Anti-silencing protein a-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

anti-silencing protein a-like protein

Species:

Leishmania major

UniProt:

Q4QF20_LEIMA

TriTrypDb:

LmjF.16.0005 , LMJLV39_160005000 , LMJSD75_160005000

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Show entries

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	17
GO:0005829	cytosol	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	17
GO:0043227	membrane-bounded organelle	3	17
GO:0043229	intracellular organelle	3	17
GO:0043231	intracellular membrane-bounded organelle	4	17
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1

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Expansion

Sequence features

Q4QF20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF20

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	17
GO:0006335	DNA replication-dependent chromatin assembly	5	3
GO:0009987	cellular process	1	17
GO:0016043	cellular component organization	3	17
GO:0071840	cellular component organization or biogenesis	2	17

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	17
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0030527	structural constituent of chromatin	2	17
GO:0042393	histone binding	3	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.708
CLV_C14_Caspase3-7	209	213	PF00656	0.635
CLV_NRD_NRD_1	17	19	PF00675	0.388
CLV_NRD_NRD_1	22	24	PF00675	0.371
CLV_NRD_NRD_1	48	50	PF00675	0.383
CLV_PCSK_FUR_1	217	221	PF00082	0.590
CLV_PCSK_KEX2_1	216	218	PF00082	0.621
CLV_PCSK_KEX2_1	219	221	PF00082	0.589
CLV_PCSK_KEX2_1	22	24	PF00082	0.380
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.644

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I1	Leptomonas seymouri	66%	100%
A0A0S4IIL8	Bodo saltans	31%	100%
A0A0S4JR86	Bodo saltans	57%	100%
A0A1X0NWK6	Trypanosomatidae	32%	100%
A0A3Q8IAD9	Leishmania donovani	96%	100%
A0A3Q8IBF3	Leishmania donovani	32%	100%
A0A3R7M8V4	Trypanosoma rangeli	29%	100%
A0A422ND92	Trypanosoma rangeli	60%	100%
A4H8C7	Leishmania braziliensis	79%	100%
A4HBH4	Leishmania braziliensis	32%	100%

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