Phosphomevalonate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphomevalonate kinase protein, putative

Species:

Leishmania major

UniProt:

Q4QF34_LEIMA

TriTrypDb:

LmjF.15.1460 , LMJLV39_150021600 , LMJSD75_150021600

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF34

Function

Biological processes
Term	Name	Level	Count
GO:0006084	acetyl-CoA metabolic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006629	lipid metabolic process	3	10
GO:0006637	acyl-CoA metabolic process	4	10
GO:0006644	phospholipid metabolic process	4	10
GO:0006720	isoprenoid metabolic process	4	2
GO:0006721	terpenoid metabolic process	5	2
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006790	sulfur compound metabolic process	3	10
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	11
GO:0008299	isoprenoid biosynthetic process	4	2
GO:0008610	lipid biosynthetic process	4	10
GO:0008654	phospholipid biosynthetic process	5	10
GO:0009058	biosynthetic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009240	isopentenyl diphosphate biosynthetic process	6	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	11
GO:0010142	farnesyl diphosphate biosynthetic process, mevalonate pathway	6	2
GO:0016114	terpenoid biosynthetic process	5	2
GO:0016310	phosphorylation	5	11
GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway	6	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0033865	nucleoside bisphosphate metabolic process	5	10
GO:0033875	ribonucleoside bisphosphate metabolic process	6	10
GO:0034032	purine nucleoside bisphosphate metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0035383	thioester metabolic process	3	10
GO:0043603	amide metabolic process	3	10
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	2
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0045337	farnesyl diphosphate biosynthetic process	6	2
GO:0045338	farnesyl diphosphate metabolic process	5	2
GO:0046483	heterocycle metabolic process	3	10
GO:0046490	isopentenyl diphosphate metabolic process	5	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1902767	isoprenoid biosynthetic process via mevalonate	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004631	phosphomevalonate kinase activity	5	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.530
CLV_C14_Caspase3-7	299	303	PF00656	0.495
CLV_NRD_NRD_1	221	223	PF00675	0.374
CLV_NRD_NRD_1	248	250	PF00675	0.510
CLV_NRD_NRD_1	293	295	PF00675	0.423
CLV_NRD_NRD_1	309	311	PF00675	0.454
CLV_NRD_NRD_1	320	322	PF00675	0.529
CLV_PCSK_KEX2_1	221	223	PF00082	0.374
CLV_PCSK_KEX2_1	248	250	PF00082	0.538
CLV_PCSK_KEX2_1	309	311	PF00082	0.484
CLV_PCSK_KEX2_1	320	322	PF00082	0.521
CLV_PCSK_SKI1_1	270	274	PF00082	0.410
CLV_PCSK_SKI1_1	370	374	PF00082	0.338
CLV_PCSK_SKI1_1	39	43	PF00082	0.465
DEG_APCC_DBOX_1	369	377	PF00400	0.486
