MGT1 magnesium transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MGT1 magnesium transporter

Species:

Leishmania major

UniProt:

Q4QF51_LEIMA

TriTrypDb:

LmjF.15.1310 , LMJLV39_150019800 , LMJSD75_150019800

Length:

831

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0005886	plasma membrane	3	2
GO:0016020	membrane	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QF51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF51

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006811	monoatomic ion transport	4	6
GO:0006812	monoatomic cation transport	5	6
GO:0015693	magnesium ion transport	7	6
GO:0030001	metal ion transport	6	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	2
GO:0005215	transporter activity	1	8
GO:0005488	binding	1	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	8
GO:0015075	monoatomic ion transmembrane transporter activity	3	8
GO:0015087	cobalt ion transmembrane transporter activity	7	2
GO:0015095	magnesium ion transmembrane transporter activity	6	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	8
GO:0022857	transmembrane transporter activity	2	8
GO:0022890	inorganic cation transmembrane transporter activity	4	8
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046873	metal ion transmembrane transporter activity	5	8
GO:0046914	transition metal ion binding	5	2
GO:0046915	transition metal ion transmembrane transporter activity	6	2
GO:0050897	cobalt ion binding	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.673
CLV_C14_Caspase3-7	494	498	PF00656	0.559
CLV_NRD_NRD_1	140	142	PF00675	0.554
CLV_NRD_NRD_1	144	146	PF00675	0.554
CLV_NRD_NRD_1	147	149	PF00675	0.546
CLV_NRD_NRD_1	475	477	PF00675	0.526
CLV_NRD_NRD_1	676	678	PF00675	0.280
CLV_NRD_NRD_1	701	703	PF00675	0.263
CLV_NRD_NRD_1	828	830	PF00675	0.315
CLV_NRD_NRD_1	86	88	PF00675	0.433
CLV_PCSK_FUR_1	138	142	PF00082	0.567
CLV_PCSK_FUR_1	145	149	PF00082	0.608
CLV_PCSK_KEX2_1	135	137	PF00082	0.554
CLV_PCSK_KEX2_1	140	142	PF00082	0.554
CLV_PCSK_KEX2_1	143	145	PF00082	0.556
CLV_PCSK_KEX2_1	147	149	PF00082	0.546
CLV_PCSK_KEX2_1	475	477	PF00082	0.526
CLV_PCSK_KEX2_1	598	600	PF00082	0.333
CLV_PCSK_KEX2_1	676	678	PF00082	0.255
CLV_PCSK_KEX2_1	701	703	PF00082	0.263
CLV_PCSK_KEX2_1	86	88	PF00082	0.433
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.554
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.317
CLV_PCSK_PC7_1	136	142	PF00082	0.550
CLV_PCSK_PC7_1	143	149	PF00082	0.559
CLV_PCSK_PC7_1	594	600	PF00082	0.317
CLV_PCSK_SKI1_1	338	342	PF00082	0.488
CLV_PCSK_SKI1_1	475	479	PF00082	0.483
CLV_PCSK_SKI1_1	548	552	PF00082	0.297
CLV_PCSK_SKI1_1	660	664	PF00082	0.294
CLV_PCSK_SKI1_1	671	675	PF00082	0.247
CLV_PCSK_SKI1_1	676	680	PF00082	0.212
CLV_PCSK_SKI1_1	719	723	PF00082	0.306
CLV_PCSK_SKI1_1	754	758	PF00082	0.263
DEG_APCC_DBOX_1	85	93	PF00400	0.620
DEG_MDM2_SWIB_1	486	493	PF02201	0.560
DEG_SCF_FBW7_1	648	654	PF00400	0.517
DEG_SPOP_SBC_1	156	160	PF00917	0.706
DOC_CDC14_PxL_1	240	248	PF14671	0.703
DOC_CKS1_1	301	306	PF01111	0.714
DOC_CKS1_1	35	40	PF01111	0.705
DOC_CKS1_1	648	653	PF01111	0.517
DOC_CKS1_1	781	786	PF01111	0.360
DOC_CYCLIN_RxL_1	671	683	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	405	411	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	781	787	PF00134	0.360
DOC_MAPK_MEF2A_6	567	574	PF00069	0.503
DOC_MAPK_MEF2A_6	575	582	PF00069	0.463
DOC_MAPK_MEF2A_6	754	763	PF00069	0.463
DOC_MAPK_NFAT4_5	754	762	PF00069	0.463
DOC_MAPK_RevD_3	815	830	PF00069	0.231
DOC_PP2B_LxvP_1	528	531	PF13499	0.572
DOC_PP4_FxxP_1	317	320	PF00568	0.679
DOC_PP4_FxxP_1	35	38	PF00568	0.681
DOC_SPAK_OSR1_1	205	209	PF12202	0.718
DOC_USP7_MATH_1	123	127	PF00917	0.677
DOC_USP7_MATH_1	156	160	PF00917	0.752
DOC_USP7_MATH_1	185	189	PF00917	0.753
DOC_USP7_MATH_1	290	294	PF00917	0.727
DOC_USP7_MATH_1	318	322	PF00917	0.808
DOC_USP7_MATH_1	331	335	PF00917	0.732
DOC_USP7_MATH_1	423	427	PF00917	0.768
DOC_USP7_MATH_1	428	432	PF00917	0.729
DOC_USP7_MATH_1	477	481	PF00917	0.717
DOC_USP7_MATH_1	651	655	PF00917	0.507
DOC_USP7_MATH_1	667	671	PF00917	0.506
DOC_USP7_MATH_1	70	74	PF00917	0.739
DOC_USP7_MATH_1	76	80	PF00917	0.717
DOC_USP7_UBL2_3	131	135	PF12436	0.753
DOC_USP7_UBL2_3	636	640	PF12436	0.506
DOC_USP7_UBL2_3	719	723	PF12436	0.551
DOC_WW_Pin1_4	246	251	PF00397	0.765
DOC_WW_Pin1_4	300	305	PF00397	0.797
DOC_WW_Pin1_4	316	321	PF00397	0.633
DOC_WW_Pin1_4	34	39	PF00397	0.737
DOC_WW_Pin1_4	533	538	PF00397	0.537
DOC_WW_Pin1_4	647	652	PF00397	0.586
DOC_WW_Pin1_4	682	687	PF00397	0.495
DOC_WW_Pin1_4	7	12	PF00397	0.733
DOC_WW_Pin1_4	780	785	PF00397	0.360
LIG_14-3-3_CanoR_1	154	164	PF00244	0.767
LIG_14-3-3_CanoR_1	338	343	PF00244	0.741
LIG_14-3-3_CanoR_1	346	352	PF00244	0.714
LIG_14-3-3_CanoR_1	424	428	PF00244	0.783
LIG_14-3-3_CanoR_1	476	482	PF00244	0.698
LIG_14-3-3_CanoR_1	548	556	PF00244	0.552
LIG_14-3-3_CanoR_1	701	706	PF00244	0.520
LIG_14-3-3_CanoR_1	767	775	PF00244	0.546
LIG_14-3-3_CanoR_1	777	781	PF00244	0.300
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_BRCT_BRCA1_1	202	206	PF00533	0.682
LIG_BRCT_BRCA1_1	32	36	PF00533	0.617
LIG_BRCT_BRCA1_1	444	448	PF00533	0.707
LIG_BRCT_BRCA1_1	478	482	PF00533	0.689
LIG_CORNRBOX	612	620	PF00104	0.506
LIG_deltaCOP1_diTrp_1	802	812	PF00928	0.263
LIG_eIF4E_1	539	545	PF01652	0.542
LIG_FHA_1	171	177	PF00498	0.771
LIG_FHA_1	290	296	PF00498	0.712
LIG_FHA_1	301	307	PF00498	0.669
LIG_FHA_1	400	406	PF00498	0.653
LIG_FHA_1	525	531	PF00498	0.676
LIG_FHA_1	549	555	PF00498	0.528
LIG_FHA_1	620	626	PF00498	0.541
LIG_FHA_1	629	635	PF00498	0.512
LIG_FHA_1	648	654	PF00498	0.565
LIG_FHA_1	711	717	PF00498	0.466
LIG_FHA_1	766	772	PF00498	0.506
LIG_FHA_2	106	112	PF00498	0.601
LIG_FHA_2	172	178	PF00498	0.743
LIG_FHA_2	20	26	PF00498	0.759
LIG_FHA_2	215	221	PF00498	0.727
LIG_FHA_2	339	345	PF00498	0.670
LIG_FHA_2	452	458	PF00498	0.669
LIG_FHA_2	492	498	PF00498	0.604
LIG_FHA_2	647	653	PF00498	0.522
LIG_IRF3_LxIS_1	756	762	PF10401	0.463
LIG_LIR_Apic_2	314	320	PF02991	0.682
LIG_LIR_Apic_2	32	38	PF02991	0.734
LIG_LIR_Apic_2	804	810	PF02991	0.260
LIG_LIR_Gen_1	203	214	PF02991	0.717
LIG_LIR_Gen_1	565	574	PF02991	0.491
LIG_LIR_Gen_1	607	616	PF02991	0.469
LIG_LIR_Nem_3	203	209	PF02991	0.720
LIG_LIR_Nem_3	212	218	PF02991	0.713
LIG_LIR_Nem_3	350	354	PF02991	0.582
LIG_LIR_Nem_3	483	489	PF02991	0.596
LIG_LIR_Nem_3	565	571	PF02991	0.489
LIG_LIR_Nem_3	595	600	PF02991	0.471
LIG_LIR_Nem_3	607	611	PF02991	0.453
LIG_LIR_Nem_3	779	785	PF02991	0.344
LIG_LIR_Nem_3	806	812	PF02991	0.308
LIG_MLH1_MIPbox_1	32	36	PF16413	0.617
LIG_MLH1_MIPbox_1	478	482	PF16413	0.689
LIG_NRBOX	674	680	PF00104	0.463
LIG_PCNA_yPIPBox_3	216	226	PF02747	0.630
LIG_Pex14_1	805	809	PF04695	0.263
LIG_Pex14_2	482	486	PF04695	0.635
LIG_Pex14_2	796	800	PF04695	0.306
LIG_SH2_CRK	339	343	PF00017	0.631
LIG_SH2_CRK	807	811	PF00017	0.280
LIG_SH2_GRB2like	384	387	PF00017	0.519
LIG_SH2_NCK_1	240	244	PF00017	0.700
LIG_SH2_NCK_1	339	343	PF00017	0.631
LIG_SH2_SRC	282	285	PF00017	0.741
LIG_SH2_STAP1	621	625	PF00017	0.512
LIG_SH2_STAT3	481	484	PF00017	0.649
LIG_SH2_STAT3	539	542	PF00017	0.556
LIG_SH2_STAT5	384	387	PF00017	0.519
LIG_SH2_STAT5	481	484	PF00017	0.649
LIG_SH2_STAT5	509	512	PF00017	0.578
LIG_SH2_STAT5	543	546	PF00017	0.551
LIG_SH2_STAT5	621	624	PF00017	0.517
LIG_SH2_STAT5	657	660	PF00017	0.506
LIG_SH3_3	244	250	PF00018	0.743
LIG_SH3_3	298	304	PF00018	0.676
LIG_SH3_3	38	44	PF00018	0.703
LIG_SH3_3	417	423	PF00018	0.716
LIG_SH3_3	424	430	PF00018	0.761
LIG_SH3_3	53	59	PF00018	0.719
LIG_SH3_3	64	70	PF00018	0.795
LIG_SH3_3	640	646	PF00018	0.504
LIG_SUMO_SIM_par_1	568	573	PF11976	0.463
LIG_SUMO_SIM_par_1	87	94	PF11976	0.662
LIG_TRAF2_1	108	111	PF00917	0.627
LIG_TRAF2_1	454	457	PF00917	0.674
LIG_TRAF2_1	460	463	PF00917	0.648
LIG_TRAF2_1	607	610	PF00917	0.463
LIG_UBA3_1	506	515	PF00899	0.321
LIG_WRC_WIRS_1	692	697	PF05994	0.349
LIG_WRC_WIRS_1	763	768	PF05994	0.300
LIG_WRC_WIRS_1	81	86	PF05994	0.490
LIG_WW_3	57	61	PF00397	0.623
MOD_CDK_SPxxK_3	682	689	PF00069	0.328
MOD_CK1_1	122	128	PF00069	0.574
MOD_CK1_1	134	140	PF00069	0.577
MOD_CK1_1	149	155	PF00069	0.530
MOD_CK1_1	157	163	PF00069	0.605
MOD_CK1_1	170	176	PF00069	0.604
MOD_CK1_1	186	192	PF00069	0.691
MOD_CK1_1	194	200	PF00069	0.755
MOD_CK1_1	3	9	PF00069	0.678
MOD_CK1_1	45	51	PF00069	0.730
MOD_CK1_1	469	475	PF00069	0.637
MOD_CK1_1	557	563	PF00069	0.452
MOD_CK1_1	604	610	PF00069	0.336
MOD_CK1_1	669	675	PF00069	0.346
MOD_CK1_1	762	768	PF00069	0.300
MOD_CK2_1	105	111	PF00069	0.511
MOD_CK2_1	3	9	PF00069	0.537
MOD_CK2_1	428	434	PF00069	0.619
MOD_CK2_1	451	457	PF00069	0.725
MOD_CK2_1	477	483	PF00069	0.623
MOD_CK2_1	557	563	PF00069	0.474
MOD_CK2_1	604	610	PF00069	0.318
MOD_CK2_1	646	652	PF00069	0.304
MOD_CK2_1	735	741	PF00069	0.376
MOD_Cter_Amidation	138	141	PF01082	0.772
MOD_Cter_Amidation	145	148	PF01082	0.635
MOD_GlcNHglycan	121	124	PF01048	0.704
MOD_GlcNHglycan	125	128	PF01048	0.612
MOD_GlcNHglycan	154	157	PF01048	0.636
MOD_GlcNHglycan	179	182	PF01048	0.670
MOD_GlcNHglycan	296	299	PF01048	0.821
MOD_GlcNHglycan	320	323	PF01048	0.637
MOD_GlcNHglycan	390	393	PF01048	0.500
MOD_GlcNHglycan	44	47	PF01048	0.628
MOD_GlcNHglycan	652	656	PF01048	0.330
MOD_GlcNHglycan	72	75	PF01048	0.612
MOD_GSK3_1	119	126	PF00069	0.566
MOD_GSK3_1	146	153	PF00069	0.695
MOD_GSK3_1	155	162	PF00069	0.636
MOD_GSK3_1	167	174	PF00069	0.621
MOD_GSK3_1	175	182	PF00069	0.586
MOD_GSK3_1	183	190	PF00069	0.670
MOD_GSK3_1	191	198	PF00069	0.704
MOD_GSK3_1	246	253	PF00069	0.646
MOD_GSK3_1	25	32	PF00069	0.702
MOD_GSK3_1	290	297	PF00069	0.752
MOD_GSK3_1	3	10	PF00069	0.562
MOD_GSK3_1	305	312	PF00069	0.640
MOD_GSK3_1	316	323	PF00069	0.768
MOD_GSK3_1	384	391	PF00069	0.466
MOD_GSK3_1	45	52	PF00069	0.774
MOD_GSK3_1	462	469	PF00069	0.591
MOD_GSK3_1	619	626	PF00069	0.326
MOD_GSK3_1	647	654	PF00069	0.395
MOD_GSK3_1	76	83	PF00069	0.641
MOD_GSK3_1	762	769	PF00069	0.450
MOD_GSK3_1	776	783	PF00069	0.262
MOD_N-GLC_1	150	155	PF02516	0.640
MOD_N-GLC_1	3	8	PF02516	0.677
MOD_N-GLC_1	604	609	PF02516	0.376
MOD_N-GLC_1	710	715	PF02516	0.360
MOD_NEK2_1	30	35	PF00069	0.638
MOD_NEK2_1	400	405	PF00069	0.576
MOD_NEK2_1	464	469	PF00069	0.663
MOD_NEK2_1	482	487	PF00069	0.529
MOD_NEK2_1	50	55	PF00069	0.672
MOD_NEK2_1	516	521	PF00069	0.442
MOD_NEK2_1	562	567	PF00069	0.360
MOD_NEK2_1	666	671	PF00069	0.322
MOD_NEK2_1	735	740	PF00069	0.360
MOD_NEK2_1	759	764	PF00069	0.300
MOD_PIKK_1	400	406	PF00454	0.572
MOD_PIKK_1	413	419	PF00454	0.668
MOD_PIKK_1	442	448	PF00454	0.647
MOD_PIKK_1	592	598	PF00454	0.448
MOD_PIKK_1	710	716	PF00454	0.300
MOD_PK_1	701	707	PF00069	0.306
MOD_PKA_1	701	707	PF00069	0.349
MOD_PKA_2	146	152	PF00069	0.690
MOD_PKA_2	162	168	PF00069	0.704
MOD_PKA_2	170	176	PF00069	0.673
MOD_PKA_2	183	189	PF00069	0.653
MOD_PKA_2	25	31	PF00069	0.611
MOD_PKA_2	423	429	PF00069	0.790
MOD_PKA_2	442	448	PF00069	0.467
MOD_PKA_2	700	706	PF00069	0.333
MOD_PKA_2	76	82	PF00069	0.620
MOD_PKA_2	766	772	PF00069	0.416
MOD_PKA_2	776	782	PF00069	0.300
MOD_PKB_1	148	156	PF00069	0.655
MOD_PKB_1	169	177	PF00069	0.670
MOD_Plk_1	17	23	PF00069	0.622
MOD_Plk_1	451	457	PF00069	0.725
MOD_Plk_1	482	488	PF00069	0.497
MOD_Plk_1	524	530	PF00069	0.485
MOD_Plk_1	557	563	PF00069	0.452
MOD_Plk_1	604	610	PF00069	0.300
MOD_Plk_1	801	807	PF00069	0.309
MOD_Plk_2-3	284	290	PF00069	0.650
MOD_Plk_4	10	16	PF00069	0.541
MOD_Plk_4	30	36	PF00069	0.649
MOD_Plk_4	477	483	PF00069	0.600
MOD_Plk_4	516	522	PF00069	0.415
MOD_Plk_4	524	530	PF00069	0.482
MOD_Plk_4	557	563	PF00069	0.393
MOD_Plk_4	691	697	PF00069	0.349
MOD_Plk_4	752	758	PF00069	0.300
MOD_Plk_4	776	782	PF00069	0.360
MOD_Plk_4	783	789	PF00069	0.171
MOD_ProDKin_1	246	252	PF00069	0.721
MOD_ProDKin_1	300	306	PF00069	0.769
MOD_ProDKin_1	316	322	PF00069	0.537
MOD_ProDKin_1	34	40	PF00069	0.686
MOD_ProDKin_1	533	539	PF00069	0.405
MOD_ProDKin_1	647	653	PF00069	0.473
MOD_ProDKin_1	682	688	PF00069	0.344
MOD_ProDKin_1	7	13	PF00069	0.677
MOD_ProDKin_1	780	786	PF00069	0.360
MOD_SUMO_rev_2	635	642	PF00179	0.314
MOD_SUMO_rev_2	748	756	PF00179	0.300
TRG_DiLeu_BaEn_2	637	643	PF01217	0.360
TRG_DiLeu_BaEn_2	690	696	PF01217	0.360
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.619
TRG_DiLeu_BaLyEn_6	674	679	PF01217	0.360
TRG_ENDOCYTIC_2	282	285	PF00928	0.668
TRG_ENDOCYTIC_2	339	342	PF00928	0.677
TRG_ENDOCYTIC_2	351	354	PF00928	0.502
TRG_ENDOCYTIC_2	503	506	PF00928	0.346
TRG_ENDOCYTIC_2	809	812	PF00928	0.326
TRG_ER_diArg_1	138	141	PF00400	0.667
TRG_ER_diArg_1	143	145	PF00400	0.622
TRG_ER_diArg_1	147	150	PF00400	0.598
TRG_ER_diArg_1	161	164	PF00400	0.586
TRG_ER_diArg_1	675	677	PF00400	0.336
TRG_ER_diArg_1	86	88	PF00400	0.538
TRG_NLS_MonoExtN_4	133	139	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.668
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	96	100	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7K4	Leptomonas seymouri	61%	99%
A0A3R7M2P8	Trypanosoma rangeli	40%	100%
A0A3S7WTL5	Leishmania donovani	94%	100%
A4H894	Leishmania braziliensis	74%	100%
A4HWL6	Leishmania infantum	94%	100%
E9AQC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%