF00069	0.543
MOD_CK1_1	144	150	PF00069	0.506
MOD_CK1_1	172	178	PF00069	0.740
MOD_CK1_1	237	243	PF00069	0.707
MOD_CK1_1	321	327	PF00069	0.519
MOD_CK1_1	349	355	PF00069	0.772
MOD_CK1_1	37	43	PF00069	0.533
MOD_CK1_1	393	399	PF00069	0.526
MOD_CK1_1	452	458	PF00069	0.766
MOD_CK1_1	572	578	PF00069	0.646
MOD_CK1_1	593	599	PF00069	0.831
MOD_CK1_1	647	653	PF00069	0.832
MOD_CK1_1	662	668	PF00069	0.710
MOD_CK1_1	680	686	PF00069	0.721
MOD_CK2_1	329	335	PF00069	0.513
MOD_CK2_1	361	367	PF00069	0.802
MOD_CK2_1	386	392	PF00069	0.619
MOD_CK2_1	497	503	PF00069	0.561
MOD_CK2_1	510	516	PF00069	0.417
MOD_CK2_1	654	660	PF00069	0.828
MOD_CK2_1	7	13	PF00069	0.446
MOD_CK2_1	786	792	PF00069	0.720
MOD_GlcNHglycan	110	113	PF01048	0.492
MOD_GlcNHglycan	142	146	PF01048	0.473
MOD_GlcNHglycan	174	177	PF01048	0.718
MOD_GlcNHglycan	178	183	PF01048	0.725
MOD_GlcNHglycan	239	242	PF01048	0.726
MOD_GlcNHglycan	253	256	PF01048	0.529
MOD_GlcNHglycan	324	327	PF01048	0.541
MOD_GlcNHglycan	335	338	PF01048	0.571
MOD_GlcNHglycan	355	358	PF01048	0.469
MOD_GlcNHglycan	363	366	PF01048	0.666
MOD_GlcNHglycan	367	370	PF01048	0.712
MOD_GlcNHglycan	374	377	PF01048	0.685
MOD_GlcNHglycan	407	410	PF01048	0.699
MOD_GlcNHglycan	454	457	PF01048	0.760
MOD_GlcNHglycan	461	464	PF01048	0.633
MOD_GlcNHglycan	524	527	PF01048	0.632
MOD_GlcNHglycan	571	574	PF01048	0.470
MOD_GlcNHglycan	579	582	PF01048	0.711
MOD_GlcNHglycan	599	602	PF01048	0.501
MOD_GlcNHglycan	646	649	PF01048	0.859
MOD_GlcNHglycan	652	655	PF01048	0.753
MOD_GlcNHglycan	688	691	PF01048	0.839
MOD_GlcNHglycan	716	719	PF01048	0.754
MOD_GlcNHglycan	744	747	PF01048	0.782
MOD_GlcNHglycan	755	758	PF01048	0.782
MOD_GlcNHglycan	788	791	PF01048	0.644
MOD_GlcNHglycan	95	99	PF01048	0.687
MOD_GSK3_1	102	109	PF00069	0.326
MOD_GSK3_1	17	24	PF00069	0.558
MOD_GSK3_1	178	185	PF00069	0.729
MOD_GSK3_1	209	216	PF00069	0.444
MOD_GSK3_1	220	227	PF00069	0.545
MOD_GSK3_1	231	238	PF00069	0.495
MOD_GSK3_1	273	280	PF00069	0.464
MOD_GSK3_1	314	321	PF00069	0.489
MOD_GSK3_1	329	336	PF00069	0.523
MOD_GSK3_1	346	353	PF00069	0.671
MOD_GSK3_1	35	42	PF00069	0.499
MOD_GSK3_1	361	368	PF00069	0.673
MOD_GSK3_1	382	389	PF00069	0.599
MOD_GSK3_1	403	410	PF00069	0.677
MOD_GSK3_1	459	466	PF00069	0.720
MOD_GSK3_1	531	538	PF00069	0.781
MOD_GSK3_1	589	596	PF00069	0.728
MOD_GSK3_1	597	604	PF00069	0.706
MOD_GSK3_1	606	613	PF00069	0.655
MOD_GSK3_1	643	650	PF00069	0.733
MOD_GSK3_1	659	666	PF00069	0.715
MOD_GSK3_1	686	693	PF00069	0.691
MOD_GSK3_1	694	701	PF00069	0.625
MOD_GSK3_1	705	712	PF00069	0.548
