LeishMANIAdb
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Putative solanesyl-diphosphate synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative solanesyl-diphosphate synthase
Gene product:
solanesyl-diphosphate synthase, putative
Species:
Leishmania major
UniProt:
Q4QF82_LEIMA
TriTrypDb:
LmjF.15.1020 , LMJLV39_150017200 , LMJSD75_150017200 *
Length:
359

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005777 peroxisome 6 2
GO:0020015 glycosome 7 2
GO:0032991 protein-containing complex 1 2
GO:0042579 microbody 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2
GO:1902494 catalytic complex 2 2
GO:1990234 transferase complex 3 2

Expansion

Sequence features

Q4QF82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF82

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 11
GO:0006720 isoprenoid metabolic process 4 11
GO:0006743 ubiquinone metabolic process 5 2
GO:0006744 ubiquinone biosynthetic process 6 2
GO:0008152 metabolic process 1 11
GO:0008299 isoprenoid biosynthetic process 4 11
GO:0008610 lipid biosynthetic process 4 11
GO:0009058 biosynthetic process 2 11
GO:0009987 cellular process 1 11
GO:0042180 cellular ketone metabolic process 3 2
GO:0042181 ketone biosynthetic process 4 2
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044255 cellular lipid metabolic process 3 11
GO:0044281 small molecule metabolic process 2 2
GO:0044283 small molecule biosynthetic process 3 2
GO:0071704 organic substance metabolic process 2 11
GO:1901576 organic substance biosynthetic process 3 11
GO:1901661 quinone metabolic process 4 2
GO:1901663 quinone biosynthetic process 5 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 11
GO:0004659 prenyltransferase activity 4 3
GO:0016740 transferase activity 2 11
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups 3 3
GO:0052924 all-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific) activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.321
CLV_NRD_NRD_1 136 138 PF00675 0.306
CLV_NRD_NRD_1 285 287 PF00675 0.361
CLV_NRD_NRD_1 296 298 PF00675 0.268
CLV_NRD_NRD_1 356 358 PF00675 0.612
CLV_PCSK_KEX2_1 136 138 PF00082 0.313
CLV_PCSK_KEX2_1 149 151 PF00082 0.313
CLV_PCSK_KEX2_1 285 287 PF00082 0.372
CLV_PCSK_KEX2_1 296 298 PF00082 0.271
CLV_PCSK_PC1ET2_1 149 151 PF00082 0.332
CLV_PCSK_SKI1_1 139 143 PF00082 0.334
CLV_PCSK_SKI1_1 150 154 PF00082 0.278
CLV_PCSK_SKI1_1 286 290 PF00082 0.356
CLV_PCSK_SKI1_1 33 37 PF00082 0.390
CLV_PCSK_SKI1_1 344 348 PF00082 0.507
CLV_PCSK_SKI1_1 59 63 PF00082 0.332
CLV_PCSK_SKI1_1 70 74 PF00082 0.330
CLV_TASPASE1 192 198 PF01112 0.332
DEG_APCC_DBOX_1 138 146 PF00400 0.386
DEG_APCC_DBOX_1 328 336 PF00400 0.461
DEG_APCC_DBOX_1 69 77 PF00400 0.313
