SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SET domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QF56_LEIMA

TriTrypDb:

LmjF.15.1260 , LMJLV39_150019300 , LMJSD75_150019300

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	398	404	PF00089	0.595
CLV_NRD_NRD_1	238	240	PF00675	0.261
CLV_NRD_NRD_1	242	244	PF00675	0.259
CLV_NRD_NRD_1	245	247	PF00675	0.256
CLV_NRD_NRD_1	3	5	PF00675	0.604
CLV_NRD_NRD_1	359	361	PF00675	0.584
CLV_NRD_NRD_1	404	406	PF00675	0.717
CLV_PCSK_FUR_1	239	243	PF00082	0.291
CLV_PCSK_KEX2_1	238	240	PF00082	0.240
CLV_PCSK_KEX2_1	241	243	PF00082	0.237
CLV_PCSK_KEX2_1	245	247	PF00082	0.235
CLV_PCSK_KEX2_1	3	5	PF00082	0.602
CLV_PCSK_KEX2_1	359	361	PF00082	0.463
CLV_PCSK_KEX2_1	404	406	PF00082	0.712
CLV_PCSK_PC7_1	238	244	PF00082	0.294
CLV_PCSK_SKI1_1	216	220	PF00082	0.383
CLV_PCSK_SKI1_1	295	299	PF00082	0.354
CLV_PCSK_SKI1_1	344	348	PF00082	0.641
CLV_PCSK_SKI1_1	52	56	PF00082	0.336
DEG_Nend_Nbox_1	1	3	PF02207	0.553
DOC_CYCLIN_RxL_1	47	59	PF00134	0.404
DOC_MAPK_DCC_7	87	96	PF00069	0.475
DOC_MAPK_gen_1	189	195	PF00069	0.473
DOC_MAPK_HePTP_8	84	96	PF00069	0.472
DOC_MAPK_MEF2A_6	87	96	PF00069	0.475
DOC_USP7_MATH_1	175	179	PF00917	0.476
DOC_USP7_MATH_1	375	379	PF00917	0.579
DOC_USP7_MATH_1	384	388	PF00917	0.707
DOC_USP7_MATH_1	394	398	PF00917	0.642
DOC_USP7_UBL2_3	83	87	PF12436	0.350
DOC_WW_Pin1_4	149	154	PF00397	0.470
DOC_WW_Pin1_4	385	390	PF00397	0.699
DOC_WW_Pin1_4	59	64	PF00397	0.495
LIG_14-3-3_CanoR_1	133	140	PF00244	0.528
LIG_14-3-3_CanoR_1	181	185	PF00244	0.388
LIG_14-3-3_CanoR_1	313	320	PF00244	0.423
LIG_14-3-3_CanoR_1	348	355	PF00244	0.492
LIG_14-3-3_CanoR_1	47	55	PF00244	0.374
LIG_14-3-3_CanoR_1	58	63	PF00244	0.421
LIG_Actin_WH2_2	233	250	PF00022	0.273
LIG_APCC_ABBA_1	258	263	PF00400	0.533
LIG_APCC_ABBA_1	36	41	PF00400	0.385
LIG_BRCT_BRCA1_1	314	318	PF00533	0.457
LIG_BRCT_BRCA1_1	7	11	PF00533	0.524
LIG_BRCT_BRCA1_2	7	13	PF00533	0.501
LIG_CaM_IQ_9	208	223	PF13499	0.450
LIG_eIF4E_1	230	236	PF01652	0.504
LIG_FHA_1	142	148	PF00498	0.412
LIG_FHA_1	213	219	PF00498	0.339
LIG_FHA_1	272	278	PF00498	0.454
LIG_FHA_1	59	65	PF00498	0.466
LIG_FHA_1	70	76	PF00498	0.262
LIG_FHA_2	291	297	PF00498	0.487
LIG_LIR_Gen_1	152	158	PF02991	0.534
LIG_LIR_Gen_1	183	191	PF02991	0.371
LIG_LIR_Gen_1	209	219	PF02991	0.428
LIG_LIR_Nem_3	166	172	PF02991	0.574
LIG_LIR_Nem_3	209	214	PF02991	0.319
LIG_LIR_Nem_3	345	350	PF02991	0.419
LIG_LIR_Nem_3	8	14	PF02991	0.497
LIG_Pex14_2	163	167	PF04695	0.398
LIG_Pex14_2	318	322	PF04695	0.332
LIG_PTB_Apo_2	200	207	PF02174	0.461
LIG_SH2_CRK	320	324	PF00017	0.346
LIG_SH2_PTP2	261	264	PF00017	0.390
LIG_SH2_STAP1	154	158	PF00017	0.453
LIG_SH2_STAT5	116	119	PF00017	0.300
LIG_SH2_STAT5	261	264	PF00017	0.533
LIG_SH3_5	226	230	PF00018	0.470
LIG_SUMO_SIM_anti_2	326	332	PF11976	0.476
LIG_SUMO_SIM_par_1	326	332	PF11976	0.476
LIG_SUMO_SIM_par_1	76	82	PF11976	0.402
LIG_TRAF2_1	183	186	PF00917	0.406
LIG_TRAF2_1	299	302	PF00917	0.438
LIG_TYR_ITIM	259	264	PF00017	0.341
MOD_CDK_SPxxK_3	149	156	PF00069	0.467
MOD_CDK_SPxxK_3	385	392	PF00069	0.621
MOD_CK1_1	141	147	PF00069	0.396
MOD_CK1_1	281	287	PF00069	0.206
MOD_CK1_1	59	65	PF00069	0.477
MOD_CK1_1	82	88	PF00069	0.407
MOD_CK2_1	133	139	PF00069	0.539
MOD_CK2_1	180	186	PF00069	0.392
MOD_CK2_1	326	332	PF00069	0.472
MOD_CK2_1	400	406	PF00069	0.592
MOD_GlcNHglycan	121	124	PF01048	0.299
MOD_GlcNHglycan	135	138	PF01048	0.372
MOD_GlcNHglycan	231	234	PF01048	0.442
MOD_GlcNHglycan	283	286	PF01048	0.294
MOD_GlcNHglycan	314	317	PF01048	0.459
MOD_GlcNHglycan	381	384	PF01048	0.638
MOD_GSK3_1	129	136	PF00069	0.456
MOD_GSK3_1	277	284	PF00069	0.206
MOD_GSK3_1	375	382	PF00069	0.635
MOD_GSK3_1	39	46	PF00069	0.411
MOD_GSK3_1	396	403	PF00069	0.616
MOD_GSK3_1	54	61	PF00069	0.377
MOD_GSK3_1	69	76	PF00069	0.241
MOD_GSK3_1	79	86	PF00069	0.363
MOD_N-GLC_1	265	270	PF02516	0.273
MOD_N-GLC_1	271	276	PF02516	0.273
MOD_NEK2_1	119	124	PF00069	0.302
MOD_NEK2_1	193	198	PF00069	0.409
MOD_NEK2_1	2	7	PF00069	0.536
MOD_NEK2_1	43	48	PF00069	0.493
MOD_NEK2_1	54	59	PF00069	0.327
MOD_NEK2_1	79	84	PF00069	0.424
MOD_NEK2_2	271	276	PF00069	0.335
MOD_PIKK_1	46	52	PF00454	0.408
MOD_PKA_2	180	186	PF00069	0.371
MOD_PKA_2	2	8	PF00069	0.627
MOD_PKA_2	212	218	PF00069	0.328
MOD_PKA_2	312	318	PF00069	0.486
MOD_PKA_2	400	406	PF00069	0.693
MOD_PKA_2	46	52	PF00069	0.408
MOD_Plk_1	271	277	PF00069	0.228
MOD_Plk_1	39	45	PF00069	0.491
MOD_Plk_2-3	326	332	PF00069	0.476
MOD_Plk_4	278	284	PF00069	0.348
MOD_Plk_4	39	45	PF00069	0.340
MOD_Plk_4	74	80	PF00069	0.352
MOD_ProDKin_1	149	155	PF00069	0.466
MOD_ProDKin_1	385	391	PF00069	0.700
MOD_ProDKin_1	59	65	PF00069	0.494
MOD_SUMO_for_1	206	209	PF00179	0.479
MOD_SUMO_rev_2	369	378	PF00179	0.573
TRG_DiLeu_BaEn_1	142	147	PF01217	0.370
TRG_DiLeu_BaEn_4	363	369	PF01217	0.536
TRG_ENDOCYTIC_2	116	119	PF00928	0.295
TRG_ENDOCYTIC_2	154	157	PF00928	0.512
TRG_ENDOCYTIC_2	184	187	PF00928	0.403
TRG_ENDOCYTIC_2	261	264	PF00928	0.406
TRG_ENDOCYTIC_2	320	323	PF00928	0.379
TRG_ER_diArg_1	2	4	PF00400	0.663
TRG_ER_diArg_1	237	239	PF00400	0.277
TRG_ER_diArg_1	240	243	PF00400	0.272
TRG_ER_diArg_1	244	246	PF00400	0.267
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL6	Leptomonas seymouri	69%	100%
A0A0S4JNX3	Bodo saltans	50%	100%
A0A1X0P9L0	Trypanosomatidae	57%	100%
A0A3S5H6V7	Leishmania donovani	94%	100%
A4H888	Leishmania braziliensis	86%	100%
A4HWL1	Leishmania infantum	94%	100%
C9ZMN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AQB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BKH7	Trypanosoma cruzi	62%	100%