DUF4220 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF29_LEIMA

TriTrypDb:

LmjF.15.1500 , LMJLV39_150022200 , LMJSD75_150022200

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.623
CLV_NRD_NRD_1	256	258	PF00675	0.472
CLV_NRD_NRD_1	34	36	PF00675	0.561
CLV_PCSK_FUR_1	32	36	PF00082	0.554
CLV_PCSK_KEX2_1	103	105	PF00082	0.623
CLV_PCSK_KEX2_1	256	258	PF00082	0.457
CLV_PCSK_KEX2_1	34	36	PF00082	0.526
CLV_PCSK_SKI1_1	21	25	PF00082	0.420
CLV_PCSK_SKI1_1	34	38	PF00082	0.425
CLV_PCSK_SKI1_1	81	85	PF00082	0.586
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DOC_CKS1_1	131	136	PF01111	0.614
DOC_CYCLIN_RxL_1	256	270	PF00134	0.471
DOC_CYCLIN_RxL_1	280	291	PF00134	0.548
DOC_CYCLIN_RxL_1	76	85	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.654
DOC_MAPK_gen_1	202	211	PF00069	0.659
DOC_MAPK_gen_1	32	41	PF00069	0.590
DOC_MAPK_HePTP_8	29	41	PF00069	0.580
DOC_MAPK_HePTP_8	83	95	PF00069	0.545
DOC_MAPK_MEF2A_6	32	41	PF00069	0.591
DOC_MAPK_MEF2A_6	86	95	PF00069	0.489
DOC_PP2B_LxvP_1	37	40	PF13499	0.613
DOC_USP7_MATH_1	155	159	PF00917	0.718
DOC_USP7_MATH_1	251	255	PF00917	0.537
DOC_WW_Pin1_4	1	6	PF00397	0.741
DOC_WW_Pin1_4	130	135	PF00397	0.563
DOC_WW_Pin1_4	158	163	PF00397	0.778
LIG_14-3-3_CanoR_1	103	111	PF00244	0.315
LIG_14-3-3_CanoR_1	156	162	PF00244	0.787
LIG_14-3-3_CanoR_1	177	186	PF00244	0.626
LIG_14-3-3_CanoR_1	202	211	PF00244	0.559
LIG_14-3-3_CanoR_1	256	260	PF00244	0.450
LIG_14-3-3_CanoR_1	268	272	PF00244	0.444
LIG_14-3-3_CanoR_1	278	284	PF00244	0.454
LIG_14-3-3_CanoR_1	47	53	PF00244	0.536
LIG_14-3-3_CanoR_1	78	84	PF00244	0.529
LIG_14-3-3_CanoR_1	86	92	PF00244	0.498
LIG_Actin_WH2_2	88	105	PF00022	0.488
LIG_BRCT_BRCA1_1	143	147	PF00533	0.745
LIG_BRCT_BRCA1_1	192	196	PF00533	0.615
LIG_BRCT_BRCA1_1	217	221	PF00533	0.584
LIG_deltaCOP1_diTrp_1	173	176	PF00928	0.549
LIG_FHA_1	210	216	PF00498	0.468
LIG_FHA_1	61	67	PF00498	0.617
LIG_LIR_Gen_1	112	120	PF02991	0.463
LIG_LIR_Gen_1	279	289	PF02991	0.545
LIG_LIR_Nem_3	112	117	PF02991	0.464
LIG_LIR_Nem_3	173	179	PF02991	0.586
LIG_LIR_Nem_3	20	26	PF02991	0.408
LIG_LIR_Nem_3	279	284	PF02991	0.564
LIG_LIR_Nem_3	90	95	PF02991	0.586
LIG_MLH1_MIPbox_1	217	221	PF16413	0.549
LIG_PCNA_yPIPBox_3	202	215	PF02747	0.611
LIG_Pex14_1	174	178	PF04695	0.658
LIG_Pex14_1	245	249	PF04695	0.642
LIG_Pex14_1	88	92	PF04695	0.622
LIG_Pex14_2	65	69	PF04695	0.494
LIG_PTB_Apo_2	214	221	PF02174	0.499
LIG_REV1ctd_RIR_1	21	29	PF16727	0.515
LIG_REV1ctd_RIR_1	218	228	PF16727	0.507
LIG_SH2_GRB2like	113	116	PF00017	0.511
LIG_SH2_NCK_1	138	142	PF00017	0.728
LIG_SH2_STAP1	98	102	PF00017	0.505
LIG_SH2_STAT5	178	181	PF00017	0.549
LIG_SH2_STAT5	28	31	PF00017	0.421
LIG_SH2_STAT5	73	76	PF00017	0.598
LIG_SH2_STAT5	92	95	PF00017	0.301
LIG_SH3_3	149	155	PF00018	0.744
LIG_SH3_CIN85_PxpxPR_1	151	156	PF14604	0.663
LIG_SUMO_SIM_anti_2	184	190	PF11976	0.498
LIG_WRC_WIRS_1	246	251	PF05994	0.591
LIG_WW_2	152	155	PF00397	0.699
MOD_CDK_SPxK_1	130	136	PF00069	0.611
MOD_CK1_1	116	122	PF00069	0.533
MOD_CK1_1	158	164	PF00069	0.724
MOD_CK1_1	4	10	PF00069	0.657
MOD_CK2_1	4	10	PF00069	0.627
MOD_GlcNHglycan	147	150	PF01048	0.756
MOD_GSK3_1	141	148	PF00069	0.693
MOD_GSK3_1	156	163	PF00069	0.651
MOD_GSK3_1	177	184	PF00069	0.551
MOD_GSK3_1	245	252	PF00069	0.609
MOD_GSK3_1	6	13	PF00069	0.667
MOD_N-GLC_1	233	238	PF02516	0.628
MOD_N-GLC_1	239	244	PF02516	0.594
MOD_NEK2_1	102	107	PF00069	0.408
MOD_NEK2_1	187	192	PF00069	0.553
MOD_NEK2_1	196	201	PF00069	0.512
MOD_NEK2_1	255	260	PF00069	0.457
MOD_NEK2_1	266	271	PF00069	0.429
MOD_NEK2_1	67	72	PF00069	0.540
MOD_NEK2_1	87	92	PF00069	0.293
MOD_NEK2_2	239	244	PF00069	0.603
MOD_NEK2_2	251	256	PF00069	0.534
MOD_PIKK_1	10	16	PF00454	0.538
MOD_PK_1	35	41	PF00069	0.602
MOD_PKA_1	103	109	PF00069	0.607
MOD_PKA_2	102	108	PF00069	0.490
MOD_PKA_2	155	161	PF00069	0.789
MOD_PKA_2	203	209	PF00069	0.614
MOD_PKA_2	255	261	PF00069	0.416
MOD_PKA_2	267	273	PF00069	0.416
MOD_PKA_2	46	52	PF00069	0.549
MOD_Plk_1	209	215	PF00069	0.525
MOD_Plk_1	239	245	PF00069	0.585
MOD_Plk_1	266	272	PF00069	0.517
MOD_Plk_4	182	188	PF00069	0.583
MOD_ProDKin_1	1	7	PF00069	0.735
MOD_ProDKin_1	130	136	PF00069	0.575
MOD_ProDKin_1	158	164	PF00069	0.776
TRG_DiLeu_BaEn_1	210	215	PF01217	0.575
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.501
TRG_ENDOCYTIC_2	92	95	PF00928	0.455
TRG_ER_diArg_1	102	104	PF00400	0.640
TRG_ER_diArg_1	201	204	PF00400	0.653
TRG_ER_diArg_1	255	257	PF00400	0.414
TRG_ER_diArg_1	32	35	PF00400	0.449
TRG_ER_diArg_1	75	78	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	262	267	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM1	Leptomonas seymouri	63%	100%
A0A1X0NU20	Trypanosomatidae	41%	100%
A0A3S7WTP0	Leishmania donovani	98%	100%
A0A422N5B2	Trypanosoma rangeli	39%	100%
A4H8B8	Leishmania braziliensis	90%	72%
A4HWN9	Leishmania infantum	98%	100%
C9ZXP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AQE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BFJ3	Trypanosoma cruzi	38%	100%