Fe2OG dioxygenase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4QF16_LEIMA

TriTrypDb:

LmjF.16.0040 , LMJLV39_160005400 , LMJSD75_160005400

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QF16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF16

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0018126	protein hydroxylation	5	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	7	2
GO:0019511	peptidyl-proline hydroxylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004656	procollagen-proline 4-dioxygenase activity	5	2
GO:0005488	binding	1	12
GO:0005506	iron ion binding	6	12
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	12
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	2
GO:0019798	procollagen-proline dioxygenase activity	4	2
GO:0019842	vitamin binding	3	12
GO:0030246	carbohydrate binding	2	12
GO:0031406	carboxylic acid binding	4	12
GO:0031418	L-ascorbic acid binding	3	12
GO:0031543	peptidyl-proline dioxygenase activity	3	2
GO:0031545	peptidyl-proline 4-dioxygenase activity	4	2
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0043169	cation binding	3	12
GO:0043177	organic acid binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0048029	monosaccharide binding	3	12
GO:0051213	dioxygenase activity	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.514
CLV_C14_Caspase3-7	371	375	PF00656	0.538
CLV_NRD_NRD_1	385	387	PF00675	0.365
CLV_NRD_NRD_1	5	7	PF00675	0.411
CLV_NRD_NRD_1	64	66	PF00675	0.493
CLV_PCSK_KEX2_1	5	7	PF00082	0.411
CLV_PCSK_KEX2_1	64	66	PF00082	0.493
CLV_PCSK_SKI1_1	358	362	PF00082	0.335
DEG_APCC_KENBOX_2	293	297	PF00400	0.278
DOC_CKS1_1	111	116	PF01111	0.462
DOC_MAPK_HePTP_8	257	269	PF00069	0.274
DOC_MAPK_MEF2A_6	260	269	PF00069	0.274
DOC_PIKK_1	208	216	PF02985	0.508
DOC_PP2B_LxvP_1	15	18	PF13499	0.403
DOC_PP4_FxxP_1	111	114	PF00568	0.456
DOC_SPAK_OSR1_1	23	27	PF12202	0.401
DOC_USP7_MATH_1	11	15	PF00917	0.412
DOC_USP7_MATH_1	18	22	PF00917	0.393
DOC_WW_Pin1_4	110	115	PF00397	0.522
DOC_WW_Pin1_4	24	29	PF00397	0.400
DOC_WW_Pin1_4	344	349	PF00397	0.501
LIG_14-3-3_CanoR_1	197	202	PF00244	0.486
LIG_14-3-3_CanoR_1	260	266	PF00244	0.274
LIG_14-3-3_CanoR_1	299	309	PF00244	0.410
LIG_APCC_ABBA_1	245	250	PF00400	0.274
LIG_BIR_III_4	160	164	PF00653	0.546
LIG_BRCT_BRCA1_1	20	24	PF00533	0.400
LIG_BRCT_BRCA1_1	314	318	PF00533	0.286
LIG_BRCT_BRCA1_1	35	39	PF00533	0.391
LIG_CSL_BTD_1	224	227	PF09270	0.361
LIG_FHA_1	149	155	PF00498	0.545
LIG_FHA_1	262	268	PF00498	0.284
LIG_FHA_1	301	307	PF00498	0.474
LIG_FHA_1	345	351	PF00498	0.490
LIG_FHA_2	132	138	PF00498	0.467
LIG_FHA_2	251	257	PF00498	0.289
LIG_LIR_Apic_2	109	114	PF02991	0.469
LIG_LIR_Gen_1	261	269	PF02991	0.274
LIG_LIR_Gen_1	85	90	PF02991	0.433
