TLC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TMEM164 family, putative

Species:

Leishmania major

UniProt:

Q4QF41_LEIMA

TriTrypDb:

LmjF.15.1390 , LMJLV39_150020900 , LMJSD75_150020900

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QF41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	255	259	PF00082	0.582
CLV_PCSK_SKI1_1	260	264	PF00082	0.497
CLV_PCSK_SKI1_1	291	295	PF00082	0.405
CLV_PCSK_SKI1_1	84	88	PF00082	0.413
DEG_APCC_DBOX_1	259	267	PF00400	0.361
DEG_MDM2_SWIB_1	129	136	PF02201	0.384
DEG_ODPH_VHL_1	226	237	PF01847	0.456
DOC_CDC14_PxL_1	214	222	PF14671	0.344
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.354
DOC_CYCLIN_yCln2_LP_2	258	264	PF00134	0.361
DOC_MAPK_DCC_7	260	268	PF00069	0.361
DOC_MAPK_gen_1	109	119	PF00069	0.319
DOC_MAPK_MEF2A_6	112	119	PF00069	0.319
DOC_MAPK_MEF2A_6	260	268	PF00069	0.310
DOC_PP2B_LxvP_1	122	125	PF13499	0.384
DOC_PP2B_LxvP_1	191	194	PF13499	0.354
DOC_PP2B_LxvP_1	241	244	PF13499	0.258
DOC_PP4_FxxP_1	225	228	PF00568	0.375
DOC_PP4_FxxP_1	42	45	PF00568	0.344
DOC_USP7_UBL2_3	283	287	PF12436	0.543
LIG_14-3-3_CanoR_1	245	251	PF00244	0.465
LIG_14-3-3_CanoR_1	67	77	PF00244	0.542
LIG_BIR_II_1	1	5	PF00653	0.333
LIG_BRCT_BRCA1_1	65	69	PF00533	0.580
LIG_CSL_BTD_1	215	218	PF09270	0.400
LIG_deltaCOP1_diTrp_1	157	160	PF00928	0.408
LIG_deltaCOP1_diTrp_1	170	178	PF00928	0.274
LIG_eIF4E_1	150	156	PF01652	0.456
LIG_FHA_1	201	207	PF00498	0.516
LIG_FHA_1	77	83	PF00498	0.604
LIG_FHA_1	95	101	PF00498	0.125
LIG_GBD_Chelix_1	272	280	PF00786	0.436
LIG_GBD_Chelix_1	94	102	PF00786	0.417
LIG_HCF-1_HBM_1	173	176	PF13415	0.289
LIG_LIR_Apic_2	10	14	PF02991	0.416
LIG_LIR_Gen_1	130	138	PF02991	0.326
LIG_LIR_Gen_1	15	24	PF02991	0.372
LIG_LIR_Gen_1	179	189	PF02991	0.373
LIG_LIR_Gen_1	207	214	PF02991	0.551
LIG_LIR_Nem_3	130	136	PF02991	0.296
LIG_LIR_Nem_3	15	20	PF02991	0.371
LIG_LIR_Nem_3	157	163	PF02991	0.423
LIG_LIR_Nem_3	179	184	PF02991	0.310
LIG_LIR_Nem_3	207	211	PF02991	0.510
LIG_MYND_1	261	265	PF01753	0.456
LIG_NRBOX	118	124	PF00104	0.308
LIG_NRBOX	150	156	PF00104	0.456
LIG_Pex14_1	133	137	PF04695	0.410
LIG_Pex14_1	208	212	PF04695	0.491
LIG_Pex14_2	129	133	PF04695	0.384
LIG_PTB_Apo_2	219	226	PF02174	0.375
LIG_SH2_CRK	201	205	PF00017	0.489
LIG_SH2_PTP2	11	14	PF00017	0.413
LIG_SH2_SRC	143	146	PF00017	0.395
LIG_SH2_STAP1	96	100	PF00017	0.339
LIG_SH2_STAT3	40	43	PF00017	0.426
LIG_SH2_STAT5	11	14	PF00017	0.413
LIG_SH2_STAT5	135	138	PF00017	0.367
LIG_SH2_STAT5	150	153	PF00017	0.183
LIG_SH2_STAT5	176	179	PF00017	0.294
LIG_SH2_STAT5	181	184	PF00017	0.317
LIG_SH2_STAT5	196	199	PF00017	0.125
LIG_SH2_STAT5	96	99	PF00017	0.442
LIG_SH3_3	79	85	PF00018	0.483
LIG_SH3_4	114	121	PF00018	0.393
LIG_Sin3_3	152	159	PF02671	0.222
LIG_Sin3_3	250	257	PF02671	0.356
LIG_SUMO_SIM_anti_2	19	26	PF11976	0.430
LIG_TRFH_1	239	243	PF08558	0.247
LIG_WW_3	242	246	PF00397	0.456
MOD_CK2_1	297	303	PF00069	0.677
MOD_GlcNHglycan	248	251	PF01048	0.641
MOD_GlcNHglycan	294	297	PF01048	0.479
MOD_GlcNHglycan	70	73	PF01048	0.339
MOD_GSK3_1	212	219	PF00069	0.467
MOD_GSK3_1	76	83	PF00069	0.505
MOD_NEK2_1	246	251	PF00069	0.402
MOD_NEK2_1	292	297	PF00069	0.672
MOD_NEK2_1	77	82	PF00069	0.546
MOD_NEK2_2	145	150	PF00069	0.395
MOD_PKA_2	244	250	PF00069	0.468
MOD_PKA_2	63	69	PF00069	0.522
MOD_Plk_4	150	156	PF00069	0.348
MOD_Plk_4	19	25	PF00069	0.410
MOD_Plk_4	212	218	PF00069	0.483
MOD_Plk_4	268	274	PF00069	0.335
MOD_Plk_4	94	100	PF00069	0.358
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.554
TRG_ENDOCYTIC_2	135	138	PF00928	0.412
TRG_ENDOCYTIC_2	181	184	PF00928	0.376
TRG_ENDOCYTIC_2	201	204	PF00928	0.325
TRG_ENDOCYTIC_2	96	99	PF00928	0.456
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P785	Leptomonas seymouri	54%	100%
A0A0S4JGE0	Bodo saltans	36%	100%
A0A1X0NUN8	Trypanosomatidae	36%	98%
A0A3Q8IIU5	Leishmania donovani	91%	100%
A0A422NBZ1	Trypanosoma rangeli	38%	98%
A4H8A7	Leishmania braziliensis	78%	96%
A4HWM7	Leishmania infantum	91%	100%
E9AQD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q54KD4	Dictyostelium discoideum	24%	100%
V5DL97	Trypanosoma cruzi	41%	97%