EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF48_LEIMA

TriTrypDb:

LmjF.15.1340 , LMJLV39_150020100 , LMJSD75_150020100

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF48

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	54	58	PF00656	0.614
CLV_NRD_NRD_1	118	120	PF00675	0.404
CLV_NRD_NRD_1	132	134	PF00675	0.451
CLV_NRD_NRD_1	17	19	PF00675	0.497
CLV_NRD_NRD_1	366	368	PF00675	0.673
CLV_PCSK_KEX2_1	118	120	PF00082	0.403
CLV_PCSK_KEX2_1	132	134	PF00082	0.454
CLV_PCSK_KEX2_1	16	18	PF00082	0.516
CLV_PCSK_KEX2_1	366	368	PF00082	0.673
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.455
CLV_PCSK_SKI1_1	110	114	PF00082	0.411
CLV_PCSK_SKI1_1	121	125	PF00082	0.431
CLV_PCSK_SKI1_1	142	146	PF00082	0.486
CLV_PCSK_SKI1_1	17	21	PF00082	0.541
CLV_PCSK_SKI1_1	277	281	PF00082	0.592
CLV_PCSK_SKI1_1	300	304	PF00082	0.583
DEG_Kelch_Keap1_1	230	235	PF01344	0.602
DEG_SCF_TRCP1_1	57	63	PF00400	0.585
DOC_CYCLIN_RxL_1	139	148	PF00134	0.516
DOC_MAPK_gen_1	16	24	PF00069	0.525
DOC_MAPK_gen_1	300	310	PF00069	0.657
DOC_MAPK_MEF2A_6	303	312	PF00069	0.639
DOC_MAPK_NFAT4_5	303	311	PF00069	0.638
DOC_PP4_FxxP_1	181	184	PF00568	0.620
DOC_USP7_MATH_1	126	130	PF00917	0.480
DOC_USP7_MATH_1	177	181	PF00917	0.602
DOC_USP7_MATH_1	188	192	PF00917	0.448
DOC_USP7_UBL2_3	16	20	PF12436	0.532
DOC_WW_Pin1_4	180	185	PF00397	0.616
DOC_WW_Pin1_4	250	255	PF00397	0.468
DOC_WW_Pin1_4	81	86	PF00397	0.514
LIG_14-3-3_CanoR_1	239	243	PF00244	0.517
LIG_14-3-3_CterR_2	366	371	PF00244	0.618
LIG_Actin_WH2_2	105	123	PF00022	0.522
LIG_Actin_WH2_2	12	27	PF00022	0.434
LIG_BRCT_BRCA1_1	252	256	PF00533	0.436
LIG_FHA_1	107	113	PF00498	0.444
LIG_FHA_1	262	268	PF00498	0.446
LIG_FHA_1	27	33	PF00498	0.572
LIG_FHA_2	281	287	PF00498	0.582
LIG_FHA_2	52	58	PF00498	0.605
LIG_FHA_2	6	12	PF00498	0.563
LIG_FHA_2	82	88	PF00498	0.499
LIG_HCF-1_HBM_1	325	328	PF13415	0.656
LIG_IRF3_LxIS_1	306	313	PF10401	0.480
LIG_LIR_Apic_2	178	184	PF02991	0.631
LIG_LIR_Apic_2	325	331	PF02991	0.641
LIG_LIR_Gen_1	147	157	PF02991	0.528
LIG_LIR_Gen_1	244	252	PF02991	0.377
LIG_LIR_Gen_1	316	327	PF02991	0.571
LIG_LIR_Nem_3	147	152	PF02991	0.508
LIG_LIR_Nem_3	241	245	PF02991	0.390
LIG_LIR_Nem_3	348	352	PF02991	0.523
LIG_LRP6_Inhibitor_1	4	10	PF00058	0.637
LIG_RPA_C_Fungi	114	126	PF08784	0.452
LIG_SH2_CRK	249	253	PF00017	0.417
LIG_SH2_PTP2	328	331	PF00017	0.548