LIG_LIR_Nem_3	181	187	PF02991	0.348
LIG_LIR_Nem_3	259	265	PF02991	0.279
LIG_LIR_Nem_3	315	321	PF02991	0.313
LIG_LIR_Nem_3	357	363	PF02991	0.428
LIG_LIR_Nem_3	85	89	PF02991	0.439
LIG_NRBOX	11	17	PF00104	0.411
LIG_SH2_CRK	263	267	PF00017	0.289
LIG_SH2_CRK	321	325	PF00017	0.333
LIG_SH2_CRK	86	90	PF00017	0.449
LIG_SH2_GRB2like	268	271	PF00017	0.269
LIG_SH2_GRB2like	320	323	PF00017	0.302
LIG_SH2_NCK_1	192	196	PF00017	0.470
LIG_SH2_SRC	363	366	PF00017	0.440
LIG_SH2_STAP1	150	154	PF00017	0.430
LIG_SH2_STAP1	192	196	PF00017	0.355
LIG_SH2_STAP1	263	267	PF00017	0.289
LIG_SH2_STAT5	150	153	PF00017	0.389
LIG_SH2_STAT5	263	266	PF00017	0.283
LIG_SH2_STAT5	268	271	PF00017	0.283
LIG_SH2_STAT5	290	293	PF00017	0.350
LIG_SH2_STAT5	336	339	PF00017	0.274
LIG_SUMO_SIM_par_1	115	121	PF11976	0.558
LIG_SUMO_SIM_par_1	253	259	PF11976	0.276
LIG_SUMO_SIM_par_1	29	36	PF11976	0.403
LIG_TRAF2_1	134	137	PF00917	0.393
LIG_TRAF2_1	362	365	PF00917	0.360
MOD_CK1_1	261	267	PF00069	0.289
MOD_CK1_1	33	39	PF00069	0.520
MOD_CK2_1	131	137	PF00069	0.358
MOD_GlcNHglycan	168	171	PF01048	0.547
MOD_GlcNHglycan	187	190	PF01048	0.228
MOD_GlcNHglycan	314	317	PF01048	0.308
MOD_GlcNHglycan	71	74	PF01048	0.402
MOD_GSK3_1	106	113	PF00069	0.486
MOD_GSK3_1	26	33	PF00069	0.402
MOD_GSK3_1	346	353	PF00069	0.339
MOD_N-GLC_1	300	305	PF02516	0.302
MOD_N-GLC_2	270	272	PF02516	0.284
MOD_NEK2_1	221	226	PF00069	0.413
MOD_NEK2_1	368	373	PF00069	0.530
MOD_NEK2_2	391	396	PF00069	0.341
MOD_PIKK_1	300	306	PF00454	0.302
MOD_PKA_1	312	318	PF00069	0.368
MOD_PKA_1	386	392	PF00069	0.374
MOD_PKB_1	384	392	PF00069	0.396
MOD_Plk_2-3	250	256	PF00069	0.289
MOD_Plk_4	11	17	PF00069	0.411
MOD_Plk_4	112	118	PF00069	0.411
MOD_Plk_4	148	154	PF00069	0.354
MOD_Plk_4	221	227	PF00069	0.369
MOD_Plk_4	250	256	PF00069	0.289
MOD_Plk_4	261	267	PF00069	0.279
MOD_Plk_4	275	281	PF00069	0.249
MOD_Plk_4	346	352	PF00069	0.332
MOD_Plk_4	391	397	PF00069	0.351
MOD_ProDKin_1	110	116	PF00069	0.523
MOD_ProDKin_1	24	30	PF00069	0.401
MOD_ProDKin_1	344	350	PF00069	0.501
MOD_SUMO_rev_2	118	124	PF00179	0.460
MOD_SUMO_rev_2	353	360	PF00179	0.388
TRG_DiLeu_BaEn_1	137	142	PF01217	0.400
TRG_ENDOCYTIC_2	192	195	PF00928	0.454
TRG_ENDOCYTIC_2	263	266	PF00928	0.289
TRG_ENDOCYTIC_2	320	323	PF00928	0.308
TRG_ENDOCYTIC_2	86	89	PF00928	0.456
TRG_ER_diArg_1	64	67	PF00400	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX6	Leptomonas seymouri	80%	100%
A0A0S4JJ67	Bodo saltans	41%	100%
A0A1X0NZK5	Trypanosomatidae	59%	100%
A0A3Q8IA78	Leishmania donovani	97%	100%
A0A3R7K694	Trypanosoma rangeli	56%	100%
A4H8D1	Leishmania braziliensis	83%	100%
A4HWQ3	Leishmania infantum	97%	100%
C9ZPS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5D783	Trypanosoma cruzi	57%	100%