Putative inositol/phosphatidylinositol phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol/phosphatidylinositol phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QF61_LEIMA

TriTrypDb:

LmjF.15.1210 , LMJLV39_150018600 , LMJSD75_150018700

Length:

792

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	11
GO:0012506	vesicle membrane	4	11
GO:0016020	membrane	2	11
GO:0030659	cytoplasmic vesicle membrane	5	11
GO:0030666	endocytic vesicle membrane	5	11
GO:0030670	phagocytic vesicle membrane	6	11
GO:0031090	organelle membrane	3	11
GO:0031901	early endosome membrane	6	11
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QF61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF61

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	2
GO:0006066	alcohol metabolic process	3	2
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006650	glycerophospholipid metabolic process	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0007165	signal transduction	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	2
GO:0030258	lipid modification	4	11
GO:0043647	inositol phosphate metabolic process	4	2
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044262	obsolete cellular carbohydrate metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046164	alcohol catabolic process	4	2
GO:0046174	polyol catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046486	glycerolipid metabolic process	4	11
GO:0046488	phosphatidylinositol metabolic process	6	11
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	2
GO:0046839	phospholipid dephosphorylation	5	11
GO:0046855	obsolete inositol phosphate dephosphorylation	5	2
GO:0046856	phosphatidylinositol dephosphorylation	6	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0071545	inositol phosphate catabolic process	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	2
GO:1901616	organic hydroxy compound catabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	3
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	3
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	3
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	3
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	3
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004445	inositol-polyphosphate 5-phosphatase activity	8	1
GO:0046030	inositol trisphosphate phosphatase activity	7	1
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	8	1
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	8	1
GO:0052743	inositol tetrakisphosphate phosphatase activity	7	1
GO:0052745	inositol phosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.309
CLV_NRD_NRD_1	23	25	PF00675	0.608
CLV_NRD_NRD_1	255	257	PF00675	0.411
CLV_NRD_NRD_1	360	362	PF00675	0.377
CLV_NRD_NRD_1	374	376	PF00675	0.223
CLV_PCSK_KEX2_1	181	183	PF00082	0.309
CLV_PCSK_KEX2_1	22	24	PF00082	0.597
CLV_PCSK_KEX2_1	237	239	PF00082	0.309
CLV_PCSK_KEX2_1	255	257	PF00082	0.309
