LeishMANIAdb
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Putative developmentally regulated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Putative developmentally regulated protein
Gene product:
developmentally regulated protein, putative
Species:
Leishmania major
UniProt:
Q4QF77_LEIMA
TriTrypDb:
LmjF.15.1050 , LMJLV39_150017400 , LMJSD75_150017600
Length:
116

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

Q4QF77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF77

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.426
CLV_NRD_NRD_1 15 17 PF00675 0.399
CLV_PCSK_KEX2_1 11 13 PF00082 0.414
CLV_PCSK_PC1ET2_1 11 13 PF00082 0.465
DOC_CYCLIN_RxL_1 82 92 PF00134 0.501
DOC_MAPK_gen_1 22 31 PF00069 0.484
DOC_PP2B_LxvP_1 63 66 PF13499 0.493
DOC_PP4_FxxP_1 58 61 PF00568 0.458
DOC_USP7_UBL2_3 13 17 PF12436 0.671
LIG_14-3-3_CanoR_1 25 30 PF00244 0.313
LIG_BRCT_BRCA1_1 27 31 PF00533 0.352
LIG_Clathr_ClatBox_1 40 44 PF01394 0.297
LIG_MYND_1 62 66 PF01753 0.477
LIG_Pex14_2 31 35 PF04695 0.369
LIG_SH2_STAT5 45 48 PF00017 0.387
LIG_SH3_3 64 70 PF00018 0.426
LIG_SUMO_SIM_anti_2 38 44 PF11976 0.420
LIG_SUMO_SIM_par_1 38 44 PF11976 0.420
LIG_WW_2 67 70 PF00397 0.481
MOD_CK1_1 76 82 PF00069 0.499
MOD_GlcNHglycan 99 102 PF01048 0.688
MOD_GSK3_1 47 54 PF00069 0.421
MOD_GSK3_1 69 76 PF00069 0.485
MOD_N-GLC_1 51 56 PF02516 0.654
MOD_NEK2_1 35 40 PF00069 0.384
MOD_NEK2_1 73 78 PF00069 0.515
MOD_PKA_2 47 53 PF00069 0.387
MOD_Plk_4 35 41 PF00069 0.350
MOD_SUMO_rev_2 100 108 PF00179 0.501
TRG_DiLeu_BaLyEn_6 59 64 PF01217 0.392
TRG_NES_CRM1_1 80 92 PF08389 0.442
TRG_NLS_MonoExtN_4 13 20 PF00514 0.679

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY72 Leptomonas seymouri 70% 100%
A0A0S4J4H2 Bodo saltans 50% 98%
A0A1X0NDM1 Trypanosomatidae 55% 100%
A0A3Q8IA45 Leishmania donovani 95% 100%
A4H878 Leishmania braziliensis 88% 100%
A4HWK4 Leishmania infantum 95% 100%
C9ZXT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 54% 100%
E9AQA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AQA5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 69%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS