Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF47_LEIMA

TriTrypDb:

LmjF.15.1345 , LMJLV39_150020300 , LMJSD75_150020300

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.746
CLV_NRD_NRD_1	172	174	PF00675	0.754
CLV_NRD_NRD_1	65	67	PF00675	0.641
CLV_PCSK_KEX2_1	171	173	PF00082	0.779
CLV_PCSK_KEX2_1	65	67	PF00082	0.606
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.717
CLV_PCSK_SKI1_1	57	61	PF00082	0.593
CLV_PCSK_SKI1_1	65	69	PF00082	0.547
DEG_SPOP_SBC_1	184	188	PF00917	0.766
DOC_CYCLIN_RxL_1	62	72	PF00134	0.620
DOC_USP7_MATH_1	129	133	PF00917	0.686
DOC_USP7_MATH_1	164	168	PF00917	0.719
DOC_USP7_MATH_1	176	180	PF00917	0.756
DOC_USP7_MATH_1	70	74	PF00917	0.640
DOC_WW_Pin1_4	10	15	PF00397	0.634
DOC_WW_Pin1_4	118	123	PF00397	0.807
DOC_WW_Pin1_4	186	191	PF00397	0.824
DOC_WW_Pin1_4	2	7	PF00397	0.725
LIG_14-3-3_CanoR_1	17	22	PF00244	0.682
LIG_14-3-3_CanoR_1	65	74	PF00244	0.509
LIG_Actin_WH2_2	238	256	PF00022	0.560
LIG_BIR_III_2	128	132	PF00653	0.555
LIG_BIR_III_2	265	269	PF00653	0.605
LIG_BRCT_BRCA1_1	287	291	PF00533	0.622
LIG_FHA_1	14	20	PF00498	0.833
LIG_FHA_1	180	186	PF00498	0.607
LIG_FHA_1	202	208	PF00498	0.641
LIG_FHA_1	62	68	PF00498	0.600
LIG_FHA_2	105	111	PF00498	0.822
LIG_FHA_2	67	73	PF00498	0.546
LIG_Integrin_RGD_1	279	281	PF01839	0.759
LIG_RPA_C_Fungi	48	60	PF08784	0.579
LIG_SH2_STAP1	287	291	PF00017	0.682
LIG_SH3_3	12	18	PF00018	0.669
LIG_SH3_3	148	154	PF00018	0.697
LIG_SH3_3	189	195	PF00018	0.819
LIG_SH3_3	22	28	PF00018	0.662
LIG_SUMO_SIM_anti_2	229	234	PF11976	0.541
LIG_TRAF2_1	212	215	PF00917	0.639
LIG_TRAF2_1	267	270	PF00917	0.797
LIG_WW_3	196	200	PF00397	0.758
MOD_CDK_SPK_2	118	123	PF00069	0.643
MOD_CDK_SPxxK_3	10	17	PF00069	0.651
MOD_CDK_SPxxK_3	2	9	PF00069	0.750
MOD_CK1_1	116	122	PF00069	0.760
MOD_CK1_1	13	19	PF00069	0.670
MOD_CK1_1	165	171	PF00069	0.684
MOD_CK1_1	179	185	PF00069	0.762
MOD_CK1_1	186	192	PF00069	0.698
MOD_CK1_1	231	237	PF00069	0.603
MOD_CK1_1	285	291	PF00069	0.726
MOD_CK1_1	295	301	PF00069	0.634
MOD_CK2_1	139	145	PF00069	0.623
MOD_CK2_1	209	215	PF00069	0.646
MOD_CK2_1	223	229	PF00069	0.392
MOD_GlcNHglycan	115	118	PF01048	0.808
MOD_GlcNHglycan	130	134	PF01048	0.556
MOD_GlcNHglycan	141	144	PF01048	0.528
MOD_GlcNHglycan	178	181	PF01048	0.779
MOD_GlcNHglycan	199	202	PF01048	0.717
MOD_GlcNHglycan	2	5	PF01048	0.802
MOD_GlcNHglycan	209	212	PF01048	0.716
MOD_GlcNHglycan	225	228	PF01048	0.403
MOD_GlcNHglycan	235	238	PF01048	0.647
MOD_GlcNHglycan	259	262	PF01048	0.817
MOD_GlcNHglycan	298	301	PF01048	0.743
MOD_GSK3_1	112	119	PF00069	0.809
MOD_GSK3_1	13	20	PF00069	0.643
MOD_GSK3_1	154	161	PF00069	0.818
MOD_GSK3_1	162	169	PF00069	0.753
MOD_GSK3_1	179	186	PF00069	0.789
MOD_GSK3_1	197	204	PF00069	0.600
MOD_GSK3_1	281	288	PF00069	0.712
MOD_GSK3_1	292	299	PF00069	0.759
MOD_GSK3_1	66	73	PF00069	0.490
MOD_NEK2_1	207	212	PF00069	0.604
MOD_NEK2_1	228	233	PF00069	0.595
MOD_NEK2_1	61	66	PF00069	0.587
MOD_PKA_2	165	171	PF00069	0.793
MOD_PKA_2	61	67	PF00069	0.650
MOD_Plk_1	228	234	PF00069	0.585
MOD_Plk_1	70	76	PF00069	0.728
MOD_Plk_1	87	93	PF00069	0.522
MOD_Plk_4	228	234	PF00069	0.537
MOD_ProDKin_1	10	16	PF00069	0.636
MOD_ProDKin_1	118	124	PF00069	0.806
MOD_ProDKin_1	186	192	PF00069	0.823
MOD_ProDKin_1	2	8	PF00069	0.728
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.654
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.381
TRG_ER_diArg_1	50	53	PF00400	0.515
TRG_ER_diArg_1	65	67	PF00400	0.582
TRG_Pf-PMV_PEXEL_1	17	21	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	66	71	PF00026	0.470

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEC2	Leptomonas seymouri	40%	88%
A0A3Q8IDH2	Leishmania donovani	89%	100%
A4H899	Leishmania braziliensis	58%	92%
A4HWM1	Leishmania infantum	90%	100%
E9AQC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%