Ribosomal_L18e/L15P domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF19_LEIMA

TriTrypDb:

LmjF.16.0010 , LMJLV39_160005100 , LMJSD75_160005100

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	2
GO:0005737	cytoplasm	2	2
GO:0005762	mitochondrial large ribosomal subunit	3	2
GO:0015934	large ribosomal subunit	4	11
GO:0032991	protein-containing complex	1	11
GO:0044391	ribosomal subunit	3	11
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

Q4QF19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF19

PDB structure(s): 7aih_G , 7am2_G , 7ane_G

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.535
CLV_MEL_PAP_1	153	159	PF00089	0.335
CLV_NRD_NRD_1	134	136	PF00675	0.346
CLV_NRD_NRD_1	144	146	PF00675	0.321
CLV_NRD_NRD_1	281	283	PF00675	0.483
CLV_NRD_NRD_1	292	294	PF00675	0.448
CLV_NRD_NRD_1	315	317	PF00675	0.452
CLV_NRD_NRD_1	368	370	PF00675	0.564
CLV_NRD_NRD_1	53	55	PF00675	0.463
CLV_NRD_NRD_1	9	11	PF00675	0.568
CLV_PCSK_KEX2_1	134	136	PF00082	0.339
CLV_PCSK_KEX2_1	294	296	PF00082	0.423
CLV_PCSK_KEX2_1	315	317	PF00082	0.452
CLV_PCSK_KEX2_1	368	370	PF00082	0.491
CLV_PCSK_KEX2_1	9	11	PF00082	0.568
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.412
CLV_PCSK_SKI1_1	145	149	PF00082	0.363
CLV_PCSK_SKI1_1	150	154	PF00082	0.367
CLV_PCSK_SKI1_1	201	205	PF00082	0.447
DEG_APCC_DBOX_1	173	181	PF00400	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DOC_MAPK_MEF2A_6	225	234	PF00069	0.378
DOC_PP1_RVXF_1	177	183	PF00149	0.335
DOC_PP1_RVXF_1	207	214	PF00149	0.372
DOC_PP1_RVXF_1	43	49	PF00149	0.593
DOC_USP7_MATH_1	155	159	PF00917	0.378
DOC_USP7_MATH_1	248	252	PF00917	0.331
DOC_USP7_MATH_1	27	31	PF00917	0.462
DOC_USP7_MATH_1	289	293	PF00917	0.484
DOC_USP7_MATH_1	357	361	PF00917	0.491
DOC_USP7_MATH_1	367	371	PF00917	0.487
DOC_USP7_UBL2_3	340	344	PF12436	0.455
DOC_WW_Pin1_4	145	150	PF00397	0.335
DOC_WW_Pin1_4	97	102	PF00397	0.483
LIG_14-3-3_CanoR_1	156	162	PF00244	0.378
LIG_14-3-3_CanoR_1	174	178	PF00244	0.410
LIG_14-3-3_CanoR_1	315	323	PF00244	0.526
LIG_14-3-3_CanoR_1	368	374	PF00244	0.577
LIG_14-3-3_CanoR_1	45	49	PF00244	0.529
LIG_14-3-3_CanoR_1	73	82	PF00244	0.484
LIG_DCNL_PONY_1	1	4	PF03556	0.643
LIG_FHA_1	184	190	PF00498	0.389
LIG_FHA_1	192	198	PF00498	0.362
LIG_FHA_2	271	277	PF00498	0.591
LIG_FHA_2	323	329	PF00498	0.494
LIG_FHA_2	330	336	PF00498	0.471
LIG_LIR_Apic_2	100	106	PF02991	0.571
LIG_LIR_Apic_2	305	311	PF02991	0.467
LIG_LIR_Apic_2	317	323	PF02991	0.530
LIG_LIR_Apic_2	83	88	PF02991	0.441
LIG_LIR_Gen_1	171	180	PF02991	0.447
LIG_LIR_Gen_1	251	257	PF02991	0.436
LIG_LIR_Gen_1	260	271	PF02991	0.413
LIG_LIR_Gen_1	91	101	PF02991	0.542
LIG_LIR_Nem_3	171	175	PF02991	0.447
LIG_LIR_Nem_3	251	255	PF02991	0.414
LIG_LIR_Nem_3	260	266	PF02991	0.409
LIG_LIR_Nem_3	269	274	PF02991	0.388
LIG_LIR_Nem_3	30	35	PF02991	0.416
LIG_LIR_Nem_3	47	51	PF02991	0.457
LIG_LIR_Nem_3	80	85	PF02991	0.469
LIG_LIR_Nem_3	91	97	PF02991	0.480
LIG_NRBOX	176	182	PF00104	0.355
LIG_SH2_GRB2like	36	39	PF00017	0.553
LIG_SH2_GRB2like	85	88	PF00017	0.451
LIG_SH2_NCK_1	308	312	PF00017	0.474
LIG_SH2_PTP2	103	106	PF00017	0.599
LIG_SH2_PTP2	320	323	PF00017	0.511
LIG_SH2_PTP2	85	88	PF00017	0.576
LIG_SH2_SRC	308	311	PF00017	0.477
LIG_SH2_SRC	85	88	PF00017	0.451
LIG_SH2_STAP1	126	130	PF00017	0.535
LIG_SH2_STAP1	36	40	PF00017	0.552
LIG_SH2_STAT3	96	99	PF00017	0.356
LIG_SH2_STAT5	103	106	PF00017	0.464
LIG_SH2_STAT5	320	323	PF00017	0.491
LIG_SH2_STAT5	85	88	PF00017	0.451
LIG_SH2_STAT5	96	99	PF00017	0.477
LIG_SH3_3	208	214	PF00018	0.394
LIG_SH3_3	223	229	PF00018	0.276
LIG_TRAF2_1	332	335	PF00917	0.499
LIG_TRFH_1	151	155	PF08558	0.335
LIG_WRC_WIRS_1	271	276	PF05994	0.593
MOD_CDK_SPK_2	145	150	PF00069	0.335
MOD_CK1_1	173	179	PF00069	0.424
MOD_CK1_1	360	366	PF00069	0.473
MOD_CK2_1	270	276	PF00069	0.590
MOD_CK2_1	329	335	PF00069	0.472
MOD_CMANNOS	79	82	PF00535	0.464
MOD_Cter_Amidation	313	316	PF01082	0.450
MOD_Cter_Amidation	52	55	PF01082	0.469
MOD_GlcNHglycan	107	110	PF01048	0.452
MOD_GlcNHglycan	157	160	PF01048	0.358
MOD_GlcNHglycan	237	240	PF01048	0.360
MOD_GlcNHglycan	351	354	PF01048	0.517
MOD_GlcNHglycan	369	372	PF01048	0.385
MOD_GlcNHglycan	4	7	PF01048	0.666
MOD_GSK3_1	120	127	PF00069	0.470
MOD_GSK3_1	73	80	PF00069	0.552
MOD_N-GLC_1	191	196	PF02516	0.437
MOD_N-GLC_1	235	240	PF02516	0.355
MOD_NEK2_1	175	180	PF00069	0.423
MOD_NEK2_1	2	7	PF00069	0.572
MOD_NEK2_1	95	100	PF00069	0.536
MOD_NEK2_2	27	32	PF00069	0.434
MOD_PIKK_1	88	94	PF00454	0.519
MOD_PIKK_1	95	101	PF00454	0.493
MOD_PKA_2	155	161	PF00069	0.355
MOD_PKA_2	173	179	PF00069	0.380
MOD_PKA_2	314	320	PF00069	0.523
MOD_PKA_2	367	373	PF00069	0.537
MOD_PKA_2	44	50	PF00069	0.523
MOD_PKA_2	72	78	PF00069	0.495
MOD_Plk_1	191	197	PF00069	0.447
MOD_Plk_1	303	309	PF00069	0.560
MOD_Plk_2-3	270	276	PF00069	0.623
MOD_Plk_4	27	33	PF00069	0.434
MOD_Plk_4	270	276	PF00069	0.590
MOD_Plk_4	351	357	PF00069	0.459
MOD_Plk_4	90	96	PF00069	0.503
MOD_ProDKin_1	145	151	PF00069	0.335
MOD_ProDKin_1	97	103	PF00069	0.481
MOD_SUMO_rev_2	276	285	PF00179	0.499
TRG_DiLeu_BaEn_3	269	275	PF01217	0.584
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.406
TRG_ENDOCYTIC_2	11	14	PF00928	0.472
TRG_ENDOCYTIC_2	263	266	PF00928	0.430
TRG_ER_diArg_1	162	165	PF00400	0.355
TRG_ER_diArg_1	9	11	PF00400	0.552
TRG_NLS_Bipartite_1	282	297	PF00514	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PET7	Leptomonas seymouri	90%	100%
A0A0S4JQJ9	Bodo saltans	59%	100%
A0A1X0NZG0	Trypanosomatidae	74%	100%
A0A3Q8IA98	Leishmania donovani	98%	100%
A4H8C8	Leishmania braziliensis	92%	100%
A4HWQ0	Leishmania infantum	98%	100%
C9ZPT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	100%
E9AQF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
V5BFU8	Trypanosoma cruzi	74%	100%