LIG_SH2_SRC	328	331	PF00017	0.559
LIG_SH2_STAP1	242	246	PF00017	0.504
LIG_SH2_STAT5	245	248	PF00017	0.435
LIG_SH2_STAT5	301	304	PF00017	0.649
LIG_SH2_STAT5	328	331	PF00017	0.537
LIG_SH2_STAT5	349	352	PF00017	0.522
LIG_SH2_STAT5	90	93	PF00017	0.390
LIG_SH3_1	328	334	PF00018	0.547
LIG_SH3_3	161	167	PF00018	0.566
LIG_SH3_3	328	334	PF00018	0.522
LIG_SUMO_SIM_par_1	292	297	PF11976	0.542
LIG_WRC_WIRS_1	146	151	PF05994	0.448
MOD_CK1_1	104	110	PF00069	0.529
MOD_CK1_1	180	186	PF00069	0.445
MOD_CK1_1	313	319	PF00069	0.547
MOD_CK1_1	55	61	PF00069	0.679
MOD_CK2_1	238	244	PF00069	0.468
MOD_CK2_1	280	286	PF00069	0.612
MOD_CK2_1	5	11	PF00069	0.579
MOD_CK2_1	81	87	PF00069	0.467
MOD_GlcNHglycan	103	106	PF01048	0.520
MOD_GlcNHglycan	136	139	PF01048	0.610
MOD_GlcNHglycan	215	218	PF01048	0.706
MOD_GlcNHglycan	232	235	PF01048	0.536
MOD_GlcNHglycan	57	60	PF01048	0.694
MOD_GlcNHglycan	99	102	PF01048	0.547
MOD_GSK3_1	106	113	PF00069	0.454
MOD_GSK3_1	134	141	PF00069	0.522
MOD_GSK3_1	175	182	PF00069	0.669
MOD_GSK3_1	313	320	PF00069	0.534
MOD_GSK3_1	341	348	PF00069	0.593
MOD_GSK3_1	51	58	PF00069	0.643
MOD_GSK3_1	97	104	PF00069	0.534
MOD_N-GLC_1	317	322	PF02516	0.542
MOD_N-GLC_1	5	10	PF02516	0.528
MOD_NEK2_1	144	149	PF00069	0.433
MOD_NEK2_1	189	194	PF00069	0.463
MOD_NEK2_1	280	285	PF00069	0.594
MOD_NEK2_1	310	315	PF00069	0.605
MOD_NEK2_1	341	346	PF00069	0.566
MOD_PKA_2	213	219	PF00069	0.563
MOD_PKA_2	238	244	PF00069	0.521
MOD_PKA_2	50	56	PF00069	0.578
MOD_Plk_1	317	323	PF00069	0.544
MOD_Plk_1	5	11	PF00069	0.613
MOD_Plk_2-3	238	244	PF00069	0.528
MOD_Plk_4	207	213	PF00069	0.609
MOD_ProDKin_1	180	186	PF00069	0.608
MOD_ProDKin_1	250	256	PF00069	0.467
MOD_ProDKin_1	81	87	PF00069	0.509
TRG_ENDOCYTIC_2	245	248	PF00928	0.445
TRG_ENDOCYTIC_2	249	252	PF00928	0.383
TRG_ENDOCYTIC_2	319	322	PF00928	0.645
TRG_ENDOCYTIC_2	349	352	PF00928	0.580
TRG_ER_diArg_1	118	121	PF00400	0.457
TRG_ER_diArg_1	17	19	PF00400	0.489
TRG_NLS_MonoExtC_3	15	20	PF00514	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCG2	Leptomonas seymouri	56%	100%
A0A0S4JMV6	Bodo saltans	29%	100%
A0A1X0NUM9	Trypanosomatidae	37%	100%
A0A3R7MLD6	Trypanosoma rangeli	35%	100%
A0A3S7WTM7	Leishmania donovani	93%	100%
A4H897	Leishmania braziliensis	75%	100%
A4HWL9	Leishmania infantum	92%	100%
E9AQC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BUD9	Trypanosoma cruzi	34%	100%