Rab-GAP TBC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF46_LEIMA

TriTrypDb:

LmjF.15.1350 , LMJLV39_150020400 , LMJSD75_150020400

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF46

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF46

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	379	383	PF00656	0.314
CLV_C14_Caspase3-7	492	496	PF00656	0.291
CLV_C14_Caspase3-7	607	611	PF00656	0.343
CLV_NRD_NRD_1	206	208	PF00675	0.480
CLV_NRD_NRD_1	366	368	PF00675	0.249
CLV_NRD_NRD_1	419	421	PF00675	0.573
CLV_NRD_NRD_1	631	633	PF00675	0.595
CLV_PCSK_KEX2_1	366	368	PF00082	0.249
CLV_PCSK_KEX2_1	418	420	PF00082	0.572
CLV_PCSK_KEX2_1	631	633	PF00082	0.608
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.632
CLV_PCSK_PC7_1	414	420	PF00082	0.576
CLV_PCSK_PC7_1	627	633	PF00082	0.583
CLV_PCSK_SKI1_1	219	223	PF00082	0.476
CLV_PCSK_SKI1_1	366	370	PF00082	0.244
CLV_PCSK_SKI1_1	384	388	PF00082	0.553
CLV_PCSK_SKI1_1	404	408	PF00082	0.405
CLV_PCSK_SKI1_1	439	443	PF00082	0.536
CLV_PCSK_SKI1_1	491	495	PF00082	0.475
CLV_PCSK_SKI1_1	599	603	PF00082	0.502
CLV_PCSK_SKI1_1	695	699	PF00082	0.336
DEG_APCC_DBOX_1	234	242	PF00400	0.602
DEG_APCC_DBOX_1	438	446	PF00400	0.370
DEG_APCC_DBOX_1	694	702	PF00400	0.475
DOC_ANK_TNKS_1	245	252	PF00023	0.570
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	577	583	PF00134	0.373
DOC_MAPK_DCC_7	235	243	PF00069	0.588
DOC_MAPK_gen_1	433	442	PF00069	0.384
DOC_MAPK_gen_1	631	637	PF00069	0.326
DOC_MAPK_MEF2A_6	235	243	PF00069	0.588
DOC_MAPK_MEF2A_6	372	380	PF00069	0.300
DOC_MAPK_MEF2A_6	587	596	PF00069	0.283
DOC_MAPK_MEF2A_6	677	686	PF00069	0.588
DOC_PP2B_LxvP_1	374	377	PF13499	0.325
DOC_PP2B_LxvP_1	475	478	PF13499	0.269
DOC_PP2B_LxvP_1	577	580	PF13499	0.381
DOC_PP2B_LxvP_1	635	638	PF13499	0.334
DOC_PP2B_LxvP_1	84	87	PF13499	0.438
DOC_USP7_MATH_1	160	164	PF00917	0.589
DOC_USP7_MATH_1	27	31	PF00917	0.500
DOC_USP7_MATH_1	271	275	PF00917	0.653
DOC_USP7_MATH_1	328	332	PF00917	0.622
DOC_USP7_MATH_1	58	62	PF00917	0.529
DOC_WW_Pin1_4	214	219	PF00397	0.713
DOC_WW_Pin1_4	37	42	PF00397	0.550
DOC_WW_Pin1_4	557	562	PF00397	0.257
DOC_WW_Pin1_4	630	635	PF00397	0.376
DOC_WW_Pin1_4	648	653	PF00397	0.406
DOC_WW_Pin1_4	92	97	PF00397	0.433
LIG_14-3-3_CanoR_1	195	203	PF00244	0.543
LIG_14-3-3_CanoR_1	45	52	PF00244	0.534
LIG_14-3-3_CanoR_1	632	638	PF00244	0.349
LIG_14-3-3_CanoR_1	693	698	PF00244	0.558
LIG_APCC_ABBAyCdc20_2	454	460	PF00400	0.295
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BRCT_BRCA1_1	197	201	PF00533	0.542
LIG_BRCT_BRCA1_1	241	245	PF00533	0.497
LIG_deltaCOP1_diTrp_1	66	71	PF00928	0.468
LIG_DLG_GKlike_1	693	701	PF00625	0.575
LIG_eIF4E_1	503	509	PF01652	0.377
LIG_FHA_1	220	226	PF00498	0.759
LIG_FHA_1	261	267	PF00498	0.535
LIG_FHA_1	330	336	PF00498	0.638
LIG_FHA_1	393	399	PF00498	0.489
LIG_FHA_1	457	463	PF00498	0.291
LIG_FHA_1	465	471	PF00498	0.266
LIG_FHA_1	504	510	PF00498	0.311
LIG_FHA_1	558	564	PF00498	0.254
LIG_FHA_1	584	590	PF00498	0.292
LIG_FHA_1	67	73	PF00498	0.419
LIG_FHA_1	692	698	PF00498	0.560
LIG_FHA_2	142	148	PF00498	0.433
LIG_FHA_2	154	160	PF00498	0.537
LIG_FHA_2	284	290	PF00498	0.520
LIG_FHA_2	377	383	PF00498	0.314
LIG_FHA_2	676	682	PF00498	0.489
LIG_GBD_Chelix_1	544	552	PF00786	0.499
LIG_LIR_Gen_1	310	320	PF02991	0.566
LIG_LIR_Gen_1	341	349	PF02991	0.547
LIG_LIR_Gen_1	443	453	PF02991	0.381
LIG_LIR_Gen_1	522	531	PF02991	0.317
LIG_LIR_Gen_1	6	15	PF02991	0.522
LIG_LIR_Gen_1	603	612	PF02991	0.276
LIG_LIR_Gen_1	616	626	PF02991	0.235
LIG_LIR_Nem_3	242	248	PF02991	0.518
LIG_LIR_Nem_3	297	301	PF02991	0.600
LIG_LIR_Nem_3	310	315	PF02991	0.487
LIG_LIR_Nem_3	341	346	PF02991	0.541
LIG_LIR_Nem_3	443	449	PF02991	0.317
LIG_LIR_Nem_3	452	458	PF02991	0.274
LIG_LIR_Nem_3	495	500	PF02991	0.292
LIG_LIR_Nem_3	522	527	PF02991	0.298
LIG_LIR_Nem_3	6	12	PF02991	0.538
LIG_LIR_Nem_3	603	608	PF02991	0.258
LIG_LIR_Nem_3	610	615	PF02991	0.272
LIG_LIR_Nem_3	616	621	PF02991	0.252
LIG_LIR_Nem_3	66	71	PF02991	0.468
LIG_LYPXL_yS_3	591	594	PF13949	0.279
LIG_MYND_3	302	306	PF01753	0.582
LIG_NRBOX	181	187	PF00104	0.302
LIG_NRBOX	697	703	PF00104	0.472
LIG_PCNA_yPIPBox_3	281	290	PF02747	0.612
LIG_SH2_CRK	9	13	PF00017	0.544
LIG_SH2_NCK_1	542	546	PF00017	0.271
LIG_SH2_STAP1	370	374	PF00017	0.281
LIG_SH2_STAP1	458	462	PF00017	0.387
LIG_SH2_STAP1	542	546	PF00017	0.351
LIG_SH2_STAP1	661	665	PF00017	0.413
LIG_SH2_STAP1	9	13	PF00017	0.400
LIG_SH2_STAT5	311	314	PF00017	0.522
LIG_SH2_STAT5	405	408	PF00017	0.357
LIG_SH2_STAT5	455	458	PF00017	0.293
LIG_SH2_STAT5	497	500	PF00017	0.284
LIG_SH2_STAT5	52	55	PF00017	0.475
LIG_SH3_3	113	119	PF00018	0.282
LIG_SH3_3	233	239	PF00018	0.628
LIG_SH3_3	90	96	PF00018	0.480
LIG_SUMO_SIM_anti_2	459	467	PF11976	0.355
LIG_SUMO_SIM_anti_2	681	686	PF11976	0.583
LIG_SUMO_SIM_par_1	283	289	PF11976	0.525
LIG_SUMO_SIM_par_1	330	337	PF11976	0.633
LIG_SUMO_SIM_par_1	376	382	PF11976	0.327
LIG_SUMO_SIM_par_1	633	639	PF11976	0.341
LIG_TRAF2_1	128	131	PF00917	0.416
LIG_TRAF2_1	230	233	PF00917	0.655
LIG_TRAF2_1	428	431	PF00917	0.396
LIG_TYR_ITIM	589	594	PF00017	0.346
LIG_TYR_ITIM	7	12	PF00017	0.701
LIG_WRC_WIRS_1	614	619	PF05994	0.344
MOD_CDC14_SPxK_1	217	220	PF00782	0.663
MOD_CDK_SPK_2	214	219	PF00069	0.608
MOD_CDK_SPxK_1	214	220	PF00069	0.658
MOD_CK1_1	104	110	PF00069	0.432
MOD_CK1_1	141	147	PF00069	0.605
MOD_CK1_1	16	22	PF00069	0.574
MOD_CK1_1	2	8	PF00069	0.693
MOD_CK1_1	209	215	PF00069	0.598
MOD_CK1_1	496	502	PF00069	0.418
MOD_CK1_1	61	67	PF00069	0.627
MOD_CK1_1	633	639	PF00069	0.471
MOD_CK1_1	85	91	PF00069	0.544
MOD_CK2_1	141	147	PF00069	0.588
MOD_CK2_1	153	159	PF00069	0.694
MOD_CK2_1	283	289	PF00069	0.554
MOD_CK2_1	328	334	PF00069	0.524
MOD_CK2_1	424	430	PF00069	0.578
MOD_CK2_1	675	681	PF00069	0.355
MOD_GlcNHglycan	144	147	PF01048	0.711
MOD_GlcNHglycan	18	21	PF01048	0.705