DEG_Nend_Nbox_1 1 3 PF02207 0.551
DOC_CDC14_PxL_1 275 283 PF14671 0.332
DOC_CYCLIN_yCln2_LP_2 68 74 PF00134 0.373
DOC_MAPK_gen_1 67 76 PF00069 0.425
DOC_MAPK_MEF2A_6 67 75 PF00069 0.380
DOC_PP2B_LxvP_1 169 172 PF13499 0.332
DOC_PP2B_PxIxI_1 171 177 PF00149 0.356
DOC_PP4_FxxP_1 197 200 PF00568 0.425
DOC_PP4_FxxP_1 298 301 PF00568 0.290
DOC_USP7_MATH_1 160 164 PF00917 0.313
DOC_USP7_MATH_1 346 350 PF00917 0.537
DOC_USP7_MATH_1 94 98 PF00917 0.346
DOC_USP7_UBL2_3 205 209 PF12436 0.313
DOC_USP7_UBL2_3 261 265 PF12436 0.313
DOC_WW_Pin1_4 338 343 PF00397 0.422
DOC_WW_Pin1_4 99 104 PF00397 0.364
LIG_14-3-3_CanoR_1 161 165 PF00244 0.332
LIG_14-3-3_CterR_2 357 359 PF00244 0.644
LIG_Clathr_ClatBox_1 190 194 PF01394 0.386
LIG_FHA_1 114 120 PF00498 0.313
LIG_FHA_1 166 172 PF00498 0.359
LIG_FHA_1 177 183 PF00498 0.277
LIG_FHA_1 208 214 PF00498 0.313
LIG_FHA_1 219 225 PF00498 0.313
LIG_FHA_1 275 281 PF00498 0.332
LIG_FHA_2 178 184 PF00498 0.313
LIG_FHA_2 233 239 PF00498 0.434
LIG_FHA_2 255 261 PF00498 0.313
LIG_FHA_2 47 53 PF00498 0.577
LIG_LIR_Apic_2 194 200 PF02991 0.425
LIG_LIR_Gen_1 27 35 PF02991 0.454
LIG_LIR_Nem_3 27 31 PF02991 0.461
LIG_PCNA_yPIPBox_3 285 294 PF02747 0.452
LIG_SH2_STAT5 165 168 PF00017 0.439
LIG_SH2_STAT5 60 63 PF00017 0.334
LIG_SUMO_SIM_par_1 173 180 PF11976 0.314
LIG_SUMO_SIM_par_1 82 87 PF11976 0.458
LIG_TRAF2_1 181 184 PF00917 0.425
MOD_CDC14_SPxK_1 341 344 PF00782 0.408
MOD_CDK_SPxK_1 338 344 PF00069 0.418
MOD_CK1_1 217 223 PF00069 0.334
MOD_CK1_1 349 355 PF00069 0.500
MOD_CK1_1 44 50 PF00069 0.568
MOD_CK2_1 177 183 PF00069 0.313
MOD_CK2_1 254 260 PF00069 0.332
MOD_CK2_1 46 52 PF00069 0.576
MOD_CK2_1 94 100 PF00069 0.377
MOD_GlcNHglycan 186 189 PF01048 0.402
MOD_GlcNHglycan 348 351 PF01048 0.573
MOD_GlcNHglycan 85 89 PF01048 0.382
MOD_GSK3_1 203 210 PF00069 0.317
MOD_GSK3_1 214 221 PF00069 0.262
MOD_NEK2_1 118 123 PF00069 0.313
MOD_NEK2_1 177 182 PF00069 0.320
MOD_NEK2_1 2 7 PF00069 0.657
MOD_NEK2_1 207 212 PF00069 0.361
MOD_NEK2_1 218 223 PF00069 0.250
MOD_NEK2_1 232 237 PF00069 0.438
MOD_NEK2_1 84 89 PF00069 0.439
MOD_NEK2_2 160 165 PF00069 0.425
MOD_NEK2_2 331 336 PF00069 0.478
MOD_PKA_2 160 166 PF00069 0.313
MOD_Plk_1 232 238 PF00069 0.438
MOD_Plk_1 33 39 PF00069 0.488
MOD_Plk_4 102 108 PF00069 0.412
MOD_Plk_4 120 126 PF00069 0.181
MOD_Plk_4 160 166 PF00069 0.313
MOD_Plk_4 209 215 PF00069 0.313
MOD_Plk_4 349 355 PF00069 0.532
MOD_Plk_4 41 47 PF00069 0.514
MOD_ProDKin_1 338 344 PF00069 0.418
MOD_ProDKin_1 99 105 PF00069 0.364
MOD_SUMO_rev_2 198 207 PF00179 0.313
MOD_SUMO_rev_2 255 263 PF00179 0.313
TRG_DiLeu_BaEn_1 114 119 PF01217 0.313
TRG_ER_diArg_1 136 139 PF00400 0.387
TRG_ER_diArg_1 296 298 PF00400 0.313
TRG_NES_CRM1_1 189 203 PF08389 0.313

