Putative peroxisome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxisome assembly protein, putative

Species:

Leishmania major

UniProt:

Q4QF14_LEIMA

TriTrypDb:

LmjF.16.0060 , LMJLV39_160005600 , LMJSD75_160005600

Length:

959

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005778	peroxisomal membrane	6	2
GO:0005829	cytosol	2	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF14

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006625	protein targeting to peroxisome	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007031	peroxisome organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0015919	peroxisomal membrane transport	5	2
GO:0016043	cellular component organization	3	2
GO:0016558	protein import into peroxisome matrix	5	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0043574	peroxisomal transport	4	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072662	protein localization to peroxisome	6	2
GO:0072663	establishment of protein localization to peroxisome	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.611
CLV_C14_Caspase3-7	536	540	PF00656	0.482
CLV_C14_Caspase3-7	54	58	PF00656	0.493
CLV_C14_Caspase3-7	747	751	PF00656	0.315
CLV_C14_Caspase3-7	900	904	PF00656	0.499
CLV_NRD_NRD_1	318	320	PF00675	0.686
CLV_NRD_NRD_1	406	408	PF00675	0.414
CLV_NRD_NRD_1	838	840	PF00675	0.419
CLV_NRD_NRD_1	916	918	PF00675	0.649
CLV_PCSK_KEX2_1	406	408	PF00082	0.414
CLV_PCSK_KEX2_1	657	659	PF00082	0.377
CLV_PCSK_KEX2_1	680	682	PF00082	0.418
CLV_PCSK_KEX2_1	783	785	PF00082	0.382
CLV_PCSK_KEX2_1	950	952	PF00082	0.406
CLV_PCSK_PC1ET2_1	657	659	PF00082	0.364
CLV_PCSK_PC1ET2_1	680	682	PF00082	0.418
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.382
CLV_PCSK_PC1ET2_1	950	952	PF00082	0.470
CLV_PCSK_SKI1_1	12	16	PF00082	0.496
CLV_PCSK_SKI1_1	185	189	PF00082	0.539
CLV_PCSK_SKI1_1	241	245	PF00082	0.639
CLV_PCSK_SKI1_1	333	337	PF00082	0.563
CLV_PCSK_SKI1_1	407	411	PF00082	0.519
CLV_PCSK_SKI1_1	423	427	PF00082	0.315
CLV_PCSK_SKI1_1	463	467	PF00082	0.569
CLV_PCSK_SKI1_1	515	519	PF00082	0.333
CLV_PCSK_SKI1_1	552	556	PF00082	0.541
CLV_PCSK_SKI1_1	676	680	PF00082	0.465
CLV_PCSK_SKI1_1	694	698	PF00082	0.190
CLV_PCSK_SKI1_1	730	734	PF00082	0.315
CLV_PCSK_SKI1_1	756	760	PF00082	0.286
CLV_PCSK_SKI1_1	835	839	PF00082	0.404
CLV_PCSK_SKI1_1	918	922	PF00082	0.546
DEG_APCC_KENBOX_2	425	429	PF00400	0.420
