Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4QF45_LEIMA

TriTrypDb:

LmjF.15.1355 , LMJLV39_150020500 , LMJSD75_150020500

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.655
CLV_NRD_NRD_1	230	232	PF00675	0.546
CLV_NRD_NRD_1	45	47	PF00675	0.618
CLV_NRD_NRD_1	50	52	PF00675	0.611
CLV_NRD_NRD_1	53	55	PF00675	0.462
CLV_PCSK_FUR_1	228	232	PF00082	0.549
CLV_PCSK_FUR_1	51	55	PF00082	0.389
CLV_PCSK_KEX2_1	2	4	PF00082	0.515
CLV_PCSK_KEX2_1	230	232	PF00082	0.532
CLV_PCSK_KEX2_1	282	284	PF00082	0.573
CLV_PCSK_KEX2_1	45	47	PF00082	0.632
CLV_PCSK_KEX2_1	50	52	PF00082	0.648
CLV_PCSK_KEX2_1	53	55	PF00082	0.564
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.515
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.573
CLV_PCSK_PC7_1	46	52	PF00082	0.560
DEG_Nend_UBRbox_1	1	4	PF02207	0.507
DEG_SCF_FBW7_1	159	165	PF00400	0.593
DOC_CKS1_1	159	164	PF01111	0.637
DOC_CKS1_1	9	14	PF01111	0.491
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.485
DOC_MAPK_gen_1	50	61	PF00069	0.507
DOC_MAPK_MEF2A_6	269	276	PF00069	0.390
DOC_MAPK_MEF2A_6	53	61	PF00069	0.440
DOC_MAPK_NFAT4_5	54	62	PF00069	0.492
DOC_SPAK_OSR1_1	269	273	PF12202	0.494
DOC_USP7_MATH_1	100	104	PF00917	0.497
DOC_USP7_MATH_1	126	130	PF00917	0.542
DOC_USP7_MATH_1	162	166	PF00917	0.670
DOC_USP7_MATH_1	286	290	PF00917	0.641
DOC_WW_Pin1_4	158	163	PF00397	0.651
DOC_WW_Pin1_4	174	179	PF00397	0.796
DOC_WW_Pin1_4	234	239	PF00397	0.739
DOC_WW_Pin1_4	242	247	PF00397	0.724
DOC_WW_Pin1_4	296	301	PF00397	0.740
DOC_WW_Pin1_4	34	39	PF00397	0.523
DOC_WW_Pin1_4	8	13	PF00397	0.580
LIG_14-3-3_CanoR_1	116	120	PF00244	0.449
LIG_14-3-3_CanoR_1	3	12	PF00244	0.455
LIG_BRCT_BRCA1_1	264	268	PF00533	0.653
LIG_FHA_1	139	145	PF00498	0.396
LIG_FHA_1	154	160	PF00498	0.533
LIG_FHA_1	4	10	PF00498	0.525
LIG_FHA_2	67	73	PF00498	0.456
LIG_FHA_2	9	15	PF00498	0.567
LIG_LIR_Gen_1	69	78	PF02991	0.461
LIG_LIR_Nem_3	69	74	PF02991	0.456
LIG_PDZ_Class_1	299	304	PF00595	0.681
LIG_SH2_STAP1	86	90	PF00017	0.492
LIG_SH2_STAP1	92	96	PF00017	0.502
LIG_SH3_3	156	162	PF00018	0.671
LIG_SH3_3	172	178	PF00018	0.726
LIG_SH3_3	35	41	PF00018	0.577
MOD_CDK_SPK_2	234	239	PF00069	0.627
MOD_CK1_1	176	182	PF00069	0.781
MOD_CK1_1	289	295	PF00069	0.712
MOD_CK1_1	296	302	PF00069	0.713
MOD_CK1_1	33	39	PF00069	0.580
MOD_CK2_1	66	72	PF00069	0.465
MOD_CK2_1	8	14	PF00069	0.539
MOD_GlcNHglycan	103	106	PF01048	0.622
MOD_GlcNHglycan	128	131	PF01048	0.530
MOD_GlcNHglycan	146	149	PF01048	0.316
MOD_GlcNHglycan	164	167	PF01048	0.540
MOD_GlcNHglycan	217	220	PF01048	0.505
MOD_GlcNHglycan	264	267	PF01048	0.580
MOD_GlcNHglycan	288	291	PF01048	0.589
MOD_GlcNHglycan	295	298	PF01048	0.571
MOD_GlcNHglycan	32	35	PF01048	0.666
MOD_GSK3_1	158	165	PF00069	0.701
MOD_GSK3_1	173	180	PF00069	0.706
MOD_GSK3_1	184	191	PF00069	0.405
MOD_GSK3_1	28	35	PF00069	0.578
MOD_GSK3_1	285	292	PF00069	0.587
MOD_GSK3_1	295	302	PF00069	0.701
MOD_NEK2_1	144	149	PF00069	0.444
MOD_NEK2_1	151	156	PF00069	0.446
MOD_PIKK_1	289	295	PF00454	0.495
MOD_PKA_2	115	121	PF00069	0.524
MOD_Plk_2-3	66	72	PF00069	0.465
MOD_Plk_4	115	121	PF00069	0.481
MOD_Plk_4	66	72	PF00069	0.555
MOD_ProDKin_1	158	164	PF00069	0.652
MOD_ProDKin_1	174	180	PF00069	0.793
MOD_ProDKin_1	234	240	PF00069	0.745
MOD_ProDKin_1	242	248	PF00069	0.723
MOD_ProDKin_1	296	302	PF00069	0.736
MOD_ProDKin_1	34	40	PF00069	0.518
MOD_ProDKin_1	8	14	PF00069	0.580
TRG_DiLeu_BaLyEn_6	76	81	PF01217	0.425
TRG_ENDOCYTIC_2	71	74	PF00928	0.508
TRG_ER_diArg_1	228	231	PF00400	0.539
TRG_ER_diArg_1	50	53	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILL8	Leptomonas seymouri	52%	90%
A0A0S4JQ23	Bodo saltans	30%	98%
A0A3R7RI28	Trypanosoma rangeli	33%	100%
A0A3S7WTT4	Leishmania donovani	91%	100%
A4H8A3	Leishmania braziliensis	73%	91%
A4HWM3	Leishmania infantum	91%	100%
C9ZXR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AQD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%