Ribosomal protein L6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L6, putative

Species:

Leishmania major

UniProt:

Q4QF84_LEIMA

TriTrypDb:

LmjF.15.1000 , LMJLV39_150017000 , LMJSD75_150017000

Length:

195

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	3
GO:0022625	cytosolic large ribosomal subunit	5	3
GO:0032991	protein-containing complex	1	17
GO:0044391	ribosomal subunit	3	3
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	15
GO:0005840	ribosome	5	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14

Expansion

Sequence features

Q4QF84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF84

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	3
GO:0002181	cytoplasmic translation	5	3
GO:0006412	translation	4	17
GO:0006518	peptide metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009058	biosynthetic process	2	17
GO:0009059	macromolecule biosynthetic process	4	17
GO:0009987	cellular process	1	17
GO:0016043	cellular component organization	3	3
GO:0019538	protein metabolic process	3	17
GO:0022607	cellular component assembly	4	3
GO:0022618	ribonucleoprotein complex assembly	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	17
GO:0043043	peptide biosynthetic process	5	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043603	amide metabolic process	3	17
GO:0043604	amide biosynthetic process	4	17
GO:0043933	protein-containing complex organization	4	3
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0044249	cellular biosynthetic process	3	17
GO:0044260	obsolete cellular macromolecule metabolic process	3	17
GO:0044271	cellular nitrogen compound biosynthetic process	4	17
GO:0065003	protein-containing complex assembly	5	3
GO:0071704	organic substance metabolic process	2	17
GO:0071826	ribonucleoprotein complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1901564	organonitrogen compound metabolic process	3	17
GO:1901566	organonitrogen compound biosynthetic process	4	17
GO:1901576	organic substance biosynthetic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.666
CLV_NRD_NRD_1	20	22	PF00675	0.583
CLV_NRD_NRD_1	29	31	PF00675	0.520
CLV_NRD_NRD_1	49	51	PF00675	0.553
CLV_NRD_NRD_1	77	79	PF00675	0.306
CLV_PCSK_FUR_1	47	51	PF00082	0.553
CLV_PCSK_KEX2_1	12	14	PF00082	0.734
CLV_PCSK_KEX2_1	49	51	PF00082	0.548
CLV_PCSK_KEX2_1	77	79	PF00082	0.306
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.734
CLV_PCSK_PC7_1	45	51	PF00082	0.546
CLV_PCSK_SKI1_1	132	136	PF00082	0.337
CLV_PCSK_SKI1_1	14	18	PF00082	0.642
CLV_PCSK_SKI1_1	179	183	PF00082	0.363
DEG_SPOP_SBC_1	86	90	PF00917	0.483
DOC_MAPK_gen_1	45	54	PF00069	0.547
DOC_MAPK_RevD_3	63	78	PF00069	0.577
DOC_PP4_FxxP_1	106	109	PF00568	0.515
DOC_USP7_MATH_1	114	118	PF00917	0.582
DOC_USP7_MATH_1	3	7	PF00917	0.684
DOC_USP7_UBL2_3	125	129	PF12436	0.520
DOC_USP7_UBL2_3	132	136	PF12436	0.494
DOC_USP7_UBL2_3	139	143	PF12436	0.467
DOC_USP7_UBL2_3	14	18	PF12436	0.649
DOC_WW_Pin1_4	20	25	PF00397	0.650
LIG_14-3-3_CanoR_1	179	185	PF00244	0.598
