Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF40_LEIMA

TriTrypDb:

LmjF.15.1400 , LMJLV39_150021000 , LMJSD75_150021000

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF40

PDB structure(s): 7ane_aq

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.696
CLV_NRD_NRD_1	15	17	PF00675	0.405
CLV_NRD_NRD_1	163	165	PF00675	0.418
CLV_NRD_NRD_1	187	189	PF00675	0.448
CLV_PCSK_FUR_1	13	17	PF00082	0.412
CLV_PCSK_KEX2_1	15	17	PF00082	0.405
CLV_PCSK_KEX2_1	163	165	PF00082	0.515
CLV_PCSK_KEX2_1	187	189	PF00082	0.469
CLV_PCSK_KEX2_1	198	200	PF00082	0.482
CLV_PCSK_KEX2_1	74	76	PF00082	0.401
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.571
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.401
CLV_PCSK_SKI1_1	75	79	PF00082	0.428
CLV_PCSK_SKI1_1	92	96	PF00082	0.391
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DOC_CYCLIN_RxL_1	121	129	PF00134	0.392
DOC_MAPK_gen_1	13	23	PF00069	0.401
DOC_MAPK_gen_1	198	204	PF00069	0.604
DOC_USP7_MATH_1	218	222	PF00917	0.617
DOC_USP7_MATH_1	244	248	PF00917	0.715
DOC_USP7_MATH_1	86	90	PF00917	0.540
DOC_USP7_UBL2_3	235	239	PF12436	0.634
DOC_WW_Pin1_4	197	202	PF00397	0.474
LIG_14-3-3_CanoR_1	145	153	PF00244	0.449
LIG_APCC_ABBA_1	151	156	PF00400	0.378
LIG_BRCT_BRCA1_1	4	8	PF00533	0.433
LIG_CaM_NSCaTE_8	19	26	PF13499	0.520
LIG_CtBP_PxDLS_1	125	129	PF00389	0.386
LIG_deltaCOP1_diTrp_1	96	104	PF00928	0.399
LIG_FHA_1	41	47	PF00498	0.412
LIG_FHA_2	109	115	PF00498	0.414
LIG_FHA_2	264	270	PF00498	0.608
LIG_FHA_2	86	92	PF00498	0.393
LIG_LIR_Apic_2	11	17	PF02991	0.429
LIG_LIR_Apic_2	55	61	PF02991	0.406
LIG_LIR_Gen_1	117	126	PF02991	0.460
LIG_LIR_Gen_1	148	159	PF02991	0.371
LIG_LIR_Nem_3	117	122	PF02991	0.430
LIG_LIR_Nem_3	148	154	PF02991	0.431
LIG_LIR_Nem_3	176	182	PF02991	0.437
LIG_LIR_Nem_3	203	209	PF02991	0.517
LIG_LIR_Nem_3	27	32	PF02991	0.410
LIG_LIR_Nem_3	96	101	PF02991	0.545
LIG_PCNA_yPIPBox_3	24	35	PF02747	0.431
LIG_Pex14_1	97	101	PF04695	0.395
LIG_SH2_CRK	14	18	PF00017	0.428
LIG_SH2_CRK	32	36	PF00017	0.404
LIG_SH2_NCK_1	32	36	PF00017	0.419
LIG_SH2_PTP2	143	146	PF00017	0.523
LIG_SH2_PTP2	58	61	PF00017	0.503
LIG_SH2_STAP1	130	134	PF00017	0.376
LIG_SH2_STAT3	130	133	PF00017	0.383
LIG_SH2_STAT5	143	146	PF00017	0.518
LIG_SH2_STAT5	189	192	PF00017	0.439
LIG_SH2_STAT5	32	35	PF00017	0.397
LIG_SH2_STAT5	58	61	PF00017	0.398
LIG_SH2_STAT5	93	96	PF00017	0.379
LIG_SH3_3	119	125	PF00018	0.400
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.605
LIG_SUMO_SIM_par_1	123	129	PF11976	0.397
LIG_TRAF2_1	208	211	PF00917	0.498
LIG_TYR_ITIM	204	209	PF00017	0.603
LIG_UBA3_1	20	24	PF00899	0.414
LIG_WRC_WIRS_1	101	106	PF05994	0.410
MOD_CK1_1	147	153	PF00069	0.445
MOD_CK1_1	247	253	PF00069	0.777
MOD_CK2_1	263	269	PF00069	0.645
MOD_CK2_1	85	91	PF00069	0.398
MOD_GlcNHglycan	220	223	PF01048	0.603
MOD_GlcNHglycan	225	228	PF01048	0.597
MOD_GlcNHglycan	246	249	PF01048	0.751
MOD_GlcNHglycan	250	253	PF01048	0.711
MOD_GlcNHglycan	255	258	PF01048	0.695
MOD_GSK3_1	100	107	PF00069	0.417
MOD_GSK3_1	214	221	PF00069	0.529
MOD_GSK3_1	243	250	PF00069	0.721
MOD_N-GLC_2	136	138	PF02516	0.383
MOD_NEK2_1	1	6	PF00069	0.594
MOD_NEK2_1	126	131	PF00069	0.374
MOD_NEK2_1	8	13	PF00069	0.500
MOD_PIKK_1	2	8	PF00454	0.668
MOD_PKA_2	108	114	PF00069	0.461
MOD_PKA_2	144	150	PF00069	0.455
MOD_PKA_2	214	220	PF00069	0.536
MOD_PKA_2	244	250	PF00069	0.665
MOD_Plk_1	126	132	PF00069	0.377
MOD_Plk_1	147	153	PF00069	0.438
MOD_Plk_1	192	198	PF00069	0.426
MOD_Plk_1	86	92	PF00069	0.539
MOD_Plk_4	192	198	PF00069	0.426
MOD_Plk_4	30	36	PF00069	0.425
MOD_ProDKin_1	197	203	PF00069	0.479
MOD_SUMO_rev_2	231	240	PF00179	0.647
TRG_ENDOCYTIC_2	143	146	PF00928	0.523
TRG_ENDOCYTIC_2	18	21	PF00928	0.386
TRG_ENDOCYTIC_2	206	209	PF00928	0.489
TRG_ENDOCYTIC_2	32	35	PF00928	0.397
TRG_ENDOCYTIC_2	98	101	PF00928	0.553
TRG_ER_diArg_1	14	16	PF00400	0.424
TRG_ER_diArg_1	187	189	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILX7	Leptomonas seymouri	77%	100%
A0A0S4JNA3	Bodo saltans	61%	100%
A0A1X0NU24	Trypanosomatidae	66%	100%
A0A3S7WTN6	Leishmania donovani	94%	100%
A0A422NC20	Trypanosoma rangeli	64%	96%
A4H8A8	Leishmania braziliensis	84%	100%
A4HWM8	Leishmania infantum	94%	100%
C9ZXR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AQD5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BPT4	Trypanosoma cruzi	64%	99%