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DEG_SPOP_SBC_1	166	170	PF00917	0.500
DOC_CDC14_PxL_1	340	348	PF14671	0.551
DOC_CYCLIN_RxL_1	364	375	PF00134	0.546
DOC_CYCLIN_RxL_1	5	14	PF00134	0.430
DOC_MAPK_DCC_7	144	152	PF00069	0.544
DOC_MAPK_DCC_7	438	446	PF00069	0.408
DOC_MAPK_MEF2A_6	144	152	PF00069	0.544
DOC_MAPK_MEF2A_6	264	273	PF00069	0.436
DOC_PP4_FxxP_1	263	266	PF00568	0.416
DOC_USP7_MATH_1	102	106	PF00917	0.480
DOC_USP7_MATH_1	366	370	PF00917	0.534
DOC_USP7_MATH_1	71	75	PF00917	0.520
DOC_WW_Pin1_4	19	24	PF00397	0.519
DOC_WW_Pin1_4	280	285	PF00397	0.500
DOC_WW_Pin1_4	297	302	PF00397	0.459
DOC_WW_Pin1_4	57	62	PF00397	0.464
DOC_WW_Pin1_4	86	91	PF00397	0.447
LIG_14-3-3_CanoR_1	227	231	PF00244	0.489
LIG_14-3-3_CanoR_1	294	298	PF00244	0.458
LIG_14-3-3_CanoR_1	35	41	PF00244	0.479
LIG_14-3-3_CanoR_1	64	68	PF00244	0.551
LIG_BRCT_BRCA1_1	59	63	PF00533	0.405
LIG_BRCT_BRCA1_1	65	69	PF00533	0.408
LIG_CSL_BTD_1	256	259	PF09270	0.539
LIG_CtBP_PxDLS_1	386	390	PF00389	0.556
LIG_deltaCOP1_diTrp_1	255	263	PF00928	0.463
LIG_EVH1_2	259	263	PF00568	0.517
LIG_FHA_1	166	172	PF00498	0.488
LIG_FHA_1	35	41	PF00498	0.426
LIG_FHA_1	388	394	PF00498	0.494
LIG_FHA_1	76	82	PF00498	0.424
LIG_FHA_2	108	114	PF00498	0.551
LIG_LIR_Apic_2	255	260	PF02991	0.523
LIG_LIR_Apic_2	261	266	PF02991	0.485
LIG_LIR_Gen_1	113	120	PF02991	0.496
LIG_LIR_Gen_1	14	23	PF02991	0.471
LIG_LIR_Gen_1	209	219	PF02991	0.542
LIG_LIR_Gen_1	414	421	PF02991	0.486
LIG_LIR_Gen_1	434	444	PF02991	0.221
LIG_LIR_Gen_1	66	75	PF02991	0.452
LIG_LIR_Nem_3	113	118	PF02991	0.444
LIG_LIR_Nem_3	14	18	PF02991	0.440
LIG_LIR_Nem_3	206	211	PF02991	0.486
LIG_LIR_Nem_3	217	223	PF02991	0.366
LIG_LIR_Nem_3	302	308	PF02991	0.411
LIG_LIR_Nem_3	414	420	PF02991	0.486
LIG_LIR_Nem_3	430	436	PF02991	0.524
LIG_LIR_Nem_3	66	70	PF02991	0.444
LIG_NRBOX	388	394	PF00104	0.500
LIG_Pex14_2	63	67	PF04695	0.449
LIG_RPA_C_Fungi	359	371	PF08784	0.484
LIG_SH2_CRK	211	215	PF00017	0.451
LIG_SH2_CRK	413	417	PF00017	0.377
LIG_SH2_NCK_1	211	215	PF00017	0.451
LIG_SH2_NCK_1	413	417	PF00017	0.377
LIG_SH2_NCK_1	98	102	PF00017	0.374
LIG_SH2_SRC	130	133	PF00017	0.474
LIG_SH2_SRC	15	18	PF00017	0.415
LIG_SH2_STAP1	211	215	PF00017	0.359
LIG_SH2_STAP1	333	337	PF00017	0.460
LIG_SH2_STAP1	413	417	PF00017	0.359
LIG_SH2_STAP1	98	102	PF00017	0.411
LIG_SH2_STAT5	130	133	PF00017	0.431
LIG_SH2_STAT5	15	18	PF00017	0.392
LIG_SH2_STAT5	188	191	PF00017	0.484
LIG_SH2_STAT5	211	214	PF00017	0.359
LIG_SH2_STAT5	315	318	PF00017	0.383
LIG_SH2_STAT5	436	439	PF00017	0.440
LIG_SH3_3	145	151	PF00018	0.503
LIG_SH3_3	253	259	PF00018	0.490
LIG_SH3_3	341	347	PF00018	0.550
LIG_SH3_3	402	408	PF00018	0.339
LIG_SH3_3	84	90	PF00018	0.414
LIG_SUMO_SIM_par_1	385	391	PF11976	0.438
LIG_SUMO_SIM_par_1	442	449	PF11976	0.409
LIG_SUMO_SIM_par_1	8	14	PF11976	0.433
LIG_TRFH_1	263	267	PF08558	0.515
