AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

adenylate kinase, putative

Species:

Leishmania major

UniProt:

Q4QF18_LEIMA

TriTrypDb:

LmjF.16.0020 , LMJLV39_160005200 , LMJSD75_160005200

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF18

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	2
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009132	nucleoside diphosphate metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009142	nucleoside triphosphate biosynthetic process	6	2
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	7
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	6
GO:0046939	obsolete nucleotide phosphorylation	6	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	6
GO:0090407	organophosphate biosynthetic process	4	2
GO:1901293	nucleoside phosphate biosynthetic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0033554	cellular response to stress	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0090304	nucleic acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004017	adenylate kinase activity	6	4
GO:0004127	cytidylate kinase activity	6	2
GO:0004550	nucleoside diphosphate kinase activity	5	2
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	4
GO:0017076	purine nucleotide binding	4	8
GO:0019205	nucleobase-containing compound kinase activity	5	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0050145	nucleoside monophosphate kinase activity	5	4
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0003678	DNA helicase activity	3	1
GO:0004386	helicase activity	2	2
GO:0008094	ATP-dependent activity, acting on DNA	2	1
GO:0009378	four-way junction helicase activity	4	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:0140657	ATP-dependent activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.414
CLV_NRD_NRD_1	176	178	PF00675	0.365
CLV_NRD_NRD_1	47	49	PF00675	0.419
CLV_PCSK_KEX2_1	176	178	PF00082	0.398
CLV_PCSK_KEX2_1	47	49	PF00082	0.617
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.349
DOC_CYCLIN_yCln2_LP_2	32	38	PF00134	0.368
DOC_MAPK_gen_1	47	54	PF00069	0.367
DOC_MAPK_MEF2A_6	47	56	PF00069	0.355
DOC_PP2B_LxvP_1	138	141	PF13499	0.413
DOC_PP2B_LxvP_1	32	35	PF13499	0.463
DOC_PP4_FxxP_1	46	49	PF00568	0.572
DOC_USP7_MATH_1	154	158	PF00917	0.499
DOC_USP7_UBL2_3	101	105	PF12436	0.380
DOC_WW_Pin1_4	128	133	PF00397	0.307
DOC_WW_Pin1_4	47	52	PF00397	0.509
DOC_WW_Pin1_4	80	85	PF00397	0.502
LIG_BIR_II_1	1	5	PF00653	0.470
LIG_Clathr_ClatBox_1	39	43	PF01394	0.383
LIG_FHA_1	1	7	PF00498	0.425
LIG_FHA_2	116	122	PF00498	0.377
LIG_LIR_Apic_2	43	49	PF02991	0.553
LIG_SH2_STAT5	13	16	PF00017	0.384
LIG_SH3_3	32	38	PF00018	0.369
LIG_TRAF2_1	196	199	PF00917	0.463
MOD_CK1_1	128	134	PF00069	0.469
MOD_CK1_1	2	8	PF00069	0.520
MOD_CK1_1	62	68	PF00069	0.492
MOD_CK2_1	193	199	PF00069	0.436
MOD_GlcNHglycan	127	130	PF01048	0.425
MOD_GlcNHglycan	195	198	PF01048	0.448
MOD_GlcNHglycan	6	9	PF01048	0.398
MOD_GlcNHglycan	61	64	PF01048	0.249
MOD_GSK3_1	124	131	PF00069	0.425
MOD_GSK3_1	59	66	PF00069	0.465
MOD_NEK2_1	125	130	PF00069	0.559
MOD_NEK2_1	178	183	PF00069	0.278
MOD_Plk_1	161	167	PF00069	0.397
MOD_Plk_1	191	197	PF00069	0.398
MOD_Plk_4	18	24	PF00069	0.371
MOD_ProDKin_1	128	134	PF00069	0.303
MOD_ProDKin_1	47	53	PF00069	0.501
MOD_ProDKin_1	80	86	PF00069	0.508
MOD_SUMO_rev_2	95	103	PF00179	0.355
TRG_ENDOCYTIC_2	188	191	PF00928	0.368
TRG_ER_diArg_1	175	177	PF00400	0.461
TRG_ER_diArg_1	46	48	PF00400	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M7	Leptomonas seymouri	28%	74%
A0A0N1I7A0	Leptomonas seymouri	53%	100%
A0A0S4JIH6	Bodo saltans	28%	83%
A0A0S4JLR6	Bodo saltans	28%	83%
A0A1X0NZB3	Trypanosomatidae	27%	82%
A0A1X0P0N7	Trypanosomatidae	29%	82%
A0A3R7KVX5	Trypanosoma rangeli	30%	82%
A0A3S7WTR3	Leishmania donovani	93%	100%
A0A3S7WWN3	Leishmania donovani	27%	80%
A0A422MYT1	Trypanosoma rangeli	26%	82%
A4H8C9	Leishmania braziliensis	70%	100%
A4HWQ1	Leishmania infantum	93%	100%
A4HZC2	Leishmania infantum	27%	80%
B2I757	Xylella fastidiosa (strain M23)	28%	100%
C9ZJR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	82%
C9ZPT0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	82%
D0A165	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	82%
E9AQF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
O61069	Trypanosoma brucei rhodesiense	22%	100%
P49982	Giardia intestinalis	24%	86%
Q5LGH0	Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow)	24%	100%
Q64XA6	Bacteroides fragilis (strain YCH46)	24%	100%
Q6ZC69	Oryza sativa subsp. japonica	25%	74%
Q87ES6	Xylella fastidiosa (strain Temecula1 / ATCC 700964)	28%	100%
Q8DML4	Thermosynechococcus vestitus (strain NIES-2133 / IAM M-273 / BP-1)	30%	100%
V5B6T5	Trypanosoma cruzi	29%	68%
V5BH98	Trypanosoma cruzi	28%	82%