MOD_GlcNHglycan	24	27	PF01048	0.631
MOD_GlcNHglycan	269	272	PF01048	0.500
MOD_GlcNHglycan	273	276	PF01048	0.563
MOD_GlcNHglycan	29	32	PF01048	0.593
MOD_GlcNHglycan	325	328	PF01048	0.615
MOD_GlcNHglycan	96	99	PF01048	0.539
MOD_GSK3_1	100	107	PF00069	0.459
MOD_GSK3_1	138	145	PF00069	0.702
MOD_GSK3_1	149	156	PF00069	0.660
MOD_GSK3_1	18	25	PF00069	0.641
MOD_GSK3_1	208	215	PF00069	0.650
MOD_GSK3_1	267	274	PF00069	0.435
MOD_GSK3_1	37	44	PF00069	0.570
MOD_GSK3_1	445	452	PF00069	0.416
MOD_GSK3_1	60	67	PF00069	0.552
MOD_LATS_1	422	428	PF00433	0.382
MOD_N-GLC_1	532	537	PF02516	0.456
MOD_NEK2_1	1	6	PF00069	0.671
MOD_NEK2_1	101	106	PF00069	0.495
MOD_NEK2_1	140	145	PF00069	0.663
MOD_NEK2_1	406	411	PF00069	0.442
MOD_NEK2_1	445	450	PF00069	0.520
MOD_NEK2_1	493	498	PF00069	0.295
MOD_NEK2_1	583	588	PF00069	0.295
MOD_NEK2_1	620	625	PF00069	0.292
MOD_NEK2_1	71	76	PF00069	0.542
MOD_NEK2_1	82	87	PF00069	0.659
MOD_NEK2_2	283	288	PF00069	0.362
MOD_NEK2_2	76	81	PF00069	0.606
MOD_NEK2_2	8	13	PF00069	0.500
MOD_PIKK_1	138	144	PF00454	0.624
MOD_PIKK_1	173	179	PF00454	0.472
MOD_PIKK_1	195	201	PF00454	0.474
MOD_PIKK_1	71	77	PF00454	0.598
MOD_PKA_1	207	213	PF00069	0.577
MOD_PKA_1	219	225	PF00069	0.604
MOD_PKA_2	16	22	PF00069	0.654
MOD_PKA_2	206	212	PF00069	0.573
MOD_PKA_2	27	33	PF00069	0.607
MOD_PKA_2	423	429	PF00069	0.588
MOD_PKA_2	44	50	PF00069	0.674
MOD_Plk_1	173	179	PF00069	0.480
MOD_Plk_1	329	335	PF00069	0.576
MOD_Plk_1	471	477	PF00069	0.379
MOD_Plk_2-3	613	619	PF00069	0.338
MOD_Plk_4	104	110	PF00069	0.384
MOD_Plk_4	283	289	PF00069	0.353
MOD_Plk_4	493	499	PF00069	0.382
MOD_Plk_4	569	575	PF00069	0.379
MOD_Plk_4	613	619	PF00069	0.338
MOD_Plk_4	8	14	PF00069	0.500
MOD_ProDKin_1	214	220	PF00069	0.658
MOD_ProDKin_1	37	43	PF00069	0.711
MOD_ProDKin_1	557	563	PF00069	0.299
MOD_ProDKin_1	630	636	PF00069	0.467
MOD_ProDKin_1	648	654	PF00069	0.497
MOD_ProDKin_1	92	98	PF00069	0.541
MOD_SUMO_for_1	128	131	PF00179	0.497
TRG_DiLeu_BaEn_1	522	527	PF01217	0.407
TRG_DiLeu_BaEn_2	186	192	PF01217	0.492
TRG_DiLeu_BaEn_4	233	239	PF01217	0.540
TRG_DiLeu_BaLyEn_6	364	369	PF01217	0.307
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.516
TRG_ENDOCYTIC_2	591	594	PF00928	0.330
TRG_ENDOCYTIC_2	9	12	PF00928	0.701
TRG_ER_diArg_1	365	367	PF00400	0.326
TRG_ER_diArg_1	419	421	PF00400	0.456
TRG_ER_diArg_1	433	436	PF00400	0.404
TRG_ER_diArg_1	692	695	PF00400	0.331
TRG_NLS_MonoExtN_4	416	422	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	695	699	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZA9	Leptomonas seymouri	65%	99%
A0A1X0NU07	Trypanosomatidae	41%	94%
A0A3Q8I980	Leishmania donovani	93%	100%
A0A3R7NA24	Trypanosoma rangeli	41%	100%
A4H8A0	Leishmania braziliensis	76%	99%
A4HWM2	Leishmania infantum	93%	100%
C9ZXR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	95%
E9AQC9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5B4P0	Trypanosoma cruzi	39%	100%