MOD_CDK_SPxxK_3	57	64	PF00069	0.502
MOD_CK1_1	105	111	PF00069	0.550
MOD_CK1_1	226	232	PF00069	0.534
MOD_CK1_1	51	57	PF00069	0.589
MOD_CK2_1	107	113	PF00069	0.564
MOD_CK2_1	237	243	PF00069	0.552
MOD_GlcNHglycan	163	166	PF01048	0.338
MOD_GlcNHglycan	2	6	PF01048	0.395
MOD_GlcNHglycan	205	208	PF01048	0.339
MOD_GlcNHglycan	234	237	PF01048	0.685
MOD_GlcNHglycan	448	453	PF01048	0.525
MOD_GlcNHglycan	50	53	PF01048	0.667
MOD_GlcNHglycan	73	76	PF01048	0.564
MOD_GSK3_1	102	109	PF00069	0.457
MOD_GSK3_1	156	163	PF00069	0.328
MOD_GSK3_1	293	300	PF00069	0.500
MOD_GSK3_1	44	51	PF00069	0.682
MOD_GSK3_1	71	78	PF00069	0.417
MOD_N-GLC_1	71	76	PF02516	0.345
MOD_N-GLC_2	440	442	PF02516	0.474
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	161	166	PF00069	0.339
MOD_NEK2_1	167	172	PF00069	0.339
MOD_NEK2_1	232	237	PF00069	0.648
MOD_NEK2_1	393	398	PF00069	0.339
MOD_NEK2_1	63	68	PF00069	0.473
MOD_NEK2_2	52	57	PF00069	0.545
MOD_PIKK_1	123	129	PF00454	0.396
MOD_PIKK_1	130	136	PF00454	0.445
MOD_PIKK_1	197	203	PF00454	0.414
MOD_PKA_2	226	232	PF00069	0.517
MOD_PKA_2	293	299	PF00069	0.458
MOD_PKA_2	34	40	PF00069	0.464
MOD_PKA_2	63	69	PF00069	0.456
MOD_Plk_1	360	366	PF00069	0.293
MOD_Plk_4	11	17	PF00069	0.432
MOD_Plk_4	167	173	PF00069	0.359
MOD_Plk_4	226	232	PF00069	0.539
MOD_ProDKin_1	19	25	PF00069	0.510
MOD_ProDKin_1	280	286	PF00069	0.487
MOD_ProDKin_1	297	303	PF00069	0.452
MOD_ProDKin_1	57	63	PF00069	0.465
MOD_ProDKin_1	86	92	PF00069	0.438
MOD_SUMO_for_1	382	385	PF00179	0.417
MOD_SUMO_for_1	41	44	PF00179	0.563
MOD_SUMO_rev_2	375	384	PF00179	0.451
TRG_DiLeu_BaEn_1	388	393	PF01217	0.382
TRG_DiLeu_BaLyEn_6	440	445	PF01217	0.417
TRG_ENDOCYTIC_2	15	18	PF00928	0.392
TRG_ENDOCYTIC_2	211	214	PF00928	0.377
TRG_ENDOCYTIC_2	220	223	PF00928	0.326
TRG_ENDOCYTIC_2	413	416	PF00928	0.359
TRG_ENDOCYTIC_2	436	439	PF00928	0.412
TRG_ER_diArg_1	220	222	PF00400	0.371
TRG_ER_diArg_1	247	249	PF00400	0.508
TRG_ER_diArg_1	308	310	PF00400	0.486
TRG_ER_diArg_1	319	321	PF00400	0.501
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	370	375	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P784	Leptomonas seymouri	75%	100%
A0A0S4JMH3	Bodo saltans	56%	100%
A0A1D8PLH0	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
A0A1X0NVR4	Trypanosomatidae	55%	100%
A0A3S5IQX7	Trypanosoma rangeli	54%	98%
A0A3S7WTM8	Leishmania donovani	95%	100%
A4H8B3	Leishmania braziliensis	84%	100%
A4HWN3	Leishmania infantum	95%	100%
C9ZXQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AQE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
I1RZD0	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
P24521	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4WV38	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	31%	95%
Q9C6T1	Arabidopsis thaliana	34%	91%
Q9UT88	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%