Protein kinase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kinase

Gene product:

3-phosphoinositide-dependent protein kinase 1, putative

Species:

Leishmania major

UniProt:

Q4QF23_LEIMA

TriTrypDb:

LmjF.15.1550 , LMJLV39_150022700 , LMJSD75_150022700

Length:

386

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF23

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	11
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0004674	protein serine/threonine kinase activity	4	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.378
CLV_NRD_NRD_1	272	274	PF00675	0.383
CLV_NRD_NRD_1	63	65	PF00675	0.251
CLV_PCSK_FUR_1	338	342	PF00082	0.307
CLV_PCSK_KEX2_1	290	292	PF00082	0.349
CLV_PCSK_KEX2_1	340	342	PF00082	0.212
CLV_PCSK_KEX2_1	43	45	PF00082	0.253
CLV_PCSK_KEX2_1	63	65	PF00082	0.252
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.329
CLV_PCSK_PC1ET2_1	340	342	PF00082	0.200
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.258
CLV_PCSK_SKI1_1	148	152	PF00082	0.264
CLV_PCSK_SKI1_1	155	159	PF00082	0.245
CLV_PCSK_SKI1_1	251	255	PF00082	0.264
CLV_PCSK_SKI1_1	273	277	PF00082	0.326
CLV_PCSK_SKI1_1	287	291	PF00082	0.310
CLV_PCSK_SKI1_1	44	48	PF00082	0.302
CLV_PCSK_SKI1_1	67	71	PF00082	0.288
DOC_CYCLIN_RxL_1	269	279	PF00134	0.438
DOC_MAPK_gen_1	155	164	PF00069	0.256
DOC_MAPK_gen_1	63	70	PF00069	0.252
DOC_PP1_RVXF_1	169	176	PF00149	0.245
DOC_PP1_SILK_1	334	339	PF00149	0.266
DOC_PP2B_LxvP_1	47	50	PF13499	0.264
DOC_PP4_FxxP_1	12	15	PF00568	0.378
DOC_USP7_UBL2_3	274	278	PF12436	0.264
DOC_USP7_UBL2_3	39	43	PF12436	0.249
DOC_WW_Pin1_4	206	211	PF00397	0.245
DOC_WW_Pin1_4	313	318	PF00397	0.545
LIG_14-3-3_CanoR_1	197	202	PF00244	0.251
LIG_14-3-3_CanoR_1	341	349	PF00244	0.306
LIG_14-3-3_CanoR_1	371	380	PF00244	0.345
LIG_Actin_WH2_2	89	106	PF00022	0.378
LIG_BRCT_BRCA1_1	125	129	PF00533	0.406
LIG_BRCT_BRCA1_1	338	342	PF00533	0.268
LIG_deltaCOP1_diTrp_1	310	318	PF00928	0.384
LIG_eIF4E_1	207	213	PF01652	0.245
LIG_FHA_1	175	181	PF00498	0.245
LIG_FHA_1	243	249	PF00498	0.266
LIG_FHA_1	314	320	PF00498	0.333
LIG_FHA_1	64	70	PF00498	0.264
LIG_FHA_1	85	91	PF00498	0.378
LIG_FHA_2	187	193	PF00498	0.374
LIG_FHA_2	250	256	PF00498	0.389
LIG_FHA_2	300	306	PF00498	0.307
LIG_FHA_2	49	55	PF00498	0.310
LIG_FHA_2	84	90	PF00498	0.264
LIG_LIR_Apic_2	204	210	PF02991	0.245
LIG_LIR_Apic_2	363	369	PF02991	0.264
LIG_LIR_Apic_2	9	15	PF02991	0.378
LIG_LIR_Gen_1	123	131	PF02991	0.245
LIG_LIR_Gen_1	18	29	PF02991	0.295
LIG_LIR_Gen_1	244	254	PF02991	0.267
LIG_LIR_Nem_3	107	112	PF02991	0.333
LIG_LIR_Nem_3	123	128	PF02991	0.163
LIG_LIR_Nem_3	18	24	PF02991	0.295
LIG_LIR_Nem_3	244	250	PF02991	0.248
LIG_LIR_Nem_3	331	337	PF02991	0.361
LIG_MAD2	23	31	PF02301	0.245
LIG_PDZ_Class_1	381	386	PF00595	0.445
LIG_Pex14_2	125	129	PF04695	0.245
LIG_SH2_SRC	130	133	PF00017	0.300
LIG_SH2_STAP1	217	221	PF00017	0.245
LIG_SH2_STAP1	36	40	PF00017	0.245
LIG_SH2_STAT5	130	133	PF00017	0.279
LIG_SH2_STAT5	217	220	PF00017	0.281
LIG_SH2_STAT5	232	235	PF00017	0.263
LIG_SH2_STAT5	247	250	PF00017	0.124
LIG_SH2_STAT5	92	95	PF00017	0.245
LIG_SH3_1	139	145	PF00018	0.286
LIG_SH3_3	139	145	PF00018	0.247
LIG_SH3_3	255	261	PF00018	0.245
LIG_SH3_3	274	280	PF00018	0.333