DEG_SCF_FBW7_1	161	168	PF00400	0.565
DEG_SCF_FBW7_2	408	414	PF00400	0.498
DOC_CDC14_PxL_1	663	671	PF14671	0.509
DOC_CKS1_1	128	133	PF01111	0.649
DOC_CKS1_1	408	413	PF01111	0.492
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	804	810	PF00134	0.346
DOC_MAPK_gen_1	342	352	PF00069	0.551
DOC_MAPK_gen_1	657	668	PF00069	0.367
DOC_MAPK_gen_1	676	686	PF00069	0.390
DOC_MAPK_gen_1	814	823	PF00069	0.329
DOC_MAPK_HePTP_8	765	777	PF00069	0.402
DOC_MAPK_MEF2A_6	333	340	PF00069	0.570
DOC_MAPK_MEF2A_6	661	668	PF00069	0.364
DOC_MAPK_MEF2A_6	737	745	PF00069	0.315
DOC_MAPK_MEF2A_6	768	777	PF00069	0.268
DOC_MAPK_MEF2A_6	917	924	PF00069	0.426
DOC_MAPK_NFAT4_5	661	669	PF00069	0.369
DOC_PP1_RVXF_1	513	519	PF00149	0.347
DOC_PP1_RVXF_1	728	734	PF00149	0.268
DOC_PP2B_LxvP_1	210	213	PF13499	0.467
DOC_PP2B_LxvP_1	821	824	PF13499	0.376
DOC_PP4_FxxP_1	441	444	PF00568	0.537
DOC_PP4_FxxP_1	555	558	PF00568	0.479
DOC_PP4_FxxP_1	686	689	PF00568	0.268
DOC_USP7_MATH_1	165	169	PF00917	0.603
DOC_USP7_MATH_1	58	62	PF00917	0.504
DOC_USP7_MATH_1	615	619	PF00917	0.549
DOC_USP7_MATH_1	867	871	PF00917	0.318
DOC_USP7_MATH_1	897	901	PF00917	0.577
DOC_USP7_MATH_2	219	225	PF00917	0.526
DOC_USP7_UBL2_3	676	680	PF12436	0.465
DOC_WW_Pin1_4	127	132	PF00397	0.654
DOC_WW_Pin1_4	161	166	PF00397	0.566
DOC_WW_Pin1_4	378	383	PF00397	0.546
DOC_WW_Pin1_4	384	389	PF00397	0.523
DOC_WW_Pin1_4	407	412	PF00397	0.566
DOC_WW_Pin1_4	573	578	PF00397	0.573
DOC_WW_Pin1_4	737	742	PF00397	0.268
DOC_WW_Pin1_4	898	903	PF00397	0.642
LIG_14-3-3_CanoR_1	123	131	PF00244	0.561
LIG_14-3-3_CanoR_1	16	23	PF00244	0.516
LIG_14-3-3_CanoR_1	279	288	PF00244	0.604
LIG_14-3-3_CanoR_1	312	321	PF00244	0.648
LIG_14-3-3_CanoR_1	373	380	PF00244	0.556
LIG_14-3-3_CanoR_1	503	507	PF00244	0.523
LIG_14-3-3_CanoR_1	568	574	PF00244	0.643
LIG_14-3-3_CanoR_1	768	777	PF00244	0.402
LIG_14-3-3_CanoR_1	917	923	PF00244	0.594
LIG_Actin_WH2_2	921	937	PF00022	0.362
LIG_BIR_III_2	525	529	PF00653	0.408
LIG_BIR_III_2	57	61	PF00653	0.505
LIG_BIR_III_2	903	907	PF00653	0.490
LIG_BIR_III_4	761	765	PF00653	0.268
LIG_CaM_IQ_9	392	408	PF13499	0.365
LIG_CaM_NSCaTE_8	276	283	PF13499	0.659
LIG_Clathr_ClatBox_1	774	778	PF01394	0.286
LIG_EVH1_1	86	90	PF00568	0.550
LIG_FHA_1	234	240	PF00498	0.614
LIG_FHA_1	281	287	PF00498	0.603
LIG_FHA_1	3	9	PF00498	0.571
LIG_FHA_1	31	37	PF00498	0.646
LIG_FHA_1	408	414	PF00498	0.545
