Helicase C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase/Helicase conserved C-terminal domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QF15_LEIMA

TriTrypDb:

LmjF.16.0050 , LMJLV39_160005500 , LMJSD75_160005500

Length:

657

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF15

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	4
GO:0004386	helicase activity	2	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:0140657	ATP-dependent activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	12	14	PF00675	0.504
CLV_NRD_NRD_1	222	224	PF00675	0.563
CLV_NRD_NRD_1	290	292	PF00675	0.685
CLV_NRD_NRD_1	449	451	PF00675	0.315
CLV_NRD_NRD_1	548	550	PF00675	0.593
CLV_NRD_NRD_1	583	585	PF00675	0.463
CLV_PCSK_FUR_1	10	14	PF00082	0.502
CLV_PCSK_KEX2_1	12	14	PF00082	0.501
CLV_PCSK_KEX2_1	222	224	PF00082	0.544
CLV_PCSK_KEX2_1	289	291	PF00082	0.625
CLV_PCSK_KEX2_1	297	299	PF00082	0.636
CLV_PCSK_KEX2_1	471	473	PF00082	0.243
CLV_PCSK_KEX2_1	583	585	PF00082	0.426
CLV_PCSK_KEX2_1	626	628	PF00082	0.495
CLV_PCSK_KEX2_1	9	11	PF00082	0.497
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.678
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.243
CLV_PCSK_PC1ET2_1	626	628	PF00082	0.495
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.517
CLV_PCSK_PC7_1	218	224	PF00082	0.593
CLV_PCSK_SKI1_1	113	117	PF00082	0.266
CLV_PCSK_SKI1_1	395	399	PF00082	0.364
CLV_PCSK_SKI1_1	412	416	PF00082	0.379
CLV_PCSK_SKI1_1	47	51	PF00082	0.370
CLV_PCSK_SKI1_1	620	624	PF00082	0.397
CLV_PCSK_SKI1_1	64	68	PF00082	0.223
CLV_PCSK_SKI1_1	652	656	PF00082	0.331
DEG_APCC_DBOX_1	112	120	PF00400	0.480
DEG_SPOP_SBC_1	606	610	PF00917	0.409
DOC_CKS1_1	176	181	PF01111	0.412
DOC_CKS1_1	193	198	PF01111	0.478
DOC_CYCLIN_RxL_1	646	657	PF00134	0.485
DOC_MAPK_DCC_7	412	422	PF00069	0.430
DOC_MAPK_gen_1	166	176	PF00069	0.479
DOC_MAPK_gen_1	385	391	PF00069	0.276
DOC_MAPK_MEF2A_6	113	120	PF00069	0.414
DOC_MAPK_MEF2A_6	642	651	PF00069	0.404
DOC_PP1_RVXF_1	393	400	PF00149	0.300
DOC_PP1_RVXF_1	45	52	PF00149	0.341
DOC_PP1_RVXF_1	81	88	PF00149	0.479
DOC_PP2B_LxvP_1	27	30	PF13499	0.418
DOC_PP2B_LxvP_1	415	418	PF13499	0.436
DOC_PP2B_LxvP_1	532	535	PF13499	0.346
DOC_PP2B_LxvP_1	569	572	PF13499	0.527
DOC_PP4_FxxP_1	207	210	PF00568	0.472
DOC_PP4_FxxP_1	505	508	PF00568	0.412
DOC_PP4_FxxP_1	87	90	PF00568	0.479
DOC_SPAK_OSR1_1	249	253	PF12202	0.428
DOC_SPAK_OSR1_1	362	366	PF12202	0.355
DOC_USP7_MATH_1	348	352	PF00917	0.513
DOC_USP7_MATH_1	542	546	PF00917	0.639
DOC_USP7_MATH_1	606	610	PF00917	0.436
DOC_USP7_MATH_1	69	73	PF00917	0.443
DOC_USP7_MATH_1	78	82	PF00917	0.410
DOC_USP7_UBL2_3	292	296	PF12436	0.743
DOC_WW_Pin1_4	118	123	PF00397	0.440
DOC_WW_Pin1_4	175	180	PF00397	0.412
DOC_WW_Pin1_4	192	197	PF00397	0.471
DOC_WW_Pin1_4	260	265	PF00397	0.457
DOC_WW_Pin1_4	282	287	PF00397	0.729
DOC_WW_Pin1_4	323	328	PF00397	0.479
DOC_WW_Pin1_4	53	58	PF00397	0.433
DOC_WW_Pin1_4	538	543	PF00397	0.490
LIG_14-3-3_CanoR_1	10	16	PF00244	0.624
LIG_14-3-3_CanoR_1	241	251	PF00244	0.406
LIG_14-3-3_CanoR_1	267	271	PF00244	0.449
LIG_14-3-3_CanoR_1	289	299	PF00244	0.728
LIG_14-3-3_CanoR_1	555	560	PF00244	0.572
LIG_14-3-3_CanoR_1	612	622	PF00244	0.346
LIG_14-3-3_CanoR_1	627	633	PF00244	0.500
LIG_14-3-3_CanoR_1	94	103	PF00244	0.570
LIG_Actin_WH2_2	608	625	PF00022	0.411
LIG_APCC_ABBA_1	329	334	PF00400	0.317
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BRCT_BRCA1_1	203	207	PF00533	0.485
LIG_BRCT_BRCA1_1	238	242	PF00533	0.553
LIG_BRCT_BRCA1_1	359	363	PF00533	0.436
LIG_BRCT_BRCA1_1	552	556	PF00533	0.591
LIG_FHA_1	128	134	PF00498	0.422
LIG_FHA_1	171	177	PF00498	0.427
LIG_FHA_1	344	350	PF00498	0.380
LIG_FHA_1	409	415	PF00498	0.457
LIG_FHA_1	478	484	PF00498	0.496
LIG_FHA_1	564	570	PF00498	0.499
LIG_FHA_1	606	612	PF00498	0.380
LIG_FHA_1	69	75	PF00498	0.446
LIG_FHA_2	123	129	PF00498	0.515
LIG_FHA_2	176	182	PF00498	0.412
LIG_FHA_2	226	232	PF00498	0.741
LIG_FHA_2	539	545	PF00498	0.691
LIG_FHA_2	614	620	PF00498	0.384
LIG_LIR_Apic_2	204	210	PF02991	0.477
LIG_LIR_Apic_2	258	264	PF02991	0.391
LIG_LIR_Apic_2	597	602	PF02991	0.476
LIG_LIR_Apic_2	641	647	PF02991	0.430
LIG_LIR_Apic_2	84	90	PF02991	0.479
LIG_LIR_Gen_1	100	110	PF02991	0.364
LIG_LIR_Gen_1	181	189	PF02991	0.515
LIG_LIR_Gen_1	247	257	PF02991	0.301
LIG_LIR_Gen_1	28	38	PF02991	0.378
LIG_LIR_Gen_1	315	324	PF02991	0.433
LIG_LIR_Gen_1	434	443	PF02991	0.430
LIG_LIR_Nem_3	100	105	PF02991	0.412
LIG_LIR_Nem_3	181	185	PF02991	0.515
LIG_LIR_Nem_3	247	253	PF02991	0.323
LIG_LIR_Nem_3	28	34	PF02991	0.384
LIG_LIR_Nem_3	315	319	PF02991	0.413
LIG_LIR_Nem_3	434	439	PF02991	0.432
LIG_LIR_Nem_3	553	559	PF02991	0.568
LIG_MYND_3	186	190	PF01753	0.461
LIG_Pex14_2	143	147	PF04695	0.515
LIG_Pex14_2	371	375	PF04695	0.497
LIG_Pex14_2	390	394	PF04695	0.220
LIG_Pex14_2	466	470	PF04695	0.479
LIG_PTB_Apo_2	45	52	PF02174	0.341
LIG_SH2_CRK	599	603	PF00017	0.415
LIG_SH2_NCK_1	261	265	PF00017	0.510
LIG_SH2_NCK_1	599	603	PF00017	0.475
