Anti-silencing protein a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anti-silencing protein a-like protein

Species:

Leishmania major

UniProt:

Q4QF20_LEIMA

TriTrypDb:

LmjF.16.0005 , LMJLV39_160005000 , LMJSD75_160005000

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	17
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043231	intracellular membrane-bounded organelle	4	17
GO:0110165	cellular anatomical entity	1	17
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

Expansion

Sequence features

Q4QF20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF20

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	17
GO:0006335	DNA replication-dependent chromatin assembly	5	3
GO:0009987	cellular process	1	17
GO:0016043	cellular component organization	3	17
GO:0071840	cellular component organization or biogenesis	2	17

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	17
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030527	structural constituent of chromatin	2	17
GO:0042393	histone binding	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.708
CLV_C14_Caspase3-7	209	213	PF00656	0.635
CLV_NRD_NRD_1	17	19	PF00675	0.388
CLV_NRD_NRD_1	22	24	PF00675	0.371
CLV_NRD_NRD_1	48	50	PF00675	0.383
CLV_PCSK_FUR_1	217	221	PF00082	0.590
CLV_PCSK_KEX2_1	216	218	PF00082	0.621
CLV_PCSK_KEX2_1	219	221	PF00082	0.589
CLV_PCSK_KEX2_1	22	24	PF00082	0.380
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.644
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.639
CLV_PCSK_PC7_1	18	24	PF00082	0.381
CLV_PCSK_SKI1_1	216	220	PF00082	0.613
DEG_APCC_DBOX_1	44	52	PF00400	0.273
DEG_Nend_Nbox_1	1	3	PF02207	0.396
DOC_MAPK_gen_1	76	86	PF00069	0.455
DOC_MAPK_MEF2A_6	60	69	PF00069	0.383
DOC_MAPK_MEF2A_6	79	86	PF00069	0.174
DOC_MAPK_NFAT4_5	66	74	PF00069	0.300
DOC_PP1_RVXF_1	183	190	PF00149	0.403
DOC_PP4_FxxP_1	61	64	PF00568	0.273
DOC_PP4_FxxP_1	74	77	PF00568	0.273
DOC_USP7_MATH_1	197	201	PF00917	0.688
DOC_USP7_MATH_1	56	60	PF00917	0.480
DOC_USP7_UBL2_3	179	183	PF12436	0.261
DOC_WW_Pin1_4	190	195	PF00397	0.600
DOC_WW_Pin1_4	30	35	PF00397	0.382
DOC_WW_Pin1_4	86	91	PF00397	0.348
LIG_Actin_WH2_2	170	187	PF00022	0.385
LIG_BRCT_BRCA1_1	11	15	PF00533	0.375
LIG_BRCT_BRCA1_1	5	9	PF00533	0.385
LIG_CSL_BTD_1	87	90	PF09270	0.352
LIG_DCNL_PONY_1	1	4	PF03556	0.393
LIG_FHA_1	133	139	PF00498	0.349
LIG_FHA_1	172	178	PF00498	0.364
LIG_FHA_1	31	37	PF00498	0.497
LIG_FHA_1	41	47	PF00498	0.194
LIG_FHA_2	166	172	PF00498	0.408
LIG_FHA_2	42	48	PF00498	0.318
LIG_GBD_Chelix_1	16	24	PF00786	0.380
LIG_LIR_Apic_2	186	192	PF02991	0.241
LIG_LIR_Apic_2	59	64	PF02991	0.349
LIG_LIR_Apic_2	72	77	PF02991	0.222
LIG_LIR_Apic_2	89	95	PF02991	0.223
LIG_LIR_Gen_1	147	155	PF02991	0.341
LIG_LIR_Nem_3	147	151	PF02991	0.334
LIG_LIR_Nem_3	85	91	PF02991	0.319
LIG_LYPXL_yS_3	181	184	PF13949	0.403
LIG_SH3_3	128	134	PF00018	0.293
LIG_SH3_3	50	56	PF00018	0.442
LIG_SUMO_SIM_par_1	69	75	PF11976	0.376
LIG_UBA3_1	137	142	PF00899	0.403
MOD_CDK_SPK_2	30	35	PF00069	0.382
MOD_CDK_SPxxK_3	30	37	PF00069	0.382
MOD_CK1_1	193	199	PF00069	0.544
MOD_CK2_1	41	47	PF00069	0.173
MOD_GlcNHglycan	168	171	PF01048	0.330
MOD_GlcNHglycan	209	212	PF01048	0.708
MOD_GSK3_1	193	200	PF00069	0.615
MOD_GSK3_1	203	210	PF00069	0.544
MOD_GSK3_1	219	226	PF00069	0.595
MOD_GSK3_1	82	89	PF00069	0.403
MOD_N-GLC_1	153	158	PF02516	0.265
MOD_NEK2_1	137	142	PF00069	0.335
MOD_NEK2_1	3	8	PF00069	0.385
MOD_PKA_1	219	225	PF00069	0.592
MOD_PKA_2	219	225	PF00069	0.540
MOD_Plk_1	114	120	PF00069	0.387
MOD_Plk_1	153	159	PF00069	0.261
MOD_Plk_1	185	191	PF00069	0.323
MOD_Plk_1	82	88	PF00069	0.403
MOD_Plk_4	3	9	PF00069	0.387
MOD_ProDKin_1	190	196	PF00069	0.610
MOD_ProDKin_1	30	36	PF00069	0.382
MOD_ProDKin_1	86	92	PF00069	0.348
MOD_SUMO_for_1	218	221	PF00179	0.586
TRG_ENDOCYTIC_2	181	184	PF00928	0.403
TRG_ER_diArg_1	22	24	PF00400	0.380
TRG_ER_diArg_1	34	37	PF00400	0.362
TRG_NLS_MonoExtC_3	215	220	PF00514	0.582
TRG_NLS_MonoExtN_4	214	220	PF00514	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	66%	100%
A0A0S4IIL8	Bodo saltans	31%	100%
A0A0S4JR86	Bodo saltans	57%	100%
A0A1X0NWK6	Trypanosomatidae	32%	100%
A0A3Q8IAD9	Leishmania donovani	96%	100%
A0A3Q8IBF3	Leishmania donovani	32%	100%
A0A3R7M8V4	Trypanosoma rangeli	29%	100%
A0A422ND92	Trypanosoma rangeli	60%	100%
A4H8C7	Leishmania braziliensis	79%	100%
A4HBH4	Leishmania braziliensis	32%	100%
A4HWP9	Leishmania infantum	96%	100%
A4HYJ8	Leishmania infantum	32%	100%
C9ZW62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AQF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AUE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
O74515	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	86%
P32447	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	81%
Q2GQS2	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	29%	82%
Q2UKV7	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	79%
Q4IR08	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	31%	81%
Q59MV1	Candida albicans (strain SC5314 / ATCC MYA-2876)	28%	91%
Q69DB9	Xenopus laevis	30%	100%
Q6CI62	Yarrowia lipolytica (strain CLIB 122 / E 150)	29%	85%
Q6FL84	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	74%
Q6NY34	Danio rerio	31%	100%
Q759F6	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	82%
Q9BJ46	Leishmania major	31%	100%
V5B915	Trypanosoma cruzi	54%	100%
V5C0E3	Trypanosoma cruzi	31%	100%