60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania major

UniProt:

Q4QF62_LEIMA

TriTrypDb:

Length:

111

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	11
GO:0022625	cytosolic large ribosomal subunit	5	11
GO:0032991	protein-containing complex	1	11
GO:0044391	ribosomal subunit	3	11
GO:1990904	ribonucleoprotein complex	2	11

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Expansion

Sequence features

Q4QF62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF62

Function

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Biological processes
Term	Name	Level	Count
GO:0002182	cytoplasmic translational elongation	6	11
GO:0006414	translational elongation	5	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11

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Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DOC_USP7_MATH_1	10	14	PF00917	0.481
DOC_USP7_MATH_1	17	21	PF00917	0.367
DOC_USP7_MATH_1	61	65	PF00917	0.564
DOC_USP7_MATH_1	67	71	PF00917	0.574
DOC_WW_Pin1_4	15	20	PF00397	0.558
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_2	84	88	PF00653	0.568
LIG_FHA_1	1	7	PF00498	0.606
LIG_FHA_2	46	52	PF00498	0.568
LIG_LIR_Nem_3	104	110	PF02991	0.528

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZR2	Leptomonas seymouri	50%	100%
A0A0S4JJB8	Bodo saltans	51%	100%
A0A1X0NVF0	Trypanosomatidae	65%	100%
A0A1X0P2R9	Trypanosomatidae	47%	100%
A0A3Q8ICC2	Leishmania donovani	96%	100%
A0A3Q8IG52	Leishmania donovani	50%	100%
A0A422NR90	Trypanosoma rangeli	69%	100%
A4H884	Leishmania braziliensis	77%	99%
A4I5Z9	Leishmania infantum	49%	94%
A4I600	Leishmania infantum	50%	100%

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