LIG_SH2_PTP2	102	105	PF00017	0.364
LIG_SH2_SRC	501	504	PF00017	0.412
LIG_SH2_STAP1	332	336	PF00017	0.314
LIG_SH2_STAT3	374	377	PF00017	0.357
LIG_SH2_STAT3	614	617	PF00017	0.354
LIG_SH2_STAT5	102	105	PF00017	0.454
LIG_SH2_STAT5	114	117	PF00017	0.454
LIG_SH2_STAT5	219	222	PF00017	0.589
LIG_SH2_STAT5	374	377	PF00017	0.372
LIG_SH2_STAT5	405	408	PF00017	0.224
LIG_SH2_STAT5	416	419	PF00017	0.340
LIG_SH2_STAT5	501	504	PF00017	0.412
LIG_SH2_STAT5	514	517	PF00017	0.448
LIG_SH2_STAT5	586	589	PF00017	0.376
LIG_SH2_STAT5	599	602	PF00017	0.462
LIG_SH2_STAT5	614	617	PF00017	0.568
LIG_SH3_3	151	157	PF00018	0.531
LIG_SH3_3	173	179	PF00018	0.423
LIG_SH3_3	193	199	PF00018	0.489
LIG_SH3_3	280	286	PF00018	0.697
LIG_SH3_3	600	606	PF00018	0.451
LIG_SH3_3	72	78	PF00018	0.414
LIG_SH3_4	564	571	PF00018	0.519
LIG_SUMO_SIM_anti_2	529	535	PF11976	0.310
LIG_SUMO_SIM_par_1	172	178	PF11976	0.479
LIG_SUMO_SIM_par_1	250	256	PF11976	0.360
LIG_SUMO_SIM_par_1	345	351	PF11976	0.516
LIG_TRAF2_1	595	598	PF00917	0.502
LIG_TRFH_1	599	603	PF08558	0.440
LIG_UBA3_1	378	386	PF00899	0.313
LIG_UBA3_1	414	419	PF00899	0.375
LIG_UBA3_1	43	47	PF00899	0.396
LIG_UBA3_1	621	626	PF00899	0.349
MOD_CDC14_SPxK_1	121	124	PF00782	0.281
MOD_CDC14_SPxK_1	287	290	PF00782	0.593
MOD_CDK_SPK_2	175	180	PF00069	0.341
MOD_CDK_SPK_2	284	289	PF00069	0.578
MOD_CDK_SPxK_1	118	124	PF00069	0.281
MOD_CDK_SPxK_1	284	290	PF00069	0.581
MOD_CDK_SPxxK_3	260	267	PF00069	0.400
MOD_CDK_SPxxK_3	282	289	PF00069	0.567
MOD_CDK_SPxxK_3	323	330	PF00069	0.461
MOD_CK1_1	201	207	PF00069	0.624
MOD_CK1_1	236	242	PF00069	0.512
MOD_CK1_1	357	363	PF00069	0.430
MOD_CK1_1	477	483	PF00069	0.259
MOD_CK1_1	53	59	PF00069	0.279
MOD_CK1_1	575	581	PF00069	0.505
MOD_CK1_1	81	87	PF00069	0.347
MOD_CK1_1	98	104	PF00069	0.405
MOD_CK2_1	122	128	PF00069	0.392
MOD_CK2_1	225	231	PF00069	0.729
MOD_CK2_1	241	247	PF00069	0.429
MOD_CK2_1	454	460	PF00069	0.281
MOD_CK2_1	538	544	PF00069	0.566
MOD_CK2_1	575	581	PF00069	0.474
MOD_CK2_1	591	597	PF00069	0.297
MOD_CK2_1	613	619	PF00069	0.289
MOD_CK2_1	628	634	PF00069	0.402
MOD_GlcNHglycan	202	206	PF01048	0.568
MOD_GlcNHglycan	292	295	PF01048	0.647
MOD_GlcNHglycan	429	432	PF01048	0.311
MOD_GlcNHglycan	467	470	PF01048	0.276
MOD_GlcNHglycan	544	547	PF01048	0.563
MOD_GlcNHglycan	574	577	PF01048	0.517
MOD_GlcNHglycan	593	596	PF01048	0.463
MOD_GlcNHglycan	71	74	PF01048	0.317
MOD_GlcNHglycan	80	83	PF01048	0.367
MOD_GSK3_1	118	125	PF00069	0.369
MOD_GSK3_1	170	177	PF00069	0.281
