Papain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative papain-like cysteine peptidase (DUF1796), putative

Species:

Leishmania major

UniProt:

Q4QF43_LEIMA

TriTrypDb:

LmjF.15.1370 , LMJLV39_150020700 , LMJSD75_150020700

Length:

405

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 20
NetGPI	no	yes: 0, no: 20

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.353
CLV_NRD_NRD_1	155	157	PF00675	0.295
CLV_NRD_NRD_1	20	22	PF00675	0.256
CLV_NRD_NRD_1	316	318	PF00675	0.452
CLV_NRD_NRD_1	373	375	PF00675	0.532
CLV_NRD_NRD_1	6	8	PF00675	0.711
CLV_PCSK_FUR_1	314	318	PF00082	0.429
CLV_PCSK_KEX2_1	115	117	PF00082	0.386
CLV_PCSK_KEX2_1	155	157	PF00082	0.436
CLV_PCSK_KEX2_1	316	318	PF00082	0.579
CLV_PCSK_KEX2_1	373	375	PF00082	0.478
CLV_PCSK_KEX2_1	6	8	PF00082	0.508
CLV_PCSK_SKI1_1	10	14	PF00082	0.641
CLV_PCSK_SKI1_1	126	130	PF00082	0.399
CLV_PCSK_SKI1_1	132	136	PF00082	0.385
CLV_PCSK_SKI1_1	163	167	PF00082	0.450
CLV_PCSK_SKI1_1	338	342	PF00082	0.431
DEG_APCC_DBOX_1	185	193	PF00400	0.360
DEG_APCC_DBOX_1	51	59	PF00400	0.328
DEG_Nend_Nbox_1	1	3	PF02207	0.580
DEG_SIAH_1	233	241	PF03145	0.418
DOC_CKS1_1	230	235	PF01111	0.591
DOC_MAPK_gen_1	155	162	PF00069	0.398
DOC_MAPK_MEF2A_6	155	162	PF00069	0.295
DOC_PP1_RVXF_1	124	131	PF00149	0.413
DOC_PP1_RVXF_1	161	167	PF00149	0.389
DOC_PP4_FxxP_1	70	73	PF00568	0.278
DOC_USP7_MATH_1	273	277	PF00917	0.400
DOC_USP7_MATH_1	400	404	PF00917	0.572
DOC_WW_Pin1_4	120	125	PF00397	0.436
DOC_WW_Pin1_4	181	186	PF00397	0.450
DOC_WW_Pin1_4	229	234	PF00397	0.601
DOC_WW_Pin1_4	398	403	PF00397	0.715
LIG_14-3-3_CanoR_1	126	131	PF00244	0.360
LIG_14-3-3_CanoR_1	132	139	PF00244	0.334
LIG_14-3-3_CanoR_1	186	190	PF00244	0.368
LIG_14-3-3_CanoR_1	205	214	PF00244	0.355
LIG_14-3-3_CanoR_1	21	27	PF00244	0.330
LIG_14-3-3_CanoR_1	332	340	PF00244	0.510
LIG_14-3-3_CanoR_1	52	56	PF00244	0.328
LIG_14-3-3_CanoR_1	90	99	PF00244	0.277
LIG_BRCT_BRCA1_1	158	162	PF00533	0.402
LIG_FHA_1	257	263	PF00498	0.422
LIG_FHA_1	297	303	PF00498	0.503
LIG_FHA_1	374	380	PF00498	0.555
LIG_FHA_2	199	205	PF00498	0.504
LIG_FHA_2	339	345	PF00498	0.434
LIG_FHA_2	355	361	PF00498	0.435
LIG_LIR_Apic_2	68	73	PF02991	0.350
LIG_LIR_Gen_1	376	385	PF02991	0.563
LIG_LIR_Gen_1	49	58	PF02991	0.466
LIG_LIR_Gen_1	94	104	PF02991	0.298
LIG_LIR_Nem_3	129	134	PF02991	0.312
LIG_LIR_Nem_3	159	165	PF02991	0.283
LIG_LIR_Nem_3	191	197	PF02991	0.456
LIG_LIR_Nem_3	208	213	PF02991	0.445
LIG_LIR_Nem_3	220	226	PF02991	0.540
LIG_LIR_Nem_3	376	380	PF02991	0.548
LIG_LIR_Nem_3	49	53	PF02991	0.379
LIG_LIR_Nem_3	94	99	PF02991	0.287
LIG_PCNA_PIPBox_1	346	355	PF02747	0.462
LIG_Pex14_1	190	194	PF04695	0.322
LIG_Pex14_2	162	166	PF04695	0.315
LIG_Pex14_2	66	70	PF04695	0.277
LIG_REV1ctd_RIR_1	128	136	PF16727	0.312
LIG_SH2_CRK	194	198	PF00017	0.559
LIG_SH2_CRK	210	214	PF00017	0.457
LIG_SH2_CRK	353	357	PF00017	0.477
LIG_SH2_PTP2	23	26	PF00017	0.388
LIG_SH2_STAT3	138	141	PF00017	0.198
LIG_SH2_STAT5	23	26	PF00017	0.311
