Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF55_LEIMA

TriTrypDb:

LmjF.15.1270 , LMJLV39_150019400 , LMJSD75_150019400

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QF55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.421
CLV_C14_Caspase3-7	448	452	PF00656	0.494
CLV_NRD_NRD_1	101	103	PF00675	0.445
CLV_NRD_NRD_1	120	122	PF00675	0.468
CLV_NRD_NRD_1	14	16	PF00675	0.690
CLV_NRD_NRD_1	338	340	PF00675	0.379
CLV_NRD_NRD_1	409	411	PF00675	0.595
CLV_PCSK_KEX2_1	120	122	PF00082	0.507
CLV_PCSK_KEX2_1	14	16	PF00082	0.675
CLV_PCSK_KEX2_1	409	411	PF00082	0.661
CLV_PCSK_KEX2_1	75	77	PF00082	0.451
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.458
CLV_PCSK_SKI1_1	246	250	PF00082	0.380
CLV_PCSK_SKI1_1	324	328	PF00082	0.545
CLV_PCSK_SKI1_1	340	344	PF00082	0.313
CLV_PCSK_SKI1_1	345	349	PF00082	0.364
CLV_PCSK_SKI1_1	352	356	PF00082	0.406
CLV_PCSK_SKI1_1	410	414	PF00082	0.626
CLV_PCSK_SKI1_1	480	484	PF00082	0.730
DEG_APCC_DBOX_1	154	162	PF00400	0.446
DEG_APCC_DBOX_1	344	352	PF00400	0.374
DEG_SPOP_SBC_1	2	6	PF00917	0.513
DEG_SPOP_SBC_1	286	290	PF00917	0.655
DOC_CKS1_1	516	521	PF01111	0.494
DOC_CYCLIN_RxL_1	349	358	PF00134	0.393
DOC_CYCLIN_yClb1_LxF_4	220	226	PF00134	0.360
DOC_MAPK_FxFP_2	365	368	PF00069	0.551
DOC_MAPK_gen_1	102	110	PF00069	0.484
DOC_MAPK_gen_1	14	20	PF00069	0.555
DOC_MAPK_MEF2A_6	397	405	PF00069	0.434
DOC_PP2B_LxvP_1	354	357	PF13499	0.421
DOC_PP2B_LxvP_1	52	55	PF13499	0.603
DOC_PP4_FxxP_1	365	368	PF00568	0.551
DOC_PP4_FxxP_1	80	83	PF00568	0.470
DOC_USP7_MATH_1	2	6	PF00917	0.547
DOC_USP7_MATH_1	267	271	PF00917	0.542
DOC_USP7_MATH_1	286	290	PF00917	0.579
DOC_USP7_MATH_1	296	300	PF00917	0.724
DOC_USP7_MATH_1	488	492	PF00917	0.593
DOC_USP7_MATH_1	520	524	PF00917	0.516
DOC_USP7_MATH_2	57	63	PF00917	0.505
DOC_USP7_UBL2_3	327	331	PF12436	0.464
DOC_USP7_UBL2_3	467	471	PF12436	0.652
DOC_WW_Pin1_4	254	259	PF00397	0.493
DOC_WW_Pin1_4	492	497	PF00397	0.567
DOC_WW_Pin1_4	515	520	PF00397	0.491
DOC_WW_Pin1_4	8	13	PF00397	0.529
LIG_14-3-3_CanoR_1	26	32	PF00244	0.587
LIG_14-3-3_CanoR_1	339	347	PF00244	0.520
LIG_14-3-3_CanoR_1	35	41	PF00244	0.683
LIG_Actin_WH2_2	400	415	PF00022	0.482
LIG_Clathr_ClatBox_1	162	166	PF01394	0.354
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.587
LIG_deltaCOP1_diTrp_1	399	405	PF00928	0.528
LIG_FHA_1	20	26	PF00498	0.745
LIG_FHA_1	339	345	PF00498	0.316
LIG_FHA_2	232	238	PF00498	0.306
LIG_FHA_2	371	377	PF00498	0.502
LIG_FHA_2	507	513	PF00498	0.490
LIG_GBD_Chelix_1	383	391	PF00786	0.387
LIG_LIR_Gen_1	109	119	PF02991	0.414
LIG_LIR_Gen_1	141	150	PF02991	0.617
LIG_LIR_Gen_1	156	165	PF02991	0.242
LIG_LIR_Gen_1	218	226	PF02991	0.352
LIG_LIR_Gen_1	399	407	PF02991	0.479
LIG_LIR_Nem_3	109	115	PF02991	0.483
LIG_LIR_Nem_3	141	146	PF02991	0.522
LIG_LIR_Nem_3	156	162	PF02991	0.253
LIG_LIR_Nem_3	218	222	PF02991	0.358
LIG_LIR_Nem_3	399	405	PF02991	0.460
LIG_NRBOX	350	356	PF00104	0.499
LIG_NRP_CendR_1	532	533	PF00754	0.514
LIG_PCNA_yPIPBox_3	90	103	PF02747	0.445
LIG_Pex14_2	207	211	PF04695	0.424
LIG_SH2_CRK	112	116	PF00017	0.473
LIG_SH2_CRK	143	147	PF00017	0.465
LIG_SH2_CRK	159	163	PF00017	0.220
LIG_SH2_CRK	219	223	PF00017	0.385
LIG_SH2_GRB2like	219	222	PF00017	0.390
LIG_SH2_GRB2like	276	279	PF00017	0.528
LIG_SH2_STAP1	112	116	PF00017	0.422
LIG_SH2_STAP1	159	163	PF00017	0.359
LIG_SH2_STAP1	219	223	PF00017	0.385
LIG_SH2_STAP1	276	280	PF00017	0.529
LIG_SH2_STAT3	443	446	PF00017	0.543
LIG_SH2_STAT5	180	183	PF00017	0.458
LIG_SH2_STAT5	242	245	PF00017	0.372
LIG_SH3_1	252	258	PF00018	0.399
LIG_SH3_3	252	258	PF00018	0.451
LIG_SH3_3	421	427	PF00018	0.593
LIG_SH3_3	51	57	PF00018	0.711
LIG_SUMO_SIM_par_1	370	376	PF11976	0.418
LIG_SUMO_SIM_par_1	382	388	PF11976	0.403
LIG_TRAF2_1	332	335	PF00917	0.590
LIG_TRAF2_1	357	360	PF00917	0.495
LIG_TYR_ITIM	110	115	PF00017	0.553
LIG_WRC_WIRS_1	128	133	PF05994	0.582
MOD_CDC14_SPxK_1	11	14	PF00782	0.515
MOD_CDK_SPxK_1	515	521	PF00069	0.494
MOD_CDK_SPxK_1	8	14	PF00069	0.528
MOD_CDK_SPxxK_3	8	15	PF00069	0.529
MOD_CK1_1	176	182	PF00069	0.583
MOD_CK1_1	270	276	PF00069	0.539
MOD_CK1_1	285	291	PF00069	0.494
MOD_CK1_1	294	300	PF00069	0.771
MOD_CK1_1	3	9	PF00069	0.763
MOD_CK1_1	33	39	PF00069	0.764
MOD_CK1_1	338	344	PF00069	0.487
MOD_CK1_1	492	498	PF00069	0.752
MOD_CK1_1	523	529	PF00069	0.516
MOD_CK2_1	329	335	PF00069	0.626
MOD_CK2_1	370	376	PF00069	0.508
MOD_CK2_1	488	494	PF00069	0.586
MOD_Cter_Amidation	100	103	PF01082	0.448
MOD_GlcNHglycan	270	273	PF01048	0.540
MOD_GlcNHglycan	284	287	PF01048	0.512
MOD_GlcNHglycan	293	296	PF01048	0.721
MOD_GlcNHglycan	298	301	PF01048	0.733
MOD_GlcNHglycan	304	307	PF01048	0.689
MOD_GlcNHglycan	310	313	PF01048	0.541
MOD_GlcNHglycan	414	417	PF01048	0.519
MOD_GlcNHglycan	447	450	PF01048	0.612
MOD_GlcNHglycan	497	500	PF01048	0.752
MOD_GlcNHglycan	522	525	PF01048	0.542
MOD_GSK3_1	145	152	PF00069	0.528
MOD_GSK3_1	172	179	PF00069	0.519
MOD_GSK3_1	26	33	PF00069	0.685
MOD_GSK3_1	282	289	PF00069	0.612
MOD_GSK3_1	290	297	PF00069	0.678
MOD_GSK3_1	441	448	PF00069	0.712
MOD_GSK3_1	488	495	PF00069	0.722
MOD_GSK3_1	55	62	PF00069	0.567
MOD_N-GLC_1	30	35	PF02516	0.525
MOD_NEK2_1	110	115	PF00069	0.435
MOD_NEK2_1	25	30	PF00069	0.605
MOD_NEK2_1	280	285	PF00069	0.540
MOD_NEK2_1	412	417	PF00069	0.725
MOD_NEK2_1	442	447	PF00069	0.568
MOD_PIKK_1	110	116	PF00454	0.409
MOD_PIKK_1	442	448	PF00454	0.699
MOD_PKA_2	176	182	PF00069	0.417
MOD_PKA_2	25	31	PF00069	0.616
MOD_PKA_2	338	344	PF00069	0.400
MOD_PKA_2	36	42	PF00069	0.681
MOD_Plk_1	472	478	PF00069	0.735
MOD_Plk_4	127	133	PF00069	0.501
MOD_Plk_4	176	182	PF00069	0.438
MOD_Plk_4	231	237	PF00069	0.318
MOD_Plk_4	3	9	PF00069	0.547
MOD_Plk_4	64	70	PF00069	0.606
MOD_ProDKin_1	254	260	PF00069	0.498
MOD_ProDKin_1	492	498	PF00069	0.567
MOD_ProDKin_1	515	521	PF00069	0.494
MOD_ProDKin_1	8	14	PF00069	0.528
MOD_SUMO_for_1	163	166	PF00179	0.405
TRG_ENDOCYTIC_2	112	115	PF00928	0.392
TRG_ENDOCYTIC_2	143	146	PF00928	0.607
TRG_ENDOCYTIC_2	159	162	PF00928	0.253
TRG_ENDOCYTIC_2	219	222	PF00928	0.390
TRG_ENDOCYTIC_2	432	435	PF00928	0.542
TRG_ENDOCYTIC_2	66	69	PF00928	0.578
TRG_ER_diArg_1	119	121	PF00400	0.480
TRG_ER_diArg_1	13	15	PF00400	0.679
TRG_ER_diArg_1	35	38	PF00400	0.653
TRG_NES_CRM1_1	346	360	PF08389	0.389
TRG_NLS_MonoExtC_3	459	464	PF00514	0.483
TRG_NLS_MonoExtN_4	409	414	PF00514	0.491
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	437	441	PF00026	0.688
TRG_Pf-PMV_PEXEL_1	95	100	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P950	Leptomonas seymouri	23%	95%
A0A0N1ILX4	Leptomonas seymouri	61%	100%
A0A0S4JKE9	Bodo saltans	50%	100%
A0A1X0NTZ8	Trypanosomatidae	54%	100%
A0A3Q8IAB6	Leishmania donovani	95%	98%
A0A3S5IRP3	Trypanosoma rangeli	55%	100%
A0A3S7X2J5	Leishmania donovani	25%	99%
A4H889	Leishmania braziliensis	86%	100%
A4HHF5	Leishmania braziliensis	26%	100%
A4HWL2	Leishmania infantum	96%	98%
A4I4K3	Leishmania infantum	25%	99%
C9ZL87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
C9ZXS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AE02	Leishmania major	25%	100%
E9ALT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AQB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
V5B4N1	Trypanosoma cruzi	54%	100%
V5D9T1	Trypanosoma cruzi	24%	100%