Putative nucleolar RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA binding protein, putative

Species:

Leishmania major

UniProt:

Q4QF42_LEIMA

TriTrypDb:

LmjF.15.1380 , LMJLV39_150020800 , LMJSD75_150020800

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	12
GO:0030684	preribosome	3	12
GO:0031428	box C/D RNP complex	4	12
GO:0032040	small-subunit processome	4	12
GO:0032991	protein-containing complex	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QF42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF42

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0030515	snoRNA binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.424
CLV_C14_Caspase3-7	560	564	PF00656	0.778
CLV_NRD_NRD_1	178	180	PF00675	0.494
CLV_NRD_NRD_1	209	211	PF00675	0.442
CLV_NRD_NRD_1	79	81	PF00675	0.460
CLV_PCSK_KEX2_1	13	15	PF00082	0.502
CLV_PCSK_KEX2_1	178	180	PF00082	0.504
CLV_PCSK_KEX2_1	570	572	PF00082	0.694
CLV_PCSK_KEX2_1	79	81	PF00082	0.460
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.502
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.706
CLV_PCSK_SKI1_1	179	183	PF00082	0.421
CLV_PCSK_SKI1_1	210	214	PF00082	0.427
CLV_PCSK_SKI1_1	232	236	PF00082	0.442
CLV_PCSK_SKI1_1	256	260	PF00082	0.510
CLV_PCSK_SKI1_1	345	349	PF00082	0.271
CLV_PCSK_SKI1_1	462	466	PF00082	0.271
CLV_PCSK_SKI1_1	471	475	PF00082	0.271
CLV_PCSK_SKI1_1	74	78	PF00082	0.490
DEG_APCC_DBOX_1	117	125	PF00400	0.465
DEG_APCC_DBOX_1	177	185	PF00400	0.554
DEG_SPOP_SBC_1	39	43	PF00917	0.476
DOC_CDC14_PxL_1	49	57	PF14671	0.468
DOC_CKS1_1	472	477	PF01111	0.471
DOC_CYCLIN_RxL_1	178	189	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	123	126	PF00134	0.647
DOC_CYCLIN_yCln2_LP_2	147	150	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.366
DOC_MAPK_gen_1	178	187	PF00069	0.426
DOC_MAPK_gen_1	235	243	PF00069	0.420
DOC_PP1_RVXF_1	287	293	PF00149	0.460
DOC_PP2B_LxvP_1	123	126	PF13499	0.473
DOC_PP2B_LxvP_1	147	150	PF13499	0.653
DOC_PP2B_LxvP_1	163	166	PF13499	0.364
DOC_PP2B_LxvP_1	241	244	PF13499	0.444
DOC_PP4_FxxP_1	569	572	PF00568	0.727
DOC_USP7_MATH_1	151	155	PF00917	0.455
DOC_USP7_MATH_1	244	248	PF00917	0.538
DOC_USP7_MATH_1	377	381	PF00917	0.483
DOC_USP7_MATH_1	503	507	PF00917	0.471
DOC_USP7_MATH_1	58	62	PF00917	0.654
DOC_USP7_UBL2_3	207	211	PF12436	0.407
DOC_USP7_UBL2_3	313	317	PF12436	0.471
DOC_WW_Pin1_4	138	143	PF00397	0.491
DOC_WW_Pin1_4	21	26	PF00397	0.508
DOC_WW_Pin1_4	290	295	PF00397	0.474
DOC_WW_Pin1_4	471	476	PF00397	0.471
DOC_WW_Pin1_4	517	522	PF00397	0.576
LIG_14-3-3_CanoR_1	118	124	PF00244	0.467
LIG_14-3-3_CanoR_1	57	63	PF00244	0.620
LIG_Actin_WH2_2	278	293	PF00022	0.436
LIG_Clathr_ClatBox_1	171	175	PF01394	0.391
LIG_CtBP_PxDLS_1	125	129	PF00389	0.477
LIG_deltaCOP1_diTrp_1	324	330	PF00928	0.471
LIG_FHA_1	106	112	PF00498	0.443
LIG_FHA_1	142	148	PF00498	0.773
LIG_FHA_1	195	201	PF00498	0.407
LIG_FHA_1	238	244	PF00498	0.496
LIG_FHA_1	28	34	PF00498	0.504
LIG_FHA_1	424	430	PF00498	0.471
LIG_FHA_1	452	458	PF00498	0.471
LIG_FHA_1	46	52	PF00498	0.408
LIG_FHA_1	518	524	PF00498	0.576
LIG_FHA_1	79	85	PF00498	0.709
LIG_GBD_Chelix_1	233	241	PF00786	0.418
LIG_LIR_Apic_2	114	119	PF02991	0.451
LIG_LIR_Gen_1	358	369	PF02991	0.471
LIG_LIR_Nem_3	254	258	PF02991	0.423
LIG_LIR_Nem_3	358	364	PF02991	0.471
LIG_LIR_Nem_3	474	480	PF02991	0.471
LIG_NRBOX	180	186	PF00104	0.509
LIG_SH2_CRK	343	347	PF00017	0.471
LIG_SH2_CRK	477	481	PF00017	0.471
LIG_SH2_STAP1	318	322	PF00017	0.453
LIG_SH2_STAT3	406	409	PF00017	0.532
LIG_SH2_STAT5	217	220	PF00017	0.587
LIG_SH2_STAT5	343	346	PF00017	0.558
LIG_SH2_STAT5	413	416	PF00017	0.471
LIG_SH3_1	23	29	PF00018	0.500
LIG_SH3_1	65	71	PF00018	0.494