LIG_SH2_STAT5	321	324	PF00017	0.519
LIG_SH2_STAT5	385	388	PF00017	0.460
LIG_SH3_3	121	127	PF00018	0.298
LIG_SH3_3	179	185	PF00018	0.407
LIG_SH3_3	227	233	PF00018	0.608
LIG_SH3_3	396	402	PF00018	0.712
LIG_SH3_3	69	75	PF00018	0.325
LIG_SUMO_SIM_anti_2	278	284	PF11976	0.536
LIG_SUMO_SIM_anti_2	341	351	PF11976	0.427
LIG_TRAF2_1	139	142	PF00917	0.337
LIG_TRAF2_1	341	344	PF00917	0.414
LIG_TYR_ITIM	192	197	PF00017	0.365
LIG_TYR_ITSM	206	213	PF00017	0.355
MOD_CDC14_SPxK_1	123	126	PF00782	0.276
MOD_CDK_SPK_2	181	186	PF00069	0.428
MOD_CDK_SPxK_1	120	126	PF00069	0.276
MOD_CK1_1	265	271	PF00069	0.363
MOD_CK1_1	51	57	PF00069	0.312
MOD_CK2_1	214	220	PF00069	0.404
MOD_CK2_1	338	344	PF00069	0.433
MOD_GlcNHglycan	247	250	PF01048	0.413
MOD_GlcNHglycan	303	308	PF01048	0.642
MOD_GSK3_1	126	133	PF00069	0.371
MOD_GSK3_1	181	188	PF00069	0.383
MOD_GSK3_1	205	212	PF00069	0.578
MOD_GSK3_1	214	221	PF00069	0.436
MOD_GSK3_1	285	292	PF00069	0.522
MOD_GSK3_1	384	391	PF00069	0.557
MOD_GSK3_1	398	405	PF00069	0.686
MOD_N-GLC_1	387	392	PF02516	0.531
MOD_NEK2_1	130	135	PF00069	0.328
MOD_NEK2_1	2	7	PF00069	0.558
MOD_NEK2_1	203	208	PF00069	0.474
MOD_NEK2_1	214	219	PF00069	0.295
MOD_NEK2_1	386	391	PF00069	0.510
MOD_NEK2_1	48	53	PF00069	0.302
MOD_NEK2_2	198	203	PF00069	0.493
MOD_PKA_1	373	379	PF00069	0.354
MOD_PKA_2	185	191	PF00069	0.378
MOD_PKA_2	373	379	PF00069	0.519
MOD_PKA_2	51	57	PF00069	0.311
MOD_Plk_1	265	271	PF00069	0.449
MOD_Plk_1	323	329	PF00069	0.448
MOD_Plk_1	48	54	PF00069	0.432
MOD_Plk_4	126	132	PF00069	0.337
MOD_Plk_4	185	191	PF00069	0.351
MOD_Plk_4	198	204	PF00069	0.547
MOD_ProDKin_1	120	126	PF00069	0.436
MOD_ProDKin_1	181	187	PF00069	0.442
MOD_ProDKin_1	229	235	PF00069	0.591
MOD_ProDKin_1	398	404	PF00069	0.591
TRG_DiLeu_BaEn_1	343	348	PF01217	0.376
TRG_ENDOCYTIC_2	194	197	PF00928	0.542
TRG_ENDOCYTIC_2	210	213	PF00928	0.404
TRG_ENDOCYTIC_2	23	26	PF00928	0.311
TRG_ENDOCYTIC_2	353	356	PF00928	0.475
TRG_ENDOCYTIC_2	377	380	PF00928	0.562
TRG_ER_diArg_1	114	116	PF00400	0.386
TRG_ER_diArg_1	314	317	PF00400	0.630
TRG_ER_diArg_1	372	374	PF00400	0.541
TRG_ER_diArg_1	6	8	PF00400	0.489
TRG_NLS_MonoExtN_4	314	321	PF00514	0.589
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7L5	Leptomonas seymouri	70%	100%
A0A0S4JE30	Bodo saltans	36%	100%
A0A0S4JK16	Bodo saltans	54%	93%
A0A1X0NVQ6	Trypanosomatidae	61%	100%
A0A1X0P1X9	Trypanosomatidae	33%	100%
A0A3Q8IFT0	Leishmania donovani	29%	98%
A0A3R7KWZ0	Trypanosoma rangeli	61%	100%
A0A3R7KYN0	Trypanosoma rangeli	35%	100%
A0A3S7WTN3	Leishmania donovani	97%	100%
A4H8A5	Leishmania braziliensis	88%	100%
A4HIA2	Leishmania braziliensis	29%	98%
A4HWM5	Leishmania infantum	97%	100%
A4I5I6	Leishmania infantum	29%	98%
C9ZXR2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AQD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9B0T1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	98%
Q4Q7E7	Leishmania major	28%	92%
V5BPI9	Trypanosoma cruzi	34%	100%
V5BUE5	Trypanosoma cruzi	58%	100%