LIG_TRAF2_1	189	192	PF00917	0.310
LIG_TRAF2_1	51	54	PF00917	0.245
LIG_TYR_ITIM	230	235	PF00017	0.245
LIG_TYR_ITSM	243	250	PF00017	0.245
LIG_UBA3_1	249	256	PF00899	0.264
LIG_UBA3_1	271	278	PF00899	0.245
MOD_CK1_1	140	146	PF00069	0.316
MOD_CK1_1	215	221	PF00069	0.310
MOD_CK1_1	42	48	PF00069	0.392
MOD_CK1_1	83	89	PF00069	0.264
MOD_CK2_1	180	186	PF00069	0.226
MOD_CK2_1	249	255	PF00069	0.258
MOD_CK2_1	48	54	PF00069	0.245
MOD_GlcNHglycan	125	128	PF01048	0.302
MOD_GlcNHglycan	139	142	PF01048	0.274
MOD_GlcNHglycan	164	167	PF01048	0.244
MOD_GlcNHglycan	194	197	PF01048	0.374
MOD_GlcNHglycan	324	327	PF01048	0.320
MOD_GSK3_1	15	22	PF00069	0.249
MOD_GSK3_1	186	193	PF00069	0.300
MOD_GSK3_1	197	204	PF00069	0.202
MOD_GSK3_1	215	222	PF00069	0.245
MOD_GSK3_1	294	301	PF00069	0.404
MOD_GSK3_1	80	87	PF00069	0.323
MOD_N-GLC_1	298	303	PF02516	0.465
MOD_N-GLC_2	352	354	PF02516	0.323
MOD_NEK2_1	201	206	PF00069	0.245
MOD_NEK2_1	212	217	PF00069	0.245
MOD_NEK2_1	241	246	PF00069	0.346
MOD_NEK2_1	249	254	PF00069	0.196
MOD_NEK2_1	294	299	PF00069	0.418
MOD_NEK2_1	342	347	PF00069	0.309
MOD_NEK2_1	80	85	PF00069	0.245
MOD_OFUCOSY	346	351	PF10250	0.461
MOD_PIKK_1	242	248	PF00454	0.378
MOD_PKA_1	63	69	PF00069	0.264
MOD_PKA_2	347	353	PF00069	0.266
MOD_PKA_2	63	69	PF00069	0.267
MOD_Plk_1	213	219	PF00069	0.358
MOD_Plk_1	298	304	PF00069	0.482
MOD_Plk_1	320	326	PF00069	0.284
MOD_Plk_1	53	59	PF00069	0.378
MOD_Plk_2-3	48	54	PF00069	0.378
MOD_Plk_4	148	154	PF00069	0.452
MOD_Plk_4	202	208	PF00069	0.372
MOD_Plk_4	249	255	PF00069	0.245
MOD_ProDKin_1	206	212	PF00069	0.245
MOD_ProDKin_1	313	319	PF00069	0.542
MOD_SUMO_for_1	157	160	PF00179	0.245
MOD_SUMO_rev_2	183	189	PF00179	0.266
MOD_SUMO_rev_2	262	271	PF00179	0.245
TRG_AP2beta_CARGO_1	331	341	PF09066	0.179
TRG_DiLeu_BaEn_1	65	70	PF01217	0.264
TRG_DiLeu_BaEn_1	98	103	PF01217	0.378
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.323
TRG_ENDOCYTIC_2	232	235	PF00928	0.250
TRG_ENDOCYTIC_2	247	250	PF00928	0.124
TRG_ER_diArg_1	55	58	PF00400	0.246
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S2	Leptomonas seymouri	27%	69%
A0A0N0P3N5	Leptomonas seymouri	27%	90%
A0A0N0P3Q8	Leptomonas seymouri	28%	100%
A0A0N0P787	Leptomonas seymouri	80%	100%
A0A0N0P8H5	Leptomonas seymouri	30%	100%
A0A0N1HWQ2	Leptomonas seymouri	28%	100%
A0A0N1I2Z5	Leptomonas seymouri	27%	100%
A0A0N1I6T8	Leptomonas seymouri	34%	100%
A0A0N1IIF9	Leptomonas seymouri	31%	100%
A0A0N1IM47	Leptomonas seymouri	25%	100%
A0A0N1PC31	Leptomonas seymouri	32%	99%
A0A0N1PDW7	Leptomonas seymouri	28%	98%
A0A0N1PE80	Leptomonas seymouri	26%	69%
A0A0N1PEV2	Leptomonas seymouri	29%	71%
A0A0S4IKH2	Bodo saltans	28%	78%
A0A0S4IQ75	Bodo saltans	26%	77%
A0A0S4IRG0	Bodo saltans	28%	100%
A0A0S4IRU8	Bodo saltans	33%	89%
A0A0S4IRZ7	Bodo saltans	27%	78%
A0A0S4ISS4	Bodo saltans	31%	100%
A0A0S4IZY3	Bodo saltans	30%	100%
A0A0S4J3Y5	Bodo saltans	26%	90%
A0A0S4J4B3	Bodo saltans	34%	86%
A0A0S4J4X4	Bodo saltans	28%	100%
A0A0S4J6L4	Bodo saltans	32%	100%
A0A0S4J7K4	Bodo saltans	27%	80%
A0A0S4J842	Bodo saltans	30%	72%
A0A0S4JBR3	Bodo saltans	28%	100%
A0A0S4JCG2	Bodo saltans	33%	86%
A0A0S4JER5	Bodo saltans	31%	85%
A0A0S4JF22	Bodo saltans	27%	100%
A0A0S4JI67	Bodo saltans	28%	84%
A0A0S4JK24	Bodo saltans	25%	89%
A0A0S4JPZ1	Bodo saltans	29%	86%
A0A0S4JPZ7	Bodo saltans	28%	92%
A0A0S4JTJ8	Bodo saltans	27%	84%
A0A0S4JUJ2	Bodo saltans	29%	100%
A0A0S4JWD5	Bodo saltans	27%	99%
A0A0S4KFT7	Bodo saltans	31%	100%
A0A0S4KMV7	Bodo saltans	28%	100%
A0A1X0NF53	Trypanosomatidae	24%	83%
A0A1X0NIX2	Trypanosomatidae	27%	88%
A0A1X0NJV4	Trypanosomatidae	25%	75%
A0A1X0NLC8	Trypanosomatidae	26%	81%
A0A1X0NNE5	Trypanosomatidae	27%	76%
A0A1X0NQ63	Trypanosomatidae	34%	100%
A0A1X0NTL6	Trypanosomatidae	24%	83%
A0A1X0NTP1	Trypanosomatidae	29%	66%
A0A1X0NTR6	Trypanosomatidae	29%	100%
A0A1X0NUQ4	Trypanosomatidae	60%	100%
A0A1X0NWB9	Trypanosomatidae	23%	80%
A0A1X0NY93	Trypanosomatidae	33%	98%
A0A1X0NYK8	Trypanosomatidae	28%	100%
A0A1X0P1A2	Trypanosomatidae	26%	84%
A0A1X0P3J5	Trypanosomatidae	31%	84%
A0A1X0P527	Trypanosomatidae	27%	87%
A0A1X0P549	Trypanosomatidae	28%	81%
A0A1X0P5B1	Trypanosomatidae	32%	100%
A0A1X0P5F2	Trypanosomatidae	32%	100%
A0A1X0P5U3	Trypanosomatidae	29%	75%
A0A1X0P6F5	Trypanosomatidae	27%	100%
A0A1X0P6V1	Trypanosomatidae	29%	100%
A0A1X0P735	Trypanosomatidae	28%	100%
A0A1X0P7V0	Trypanosomatidae	31%	100%
A0A1X0P8F7	Trypanosomatidae	28%	89%
A0A1X0P919	Trypanosomatidae	26%	100%
A0A1X0P963	Trypanosomatidae	31%	80%
A0A1X0P994	Trypanosomatidae	27%	77%
A0A1X0P9C4	Trypanosomatidae	28%	77%
A0A3Q8IAQ1	Leishmania donovani	25%	100%
A0A3Q8IB30	Leishmania donovani	30%	100%
A0A3Q8IC87	Leishmania donovani	26%	100%
A0A3Q8IDK8	Leishmania donovani	25%	69%
A0A3Q8IEH3	Leishmania donovani	27%	100%
A0A3Q8IFK8	Leishmania donovani	26%	88%
A0A3Q8IFW0	Leishmania donovani	28%	90%
A0A3Q8INQ4	Leishmania donovani	32%	99%
A0A3Q8IRT6	Leishmania donovani	33%	76%
A0A3R7K109	Trypanosoma rangeli	28%	82%
A0A3R7K5P9	Trypanosoma rangeli	26%	100%
A0A3R7K681	Trypanosoma rangeli	26%	76%
A0A3R7KRP1	Trypanosoma rangeli	26%	81%
A0A3R7M5C7	Trypanosoma rangeli	33%	100%
A0A3R7MGA2	Trypanosoma rangeli	28%	100%
A0A3R7MHW5	Trypanosoma rangeli	29%	97%
A0A3R7MKG5	Trypanosoma rangeli	27%	88%
A0A3R7MKJ1	Trypanosoma rangeli	30%	71%
A0A3R7N4D8	Trypanosoma rangeli	32%	96%
A0A3R7N5S4	Trypanosoma rangeli	61%	100%
A0A3R7NKI8	Trypanosoma rangeli	30%	100%
A0A3R7RIN5	Trypanosoma rangeli	29%	77%
A0A3R7RLL1	Trypanosoma rangeli	27%	89%
A0A3S5H5G0	Leishmania donovani	24%	100%
A0A3S5H5U5	Leishmania donovani	25%	85%
A0A3S5H606	Leishmania donovani	33%	100%
A0A3S5H7M0	Leishmania donovani	30%	74%
A0A3S7WTN9	Leishmania donovani	97%	100%
A0A3S7WUE7	Leishmania donovani	32%	70%
A0A3S7WUX5	Leishmania donovani	30%	100%
A0A3S7WVE9	Leishmania donovani	29%	100%
A0A3S7WWE7	Leishmania donovani	27%	100%
A0A3S7WY10	Leishmania donovani	23%	100%
A0A3S7X6T8	Leishmania donovani	26%	86%
A0A3S7X8Z8	Leishmania donovani	23%	79%
A0A3S7X9R4	Leishmania donovani	32%	100%
A0A3S7X9S2	Leishmania donovani	32%	100%
A0A422MYB4	Trypanosoma rangeli	32%	100%
A0A422NCU3	Trypanosoma rangeli	27%	100%
A0A422NFN4	Trypanosoma rangeli	26%	76%
A0A422NUF0	Trypanosoma rangeli	26%	97%
A0A422P0J2	Trypanosoma rangeli	31%	100%
A0A422P0N6	Trypanosoma rangeli	23%	100%
A0A422P1R5	Trypanosoma rangeli	27%	100%
A0A422P270	Trypanosoma rangeli	28%	87%
A0A422P4V9	Trypanosoma rangeli	30%	84%
A0A422P4X7	Trypanosoma rangeli	25%	76%
A0A509AQE6	Plasmodium berghei (strain Anka)	29%	69%
A0A8I3S724	Canis lupus familiaris	30%	95%
A0AUV4	Mus musculus	30%	76%
A2KF29	Mus musculus	29%	80%
A2XFF4	Oryza sativa subsp. indica	30%	76%
A2ZVI7	Oryza sativa subsp. japonica	30%	75%
A3B529	Oryza sativa subsp. japonica	26%	89%
A4H459	Leishmania braziliensis	25%	100%
A4H4S9	Leishmania braziliensis	26%	85%
A4H539	Leishmania braziliensis	33%	100%
A4H8C4	Leishmania braziliensis	89%	100%
A4H8V2	Leishmania braziliensis	34%	77%
A4H9H4	Leishmania braziliensis	30%	100%
A4H9L8	Leishmania braziliensis	30%	100%
A4HBL4	Leishmania braziliensis	28%	100%
A4HCD7	Leishmania braziliensis	27%	91%
A4HD79	Leishmania braziliensis	24%	100%
A4HDJ5	Leishmania braziliensis	24%	71%
A4HED7	Leishmania braziliensis	32%	99%
A4HFF3	Leishmania braziliensis	24%	77%
A4HG92	Leishmania braziliensis	28%	100%
A4HHR5	Leishmania braziliensis	28%	75%
A4HI35	Leishmania braziliensis	31%	76%
A4HJT5	Leishmania braziliensis	26%	88%
A4HJW2	Leishmania braziliensis	28%	90%
A4HLR0	Leishmania braziliensis	26%	86%
A4HN71	Leishmania braziliensis	31%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HTB4	Leishmania infantum	33%	100%
A4HWP5	Leishmania infantum	97%	100%
A4HX71	Leishmania infantum	32%	70%
A4HXU0	Leishmania infantum	30%	100%
A4HXY2	Leishmania infantum	30%	100%
A4HZA2	Leishmania infantum	27%	100%
A4HZV1	Leishmania infantum	26%	100%
A4HZW8	Leishmania infantum	25%	100%
A4I1T4	Leishmania infantum	32%	99%
A4I349	Leishmania infantum	25%	68%
A4I3C6	Leishmania infantum	27%	100%
A4I4X5	Leishmania infantum	30%	74%
A4I5B1	Leishmania infantum	33%	76%
A4I7A1	Leishmania infantum	26%	88%
A4I7C4	Leishmania infantum	29%	90%
A4I960	Leishmania infantum	26%	86%
A4IB02	Leishmania infantum	23%	79%
A4IBT4	Leishmania infantum	32%	100%
A4IBT9	Leishmania infantum	32%	100%
A4IDC1	Leishmania infantum	26%	76%
A4IGM9	Xenopus tropicalis	29%	100%
A5GFW1	Sus scrofa	30%	96%
A7MB74	Bos taurus	32%	90%
A8WXF6	Caenorhabditis briggsae	29%	72%
A8XJQ6	Caenorhabditis briggsae	30%	100%
A8XNJ6	Caenorhabditis briggsae	29%	83%
A8XW88	Caenorhabditis briggsae	28%	100%
B8BBT7	Oryza sativa subsp. indica	30%	76%
B9FKW9	Oryza sativa subsp. japonica	31%	74%
C0HKC8	Mus musculus	29%	77%
C0HKC9	Mus musculus	29%	77%
C6K3W8	Leptomonas seymouri	32%	73%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	95%
C9ZKX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	77%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	91%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	80%
C9ZPX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZQP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	84%
C9ZQR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	75%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
C9ZTU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	71%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZW46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
C9ZXP1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
C9ZYS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	98%
C9ZYT4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
C9ZZX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZZX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
D0A2M0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	82%
D0A5C6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0A820	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
D0N4E2	Phytophthora infestans (strain T30-4)	30%	97%
E9ACW7	Leishmania major	25%	69%
E9AEB9	Leishmania major	26%	77%
E9AEC9	Leishmania major	31%	74%
E9AET0	Leishmania major	23%	100%
E9AFM1	Leishmania major	31%	100%
E9AFZ2	Leishmania major	27%	81%
E9AG71	Leishmania infantum	25%	85%
E9AGR7	Leishmania infantum	29%	100%
E9AH34	Leishmania infantum	23%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9ALF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	74%
E9ALG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	77%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9ARC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	70%
E9ARK2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ARW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9ASL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	79%
E9ASS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	76%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	99%
E9AZF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	76%
E9B296	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	88%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	90%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	86%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	78%
E9B6S4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B6S9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
J9W0G9	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	32%	67%
O00141	Homo sapiens	32%	90%
O01427	Caenorhabditis elegans	29%	100%
O14965	Homo sapiens	29%	96%
O15530	Homo sapiens	35%	69%
O15865	Plasmodium falciparum (isolate K1 / Thailand)	30%	75%
O22932	Arabidopsis thaliana	30%	89%
O22971	Arabidopsis thaliana	29%	77%
O43293	Homo sapiens	29%	85%
O54784	Mus musculus	30%	86%
O55099	Rattus norvegicus	30%	100%
O55173	Rattus norvegicus	34%	69%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O64629	Arabidopsis thaliana	32%	100%
O65554	Arabidopsis thaliana	28%	88%
O70126	Mus musculus	29%	100%
O70150	Rattus norvegicus	30%	100%
O74536	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	67%
O77708	Oryctolagus cuniculus	30%	72%
O80673	Arabidopsis thaliana	30%	67%
O88445	Mus musculus	32%	100%
O88764	Rattus norvegicus	30%	86%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	67%
P00517	Bos taurus	28%	100%
P05131	Bos taurus	28%	100%
P05132	Mus musculus	28%	100%
P05383	Sus scrofa	28%	100%
P05986	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	97%
P06244	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	97%
P06245	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P08413	Rattus norvegicus	30%	71%
P08414	Mus musculus	30%	82%
P11275	Rattus norvegicus	30%	81%
P11730	Rattus norvegicus	30%	73%
P11798	Mus musculus	30%	81%
P12370	Drosophila melanogaster	28%	100%
P13234	Rattus norvegicus	30%	81%
P15735	Homo sapiens	29%	95%
P15791	Rattus norvegicus	31%	72%
P16912	Drosophila melanogaster	29%	66%
P17612	Homo sapiens	28%	100%
P21137	Caenorhabditis elegans	27%	96%
P22612	Homo sapiens	28%	100%
P22694	Homo sapiens	28%	100%
P23443	Homo sapiens	30%	74%
P25321	Cricetulus griseus	28%	100%
P25323	Dictyostelium discoideum	33%	100%
P27791	Rattus norvegicus	28%	100%
P28178	Dictyostelium discoideum	29%	81%
P28582	Daucus carota	30%	73%
P28583	Glycine max	30%	76%
P28652	Mus musculus	30%	71%
P31748	AKT8 murine leukemia virus	34%	77%
P31749	Homo sapiens	34%	80%
P31750	Mus musculus	34%	80%
P31751	Homo sapiens	35%	80%
P36887	Sus scrofa	28%	100%
P40376	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	75%
P42818	Arabidopsis thaliana	32%	83%
P47196	Rattus norvegicus	34%	80%
P47197	Rattus norvegicus	34%	80%
P49101	Zea mays	30%	75%
P49673	Ascaris suum	28%	100%
P51817	Homo sapiens	29%	100%
P53683	Oryza sativa subsp. japonica	30%	72%
P54644	Dictyostelium discoideum	31%	87%
P54645	Rattus norvegicus	28%	69%
P54646	Homo sapiens	28%	70%
P59241	Rattus norvegicus	28%	97%
P62345	Plasmodium berghei (strain Anka)	29%	73%
P67998	Oryctolagus cuniculus	30%	74%
P67999	Rattus norvegicus	30%	74%
P68180	Cricetulus griseus	28%	100%
P68181	Mus musculus	28%	100%
P68182	Rattus norvegicus	28%	100%
P92937	Arabidopsis thaliana	30%	92%
P92958	Arabidopsis thaliana	29%	75%
P93759	Arabidopsis thaliana	33%	73%
P97477	Mus musculus	28%	98%
Q00168	Drosophila melanogaster	30%	73%
Q01314	Bos taurus	34%	80%
Q02723	Secale cereale	29%	77%
Q06226	Rattus norvegicus	32%	90%
Q09137	Rattus norvegicus	28%	70%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	84%
Q09831	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	68%
Q0D4B2	Oryza sativa subsp. japonica	31%	74%
Q0JI49	Oryza sativa subsp. japonica	29%	77%
Q0VD22	Bos taurus	27%	79%
Q10LQ2	Oryza sativa subsp. japonica	29%	86%
Q10SC8	Oryza sativa subsp. japonica	30%	85%
Q12706	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	89%
Q13131	Homo sapiens	28%	69%
Q13555	Homo sapiens	30%	69%
Q13557	Homo sapiens	31%	77%
Q14012	Homo sapiens	31%	100%
Q16566	Homo sapiens	30%	82%
Q17941	Caenorhabditis elegans	33%	71%
Q1PFH8	Arabidopsis thaliana	31%	70%
Q27687	Leishmania major	30%	100%
Q28948	Sus scrofa	28%	70%
Q2HJF7	Bos taurus	31%	79%
Q2KJ16	Bos taurus	28%	95%
Q2PJ68	Caenorhabditis elegans	28%	83%
Q2QMI0	Oryza sativa subsp. japonica	29%	85%
Q2QX45	Oryza sativa subsp. japonica	31%	73%
Q2QY53	Oryza sativa subsp. japonica	30%	88%
Q2QYM3	Oryza sativa subsp. japonica	28%	88%
Q2RAX3	Oryza sativa subsp. japonica	30%	85%
Q2RBF0	Oryza sativa subsp. japonica	28%	89%
Q2TA06	Bos taurus	30%	96%
Q2V452	Arabidopsis thaliana	31%	88%
Q38868	Arabidopsis thaliana	31%	71%
Q38873	Arabidopsis thaliana	32%	72%
Q38997	Arabidopsis thaliana	28%	75%
Q39030	Arabidopsis thaliana	32%	82%
Q3E9C0	Arabidopsis thaliana	30%	74%
Q3MHJ9	Bos taurus	30%	71%
Q3SZW1	Bos taurus	30%	100%
Q42396	Arabidopsis thaliana	30%	79%
Q42438	Arabidopsis thaliana	31%	72%
Q4Q1S4	Leishmania major	26%	76%
Q4Q3Y9	Leishmania major	26%	86%
Q4Q5T9	Leishmania major	28%	90%
Q4Q5W2	Leishmania major	26%	88%
Q4Q7M5	Leishmania major	33%	76%
Q4Q9K2	Leishmania major	31%	100%
Q4QAV8	Leishmania major	24%	100%
Q4QBQ2	Leishmania major	24%	100%
Q4QBR6	Leishmania major	26%	100%
Q4QCK0	Leishmania major	26%	100%
Q4QDK6	Leishmania major	29%	100%
Q4QDX7	Leishmania major	30%	92%
Q4QEJ2	Leishmania major	34%	70%
Q4QIJ7	Leishmania major	33%	100%
Q4QIV8	Leishmania major	26%	85%
Q4QJJ0	Leishmania major	24%	100%
Q4R633	Macaca fascicularis	32%	90%
Q4V3C8	Arabidopsis thaliana	35%	79%
Q54CY9	Dictyostelium discoideum	29%	100%
Q54PB4	Dictyostelium discoideum	32%	80%
Q54WX4	Dictyostelium discoideum	28%	100%
Q59S66	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	73%
Q5BKK4	Xenopus tropicalis	32%	92%
Q5EG47	Mus musculus	28%	69%
Q5JLD8	Oryza sativa subsp. japonica	30%	87%
Q5JLQ9	Oryza sativa subsp. japonica	29%	81%
Q5JLS2	Oryza sativa subsp. japonica	30%	71%
Q5Q0U5	Fundulus heteroclitus	33%	90%
Q5QNM6	Oryza sativa subsp. japonica	30%	76%
Q5R7A7	Pongo abelii	31%	78%
Q5RCC4	Pongo abelii	30%	81%
Q5RD00	Pongo abelii	28%	70%
Q5RDH5	Pongo abelii	28%	70%
Q5VQQ5	Oryza sativa subsp. japonica	32%	75%
Q5W736	Oryza sativa subsp. japonica	28%	84%
Q5Z6X0	Oryza sativa subsp. japonica	29%	75%
Q5ZKI0	Gallus gallus	31%	81%
Q60823	Mus musculus	34%	80%
Q60EY8	Oryza sativa subsp. japonica	32%	83%
Q61241	Mus musculus	31%	100%
Q61XD3	Caenorhabditis briggsae	29%	100%
Q63450	Rattus norvegicus	31%	100%
Q63484	Rattus norvegicus	33%	81%
Q683C9	Arabidopsis thaliana	27%	100%
Q68Y49	Oryza sativa subsp. japonica	29%	76%
Q69Q47	Oryza sativa subsp. japonica	30%	85%
Q6A1A2	Homo sapiens	35%	97%
Q6BVA0	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	29%	94%
Q6CWQ4	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6DE08	Xenopus laevis	29%	100%
Q6DEH3	Danio rerio	31%	79%
Q6DGS3	Danio rerio	30%	70%
Q6ERS0	Oryza sativa subsp. japonica	30%	96%
Q6ERS4	Oryza sativa subsp. japonica	32%	85%
Q6FV07	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	32%	100%
Q6GLY8	Xenopus laevis	32%	89%
Q6GPL3	Xenopus laevis	29%	100%
Q6GPN6	Xenopus laevis	32%	89%
Q6H7U5	Oryza sativa subsp. japonica	29%	78%
Q6I587	Oryza sativa subsp. japonica	31%	71%
Q6IP76	Xenopus laevis	34%	80%
Q6NLQ6	Arabidopsis thaliana	32%	72%
Q6NW76	Danio rerio	29%	100%
Q6P2M8	Homo sapiens	30%	100%
Q6PHZ2	Mus musculus	31%	77%
Q6TJY3	Bos taurus	30%	73%
Q6U1I9	Gallus gallus	32%	89%
Q6X4A2	Oryza sativa subsp. japonica	29%	86%
Q6Z9F4	Oryza sativa subsp. japonica	30%	86%
Q6ZLP5	Oryza sativa subsp. japonica	30%	86%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	100%
Q75GE8	Oryza sativa subsp. japonica	34%	72%
Q75GK4	Oryza sativa subsp. japonica	30%	86%
Q75L42	Oryza sativa subsp. japonica	29%	85%
Q7JP68	Caenorhabditis elegans	30%	97%
Q7RJG2	Plasmodium yoelii yoelii	29%	73%
Q7X996	Oryza sativa subsp. japonica	29%	87%
Q7XSQ5	Oryza sativa subsp. japonica	29%	72%
Q7YRC6	Bos taurus	28%	100%
Q7ZTW4	Danio rerio	33%	89%
Q7ZX15	Xenopus laevis	34%	79%
Q84SL0	Oryza sativa subsp. japonica	31%	70%
Q84VQ3	Arabidopsis thaliana	33%	88%
Q852Q0	Oryza sativa subsp. japonica	30%	76%
Q852Q1	Oryza sativa subsp. japonica	30%	76%
Q852Q2	Oryza sativa subsp. japonica	29%	76%
Q869W6	Dictyostelium discoideum	31%	100%
Q86AD7	Dictyostelium discoideum	33%	98%
Q8BRK8	Mus musculus	28%	70%
Q8BSK8	Mus musculus	30%	74%
Q8BW96	Mus musculus	32%	100%
Q8GVC7	Phytophthora infestans	30%	97%
Q8IBS5	Plasmodium falciparum (isolate 3D7)	30%	73%
Q8ICR0	Plasmodium falciparum (isolate 3D7)	30%	75%
Q8IU85	Homo sapiens	32%	100%
Q8LIG4	Oryza sativa subsp. japonica	28%	87%
Q8MJ44	Canis lupus familiaris	28%	100%
Q8MYF1	Dictyostelium discoideum	29%	85%
Q8R4U9	Rattus norvegicus	35%	100%
Q8R4V0	Rattus norvegicus	31%	78%
Q8RWC9	Arabidopsis thaliana	31%	87%
Q8RWL2	Arabidopsis thaliana	30%	72%
Q8SRK8	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8SRL5	Encephalitozoon cuniculi (strain GB-M1)	28%	100%
Q8VDF3	Mus musculus	30%	100%
Q8W1D5	Arabidopsis thaliana	32%	79%
Q91819	Xenopus laevis	29%	95%
Q91820	Xenopus laevis	28%	95%
Q91YS8	Mus musculus	31%	100%
Q922R0	Mus musculus	28%	100%
Q923T9	Mus musculus	30%	73%
Q924X7	Mus musculus	26%	79%
Q93VD3	Arabidopsis thaliana	30%	80%
Q94C40	Arabidopsis thaliana	28%	89%
Q94CG0	Arabidopsis thaliana	32%	93%
Q95266	Sus scrofa	31%	77%
Q96BR1	Homo sapiens	31%	78%
Q96GD4	Homo sapiens	30%	100%
Q98TY9	Xenopus laevis	34%	80%
Q9BYT3	Homo sapiens	28%	75%
Q9C562	Arabidopsis thaliana	28%	81%
Q9C6P3	Arabidopsis thaliana	31%	74%
Q9DG02	Xenopus laevis	30%	81%
Q9ERE3	Mus musculus	31%	78%
Q9FJ54	Arabidopsis thaliana	27%	88%
Q9FJ55	Arabidopsis thaliana	28%	80%
Q9FKW4	Arabidopsis thaliana	28%	74%
Q9FLZ3	Arabidopsis thaliana	27%	78%
Q9FMP5	Arabidopsis thaliana	30%	73%
Q9GNR4	Leishmania major	31%	100%
Q9HBY8	Homo sapiens	34%	100%
Q9LDI3	Arabidopsis thaliana	29%	87%
Q9LET1	Arabidopsis thaliana	30%	67%
Q9LEU7	Arabidopsis thaliana	33%	87%
Q9LGV5	Oryza sativa subsp. japonica	30%	84%
Q9LP51	Arabidopsis thaliana	29%	74%
Q9LWM4	Oryza sativa subsp. japonica	29%	84%
Q9LYQ8	Arabidopsis thaliana	29%	85%
Q9M077	Arabidopsis thaliana	28%	100%
Q9MAM1	Arabidopsis thaliana	28%	86%
Q9MZD9	Ovis aries	28%	100%
Q9N0X0	Sus scrofa	30%	100%
Q9N2N1	Leishmania major	27%	100%
Q9NAH6	Caenorhabditis elegans	29%	70%
Q9P7J8	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	68%
Q9QYK9	Mus musculus	30%	100%
Q9QYZ3	Mus musculus	31%	80%
Q9QYZ4	Mus musculus	29%	80%
Q9QYZ6	Mus musculus	29%	77%
Q9QZS5	Mus musculus	35%	100%
Q9SEZ7	Arabidopsis thaliana	34%	82%
Q9SIQ7	Arabidopsis thaliana	30%	66%
Q9SN43	Arabidopsis thaliana	30%	79%
Q9STV4	Arabidopsis thaliana	28%	87%
Q9SUL7	Arabidopsis thaliana	29%	91%
Q9UBS0	Homo sapiens	32%	80%
Q9UIK4	Homo sapiens	30%	100%
Q9UQB9	Homo sapiens	29%	100%
Q9UQM7	Homo sapiens	30%	81%
Q9WUA6	Mus musculus	33%	81%
Q9WVC6	Mus musculus	32%	90%
Q9XF67	Arabidopsis thaliana	35%	79%
Q9XIW0	Arabidopsis thaliana	30%	90%
Q9XT18	Oryctolagus cuniculus	32%	90%
Q9XTG7	Caenorhabditis elegans	31%	73%
Q9Y243	Homo sapiens	33%	81%
Q9Y7J6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	70%
Q9Z1M4	Mus musculus	32%	80%
Q9Z2A0	Mus musculus	34%	69%
Q9ZSA2	Arabidopsis thaliana	30%	73%
V5B141	Trypanosoma cruzi	27%	81%
V5B871	Trypanosoma cruzi	28%	90%
V5BAZ8	Trypanosoma cruzi	61%	100%
V5BC28	Trypanosoma cruzi	27%	77%
V5BCH2	Trypanosoma cruzi	31%	98%
V5BEK5	Trypanosoma cruzi	30%	100%
V5BG98	Trypanosoma cruzi	28%	100%
V5BH88	Trypanosoma cruzi	29%	71%
V5BI43	Trypanosoma cruzi	27%	77%
V5BNV8	Trypanosoma cruzi	34%	100%
V5BQH6	Trypanosoma cruzi	28%	89%
V5BR65	Trypanosoma cruzi	25%	97%
V5BWC2	Trypanosoma cruzi	28%	100%
V5C224	Trypanosoma cruzi	28%	77%
V5C234	Trypanosoma cruzi	31%	71%
V5DC40	Trypanosoma cruzi	27%	71%
V5DI55	Trypanosoma cruzi	29%	93%
V5DMJ4	Trypanosoma cruzi	26%	100%
V5DPP5	Trypanosoma cruzi	28%	89%
V5DQT5	Trypanosoma cruzi	30%	84%