LIG_SH3_3	2	8	PF00018	0.460
LIG_SH3_3	23	29	PF00018	0.500
LIG_SH3_3	60	66	PF00018	0.498
LIG_SH3_4	207	214	PF00018	0.399
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.469
LIG_SUMO_SIM_anti_2	144	149	PF11976	0.637
LIG_SUMO_SIM_anti_2	46	54	PF11976	0.465
LIG_TRAF2_1	535	538	PF00917	0.569
LIG_TYR_ITIM	341	346	PF00017	0.483
LIG_UBA3_1	307	313	PF00899	0.471
LIG_UBA3_1	444	449	PF00899	0.471
LIG_UBA3_1	464	469	PF00899	0.341
LIG_WRC_WIRS_1	112	117	PF05994	0.447
LIG_WRC_WIRS_1	252	257	PF05994	0.439
LIG_WRC_WIRS_1	511	516	PF05994	0.471
LIG_WW_3	62	66	PF00397	0.498
MOD_CDC14_SPxK_1	293	296	PF00782	0.467
MOD_CDK_SPK_2	471	476	PF00069	0.471
MOD_CDK_SPxK_1	290	296	PF00069	0.473
MOD_CK1_1	129	135	PF00069	0.496
MOD_CK1_1	138	144	PF00069	0.464
MOD_CK1_1	380	386	PF00069	0.471
MOD_CK1_1	443	449	PF00069	0.471
MOD_CK1_1	91	97	PF00069	0.684
MOD_CK2_1	261	267	PF00069	0.500
MOD_CK2_1	303	309	PF00069	0.505
MOD_CK2_1	510	516	PF00069	0.479
MOD_CK2_1	592	598	PF00069	0.693
MOD_CMANNOS	325	328	PF00535	0.271
MOD_Cter_Amidation	11	14	PF01082	0.489
MOD_GlcNHglycan	153	156	PF01048	0.452
MOD_GlcNHglycan	246	249	PF01048	0.553
MOD_GlcNHglycan	267	272	PF01048	0.511
MOD_GlcNHglycan	507	510	PF01048	0.271
MOD_GlcNHglycan	544	547	PF01048	0.608
MOD_GlcNHglycan	576	579	PF01048	0.757
MOD_GlcNHglycan	60	63	PF01048	0.625
MOD_GSK3_1	134	141	PF00069	0.495
MOD_GSK3_1	17	24	PF00069	0.523
MOD_GSK3_1	244	251	PF00069	0.546
MOD_GSK3_1	39	46	PF00069	0.729
MOD_GSK3_1	408	415	PF00069	0.462
MOD_GSK3_1	91	98	PF00069	0.684
MOD_LATS_1	93	99	PF00433	0.454
MOD_N-GLC_1	129	134	PF02516	0.494
MOD_N-GLC_1	274	279	PF02516	0.434
MOD_N-GLC_1	391	396	PF02516	0.358
MOD_N-GLC_1	423	428	PF02516	0.271
MOD_N-GLC_1	481	486	PF02516	0.358
MOD_N-GLC_1	574	579	PF02516	0.794
MOD_NEK2_1	105	110	PF00069	0.458
MOD_NEK2_1	194	199	PF00069	0.401
MOD_NEK2_1	274	279	PF00069	0.434
MOD_NEK2_1	44	49	PF00069	0.650
MOD_NEK2_1	574	579	PF00069	0.768
MOD_NEK2_1	592	597	PF00069	0.447
MOD_NEK2_1	89	94	PF00069	0.715
MOD_PK_1	95	101	PF00069	0.456
MOD_PKA_2	117	123	PF00069	0.463
MOD_PKA_2	17	23	PF00069	0.524
MOD_PKA_2	356	362	PF00069	0.483
MOD_PKA_2	557	563	PF00069	0.777
MOD_PKA_2	69	75	PF00069	0.654
MOD_PKA_2	78	84	PF00069	0.557
MOD_PKB_1	16	24	PF00069	0.523
MOD_PKB_1	571	579	PF00069	0.793
MOD_Plk_1	129	135	PF00069	0.496
MOD_Plk_1	248	254	PF00069	0.445
MOD_Plk_1	274	280	PF00069	0.432
MOD_Plk_1	391	397	PF00069	0.558
MOD_Plk_1	423	429	PF00069	0.471
MOD_Plk_1	481	487	PF00069	0.558
MOD_Plk_4	111	117	PF00069	0.596
MOD_Plk_4	119	125	PF00069	0.677
MOD_Plk_4	143	149	PF00069	0.677
MOD_Plk_4	261	267	PF00069	0.546
MOD_Plk_4	28	34	PF00069	0.504
MOD_Plk_4	303	309	PF00069	0.505
MOD_Plk_4	40	46	PF00069	0.442
MOD_Plk_4	409	415	PF00069	0.527
MOD_Plk_4	424	430	PF00069	0.400
MOD_Plk_4	440	446	PF00069	0.471
MOD_Plk_4	481	487	PF00069	0.558
MOD_Plk_4	51	57	PF00069	0.426
MOD_ProDKin_1	138	144	PF00069	0.492
MOD_ProDKin_1	21	27	PF00069	0.509
MOD_ProDKin_1	290	296	PF00069	0.473
MOD_ProDKin_1	471	477	PF00069	0.471
MOD_ProDKin_1	517	523	PF00069	0.576
MOD_SUMO_rev_2	224	234	PF00179	0.413
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.471
TRG_ENDOCYTIC_2	160	163	PF00928	0.384
TRG_ENDOCYTIC_2	343	346	PF00928	0.471
TRG_ENDOCYTIC_2	477	480	PF00928	0.471
TRG_ER_diArg_1	320	323	PF00400	0.483
TRG_ER_diArg_1	571	574	PF00400	0.769
TRG_ER_diArg_1	64	67	PF00400	0.501
TRG_ER_diArg_1	78	80	PF00400	0.419
TRG_NES_CRM1_1	164	177	PF08389	0.400
TRG_NES_CRM1_1	298	310	PF08389	0.389
TRG_NLS_MonoCore_2	569	574	PF00514	0.730
TRG_NLS_MonoExtN_4	178	183	PF00514	0.551
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.574
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.271

