Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF30_LEIMA

TriTrypDb:

LmjF.15.1490 , LMJLV39_150022100 , LMJSD75_150022100

Length:

644

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF30

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.566
CLV_C14_Caspase3-7	631	635	PF00656	0.679
CLV_NRD_NRD_1	179	181	PF00675	0.706
CLV_NRD_NRD_1	290	292	PF00675	0.523
CLV_NRD_NRD_1	35	37	PF00675	0.637
CLV_NRD_NRD_1	437	439	PF00675	0.716
CLV_NRD_NRD_1	450	452	PF00675	0.596
CLV_NRD_NRD_1	571	573	PF00675	0.741
CLV_NRD_NRD_1	577	579	PF00675	0.675
CLV_NRD_NRD_1	608	610	PF00675	0.726
CLV_NRD_NRD_1	627	629	PF00675	0.494
CLV_PCSK_FUR_1	288	292	PF00082	0.509
CLV_PCSK_KEX2_1	156	158	PF00082	0.621
CLV_PCSK_KEX2_1	206	208	PF00082	0.556
CLV_PCSK_KEX2_1	290	292	PF00082	0.523
CLV_PCSK_KEX2_1	310	312	PF00082	0.502
CLV_PCSK_KEX2_1	35	37	PF00082	0.489
CLV_PCSK_KEX2_1	439	441	PF00082	0.717
CLV_PCSK_KEX2_1	474	476	PF00082	0.703
CLV_PCSK_KEX2_1	571	573	PF00082	0.752
CLV_PCSK_KEX2_1	577	579	PF00082	0.710
CLV_PCSK_KEX2_1	627	629	PF00082	0.808
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.694
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.578
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.716
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.717
CLV_PCSK_PC1ET2_1	474	476	PF00082	0.744
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.816
CLV_PCSK_SKI1_1	101	105	PF00082	0.542
CLV_PCSK_SKI1_1	181	185	PF00082	0.618
CLV_PCSK_SKI1_1	35	39	PF00082	0.649
CLV_PCSK_SKI1_1	374	378	PF00082	0.740
CLV_PCSK_SKI1_1	403	407	PF00082	0.612
CLV_PCSK_SKI1_1	41	45	PF00082	0.623
CLV_PCSK_SKI1_1	509	513	PF00082	0.781
CLV_PCSK_SKI1_1	75	79	PF00082	0.605
DEG_APCC_DBOX_1	289	297	PF00400	0.517
DOC_CKS1_1	622	627	PF01111	0.719
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.683
DOC_MAPK_DCC_7	310	318	PF00069	0.534
DOC_MAPK_DCC_7	461	469	PF00069	0.732
DOC_MAPK_gen_1	130	137	PF00069	0.495
DOC_MAPK_gen_1	280	287	PF00069	0.653
DOC_MAPK_gen_1	310	318	PF00069	0.623
DOC_MAPK_gen_1	361	369	PF00069	0.622
DOC_MAPK_gen_1	435	444	PF00069	0.741
DOC_MAPK_gen_1	44	52	PF00069	0.552
DOC_MAPK_MEF2A_6	310	318	PF00069	0.506
DOC_MAPK_MEF2A_6	461	469	PF00069	0.732
DOC_PP2B_LxvP_1	218	221	PF13499	0.632
DOC_PP2B_LxvP_1	421	424	PF13499	0.714
DOC_PP2B_LxvP_1	584	587	PF13499	0.799