LIG_14-3-3_CanoR_1	30	38	PF00244	0.578
LIG_BIR_II_1	1	5	PF00653	0.724
LIG_BIR_III_4	168	172	PF00653	0.602
LIG_FHA_1	88	94	PF00498	0.528
LIG_FHA_1	96	102	PF00498	0.488
LIG_FHA_2	113	119	PF00498	0.611
LIG_FHA_2	87	93	PF00498	0.506
LIG_LIR_Apic_2	104	109	PF02991	0.515
LIG_LIR_Gen_1	23	34	PF02991	0.698
LIG_LIR_Nem_3	23	29	PF02991	0.636
LIG_SH2_CRK	26	30	PF00017	0.672
LIG_SH2_CRK	71	75	PF00017	0.506
LIG_SH2_SRC	83	86	PF00017	0.506
LIG_SH2_STAT5	177	180	PF00017	0.506
LIG_SH2_STAT5	26	29	PF00017	0.740
LIG_SH2_STAT5	83	86	PF00017	0.506
LIG_SH3_3	62	68	PF00018	0.682
LIG_SUMO_SIM_par_1	61	66	PF11976	0.542
LIG_SUMO_SIM_par_1	87	95	PF11976	0.465
LIG_UBA3_1	161	167	PF00899	0.506
MOD_CK1_1	180	186	PF00069	0.506
MOD_CK1_1	20	26	PF00069	0.615
MOD_CK1_1	6	12	PF00069	0.688
MOD_CK1_1	95	101	PF00069	0.515
MOD_CK2_1	112	118	PF00069	0.521
MOD_Cter_Amidation	140	143	PF01082	0.351
MOD_Cter_Amidation	47	50	PF01082	0.562
MOD_GlcNHglycan	5	8	PF01048	0.664
MOD_GlcNHglycan	65	68	PF01048	0.558
MOD_GSK3_1	20	27	PF00069	0.641
MOD_GSK3_1	87	94	PF00069	0.535
MOD_GSK3_1	95	102	PF00069	0.491
MOD_NEK2_1	1	6	PF00069	0.747
MOD_NEK2_1	29	34	PF00069	0.682
MOD_NEK2_1	63	68	PF00069	0.539
MOD_NEK2_2	177	182	PF00069	0.506
MOD_PKA_1	135	141	PF00069	0.563
MOD_PKA_1	17	23	PF00069	0.663
MOD_PKA_2	29	35	PF00069	0.634
MOD_Plk_1	24	30	PF00069	0.660
MOD_Plk_1	91	97	PF00069	0.553
MOD_Plk_2-3	92	98	PF00069	0.580
MOD_Plk_4	141	147	PF00069	0.589
MOD_ProDKin_1	20	26	PF00069	0.653
MOD_SUMO_for_1	109	112	PF00179	0.508
MOD_SUMO_for_1	128	131	PF00179	0.595
TRG_ENDOCYTIC_2	26	29	PF00928	0.676
TRG_ENDOCYTIC_2	71	74	PF00928	0.506
TRG_ER_diArg_1	46	49	PF00400	0.537
TRG_ER_diArg_1	76	78	PF00400	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT06	Leptomonas seymouri	91%	100%
A0A0S4JL50	Bodo saltans	74%	98%
A0A0S4JLI9	Bodo saltans	74%	98%
A0A1D8PCX8	Candida albicans (strain SC5314 / ATCC MYA-2876)	45%	100%
A0A1X0NVD8	Trypanosomatidae	78%	100%
A0A1X0P118	Trypanosomatidae	79%	99%
A0A3Q8IAA6	Leishmania donovani	96%	100%
A0A3R7KR31	Trypanosoma rangeli	77%	100%
A0A3R7LKV1	Trypanosoma rangeli	77%	100%
A4H873	Leishmania braziliensis	95%	100%
A4HLB2	Leishmania braziliensis	93%	100%
A4HWJ8	Leishmania infantum	96%	100%
D0A4T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9AQ99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9B3Q4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P05739	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P0DJ56	Tetrahymena thermophila (strain SB210)	42%	100%
P34091	Mesembryanthemum crystallinum	39%	83%
P47991	Caenorhabditis elegans	39%	90%
P79071	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	41%	100%
Q02326	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q02878	Homo sapiens	40%	68%
Q2YGT9	Sus scrofa	40%	69%
Q4Q4D3	Leishmania major	99%	100%
Q54D63	Dictyostelium discoideum	43%	83%
Q58DQ3	Bos taurus	39%	68%
Q6QMZ4	Chinchilla lanigera	39%	68%
Q9C9C5	Arabidopsis thaliana	38%	84%
Q9C9C6	Arabidopsis thaliana	38%	84%