LIG_FHA_1	417	423	PF00498	0.448
LIG_FHA_1	472	478	PF00498	0.464
LIG_FHA_1	582	588	PF00498	0.325
LIG_FHA_1	680	686	PF00498	0.429
LIG_FHA_1	80	86	PF00498	0.529
LIG_FHA_1	888	894	PF00498	0.626
LIG_FHA_2	162	168	PF00498	0.618
LIG_FHA_2	322	328	PF00498	0.758
LIG_FHA_2	481	487	PF00498	0.406
LIG_FHA_2	52	58	PF00498	0.632
LIG_FHA_2	534	540	PF00498	0.551
LIG_FHA_2	586	592	PF00498	0.471
LIG_FHA_2	824	830	PF00498	0.363
LIG_FHA_2	859	865	PF00498	0.323
LIG_FHA_2	937	943	PF00498	0.465
LIG_GBD_Chelix_1	114	122	PF00786	0.605
LIG_KLC1_Yacidic_2	285	290	PF13176	0.540
LIG_LIR_Gen_1	588	596	PF02991	0.397
LIG_LIR_Gen_1	632	642	PF02991	0.521
LIG_LIR_Nem_3	179	184	PF02991	0.481
LIG_LIR_Nem_3	20	26	PF02991	0.481
LIG_LIR_Nem_3	208	214	PF02991	0.456
LIG_LIR_Nem_3	215	220	PF02991	0.501
LIG_LIR_Nem_3	56	62	PF02991	0.597
LIG_LIR_Nem_3	588	592	PF02991	0.427
LIG_LIR_Nem_3	632	638	PF02991	0.495
LIG_LIR_Nem_3	864	868	PF02991	0.437
LIG_LYPXL_yS_3	261	264	PF13949	0.568
LIG_LYPXL_yS_3	59	62	PF13949	0.641
LIG_MYND_1	667	671	PF01753	0.398
LIG_NRBOX	133	139	PF00104	0.533
LIG_NRBOX	515	521	PF00104	0.264
LIG_SH2_CRK	23	27	PF00017	0.514
LIG_SH2_CRK	398	402	PF00017	0.426
LIG_SH2_CRK	635	639	PF00017	0.468
LIG_SH2_CRK	687	691	PF00017	0.315
LIG_SH2_GRB2like	205	208	PF00017	0.586
LIG_SH2_NCK_1	189	193	PF00017	0.599
LIG_SH2_NCK_1	635	639	PF00017	0.468
LIG_SH2_SRC	211	214	PF00017	0.470
LIG_SH2_SRC	589	592	PF00017	0.465
LIG_SH2_STAP1	205	209	PF00017	0.524
LIG_SH2_STAP1	589	593	PF00017	0.476
LIG_SH2_STAT3	34	37	PF00017	0.551
LIG_SH2_STAT5	211	214	PF00017	0.522
LIG_SH2_STAT5	288	291	PF00017	0.729
LIG_SH2_STAT5	629	632	PF00017	0.537
LIG_SH2_STAT5	7	10	PF00017	0.550
LIG_SH2_STAT5	721	724	PF00017	0.268
LIG_SH2_STAT5	820	823	PF00017	0.380
LIG_SH2_STAT5	860	863	PF00017	0.324
LIG_SH3_3	240	246	PF00018	0.512
LIG_SH3_3	374	380	PF00018	0.553
LIG_SH3_3	405	411	PF00018	0.549
LIG_SH3_3	508	514	PF00018	0.634
LIG_SH3_3	709	715	PF00018	0.268
LIG_SH3_3	81	87	PF00018	0.512
LIG_SH3_3	849	855	PF00018	0.477
LIG_SH3_CIN85_PxpxPR_1	510	515	PF14604	0.434
LIG_SUMO_SIM_anti_2	302	309	PF11976	0.678
LIG_SUMO_SIM_anti_2	366	371	PF11976	0.628
LIG_SUMO_SIM_anti_2	474	479	PF11976	0.360
LIG_SUMO_SIM_anti_2	591	597	PF11976	0.386
LIG_SUMO_SIM_anti_2	612	619	PF11976	0.645
LIG_SUMO_SIM_par_1	591	597	PF11976	0.478
LIG_SUMO_SIM_par_1	773	778	PF11976	0.286
LIG_TRAF2_1	452	455	PF00917	0.505
