SKIP_SNW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SKIP/SNW domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QF81_LEIMA

TriTrypDb:

LmjF.15.1030 , LMJLV39_150017300 , LMJSD75_150017300

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0140513	nuclear protein-containing complex	2	8
GO:1990904	ribonucleoprotein complex	2	8

Expansion

Sequence features

Q4QF81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF81

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	8
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	8
GO:0000398	mRNA splicing, via spliceosome	8	8
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006396	RNA processing	6	8
GO:0006397	mRNA processing	7	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0008380	RNA splicing	7	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0016071	mRNA metabolic process	6	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0046483	heterocycle metabolic process	3	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.572
CLV_C14_Caspase3-7	51	55	PF00656	0.564
CLV_NRD_NRD_1	138	140	PF00675	0.277
CLV_NRD_NRD_1	152	154	PF00675	0.211
CLV_NRD_NRD_1	213	215	PF00675	0.266
CLV_NRD_NRD_1	243	245	PF00675	0.473
CLV_NRD_NRD_1	353	355	PF00675	0.545
CLV_PCSK_KEX2_1	213	215	PF00082	0.266
CLV_PCSK_KEX2_1	243	245	PF00082	0.520
CLV_PCSK_SKI1_1	227	231	PF00082	0.402
CLV_PCSK_SKI1_1	265	269	PF00082	0.458
CLV_PCSK_SKI1_1	276	280	PF00082	0.432
CLV_PCSK_SKI1_1	419	423	PF00082	0.504
CLV_PCSK_SKI1_1	72	76	PF00082	0.546
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SPOP_SBC_1	108	112	PF00917	0.534
DOC_CYCLIN_RxL_1	224	231	PF00134	0.245
DOC_MAPK_gen_1	139	145	PF00069	0.268
DOC_MAPK_gen_1	153	160	PF00069	0.213
DOC_MAPK_gen_1	243	254	PF00069	0.441
DOC_MAPK_gen_1	274	283	PF00069	0.436
DOC_MAPK_HePTP_8	273	285	PF00069	0.435
DOC_MAPK_MEF2A_6	153	160	PF00069	0.248
DOC_MAPK_MEF2A_6	247	256	PF00069	0.363
DOC_MAPK_MEF2A_6	276	285	PF00069	0.437
DOC_PP2B_LxvP_1	156	159	PF13499	0.245
DOC_USP7_MATH_1	109	113	PF00917	0.685
DOC_USP7_MATH_1	119	123	PF00917	0.508
DOC_USP7_MATH_1	132	136	PF00917	0.472
DOC_USP7_MATH_1	22	26	PF00917	0.524
DOC_USP7_MATH_1	46	50	PF00917	0.627
DOC_USP7_UBL2_3	203	207	PF12436	0.294
DOC_USP7_UBL2_3	419	423	PF12436	0.504
DOC_WW_Pin1_4	63	68	PF00397	0.538
LIG_14-3-3_CanoR_1	10	16	PF00244	0.512
LIG_14-3-3_CanoR_1	280	286	PF00244	0.400
LIG_14-3-3_CanoR_1	65	75	PF00244	0.468
LIG_Actin_WH2_2	281	298	PF00022	0.387
LIG_APCC_ABBAyCdc20_2	71	77	PF00400	0.508
LIG_FHA_1	10	16	PF00498	0.538
LIG_FHA_1	74	80	PF00498	0.548
LIG_FHA_2	282	288	PF00498	0.411
LIG_FHA_2	49	55	PF00498	0.559
LIG_SH3_3	138	144	PF00018	0.294
LIG_SH3_3	61	67	PF00018	0.537
LIG_TRAF2_1	208	211	PF00917	0.294
LIG_TRAF2_1	297	300	PF00917	0.469
MOD_CK1_1	112	118	PF00069	0.559
MOD_CK1_1	122	128	PF00069	0.527
MOD_CK1_1	31	37	PF00069	0.632
MOD_CK1_1	66	72	PF00069	0.583
MOD_CK1_1	73	79	PF00069	0.524
MOD_CK2_1	294	300	PF00069	0.400
MOD_CK2_1	319	325	PF00069	0.560
MOD_GlcNHglycan	101	104	PF01048	0.521
MOD_GlcNHglycan	111	114	PF01048	0.601
MOD_GlcNHglycan	124	127	PF01048	0.513
MOD_GlcNHglycan	134	137	PF01048	0.231
MOD_GlcNHglycan	175	178	PF01048	0.200
MOD_GlcNHglycan	28	31	PF01048	0.650
MOD_GlcNHglycan	306	309	PF01048	0.519
MOD_GlcNHglycan	313	316	PF01048	0.543
MOD_GlcNHglycan	332	335	PF01048	0.541
MOD_GlcNHglycan	399	405	PF01048	0.533
MOD_GlcNHglycan	82	85	PF01048	0.643
MOD_GSK3_1	107	114	PF00069	0.572
MOD_GSK3_1	22	29	PF00069	0.586
MOD_GSK3_1	311	318	PF00069	0.622
MOD_GSK3_1	326	333	PF00069	0.588
MOD_GSK3_1	346	353	PF00069	0.580
MOD_GSK3_1	66	73	PF00069	0.514
MOD_GSK3_1	80	87	PF00069	0.481
MOD_N-GLC_1	281	286	PF02516	0.445
MOD_N-GLC_1	31	36	PF02516	0.499
MOD_NEK2_1	107	112	PF00069	0.625
MOD_NEK2_1	145	150	PF00069	0.294
MOD_NEK2_1	2	7	PF00069	0.532
MOD_NEK2_1	330	335	PF00069	0.517
MOD_NEK2_1	39	44	PF00069	0.534
MOD_NEK2_1	80	85	PF00069	0.528
MOD_NEK2_2	119	124	PF00069	0.458
MOD_PIKK_1	33	39	PF00454	0.519
MOD_PKA_1	243	249	PF00069	0.455
MOD_PKA_2	243	249	PF00069	0.503
MOD_PKA_2	85	91	PF00069	0.580
MOD_PKA_2	9	15	PF00069	0.507
MOD_PKB_1	26	34	PF00069	0.532
MOD_PKB_1	274	282	PF00069	0.437
MOD_Plk_1	281	287	PF00069	0.444
MOD_Plk_1	299	305	PF00069	0.465
MOD_Plk_4	112	118	PF00069	0.536
MOD_Plk_4	299	305	PF00069	0.436
MOD_Plk_4	70	76	PF00069	0.551
MOD_ProDKin_1	63	69	PF00069	0.533
MOD_SUMO_for_1	206	209	PF00179	0.294
MOD_SUMO_rev_2	66	74	PF00179	0.517
TRG_ER_diArg_1	252	255	PF00400	0.410
TRG_ER_diArg_1	394	397	PF00400	0.615
TRG_ER_diLys_1	422	427	PF00400	0.552
TRG_NLS_Bipartite_1	139	157	PF00514	0.294
TRG_NLS_MonoExtC_3	421	426	PF00514	0.550
TRG_NLS_MonoExtN_4	419	426	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.402
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0X6	Leptomonas seymouri	62%	77%
A0A1X0NU15	Trypanosomatidae	46%	93%
A0A3S7WTI8	Leishmania donovani	94%	100%
A4H876	Leishmania braziliensis	84%	100%
A4HWK1	Leishmania infantum	94%	100%
E9AQA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%