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD49	Leptomonas seymouri	94%	100%
A0A0N1PE54	Leptomonas seymouri	38%	100%
A0A0S4JJS5	Bodo saltans	82%	100%
A0A1X0NRL9	Trypanosomatidae	38%	100%
A0A1X0NUB3	Trypanosomatidae	82%	100%
A0A3R7NI91	Trypanosoma rangeli	80%	100%
A0A3S5H6F4	Leishmania donovani	37%	100%
A0A3S5H6V9	Leishmania donovani	98%	100%
A3LUT0	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	50%	100%
A4H602	Leishmania braziliensis	37%	100%
A4H8A6	Leishmania braziliensis	96%	100%
A4HUC9	Leishmania infantum	37%	100%
A4HWM6	Leishmania infantum	98%	100%
A5DHW0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	49%	100%
A5E4V9	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	50%	100%
A6ZPE5	Saccharomyces cerevisiae (strain YJM789)	50%	100%
A7TIF5	Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17)	50%	100%
C9ZVG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZXR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
E9AN29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AQD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O04658	Arabidopsis thaliana	51%	100%
P0CP26	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	47%	100%
P0CP27	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	47%	100%
Q12460	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q12499	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	50%	100%
Q21276	Caenorhabditis elegans	38%	100%
Q4PBF2	Ustilago maydis (strain 521 / FGSC 9021)	45%	100%
Q4QHJ7	Leishmania major	37%	100%
Q55FI4	Dictyostelium discoideum	48%	94%
Q59S06	Candida albicans (strain SC5314 / ATCC MYA-2876)	50%	100%
Q6BIX6	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	50%	100%
Q6CKR8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	50%	100%
Q6FQ21	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	50%	100%
Q753I4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	50%	100%
Q9MAB3	Arabidopsis thaliana	50%	100%
V5AU06	Trypanosoma cruzi	38%	100%
V5BK67	Trypanosoma cruzi	83%	100%