Phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

cAMP specific phosphodiesterase, putative

Species:

Leishmania major

UniProt:

Q4QF31_LEIMA

TriTrypDb:

LmjF.15.1480 , LMJLV39_150022000 , LMJSD75_150022000

Length:

940

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 35

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QF31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF31

Function

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Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	926	930	PF00656	0.564
CLV_NRD_NRD_1	224	226	PF00675	0.520
CLV_NRD_NRD_1	36	38	PF00675	0.663
CLV_NRD_NRD_1	372	374	PF00675	0.456
CLV_NRD_NRD_1	673	675	PF00675	0.432
CLV_NRD_NRD_1	676	678	PF00675	0.466
CLV_NRD_NRD_1	823	825	PF00675	0.500
CLV_NRD_NRD_1	931	933	PF00675	0.672
CLV_PCSK_FUR_1	34	38	PF00082	0.580
CLV_PCSK_FUR_1	674	678	PF00082	0.566

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P788	Leptomonas seymouri	70%	100%
A0A1X0NUP8	Trypanosomatidae	62%	100%
A0A3Q8I987	Leishmania donovani	94%	100%
A0A3R7RI37	Trypanosoma rangeli	70%	100%
A0A3S7WTN0	Leishmania donovani	82%	100%
A4H893	Leishmania braziliensis	76%	100%
A4H8B6	Leishmania braziliensis	86%	100%
A4HWN6	Leishmania infantum	82%	100%
A4HWN7	Leishmania infantum	94%	100%
B3P3K2	Drosophila erecta	29%	83%

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