Putative developmentally regulated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

developmentally regulated protein, putative

Species:

Leishmania major

UniProt:

Q4QF77_LEIMA

TriTrypDb:

LmjF.15.1050 , LMJLV39_150017400 , LMJSD75_150017600

Length:

116

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

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Expansion

Sequence features

Q4QF77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF77

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.426
CLV_NRD_NRD_1	15	17	PF00675	0.399
CLV_PCSK_KEX2_1	11	13	PF00082	0.414
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.465
DOC_CYCLIN_RxL_1	82	92	PF00134	0.501
DOC_MAPK_gen_1	22	31	PF00069	0.484
DOC_PP2B_LxvP_1	63	66	PF13499	0.493
DOC_PP4_FxxP_1	58	61	PF00568	0.458
DOC_USP7_UBL2_3	13	17	PF12436	0.671
LIG_14-3-3_CanoR_1	25	30	PF00244	0.313

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY72	Leptomonas seymouri	70%	100%
A0A0S4J4H2	Bodo saltans	50%	98%
A0A1X0NDM1	Trypanosomatidae	55%	100%
A0A3Q8IA45	Leishmania donovani	95%	100%
A4H878	Leishmania braziliensis	88%	100%
A4HWK4	Leishmania infantum	95%	100%
C9ZXT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AQA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AQA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	69%

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