DOC_PP4_FxxP_1	158	161	PF00568	0.566
DOC_USP7_MATH_1	289	293	PF00917	0.515
DOC_USP7_MATH_1	477	481	PF00917	0.730
DOC_USP7_MATH_1	550	554	PF00917	0.581
DOC_USP7_MATH_1	579	583	PF00917	0.812
DOC_USP7_UBL2_3	101	105	PF12436	0.564
DOC_USP7_UBL2_3	134	138	PF12436	0.577
DOC_USP7_UBL2_3	361	365	PF12436	0.620
DOC_USP7_UBL2_3	403	407	PF12436	0.643
DOC_USP7_UBL2_3	435	439	PF12436	0.644
DOC_USP7_UBL2_3	509	513	PF12436	0.724
DOC_USP7_UBL2_3	569	573	PF12436	0.837
DOC_WW_Pin1_4	157	162	PF00397	0.714
DOC_WW_Pin1_4	209	214	PF00397	0.523
DOC_WW_Pin1_4	455	460	PF00397	0.730
DOC_WW_Pin1_4	602	607	PF00397	0.752
DOC_WW_Pin1_4	615	620	PF00397	0.659
DOC_WW_Pin1_4	621	626	PF00397	0.632
LIG_14-3-3_CanoR_1	146	152	PF00244	0.533
LIG_14-3-3_CanoR_1	180	187	PF00244	0.594
LIG_14-3-3_CanoR_1	207	211	PF00244	0.649
LIG_14-3-3_CanoR_1	237	242	PF00244	0.640
LIG_14-3-3_CanoR_1	250	256	PF00244	0.535
LIG_14-3-3_CanoR_1	288	294	PF00244	0.635
LIG_14-3-3_CanoR_1	300	308	PF00244	0.524
LIG_14-3-3_CanoR_1	342	348	PF00244	0.600
LIG_14-3-3_CanoR_1	374	381	PF00244	0.651
LIG_14-3-3_CanoR_1	438	443	PF00244	0.693
LIG_14-3-3_CanoR_1	494	503	PF00244	0.714
LIG_14-3-3_CanoR_1	578	587	PF00244	0.695
LIG_14-3-3_CanoR_1	6	13	PF00244	0.692
LIG_14-3-3_CanoR_1	613	619	PF00244	0.828
LIG_14-3-3_CanoR_1	627	633	PF00244	0.543
LIG_Actin_WH2_2	89	107	PF00022	0.604
LIG_BRCT_BRCA1_1	300	304	PF00533	0.507
LIG_BRCT_BRCA1_1	619	623	PF00533	0.814
LIG_CaM_IQ_9	28	43	PF13499	0.606
LIG_deltaCOP1_diTrp_1	242	246	PF00928	0.460
LIG_EH1_1	369	377	PF00400	0.741
LIG_FHA_1	186	192	PF00498	0.631
LIG_FHA_1	307	313	PF00498	0.616
LIG_FHA_1	371	377	PF00498	0.625
LIG_FHA_1	439	445	PF00498	0.814
LIG_FHA_1	466	472	PF00498	0.660
LIG_FHA_1	482	488	PF00498	0.704
LIG_FHA_1	563	569	PF00498	0.789
LIG_FHA_1	68	74	PF00498	0.680
LIG_FHA_1	87	93	PF00498	0.326
LIG_FHA_2	140	146	PF00498	0.737
LIG_FHA_2	521	527	PF00498	0.795
LIG_GBD_Chelix_1	632	640	PF00786	0.611
LIG_LIR_Apic_2	209	213	PF02991	0.450
LIG_LIR_Gen_1	109	116	PF02991	0.394
LIG_LIR_Gen_1	167	177	PF02991	0.580
LIG_LIR_Gen_1	182	191	PF02991	0.605
LIG_LIR_Gen_1	22	31	PF02991	0.530
LIG_LIR_Gen_1	346	356	PF02991	0.686
LIG_LIR_Gen_1	89	97	PF02991	0.502
LIG_LIR_Nem_3	109	114	PF02991	0.405
LIG_LIR_Nem_3	152	158	PF02991	0.628
LIG_LIR_Nem_3	182	187	PF02991	0.593
LIG_LIR_Nem_3	22	27	PF02991	0.529
LIG_LIR_Nem_3	240	246	PF02991	0.621
LIG_LIR_Nem_3	254	258	PF02991	0.647
LIG_LIR_Nem_3	269	275	PF02991	0.623
LIG_LIR_Nem_3	301	307	PF02991	0.479
LIG_LIR_Nem_3	346	351	PF02991	0.686
LIG_LIR_Nem_3	89	93	PF02991	0.449
LIG_PCNA_PIPBox_1	50	59	PF02747	0.646
LIG_PDZ_Class_1	639	644	PF00595	0.593
LIG_Pex14_2	229	233	PF04695	0.682
LIG_Pex14_2	532	536	PF04695	0.697
LIG_PTAP_UEV_1	563	568	PF05743	0.827
LIG_SH2_CRK	208	212	PF00017	0.678
LIG_SH2_SRC	348	351	PF00017	0.586
LIG_SH2_STAP1	348	352	PF00017	0.585
LIG_SH2_STAT5	203	206	PF00017	0.619
LIG_SH2_STAT5	210	213	PF00017	0.683
LIG_SH2_STAT5	286	289	PF00017	0.513
LIG_SH3_2	564	569	PF14604	0.828
LIG_SH3_2	622	627	PF14604	0.769
LIG_SH3_3	222	228	PF00018	0.496
LIG_SH3_3	313	319	PF00018	0.653
LIG_SH3_3	453	459	PF00018	0.702
LIG_SH3_3	558	564	PF00018	0.829
LIG_SH3_3	616	622	PF00018	0.717
LIG_SH3_4	403	410	PF00018	0.675
LIG_SH3_4	435	442	PF00018	0.578
LIG_SUMO_SIM_par_1	188	194	PF11976	0.637
LIG_TRAF2_1	199	202	PF00917	0.585
LIG_UBA3_1	92	101	PF00899	0.535
LIG_WRC_WIRS_1	166	171	PF05994	0.576
LIG_WRC_WIRS_1	252	257	PF05994	0.548
MOD_CDC14_SPxK_1	458	461	PF00782	0.818
MOD_CDK_SPxK_1	455	461	PF00069	0.822
MOD_CDK_SPxK_1	621	627	PF00069	0.770
MOD_CDK_SPxxK_3	602	609	PF00069	0.737
MOD_CDK_SPxxK_3	621	628	PF00069	0.569
MOD_CK1_1	147	153	PF00069	0.671
MOD_CK1_1	182	188	PF00069	0.520
MOD_CK1_1	194	200	PF00069	0.523
MOD_CK1_1	209	215	PF00069	0.357
MOD_CK1_1	274	280	PF00069	0.509
MOD_CK1_1	333	339	PF00069	0.589
MOD_CK1_1	519	525	PF00069	0.752
MOD_CK1_1	618	624	PF00069	0.737
MOD_CK1_1	8	14	PF00069	0.706
MOD_CK2_1	139	145	PF00069	0.739
MOD_CK2_1	165	171	PF00069	0.573
MOD_CK2_1	196	202	PF00069	0.598
MOD_CK2_1	220	226	PF00069	0.651
MOD_CK2_1	477	483	PF00069	0.691
MOD_Cter_Amidation	575	578	PF01082	0.709
MOD_GlcNHglycan	152	155	PF01048	0.648
MOD_GlcNHglycan	181	184	PF01048	0.595
MOD_GlcNHglycan	198	201	PF01048	0.613
MOD_GlcNHglycan	399	402	PF01048	0.683
MOD_GlcNHglycan	421	424	PF01048	0.602
MOD_GlcNHglycan	497	500	PF01048	0.754
MOD_GlcNHglycan	551	555	PF01048	0.744
MOD_GlcNHglycan	573	576	PF01048	0.725
MOD_GlcNHglycan	8	11	PF01048	0.693
MOD_GSK3_1	140	147	PF00069	0.622
MOD_GSK3_1	172	179	PF00069	0.585
MOD_GSK3_1	185	192	PF00069	0.604
MOD_GSK3_1	271	278	PF00069	0.508
MOD_GSK3_1	370	377	PF00069	0.607
MOD_GSK3_1	477	484	PF00069	0.803
MOD_GSK3_1	515	522	PF00069	0.763
MOD_GSK3_1	550	557	PF00069	0.583
MOD_GSK3_1	614	621	PF00069	0.794
MOD_LATS_1	4	10	PF00433	0.712
MOD_N-GLC_1	147	152	PF02516	0.625
MOD_N-GLC_1	194	199	PF02516	0.631
MOD_N-GLC_1	370	375	PF02516	0.539
MOD_N-GLC_1	86	91	PF02516	0.527
MOD_NEK2_1	115	120	PF00069	0.596
MOD_NEK2_1	165	170	PF00069	0.569
MOD_NEK2_1	172	177	PF00069	0.575
MOD_NEK2_1	191	196	PF00069	0.622
MOD_NEK2_1	251	256	PF00069	0.656
MOD_NEK2_1	271	276	PF00069	0.463
MOD_NEK2_1	306	311	PF00069	0.510
MOD_NEK2_1	338	343	PF00069	0.548
MOD_NEK2_1	5	10	PF00069	0.635
MOD_NEK2_1	67	72	PF00069	0.654
MOD_NEK2_2	116	121	PF00069	0.659
MOD_NEK2_2	343	348	PF00069	0.636
MOD_PIKK_1	25	31	PF00454	0.410
MOD_PIKK_1	516	522	PF00454	0.761
MOD_PIKK_1	594	600	PF00454	0.762
MOD_PIKK_1	8	14	PF00454	0.786
MOD_PK_1	189	195	PF00069	0.605
MOD_PKA_1	206	212	PF00069	0.570
MOD_PKA_1	438	444	PF00069	0.721
MOD_PKA_1	513	519	PF00069	0.717
MOD_PKA_1	571	577	PF00069	0.728
MOD_PKA_1	628	634	PF00069	0.703
MOD_PKA_2	179	185	PF00069	0.594
MOD_PKA_2	206	212	PF00069	0.648
MOD_PKA_2	289	295	PF00069	0.579
MOD_PKA_2	299	305	PF00069	0.555
MOD_PKA_2	5	11	PF00069	0.684
MOD_PKA_2	571	577	PF00069	0.728
MOD_Plk_1	126	132	PF00069	0.554
MOD_Plk_1	147	153	PF00069	0.616
MOD_Plk_1	194	200	PF00069	0.725
MOD_Plk_1	330	336	PF00069	0.588
MOD_Plk_1	370	376	PF00069	0.538
MOD_Plk_1	86	92	PF00069	0.521
MOD_Plk_4	159	165	PF00069	0.467
MOD_Plk_4	206	212	PF00069	0.453
MOD_Plk_4	333	339	PF00069	0.628
MOD_Plk_4	343	349	PF00069	0.551
MOD_Plk_4	586	592	PF00069	0.665
MOD_ProDKin_1	157	163	PF00069	0.707
MOD_ProDKin_1	209	215	PF00069	0.523
MOD_ProDKin_1	455	461	PF00069	0.728
MOD_ProDKin_1	602	608	PF00069	0.754
MOD_ProDKin_1	615	621	PF00069	0.657
MOD_SUMO_rev_2	236	246	PF00179	0.602
MOD_SUMO_rev_2	480	487	PF00179	0.587
TRG_ENDOCYTIC_2	208	211	PF00928	0.681
TRG_ENDOCYTIC_2	348	351	PF00928	0.586
TRG_ER_diArg_1	287	290	PF00400	0.505
TRG_ER_diArg_1	35	37	PF00400	0.489
TRG_ER_diArg_1	492	495	PF00400	0.692
TRG_NLS_Bipartite_1	428	442	PF00514	0.697
TRG_NLS_MonoExtN_4	435	442	PF00514	0.680
TRG_NLS_MonoExtN_4	569	575	PF00514	0.755

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZB6	Leptomonas seymouri	44%	99%
A0A3Q8ICE3	Leishmania donovani	91%	97%
A4H8B7	Leishmania braziliensis	69%	100%
A4HWN8	Leishmania infantum	91%	97%
E9AQE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%