MOD_GSK3_1	197	204	PF00069	0.685
MOD_GSK3_1	319	326	PF00069	0.343
MOD_GSK3_1	339	346	PF00069	0.373
MOD_GSK3_1	538	545	PF00069	0.519
MOD_GSK3_1	551	558	PF00069	0.519
MOD_GSK3_1	559	566	PF00069	0.515
MOD_GSK3_1	64	71	PF00069	0.342
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	266	271	PF00069	0.391
MOD_NEK2_1	381	386	PF00069	0.323
MOD_NEK2_1	427	432	PF00069	0.392
MOD_NEK2_1	50	55	PF00069	0.354
MOD_NEK2_1	526	531	PF00069	0.345
MOD_NEK2_1	551	556	PF00069	0.598
MOD_NEK2_2	340	345	PF00069	0.382
MOD_PIKK_1	354	360	PF00454	0.406
MOD_PIKK_1	613	619	PF00454	0.378
MOD_PIKK_1	64	70	PF00454	0.315
MOD_PK_1	527	533	PF00069	0.328
MOD_PKA_1	290	296	PF00069	0.633
MOD_PKA_1	563	569	PF00069	0.571
MOD_PKA_2	11	17	PF00069	0.619
MOD_PKA_2	236	242	PF00069	0.552
MOD_PKA_2	266	272	PF00069	0.504
MOD_PKA_2	290	296	PF00069	0.604
MOD_Plk_1	127	133	PF00069	0.247
MOD_Plk_1	551	557	PF00069	0.730
MOD_Plk_1	597	603	PF00069	0.551
MOD_Plk_4	127	133	PF00069	0.288
MOD_Plk_4	170	176	PF00069	0.251
MOD_Plk_4	39	45	PF00069	0.317
MOD_Plk_4	510	516	PF00069	0.260
MOD_Plk_4	527	533	PF00069	0.281
MOD_Plk_4	98	104	PF00069	0.437
MOD_ProDKin_1	118	124	PF00069	0.287
MOD_ProDKin_1	175	181	PF00069	0.247
MOD_ProDKin_1	192	198	PF00069	0.484
MOD_ProDKin_1	260	266	PF00069	0.450
MOD_ProDKin_1	282	288	PF00069	0.733
MOD_ProDKin_1	323	329	PF00069	0.471
MOD_ProDKin_1	53	59	PF00069	0.378
MOD_ProDKin_1	538	544	PF00069	0.496
MOD_SUMO_rev_2	16	21	PF00179	0.506
MOD_SUMO_rev_2	544	551	PF00179	0.551
MOD_SUMO_rev_2	634	643	PF00179	0.530
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.402
TRG_ENDOCYTIC_2	102	105	PF00928	0.180
TRG_ENDOCYTIC_2	424	427	PF00928	0.277
TRG_ENDOCYTIC_2	436	439	PF00928	0.271
TRG_ER_diArg_1	10	13	PF00400	0.502
TRG_ER_diArg_1	288	291	PF00400	0.781
TRG_NLS_MonoCore_2	449	454	PF00514	0.315
TRG_NLS_MonoExtC_3	449	454	PF00514	0.392
TRG_NLS_MonoExtC_3	8	13	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	652	657	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C1	Leptomonas seymouri	71%	98%
A0A0S4JMG7	Bodo saltans	39%	87%
A0A1X0NZ55	Trypanosomatidae	54%	100%
A0A3R7LSE5	Trypanosoma rangeli	52%	100%
A0A3S7WTP8	Leishmania donovani	94%	100%
A4H8D2	Leishmania braziliensis	83%	100%
A4HWQ4	Leishmania infantum	94%	100%
C9ZPS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	98%
E9AQG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q93Y39	Arabidopsis thaliana	21%	80%
Q9FFT9	Arabidopsis thaliana	23%	89%
V5BBA0	Trypanosoma cruzi	53%	100%