LeishMANIAdb
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60S acidic ribosomal protein P2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S acidic ribosomal protein P2
Gene product:
Protein of unknown function (DUF2946), putative
Species:
Leishmania major
UniProt:
Q4QF62_LEIMA
TriTrypDb:
Length:
111

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. yes yes: 4
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 9
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0015934 large ribosomal subunit 4 11
GO:0022625 cytosolic large ribosomal subunit 5 11
GO:0032991 protein-containing complex 1 11
GO:0044391 ribosomal subunit 3 11
GO:1990904 ribonucleoprotein complex 2 11

Expansion

Sequence features

Q4QF62
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF62

Function

Biological processes
Term Name Level Count
GO:0002182 cytoplasmic translational elongation 6 11
GO:0006414 translational elongation 5 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044260 obsolete cellular macromolecule metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:1901576 organic substance biosynthetic process 3 11
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 11
GO:0005198 structural molecule activity 1 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_USP7_MATH_1 10 14 PF00917 0.481
DOC_USP7_MATH_1 17 21 PF00917 0.367
DOC_USP7_MATH_1 61 65 PF00917 0.564
DOC_USP7_MATH_1 67 71 PF00917 0.574
DOC_WW_Pin1_4 15 20 PF00397 0.558
LIG_BIR_II_1 1 5 PF00653 0.502
LIG_BIR_III_2 84 88 PF00653 0.568
LIG_FHA_1 1 7 PF00498 0.606
LIG_FHA_2 46 52 PF00498 0.568
LIG_LIR_Nem_3 104 110 PF02991 0.528
LIG_SH2_NCK_1 9 13 PF00017 0.463
LIG_SH2_STAT5 5 8 PF00017 0.446
LIG_TRAF2_1 97 100 PF00917 0.595
MOD_CK1_1 15 21 PF00069 0.429
MOD_GlcNHglycan 63 66 PF01048 0.340
MOD_GlcNHglycan 70 73 PF01048 0.258
MOD_GlcNHglycan 79 82 PF01048 0.333
MOD_PIKK_1 17 23 PF00454 0.507
MOD_Plk_4 51 57 PF00069 0.525
MOD_ProDKin_1 15 21 PF00069 0.410

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZR2 Leptomonas seymouri 50% 100%
A0A0S4JJB8 Bodo saltans 51% 100%
A0A1X0NVF0 Trypanosomatidae 65% 100%
A0A1X0P2R9 Trypanosomatidae 47% 100%
A0A3Q8ICC2 Leishmania donovani 96% 100%
A0A3Q8IG52 Leishmania donovani 50% 100%
A0A422NR90 Trypanosoma rangeli 69% 100%
A4H884 Leishmania braziliensis 77% 99%
A4I5Z9 Leishmania infantum 49% 94%
A4I600 Leishmania infantum 50% 100%
C9ZRI4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
C9ZXT1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 59% 98%
E9AGM1 Leishmania infantum 97% 100%
E9AQB1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B1E6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 43% 90%
E9B1E7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 100%
O01504 Caenorhabditis elegans 44% 100%
O01725 Branchiostoma floridae 41% 96%
O14317 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
O24415 Zea mays 35% 98%
O44010 Leishmania braziliensis 45% 100%
O61463 Cryptochiton stelleri 42% 100%
P02399 Artemia salina 46% 100%
P02400 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 100%
P08094 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 38% 100%
P17478 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 39% 100%
P22683 Dictyostelium discoideum 47% 100%
P23632 Trypanosoma cruzi 44% 100%
P27055 Babesia bovis 38% 99%
P42037 Alternaria alternata 42% 98%
P42899 Bos taurus 36% 97%
P46252 Zea mays 39% 99%
P50879 Taenia solium 35% 92%
P51407 Arabidopsis thaliana 39% 97%
P51408 Trypanosoma brucei brucei 51% 100%
P90703 Brugia malayi 40% 97%
Q06382 Leishmania infantum 100% 100%
Q06383 Leishmania infantum 46% 100%
Q29315 Sus scrofa 33% 97%
Q4Q6R5 Leishmania major 43% 100%
Q4Q6R6 Leishmania major 44% 95%
Q8TFM9 Fusarium culmorum 46% 100%
Q96UQ7 Rhodotorula glutinis 42% 100%
Q9C3Z5 Podospora anserina 50% 100%
Q9HFQ4 Candida albicans 38% 100%
Q9HFQ5 Candida albicans 43% 100%
Q9LH85 Arabidopsis thaliana 36% 97%
Q9LXM8 Arabidopsis thaliana 40% 100%
Q9UUZ6 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS