LeishMANIAdb
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Putative nucleoside transporter 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleoside transporter 1
Gene product:
nucleoside transporter 1, putative
Species:
Leishmania major
UniProt:
Q4QF59_LEIMA
TriTrypDb:
LmjF.15.1230 * , LMJLV39_150019000 , LMJSD75_150019000
Length:
656

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 45
NetGPI no yes: 0, no: 45
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 5
GO:0016020 membrane 2 46
GO:0110165 cellular anatomical entity 1 46

Expansion

Sequence features

Q4QF59
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF59

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0015851 nucleobase transport 5 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0071702 organic substance transport 4 1
GO:0071705 nitrogen compound transport 4 1
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 46
GO:0005337 nucleoside transmembrane transporter activity 4 46
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 46
GO:0022857 transmembrane transporter activity 2 46
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 46
GO:0015205 nucleobase transmembrane transporter activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 412 416 PF00656 0.593
CLV_MEL_PAP_1 540 546 PF00089 0.280
CLV_NRD_NRD_1 131 133 PF00675 0.335
CLV_NRD_NRD_1 181 183 PF00675 0.372
CLV_NRD_NRD_1 268 270 PF00675 0.342
CLV_NRD_NRD_1 493 495 PF00675 0.232
CLV_PCSK_FUR_1 129 133 PF00082 0.337
CLV_PCSK_KEX2_1 131 133 PF00082 0.335
CLV_PCSK_KEX2_1 268 270 PF00082 0.322
CLV_PCSK_KEX2_1 493 495 PF00082 0.324
CLV_PCSK_KEX2_1 623 625 PF00082 0.246
CLV_PCSK_PC1ET2_1 623 625 PF00082 0.246
CLV_PCSK_SKI1_1 141 145 PF00082 0.321
CLV_PCSK_SKI1_1 146 150 PF00082 0.327
CLV_PCSK_SKI1_1 318 322 PF00082 0.472
CLV_PCSK_SKI1_1 359 363 PF00082 0.576
CLV_PCSK_SKI1_1 493 497 PF00082 0.388
CLV_PCSK_SKI1_1 569 573 PF00082 0.332
DEG_ODPH_VHL_1 91 102 PF01847 0.544
DOC_CYCLIN_RxL_1 138 147 PF00134 0.522
DOC_MAPK_DCC_7 569 578 PF00069 0.314
DOC_MAPK_FxFP_2 511 514 PF00069 0.422
DOC_MAPK_gen_1 268 276 PF00069 0.554
DOC_MAPK_gen_1 370 381 PF00069 0.327
DOC_MAPK_gen_1 493 500 PF00069 0.499
DOC_MAPK_gen_1 554 563 PF00069 0.539
DOC_MAPK_MEF2A_6 268 276 PF00069 0.552
DOC_MAPK_MEF2A_6 374 383 PF00069 0.385
DOC_MAPK_MEF2A_6 525 534 PF00069 0.384
DOC_MAPK_MEF2A_6 543 550 PF00069 0.298
DOC_MAPK_MEF2A_6 569 578 PF00069 0.345
DOC_PP1_RVXF_1 491 498 PF00149 0.582
DOC_PP1_RVXF_1 567 573 PF00149 0.407
DOC_PP2B_LxvP_1 91 94 PF13499 0.527
DOC_PP2B_PxIxI_1 513 519 PF00149 0.481
DOC_PP4_FxxP_1 213 216 PF00568 0.385
DOC_PP4_FxxP_1 511 514 PF00568 0.426
DOC_PP4_FxxP_1 550 553 PF00568 0.577
DOC_SPAK_OSR1_1 132 136 PF12202 0.521
DOC_USP7_MATH_1 112 116 PF00917 0.569
DOC_USP7_MATH_1 154 158 PF00917 0.539
DOC_USP7_MATH_1 160 164 PF00917 0.541
DOC_USP7_MATH_1 331 335 PF00917 0.536
DOC_USP7_MATH_1 409 413 PF00917 0.587
DOC_USP7_MATH_1 465 469 PF00917 0.541
DOC_USP7_MATH_1 6 10 PF00917 0.533
DOC_USP7_UBL2_3 370 374 PF12436 0.255
DOC_WW_Pin1_4 117 122 PF00397 0.568
DOC_WW_Pin1_4 147 152 PF00397 0.528
DOC_WW_Pin1_4 542 547 PF00397 0.394
LIG_14-3-3_CanoR_1 12 21 PF00244 0.542
LIG_14-3-3_CanoR_1 146 151 PF00244 0.529
LIG_14-3-3_CanoR_1 24 30 PF00244 0.562
LIG_14-3-3_CanoR_1 395 400 PF00244 0.519
LIG_14-3-3_CanoR_1 47 56 PF00244 0.550
LIG_APCC_ABBA_1 518 523 PF00400 0.246
LIG_BRCT_BRCA1_1 523 527 PF00533 0.382
LIG_BRCT_BRCA1_1 546 550 PF00533 0.525
LIG_BRCT_BRCA1_1 58 62 PF00533 0.542
LIG_BRCT_BRCA1_1 9 13 PF00533 0.537
LIG_deltaCOP1_diTrp_1 523 533 PF00928 0.246
LIG_FHA_1 104 110 PF00498 0.551
LIG_FHA_1 147 153 PF00498 0.528
LIG_FHA_1 24 30 PF00498 0.564
LIG_FHA_1 252 258 PF00498 0.324
LIG_FHA_1 308 314 PF00498 0.333
LIG_FHA_1 349 355 PF00498 0.361
LIG_FHA_1 507 513 PF00498 0.326
LIG_FHA_1 527 533 PF00498 0.360
LIG_FHA_1 647 653 PF00498 0.486
LIG_FHA_1 68 74 PF00498 0.563
LIG_FHA_2 166 172 PF00498 0.656
LIG_FHA_2 186 192 PF00498 0.539
LIG_FHA_2 476 482 PF00498 0.522
LIG_FHA_2 58 64 PF00498 0.545
LIG_FHA_2 649 655 PF00498 0.288
LIG_GBD_Chelix_1 484 492 PF00786 0.391
LIG_LIR_Apic_2 509 514 PF02991 0.388
LIG_LIR_Apic_2 547 553 PF02991 0.577
LIG_LIR_Gen_1 190 200 PF02991 0.462
LIG_LIR_Gen_1 245 253 PF02991 0.268
LIG_LIR_Gen_1 334 344 PF02991 0.495
LIG_LIR_Gen_1 387 396 PF02991 0.423
LIG_LIR_Gen_1 486 495 PF02991 0.561
LIG_LIR_Gen_1 524 535 PF02991 0.337
LIG_LIR_Gen_1 566 575 PF02991 0.351
LIG_LIR_Gen_1 580 589 PF02991 0.420
LIG_LIR_Nem_3 16 21 PF02991 0.544
LIG_LIR_Nem_3 190 196 PF02991 0.473
LIG_LIR_Nem_3 221 225 PF02991 0.326
LIG_LIR_Nem_3 237 243 PF02991 0.301
LIG_LIR_Nem_3 245 250 PF02991 0.289
LIG_LIR_Nem_3 265 270 PF02991 0.420
LIG_LIR_Nem_3 323 329 PF02991 0.495
LIG_LIR_Nem_3 334 339 PF02991 0.454
LIG_LIR_Nem_3 364 369 PF02991 0.306
LIG_LIR_Nem_3 373 379 PF02991 0.270
LIG_LIR_Nem_3 387 391 PF02991 0.359
LIG_LIR_Nem_3 486 492 PF02991 0.533
LIG_LIR_Nem_3 524 530 PF02991 0.309
LIG_LIR_Nem_3 566 570 PF02991 0.394
LIG_LIR_Nem_3 580 584 PF02991 0.379
LIG_LIR_Nem_3 587 592 PF02991 0.331
LIG_NRBOX 349 355 PF00104 0.280
LIG_Pex14_1 552 556 PF04695 0.582
LIG_Pex14_2 312 316 PF04695 0.471
LIG_Pex14_2 332 336 PF04695 0.448
LIG_PTB_Apo_2 12 19 PF02174 0.540
LIG_SH2_CRK 247 251 PF00017 0.360
LIG_SH2_CRK 581 585 PF00017 0.330
LIG_SH2_CRK 589 593 PF00017 0.324
LIG_SH2_GRB2like 236 239 PF00017 0.381
LIG_SH2_GRB2like 246 249 PF00017 0.298
LIG_SH2_NCK_1 247 251 PF00017 0.419
LIG_SH2_PTP2 193 196 PF00017 0.466
LIG_SH2_SRC 193 196 PF00017 0.424
LIG_SH2_SRC 583 586 PF00017 0.338
LIG_SH2_STAP1 185 189 PF00017 0.620
LIG_SH2_STAP1 236 240 PF00017 0.424
LIG_SH2_STAT3 225 228 PF00017 0.416
LIG_SH2_STAT5 193 196 PF00017 0.336
LIG_SH2_STAT5 218 221 PF00017 0.326
LIG_SH2_STAT5 236 239 PF00017 0.317
LIG_SH2_STAT5 583 586 PF00017 0.308
LIG_SH2_STAT5 591 594 PF00017 0.344
LIG_SH2_STAT5 603 606 PF00017 0.285
LIG_SH3_3 104 110 PF00018 0.549
LIG_SH3_3 26 32 PF00018 0.567
LIG_SH3_3 471 477 PF00018 0.553
LIG_SH3_3 607 613 PF00018 0.431
LIG_SH3_3 97 103 PF00018 0.554
LIG_SUMO_SIM_anti_2 259 265 PF11976 0.478
LIG_SUMO_SIM_anti_2 286 292 PF11976 0.321
LIG_SUMO_SIM_anti_2 387 393 PF11976 0.343
LIG_SUMO_SIM_anti_2 643 649 PF11976 0.364
LIG_SUMO_SIM_par_1 105 111 PF11976 0.554
LIG_SUMO_SIM_par_1 259 265 PF11976 0.445
LIG_SUMO_SIM_par_1 280 286 PF11976 0.318
LIG_SUMO_SIM_par_1 574 580 PF11976 0.435
LIG_SUMO_SIM_par_1 643 649 PF11976 0.280
LIG_TYR_ITSM 243 250 PF00017 0.306
LIG_UBA3_1 353 359 PF00899 0.377
LIG_UBA3_1 488 496 PF00899 0.566
LIG_ULM_U2AF65_1 493 498 PF00076 0.432
LIG_WRC_WIRS_1 396 401 PF05994 0.520
MOD_CDK_SPK_2 117 122 PF00069 0.568
MOD_CDK_SPxxK_3 117 124 PF00069 0.568
MOD_CDK_SPxxK_3 542 549 PF00069 0.280
MOD_CK1_1 147 153 PF00069 0.528
MOD_CK1_1 25 31 PF00069 0.566
MOD_CK1_1 334 340 PF00069 0.571
MOD_CK1_1 646 652 PF00069 0.452
MOD_CK1_1 96 102 PF00069 0.553
MOD_CK2_1 185 191 PF00069 0.551
MOD_CK2_1 316 322 PF00069 0.427
MOD_CK2_1 439 445 PF00069 0.578
MOD_CK2_1 475 481 PF00069 0.528
MOD_CK2_1 57 63 PF00069 0.543
MOD_CK2_1 648 654 PF00069 0.437
MOD_Cter_Amidation 621 624 PF01082 0.246
MOD_GlcNHglycan 110 113 PF01048 0.358
MOD_GlcNHglycan 146 149 PF01048 0.332
MOD_GlcNHglycan 162 165 PF01048 0.378
MOD_GlcNHglycan 213 216 PF01048 0.552
MOD_GlcNHglycan 346 349 PF01048 0.328
MOD_GlcNHglycan 419 422 PF01048 0.300
MOD_GlcNHglycan 441 444 PF01048 0.364
MOD_GlcNHglycan 95 98 PF01048 0.347
MOD_GSK3_1 108 115 PF00069 0.564
MOD_GSK3_1 201 208 PF00069 0.330
MOD_GSK3_1 303 310 PF00069 0.358
MOD_GSK3_1 316 323 PF00069 0.239
MOD_GSK3_1 331 338 PF00069 0.447
MOD_GSK3_1 344 351 PF00069 0.312
MOD_GSK3_1 483 490 PF00069 0.548
MOD_GSK3_1 521 528 PF00069 0.324
MOD_NEK2_1 13 18 PF00069 0.541
MOD_NEK2_1 144 149 PF00069 0.529
MOD_NEK2_1 205 210 PF00069 0.333
MOD_NEK2_1 23 28 PF00069 0.561
MOD_NEK2_1 316 321 PF00069 0.353
MOD_NEK2_1 483 488 PF00069 0.515
MOD_NEK2_1 506 511 PF00069 0.361
MOD_NEK2_1 56 61 PF00069 0.544
MOD_NEK2_1 577 582 PF00069 0.367
MOD_NEK2_1 597 602 PF00069 0.431
MOD_NEK2_1 631 636 PF00069 0.359
MOD_NEK2_1 648 653 PF00069 0.355
MOD_NEK2_2 112 117 PF00069 0.569
MOD_PIKK_1 57 63 PF00454 0.543
MOD_PIKK_1 646 652 PF00454 0.565
MOD_PKA_1 370 376 PF00069 0.246
MOD_PKA_2 23 29 PF00069 0.565
MOD_PKA_2 56 62 PF00069 0.545
MOD_PKB_1 45 53 PF00069 0.555
MOD_Plk_1 321 327 PF00069 0.522
MOD_Plk_1 465 471 PF00069 0.445
MOD_Plk_4 103 109 PF00069 0.552
MOD_Plk_4 201 207 PF00069 0.351
MOD_Plk_4 218 224 PF00069 0.286
MOD_Plk_4 242 248 PF00069 0.292
MOD_Plk_4 252 258 PF00069 0.343
MOD_Plk_4 259 265 PF00069 0.327
MOD_Plk_4 316 322 PF00069 0.396
MOD_Plk_4 335 341 PF00069 0.452
MOD_Plk_4 349 355 PF00069 0.308
MOD_Plk_4 384 390 PF00069 0.345
MOD_Plk_4 626 632 PF00069 0.510
MOD_Plk_4 640 646 PF00069 0.297
MOD_ProDKin_1 117 123 PF00069 0.567
MOD_ProDKin_1 147 153 PF00069 0.528
MOD_ProDKin_1 542 548 PF00069 0.394
MOD_SUMO_for_1 457 460 PF00179 0.591
MOD_SUMO_rev_2 615 625 PF00179 0.446
TRG_DiLeu_BaEn_1 259 264 PF01217 0.280
TRG_DiLeu_BaEn_1 286 291 PF01217 0.346
TRG_DiLeu_BaLyEn_6 272 277 PF01217 0.482
TRG_DiLeu_BaLyEn_6 571 576 PF01217 0.370
TRG_ENDOCYTIC_2 136 139 PF00928 0.518
TRG_ENDOCYTIC_2 193 196 PF00928 0.335
TRG_ENDOCYTIC_2 236 239 PF00928 0.360
TRG_ENDOCYTIC_2 246 249 PF00928 0.276
TRG_ENDOCYTIC_2 326 329 PF00928 0.499
TRG_ENDOCYTIC_2 366 369 PF00928 0.296
TRG_ENDOCYTIC_2 376 379 PF00928 0.307
TRG_ENDOCYTIC_2 581 584 PF00928 0.334
TRG_ENDOCYTIC_2 589 592 PF00928 0.324
TRG_ER_diArg_1 121 124 PF00400 0.568
TRG_ER_diArg_1 129 132 PF00400 0.537
TRG_ER_diArg_1 267 269 PF00400 0.506
TRG_ER_diArg_1 492 494 PF00400 0.440

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 33% 100%
A0A0N0P6Z5 Leptomonas seymouri 30% 100%
A0A0N1I1J0 Leptomonas seymouri 27% 100%
A0A0N1I8E8 Leptomonas seymouri 23% 100%
A0A0N1PBQ1 Leptomonas seymouri 33% 100%
A0A0S4JBS4 Bodo saltans 30% 100%
A0A1X0NN91 Trypanosomatidae 35% 100%
A0A1X0NPL0 Trypanosomatidae 34% 100%
A0A1X0NV38 Trypanosomatidae 30% 100%
A0A1X0NWJ5 Trypanosomatidae 31% 100%
A0A3Q8ICX7 Leishmania donovani 33% 100%
A0A3R7NQR3 Trypanosoma rangeli 34% 100%
A0A3S7WTL0 Leishmania donovani 96% 100%
A0A3S7XAS5 Leishmania donovani 32% 100%
A0A422MQ08 Trypanosoma rangeli 30% 100%
A0A422N8M2 Trypanosoma rangeli 31% 100%
A0A422NHH9 Trypanosoma rangeli 30% 100%
A0A422NR81 Trypanosoma rangeli 50% 100%
A1A4N1 Bos taurus 21% 100%
A4H7A5 Leishmania braziliensis 34% 100%
A4HG96 Leishmania braziliensis 23% 100%
A4HP60 Leishmania braziliensis 31% 100%
A4HUW2 Leishmania infantum 27% 100%
A4HVP9 Leishmania infantum 33% 100%
A4HWK9 Leishmania infantum 95% 100%
A4IDG6 Leishmania infantum 32% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
E9AGM5 Leishmania infantum 96% 100%
E9AGM6 Leishmania infantum 95% 100%
E9AGM7 Leishmania infantum 95% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
O76343 Leishmania donovani 95% 100%
Q4Q1M9 Leishmania major 32% 100%
Q4QF58 Leishmania major 99% 100%
Q4QG33 Leishmania major 33% 100%
Q9JIM1 Mus musculus 25% 100%
V5BGB1 Trypanosoma cruzi 33% 100%
V5BRM5 Trypanosoma cruzi 30% 100%
V5DSF4 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS