ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF21_LEIMA

TriTrypDb:

LmjF.15.1570 , LMJLV39_150023000 , LMJSD75_150023000

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.564
CLV_C14_Caspase3-7	26	30	PF00656	0.443
CLV_C14_Caspase3-7	400	404	PF00656	0.611
CLV_NRD_NRD_1	217	219	PF00675	0.369
CLV_NRD_NRD_1	271	273	PF00675	0.533
CLV_NRD_NRD_1	374	376	PF00675	0.629
CLV_NRD_NRD_1	4	6	PF00675	0.607
CLV_NRD_NRD_1	84	86	PF00675	0.470
CLV_NRD_NRD_1	9	11	PF00675	0.546
CLV_PCSK_KEX2_1	167	169	PF00082	0.478
CLV_PCSK_KEX2_1	217	219	PF00082	0.369
CLV_PCSK_KEX2_1	376	378	PF00082	0.585
CLV_PCSK_KEX2_1	4	6	PF00082	0.599
CLV_PCSK_KEX2_1	418	420	PF00082	0.557
CLV_PCSK_KEX2_1	86	88	PF00082	0.433
CLV_PCSK_KEX2_1	9	11	PF00082	0.553
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.352
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.588
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.628
CLV_PCSK_PC1ET2_1	418	420	PF00082	0.608
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.514
CLV_PCSK_PC7_1	414	420	PF00082	0.548
CLV_PCSK_PC7_1	5	11	PF00082	0.703
CLV_PCSK_SKI1_1	164	168	PF00082	0.421
CLV_PCSK_SKI1_1	243	247	PF00082	0.380
CLV_PCSK_SKI1_1	274	278	PF00082	0.528
CLV_PCSK_SKI1_1	414	418	PF00082	0.492
CLV_PCSK_SKI1_1	419	423	PF00082	0.491
CLV_PCSK_SKI1_1	437	441	PF00082	0.370
CLV_PCSK_SKI1_1	510	514	PF00082	0.689
CLV_PCSK_SKI1_1	536	540	PF00082	0.570
DOC_CKS1_1	527	532	PF01111	0.565
DOC_CYCLIN_RxL_1	414	426	PF00134	0.610
DOC_CYCLIN_RxL_1	507	517	PF00134	0.622
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.447
DOC_MAPK_gen_1	272	279	PF00069	0.459
DOC_PP1_RVXF_1	119	126	PF00149	0.461
DOC_PP4_FxxP_1	70	73	PF00568	0.384
DOC_PP4_FxxP_1	76	79	PF00568	0.459
DOC_USP7_MATH_1	195	199	PF00917	0.587
DOC_USP7_MATH_1	348	352	PF00917	0.746
DOC_USP7_MATH_1	64	68	PF00917	0.622
DOC_WW_Pin1_4	43	48	PF00397	0.404
DOC_WW_Pin1_4	460	465	PF00397	0.550
DOC_WW_Pin1_4	516	521	PF00397	0.667
DOC_WW_Pin1_4	526	531	PF00397	0.765
LIG_14-3-3_CanoR_1	101	105	PF00244	0.687
LIG_14-3-3_CanoR_1	233	242	PF00244	0.560
LIG_14-3-3_CanoR_1	431	439	PF00244	0.554
LIG_Actin_WH2_2	228	245	PF00022	0.517
LIG_BRCT_BRCA1_1	381	385	PF00533	0.591
LIG_BRCT_BRCA1_1	464	468	PF00533	0.477
LIG_BRCT_BRCA1_1	66	70	PF00533	0.349
LIG_eIF4E_1	55	61	PF01652	0.338
LIG_FHA_1	151	157	PF00498	0.374
LIG_FHA_1	48	54	PF00498	0.431
LIG_FHA_1	482	488	PF00498	0.607
LIG_FHA_1	507	513	PF00498	0.622
LIG_FHA_1	55	61	PF00498	0.336
LIG_FHA_1	79	85	PF00498	0.458
LIG_FHA_2	203	209	PF00498	0.613
LIG_FHA_2	222	228	PF00498	0.464
LIG_FHA_2	318	324	PF00498	0.539
LIG_FHA_2	338	344	PF00498	0.748
LIG_FHA_2	400	406	PF00498	0.665
LIG_Integrin_RGD_1	106	108	PF01839	0.567
LIG_LIR_Apic_2	139	144	PF02991	0.325
LIG_LIR_Apic_2	343	348	PF02991	0.689
LIG_LIR_Apic_2	67	73	PF02991	0.333
LIG_LIR_Gen_1	204	215	PF02991	0.456
LIG_LIR_Gen_1	288	297	PF02991	0.545
LIG_LIR_Gen_1	382	390	PF02991	0.489
LIG_LIR_Gen_1	426	434	PF02991	0.530
LIG_LIR_Gen_1	473	482	PF02991	0.614
LIG_LIR_Nem_3	130	135	PF02991	0.461
LIG_LIR_Nem_3	204	210	PF02991	0.495
LIG_LIR_Nem_3	248	253	PF02991	0.372
LIG_LIR_Nem_3	288	292	PF02991	0.490
LIG_LIR_Nem_3	382	388	PF02991	0.487
LIG_LIR_Nem_3	426	432	PF02991	0.459
LIG_LIR_Nem_3	473	477	PF02991	0.529
LIG_MYND_1	526	530	PF01753	0.583
LIG_PTB_Apo_2	149	156	PF02174	0.335
LIG_REV1ctd_RIR_1	437	446	PF16727	0.552
LIG_SH2_CRK	289	293	PF00017	0.377
LIG_SH2_CRK	294	298	PF00017	0.362
LIG_SH2_GRB2like	150	153	PF00017	0.342
LIG_SH2_GRB2like	249	252	PF00017	0.489
LIG_SH2_PTP2	141	144	PF00017	0.294
LIG_SH2_PTP2	345	348	PF00017	0.684
LIG_SH2_SRC	345	348	PF00017	0.603
LIG_SH2_STAP1	147	151	PF00017	0.456
LIG_SH2_STAT3	124	127	PF00017	0.447
LIG_SH2_STAT5	124	127	PF00017	0.488
LIG_SH2_STAT5	133	136	PF00017	0.492
LIG_SH2_STAT5	141	144	PF00017	0.317
LIG_SH2_STAT5	150	153	PF00017	0.443
LIG_SH2_STAT5	345	348	PF00017	0.691
LIG_SH2_STAT5	406	409	PF00017	0.482
LIG_SH2_STAT5	428	431	PF00017	0.561
LIG_SH3_2	35	40	PF14604	0.438
LIG_SH3_3	172	178	PF00018	0.390
LIG_SH3_3	32	38	PF00018	0.441
LIG_SH3_3	41	47	PF00018	0.408
LIG_SH3_3	520	526	PF00018	0.592
LIG_SH3_3	527	533	PF00018	0.733
LIG_SUMO_SIM_anti_2	115	120	PF11976	0.532
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.433
LIG_SUMO_SIM_par_1	177	183	PF11976	0.468
LIG_SUMO_SIM_par_1	198	205	PF11976	0.487
LIG_TRAF2_2	450	455	PF00917	0.677
LIG_TRFH_1	133	137	PF08558	0.446
LIG_TYR_ITIM	292	297	PF00017	0.370
MOD_CDK_SPxK_1	526	532	PF00069	0.566
MOD_CK1_1	100	106	PF00069	0.674
MOD_CK1_1	389	395	PF00069	0.575
MOD_CK1_1	396	402	PF00069	0.501
MOD_CK1_1	430	436	PF00069	0.525
MOD_CK1_1	443	449	PF00069	0.605
MOD_CK1_1	46	52	PF00069	0.360
MOD_CK1_1	519	525	PF00069	0.568
MOD_CK1_1	531	537	PF00069	0.708
MOD_CK2_1	221	227	PF00069	0.416
MOD_CK2_1	348	354	PF00069	0.631
MOD_CK2_1	363	369	PF00069	0.696
MOD_GlcNHglycan	170	173	PF01048	0.539
MOD_GlcNHglycan	191	194	PF01048	0.498
MOD_GlcNHglycan	196	200	PF01048	0.470
MOD_GlcNHglycan	235	238	PF01048	0.467
MOD_GlcNHglycan	313	316	PF01048	0.554
MOD_GlcNHglycan	380	384	PF01048	0.618
MOD_GlcNHglycan	432	435	PF01048	0.561
MOD_GlcNHglycan	465	468	PF01048	0.466
MOD_GlcNHglycan	492	496	PF01048	0.703
MOD_GlcNHglycan	66	69	PF01048	0.364
MOD_GSK3_1	221	228	PF00069	0.542
MOD_GSK3_1	389	396	PF00069	0.590
MOD_GSK3_1	397	404	PF00069	0.503
MOD_GSK3_1	43	50	PF00069	0.432
MOD_GSK3_1	528	535	PF00069	0.781
MOD_N-GLC_1	285	290	PF02516	0.526
MOD_N-GLC_1	317	322	PF02516	0.561
MOD_N-GLC_1	55	60	PF02516	0.379
MOD_NEK2_1	440	445	PF00069	0.559
MOD_NEK2_1	493	498	PF00069	0.565
MOD_NEK2_1	54	59	PF00069	0.360
MOD_NEK2_2	47	52	PF00069	0.436
MOD_PIKK_1	448	454	PF00454	0.694
MOD_PKA_2	100	106	PF00069	0.632
MOD_PKA_2	392	398	PF00069	0.663
MOD_PKA_2	430	436	PF00069	0.599
MOD_PKA_2	531	537	PF00069	0.570
MOD_PKB_1	377	385	PF00069	0.581
MOD_PKB_1	391	399	PF00069	0.584
MOD_Plk_1	285	291	PF00069	0.466
MOD_Plk_1	317	323	PF00069	0.564
MOD_Plk_1	47	53	PF00069	0.508
MOD_Plk_1	55	61	PF00069	0.331
MOD_Plk_2-3	337	343	PF00069	0.668
MOD_Plk_4	100	106	PF00069	0.622
MOD_Plk_4	202	208	PF00069	0.583
MOD_Plk_4	245	251	PF00069	0.485
MOD_Plk_4	56	62	PF00069	0.370
MOD_ProDKin_1	43	49	PF00069	0.410
MOD_ProDKin_1	460	466	PF00069	0.549
MOD_ProDKin_1	516	522	PF00069	0.670
MOD_ProDKin_1	526	532	PF00069	0.768
MOD_SUMO_for_1	489	492	PF00179	0.699
MOD_SUMO_rev_2	89	96	PF00179	0.542
TRG_DiLeu_BaEn_4	262	268	PF01217	0.463
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.613
TRG_ENDOCYTIC_2	282	285	PF00928	0.381
TRG_ENDOCYTIC_2	289	292	PF00928	0.381
TRG_ENDOCYTIC_2	294	297	PF00928	0.368
TRG_ER_diArg_1	216	218	PF00400	0.340
TRG_ER_diArg_1	240	243	PF00400	0.466
TRG_ER_diArg_1	291	294	PF00400	0.384
TRG_ER_diArg_1	390	393	PF00400	0.650
TRG_ER_diArg_1	8	10	PF00400	0.616
TRG_ER_diArg_1	84	87	PF00400	0.449
TRG_NES_CRM1_1	34	48	PF08389	0.438
TRG_NES_CRM1_1	503	517	PF08389	0.509
TRG_NLS_MonoExtC_3	3	8	PF00514	0.622
TRG_NLS_MonoExtC_3	374	379	PF00514	0.591
TRG_NLS_MonoExtN_4	2	8	PF00514	0.627
TRG_Pf-PMV_PEXEL_1	12	17	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	419	424	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P791	Leptomonas seymouri	63%	100%
A0A1X0NGQ9	Trypanosomatidae	40%	92%
A0A3R7L2Y6	Trypanosoma rangeli	39%	91%
A0A3S5H6W3	Leishmania donovani	90%	100%
A4H8C6	Leishmania braziliensis	77%	100%
A4HWP7	Leishmania infantum	90%	100%
C9ZTQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	87%
E9AQF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5DPP9	Trypanosoma cruzi	44%	92%