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0A7GEY4 Geoglobus acetivorans 28% 100%
A0A0N1IHA0 Leptomonas seymouri 84% 100%
A0A0U3BRC5 Leucosceptrum canum 28% 99%
A0A1X0NU81 Trypanosomatidae 66% 100%
A0A2I6PJ05 Hypoxylon pulicicidum 27% 93%
A0A343W970 Murgantia histrionica 29% 89%
A0A386JVA3 Nezara viridula 28% 89%
A0A3Q8IA74 Leishmania donovani 97% 100%
A0A422N164 Trypanosoma rangeli 68% 100%
A0A7D0AGU9 Matsumurasca onukii 25% 100%
A4H875 Leishmania braziliensis 87% 100%
A4HWK0 Leishmania infantum 97% 100%
B1XJV9 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) 33% 100%
C9ZXT9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AQA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O05572 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 30% 100%
O06428 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 31% 100%
O22043 Arabidopsis thaliana 26% 100%
O24743 Rhodobacter capsulatus 32% 100%
O26156 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 30% 100%
O43091 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 95%
O50410 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 29% 100%
O66126 Micrococcus luteus 32% 100%
O66129 Micrococcus luteus 31% 100%
O66952 Aquifex aeolicus (strain VF5) 28% 100%
P0AD57 Escherichia coli (strain K12) 30% 100%
P0AD58 Shigella flexneri 30% 100%
P18900 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 32% 76%
P22873 Pseudescherichia vulneris 28% 100%
P22939 Escherichia coli (strain K12) 28% 100%
P31114 Bacillus subtilis (strain 168) 28% 100%
P31171 Cyanophora paradoxa 34% 100%
P34802 Arabidopsis thaliana 30% 97%
P39464 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 28% 100%
P44916 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 30% 100%
P45204 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 31% 100%
P48368 Cyanophora paradoxa 32% 100%
P51268 Porphyra purpurea 35% 100%
P54383 Bacillus subtilis (strain 168) 33% 100%
P55785 Geobacillus stearothermophilus 32% 100%
P72580 Synechocystis sp. (strain PCC 6803 / Kazusa) 34% 100%
P80042 Capsicum annuum 32% 97%
P95999 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 27% 100%
Q08291 Geobacillus stearothermophilus 32% 100%
Q0INZ4 Oryza sativa subsp. japonica 35% 87%
Q1XDL8 Neopyropia yezoensis 35% 100%
Q33DR2 Mus musculus 34% 88%
Q33DR3 Mus musculus 27% 90%
Q3IPL1 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 30% 100%
Q42698 Catharanthus roseus 32% 100%
Q43133 Sinapis alba 29% 98%
Q53479 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) 30% 100%
Q54VJ9 Dictyostelium discoideum 38% 79%
Q56RZ3 Epichloe festucae (strain Fl1) 22% 100%
Q56RZ7 Epichloe festucae var. lolii 22% 100%
Q58270 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 30% 100%
Q5HZ00 Arabidopsis thaliana 36% 85%
Q5T2R2 Homo sapiens 34% 87%
Q5U2R1 Rattus norvegicus 27% 90%
Q653T6 Oryza sativa subsp. japonica 37% 83%
Q6CBH3 Yarrowia lipolytica (strain CLIB 122 / E 150) 32% 79%
Q75HZ9 Oryza sativa subsp. japonica 35% 89%
Q76FS5 Arabidopsis thaliana 36% 86%
Q7S565 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 36% 80%
Q86YH6 Homo sapiens 26% 90%
Q8K9A0 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 25% 100%
Q8PW34 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 28% 100%
Q8S948 Arabidopsis thaliana 38% 88%
Q92236 Gibberella fujikuroi 23% 86%
Q94ID7 Hevea brasiliensis 29% 97%
Q9LHR4 Arabidopsis thaliana 28% 100%
Q9LIA0 Arabidopsis thaliana 27% 100%
Q9LRR0 Arabidopsis thaliana 29% 99%
Q9LUD9 Arabidopsis thaliana 30% 100%
Q9LUE1 Arabidopsis thaliana 29% 100%
Q9SLG2 Arabidopsis thaliana 28% 97%
Q9TLS1 Cyanidium caldarium 33% 100%
Q9UWR6 Aeropyrum pernix 28% 100%
Q9ZU77 Arabidopsis thaliana 29% 100%
V5DL68 Trypanosoma cruzi 63% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS