cGMP-dependent protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE group serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QF64_LEIMA

TriTrypDb:

LmjF.15.1200 , LMJLV39_080016700 , LMJLV39_150018200 , LMJLV39_150018300 , LMJSD75_150018400

Length:

2689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0000160	phosphorelay signal transduction system	4	3
GO:0006355	regulation of DNA-templated transcription	6	6
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006810	transport	3	6
GO:0006811	monoatomic ion transport	4	6
GO:0007165	signal transduction	2	3
GO:0008152	metabolic process	1	6

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1012	1016	PF00656	0.576
CLV_C14_Caspase3-7	1071	1075	PF00656	0.480
CLV_C14_Caspase3-7	1086	1090	PF00656	0.396
CLV_C14_Caspase3-7	1700	1704	PF00656	0.597
CLV_C14_Caspase3-7	1721	1725	PF00656	0.505
CLV_C14_Caspase3-7	1848	1852	PF00656	0.567
CLV_C14_Caspase3-7	1977	1981	PF00656	0.436
CLV_C14_Caspase3-7	2147	2151	PF00656	0.550
CLV_C14_Caspase3-7	2455	2459	PF00656	0.555
CLV_C14_Caspase3-7	2467	2471	PF00656	0.368

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I968	Leishmania donovani	90%	100%
A4H883	Leishmania braziliensis	70%	98%
E9AGM0	Leishmania infantum	90%	100%
E9AQB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%

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