MOD_GSK3_1	755	762	PF00069	0.695
MOD_GSK3_1	763	770	PF00069	0.624
MOD_GSK3_1	806	813	PF00069	0.564
MOD_N-GLC_1	251	256	PF02516	0.628
MOD_N-GLC_1	648	653	PF02516	0.759
MOD_N-GLC_1	683	688	PF02516	0.826
MOD_N-GLC_2	327	329	PF02516	0.603
MOD_NEK2_1	106	111	PF00069	0.477
MOD_NEK2_1	209	214	PF00069	0.446
MOD_NEK2_1	281	286	PF00069	0.601
MOD_NEK2_1	318	323	PF00069	0.491
MOD_NEK2_1	36	41	PF00069	0.504
MOD_NEK2_1	391	396	PF00069	0.613
MOD_NEK2_1	546	551	PF00069	0.629
MOD_NEK2_1	663	668	PF00069	0.782
MOD_NEK2_1	705	710	PF00069	0.832
MOD_NEK2_1	783	788	PF00069	0.555
MOD_NEK2_1	806	811	PF00069	0.551
MOD_NEK2_2	771	776	PF00069	0.767
MOD_PK_1	449	455	PF00069	0.772
MOD_PKA_1	449	455	PF00069	0.772
MOD_PKA_2	102	108	PF00069	0.332
MOD_PKA_2	172	178	PF00069	0.736
MOD_PKA_2	365	371	PF00069	0.808
MOD_PKA_2	449	455	PF00069	0.772
MOD_PKA_2	577	583	PF00069	0.822
MOD_PKA_2	605	611	PF00069	0.736
MOD_PKA_2	677	683	PF00069	0.751
MOD_PKA_2	694	700	PF00069	0.817
MOD_PKA_2	726	732	PF00069	0.728
MOD_Plk_1	141	147	PF00069	0.471
MOD_Plk_1	299	305	PF00069	0.593
MOD_Plk_1	391	397	PF00069	0.607
MOD_Plk_1	590	596	PF00069	0.810
MOD_Plk_1	659	665	PF00069	0.817
MOD_Plk_1	683	689	PF00069	0.831
MOD_Plk_4	117	123	PF00069	0.383
MOD_Plk_4	209	215	PF00069	0.437
MOD_Plk_4	281	287	PF00069	0.463
MOD_Plk_4	293	299	PF00069	0.515
MOD_Plk_4	314	320	PF00069	0.485
MOD_Plk_4	383	389	PF00069	0.561
MOD_Plk_4	449	455	PF00069	0.772
MOD_Plk_4	771	777	PF00069	0.765
MOD_ProDKin_1	144	150	PF00069	0.506
MOD_ProDKin_1	403	409	PF00069	0.683
MOD_ProDKin_1	426	432	PF00069	0.718
MOD_ProDKin_1	444	450	PF00069	0.770
MOD_ProDKin_1	48	54	PF00069	0.488
MOD_ProDKin_1	510	516	PF00069	0.519
MOD_ProDKin_1	601	607	PF00069	0.730
MOD_ProDKin_1	624	630	PF00069	0.830
MOD_ProDKin_1	690	696	PF00069	0.725
MOD_ProDKin_1	709	715	PF00069	0.501
MOD_ProDKin_1	759	765	PF00069	0.803
TRG_DiLeu_BaEn_2	801	807	PF01217	0.585
TRG_DiLeu_BaEn_3	502	508	PF01217	0.526
TRG_ENDOCYTIC_2	205	208	PF00928	0.486
TRG_ENDOCYTIC_2	298	301	PF00928	0.602
TRG_ENDOCYTIC_2	315	318	PF00928	0.308
TRG_ER_diArg_1	448	450	PF00400	0.773
TRG_ER_diArg_1	520	522	PF00400	0.588
TRG_ER_diArg_1	63	66	PF00400	0.521
TRG_Pf-PMV_PEXEL_1	165	169	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	612	617	PF00026	0.767

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I126	Leptomonas seymouri	45%	100%
A0A3Q8IIS7	Leishmania donovani	90%	100%
A4H871	Leishmania braziliensis	73%	100%
A4HWJ6	Leishmania infantum	86%	95%
E9AQ97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%