CLV_PCSK_KEX2_1	359	361	PF00082	0.382
CLV_PCSK_KEX2_1	374	376	PF00082	0.211
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.309
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.400
CLV_PCSK_SKI1_1	182	186	PF00082	0.328
CLV_PCSK_SKI1_1	518	522	PF00082	0.461
CLV_PCSK_SKI1_1	662	666	PF00082	0.376
CLV_PCSK_SKI1_1	80	84	PF00082	0.454
CLV_Separin_Metazoa	591	595	PF03568	0.544
DEG_APCC_DBOX_1	181	189	PF00400	0.352
DEG_APCC_DBOX_1	380	388	PF00400	0.421
DEG_APCC_DBOX_1	533	541	PF00400	0.401
DEG_COP1_1	355	365	PF00400	0.305
DEG_SPOP_SBC_1	151	155	PF00917	0.425
DOC_CKS1_1	327	332	PF01111	0.421
DOC_CKS1_1	781	786	PF01111	0.569
DOC_CYCLIN_RxL_1	179	189	PF00134	0.421
DOC_CYCLIN_RxL_1	659	666	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	664	670	PF00134	0.304
DOC_MAPK_gen_1	22	29	PF00069	0.593
DOC_MAPK_gen_1	255	261	PF00069	0.398
DOC_MAPK_gen_1	383	393	PF00069	0.442
DOC_MAPK_gen_1	425	433	PF00069	0.448
DOC_MAPK_gen_1	682	691	PF00069	0.377
DOC_MAPK_gen_1	79	85	PF00069	0.421
DOC_MAPK_JIP1_4	104	110	PF00069	0.328
DOC_MAPK_MEF2A_6	104	113	PF00069	0.330
DOC_MAPK_MEF2A_6	169	178	PF00069	0.309
DOC_MAPK_MEF2A_6	325	334	PF00069	0.454
DOC_MAPK_MEF2A_6	406	413	PF00069	0.487
DOC_MAPK_MEF2A_6	493	501	PF00069	0.516
DOC_MAPK_RevD_3	67	80	PF00069	0.352
DOC_PP1_RVXF_1	445	451	PF00149	0.506
DOC_PP2B_LxvP_1	295	298	PF13499	0.421
DOC_PP4_FxxP_1	29	32	PF00568	0.636
DOC_SPAK_OSR1_1	346	350	PF12202	0.421
DOC_USP7_MATH_1	151	155	PF00917	0.372
DOC_USP7_MATH_1	200	204	PF00917	0.328
DOC_USP7_MATH_1	230	234	PF00917	0.372
DOC_USP7_MATH_1	263	267	PF00917	0.363
DOC_USP7_MATH_1	32	36	PF00917	0.698
DOC_USP7_MATH_1	434	438	PF00917	0.504
DOC_USP7_MATH_1	503	507	PF00917	0.522
DOC_USP7_MATH_1	716	720	PF00917	0.464
DOC_USP7_MATH_1	84	88	PF00917	0.435
DOC_WW_Pin1_4	158	163	PF00397	0.370
DOC_WW_Pin1_4	323	328	PF00397	0.317
DOC_WW_Pin1_4	335	340	PF00397	0.293
DOC_WW_Pin1_4	492	497	PF00397	0.573
DOC_WW_Pin1_4	524	529	PF00397	0.300
DOC_WW_Pin1_4	557	562	PF00397	0.465
DOC_WW_Pin1_4	780	785	PF00397	0.541
LIG_14-3-3_CanoR_1	24	30	PF00244	0.637
LIG_14-3-3_CanoR_1	374	379	PF00244	0.369
LIG_14-3-3_CanoR_1	386	393	PF00244	0.400
LIG_14-3-3_CanoR_1	394	401	PF00244	0.123
LIG_14-3-3_CanoR_1	406	412	PF00244	0.188
LIG_14-3-3_CanoR_1	518	523	PF00244	0.487
LIG_14-3-3_CanoR_1	532	538	PF00244	0.468
LIG_14-3-3_CanoR_1	623	629	PF00244	0.390
LIG_14-3-3_CanoR_1	715	724	PF00244	0.418
LIG_Actin_WH2_2	699	717	PF00022	0.304
LIG_BRCT_BRCA1_1	247	251	PF00533	0.328
LIG_CaM_NSCaTE_8	134	141	PF13499	0.352
LIG_CSL_BTD_1	525	528	PF09270	0.297
LIG_CtBP_PxDLS_1	496	500	PF00389	0.449
LIG_deltaCOP1_diTrp_1	11	21	PF00928	0.583
LIG_FHA_1	104	110	PF00498	0.395
LIG_FHA_1	191	197	PF00498	0.320
LIG_FHA_1	223	229	PF00498	0.394
LIG_FHA_1	327	333	PF00498	0.428
LIG_FHA_1	364	370	PF00498	0.309
LIG_FHA_1	443	449	PF00498	0.450
LIG_FHA_1	461	467	PF00498	0.508
LIG_FHA_1	536	542	PF00498	0.467
LIG_FHA_1	673	679	PF00498	0.337
LIG_FHA_1	71	77	PF00498	0.308
LIG_FHA_2	14	20	PF00498	0.579
LIG_FHA_2	493	499	PF00498	0.546
LIG_FHA_2	511	517	PF00498	0.510
LIG_FHA_2	60	66	PF00498	0.510
LIG_FHA_2	623	629	PF00498	0.341
LIG_GBD_Chelix_1	287	295	PF00786	0.382
LIG_LIR_Apic_2	161	167	PF02991	0.328
LIG_LIR_Apic_2	28	32	PF02991	0.590
LIG_LIR_Gen_1	11	21	PF02991	0.499
LIG_LIR_Gen_1	271	279	PF02991	0.388
LIG_LIR_Gen_1	329	339	PF02991	0.418
LIG_LIR_Gen_1	58	69	PF02991	0.454
LIG_LIR_Gen_1	588	596	PF02991	0.540
LIG_LIR_Nem_3	11	17	PF02991	0.525
LIG_LIR_Nem_3	161	166	PF02991	0.331
LIG_LIR_Nem_3	271	277	PF02991	0.387
LIG_LIR_Nem_3	329	334	PF02991	0.327
LIG_LIR_Nem_3	58	64	PF02991	0.463
LIG_LIR_Nem_3	588	592	PF02991	0.536
LIG_NRBOX	170	176	PF00104	0.309
LIG_NRBOX	660	666	PF00104	0.376
LIG_NRBOX	709	715	PF00104	0.323
LIG_SH2_CRK	164	168	PF00017	0.328
LIG_SH2_NCK_1	61	65	PF00017	0.487
LIG_SH2_STAP1	299	303	PF00017	0.320
LIG_SH2_STAP1	317	321	PF00017	0.242
LIG_SH2_STAP1	365	369	PF00017	0.328
LIG_SH2_STAP1	57	61	PF00017	0.393
LIG_SH2_STAP1	583	587	PF00017	0.508
LIG_SH2_STAP1	674	678	PF00017	0.347
LIG_SH2_STAT5	365	368	PF00017	0.328
LIG_SH2_STAT5	606	609	PF00017	0.391
LIG_SH2_STAT5	61	64	PF00017	0.369
LIG_SH2_STAT5	674	677	PF00017	0.451
LIG_SH2_STAT5	705	708	PF00017	0.304
LIG_SH2_STAT5	712	715	PF00017	0.304
LIG_SH2_STAT5	779	782	PF00017	0.384
LIG_SH3_3	324	330	PF00018	0.347
LIG_SH3_3	408	414	PF00018	0.494
LIG_SH3_3	595	601	PF00018	0.405
LIG_SH3_3	664	670	PF00018	0.304
LIG_SH3_3	78	84	PF00018	0.421
LIG_SH3_3	99	105	PF00018	0.435
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.385
LIG_SUMO_SIM_anti_2	283	288	PF11976	0.309
LIG_SUMO_SIM_anti_2	471	477	PF11976	0.349
LIG_SUMO_SIM_anti_2	498	503	PF11976	0.500
LIG_SUMO_SIM_anti_2	569	576	PF11976	0.390
LIG_SUMO_SIM_anti_2	734	740	PF11976	0.286
LIG_SUMO_SIM_anti_2	769	778	PF11976	0.493
LIG_SUMO_SIM_par_1	407	412	PF11976	0.473
LIG_TRFH_1	712	716	PF08558	0.304
LIG_TYR_ITIM	315	320	PF00017	0.376
LIG_UBA3_1	633	640	PF00899	0.418
LIG_UBA3_1	657	662	PF00899	0.418
LIG_WRC_WIRS_1	71	76	PF05994	0.309
MOD_CK1_1	145	151	PF00069	0.451
MOD_CK1_1	153	159	PF00069	0.414
MOD_CK1_1	186	192	PF00069	0.349
MOD_CK1_1	233	239	PF00069	0.440
MOD_CK1_1	326	332	PF00069	0.407
MOD_CK1_1	34	40	PF00069	0.559
MOD_CK1_1	377	383	PF00069	0.421
MOD_CK1_1	442	448	PF00069	0.404
MOD_CK1_1	487	493	PF00069	0.496
MOD_CK1_1	536	542	PF00069	0.422
MOD_CK2_1	420	426	PF00069	0.488
MOD_CK2_1	492	498	PF00069	0.547
MOD_CK2_1	59	65	PF00069	0.469
MOD_GlcNHglycan	117	121	PF01048	0.311
MOD_GlcNHglycan	129	133	PF01048	0.303
MOD_GlcNHglycan	155	158	PF01048	0.450
MOD_GlcNHglycan	185	188	PF01048	0.421
MOD_GlcNHglycan	261	264	PF01048	0.370
MOD_GlcNHglycan	34	37	PF01048	0.709
MOD_GlcNHglycan	387	390	PF01048	0.454
MOD_GlcNHglycan	437	440	PF01048	0.402
MOD_GlcNHglycan	468	471	PF01048	0.300
MOD_GlcNHglycan	733	736	PF01048	0.407
MOD_GlcNHglycan	92	95	PF01048	0.420
MOD_GSK3_1	142	149	PF00069	0.427
MOD_GSK3_1	186	193	PF00069	0.339
MOD_GSK3_1	241	248	PF00069	0.353
MOD_GSK3_1	259	266	PF00069	0.366
MOD_GSK3_1	319	326	PF00069	0.440
MOD_GSK3_1	32	39	PF00069	0.634
MOD_GSK3_1	337	344	PF00069	0.215
MOD_GSK3_1	370	377	PF00069	0.378
MOD_GSK3_1	435	442	PF00069	0.420
MOD_GSK3_1	462	469	PF00069	0.293
MOD_GSK3_1	779	786	PF00069	0.545
MOD_GSK3_1	9	16	PF00069	0.593
MOD_N-GLC_1	233	238	PF02516	0.406
MOD_N-GLC_1	32	37	PF02516	0.644
MOD_N-GLC_1	335	340	PF02516	0.454
MOD_N-GLC_1	59	64	PF02516	0.502
MOD_N-GLC_2	68	70	PF02516	0.402
MOD_NEK2_1	118	123	PF00069	0.309
MOD_NEK2_1	216	221	PF00069	0.309
MOD_NEK2_1	259	264	PF00069	0.430
MOD_NEK2_1	269	274	PF00069	0.211
MOD_NEK2_1	443	448	PF00069	0.467
MOD_NEK2_1	636	641	PF00069	0.389
MOD_PIKK_1	503	509	PF00454	0.514
MOD_PKA_1	374	380	PF00069	0.352
MOD_PKA_2	103	109	PF00069	0.421
MOD_PKA_2	145	151	PF00069	0.220
MOD_PKA_2	217	223	PF00069	0.328
MOD_PKA_2	374	380	PF00069	0.352
MOD_PKA_2	385	391	PF00069	0.352
MOD_PKA_2	393	399	PF00069	0.352
MOD_PKA_2	533	539	PF00069	0.442
MOD_PKA_2	622	628	PF00069	0.449
MOD_PKA_2	739	745	PF00069	0.519
MOD_Plk_1	269	275	PF00069	0.454
MOD_Plk_1	59	65	PF00069	0.459
MOD_Plk_2-3	13	19	PF00069	0.573
MOD_Plk_4	241	247	PF00069	0.352
MOD_Plk_4	25	31	PF00069	0.579
MOD_Plk_4	269	275	PF00069	0.342
MOD_Plk_4	487	493	PF00069	0.535
MOD_Plk_4	518	524	PF00069	0.574
MOD_Plk_4	536	542	PF00069	0.407
MOD_Plk_4	559	565	PF00069	0.348
MOD_Plk_4	705	711	PF00069	0.378
MOD_Plk_4	783	789	PF00069	0.570
MOD_ProDKin_1	158	164	PF00069	0.370
MOD_ProDKin_1	323	329	PF00069	0.317
MOD_ProDKin_1	335	341	PF00069	0.293
MOD_ProDKin_1	492	498	PF00069	0.574
MOD_ProDKin_1	524	530	PF00069	0.301
MOD_ProDKin_1	557	563	PF00069	0.462
MOD_ProDKin_1	780	786	PF00069	0.554
MOD_SUMO_for_1	124	127	PF00179	0.309
MOD_SUMO_rev_2	318	327	PF00179	0.421
MOD_SUMO_rev_2	392	401	PF00179	0.309
MOD_SUMO_rev_2	635	642	PF00179	0.388
TRG_DiLeu_BaEn_1	554	559	PF01217	0.455
TRG_DiLeu_BaLyEn_6	180	185	PF01217	0.421
TRG_ENDOCYTIC_2	163	166	PF00928	0.309
TRG_ENDOCYTIC_2	317	320	PF00928	0.419
TRG_ENDOCYTIC_2	61	64	PF00928	0.379
TRG_ER_diArg_1	180	182	PF00400	0.309
TRG_ER_diArg_1	21	24	PF00400	0.590
TRG_ER_diArg_1	293	296	PF00400	0.455
TRG_ER_diArg_1	360	362	PF00400	0.408
TRG_ER_diArg_1	381	384	PF00400	0.437
TRG_ER_diArg_1	479	482	PF00400	0.466
TRG_ER_diArg_1	532	535	PF00400	0.398
TRG_Pf-PMV_PEXEL_1	662	666	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E8	Leptomonas seymouri	78%	100%
A0A1X0NU91	Trypanosomatidae	51%	100%
A0A3S5H6V6	Leishmania donovani	95%	100%
A0A422NRC5	Trypanosoma rangeli	48%	100%
A4H885	Leishmania braziliensis	86%	100%
C9ZXT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D3ZGS3	Rattus norvegicus	27%	88%
E9AGM3	Leishmania infantum	95%	100%
E9AQB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
P32019	Homo sapiens	27%	80%
Q01968	Homo sapiens	26%	88%
Q6NVF0	Mus musculus	26%	88%
Q8K337	Mus musculus	27%	80%
V5DL78	Trypanosoma cruzi	49%	100%