LIG_TRAF2_1	547	550	PF00917	0.508
LIG_TRAF2_1	826	829	PF00917	0.389
LIG_TRAF2_1	880	883	PF00917	0.540
LIG_TRAF2_1	912	915	PF00917	0.701
LIG_TYR_ITIM	209	214	PF00017	0.396
LIG_TYR_ITIM	259	264	PF00017	0.579
LIG_TYR_ITIM	587	592	PF00017	0.465
LIG_TYR_ITIM	818	823	PF00017	0.315
LIG_UBA3_1	831	835	PF00899	0.411
LIG_WRC_WIRS_1	417	422	PF05994	0.466
MOD_CDK_SPK_2	127	132	PF00069	0.496
MOD_CDK_SPK_2	573	578	PF00069	0.544
MOD_CK1_1	163	169	PF00069	0.544
MOD_CK1_1	190	196	PF00069	0.539
MOD_CK1_1	35	41	PF00069	0.547
MOD_CK1_1	576	582	PF00069	0.378
MOD_CK1_1	618	624	PF00069	0.474
MOD_CK1_1	636	642	PF00069	0.533
MOD_CK1_1	76	82	PF00069	0.516
MOD_CK1_1	785	791	PF00069	0.310
MOD_CK2_1	591	597	PF00069	0.436
MOD_CK2_1	822	828	PF00069	0.364
MOD_DYRK1A_RPxSP_1	407	411	PF00069	0.438
MOD_GlcNHglycan	147	150	PF01048	0.569
MOD_GlcNHglycan	169	172	PF01048	0.570
MOD_GlcNHglycan	198	201	PF01048	0.698
MOD_GlcNHglycan	221	226	PF01048	0.575
MOD_GlcNHglycan	230	233	PF01048	0.588
MOD_GlcNHglycan	271	274	PF01048	0.652
MOD_GlcNHglycan	321	324	PF01048	0.614
MOD_GlcNHglycan	344	348	PF01048	0.564
MOD_GlcNHglycan	499	502	PF01048	0.576
MOD_GlcNHglycan	75	78	PF01048	0.691
MOD_GlcNHglycan	789	792	PF01048	0.389
MOD_GlcNHglycan	842	846	PF01048	0.406
MOD_GlcNHglycan	848	852	PF01048	0.363
MOD_GSK3_1	118	125	PF00069	0.527
MOD_GSK3_1	161	168	PF00069	0.638
MOD_GSK3_1	233	240	PF00069	0.601
MOD_GSK3_1	457	464	PF00069	0.414
MOD_GSK3_1	569	576	PF00069	0.423
MOD_GSK3_1	581	588	PF00069	0.349
MOD_GSK3_1	621	628	PF00069	0.453
MOD_GSK3_1	629	636	PF00069	0.392
MOD_GSK3_1	67	74	PF00069	0.639
MOD_GSK3_1	893	900	PF00069	0.571
MOD_GSK3_1	949	956	PF00069	0.511
MOD_N-GLC_1	328	333	PF02516	0.474
MOD_N-GLC_1	42	47	PF02516	0.693
MOD_NEK2_1	118	123	PF00069	0.518
MOD_NEK2_1	196	201	PF00069	0.651
MOD_NEK2_1	227	232	PF00069	0.662
MOD_NEK2_1	343	348	PF00069	0.718
MOD_NEK2_1	461	466	PF00069	0.474
MOD_NEK2_1	560	565	PF00069	0.519
MOD_NEK2_1	637	642	PF00069	0.446
MOD_NEK2_1	858	863	PF00069	0.336
MOD_NEK2_1	893	898	PF00069	0.620
MOD_NEK2_1	953	958	PF00069	0.546
MOD_PIKK_1	190	196	PF00454	0.619
MOD_PIKK_1	768	774	PF00454	0.402
MOD_PKA_1	319	325	PF00069	0.482
MOD_PKA_1	679	685	PF00069	0.449
MOD_PKA_2	122	128	PF00069	0.662
MOD_PKA_2	372	378	PF00069	0.608
MOD_PKA_2	502	508	PF00069	0.643
MOD_PKA_2	533	539	PF00069	0.560
MOD_PKA_2	607	613	PF00069	0.509
MOD_Plk_1	118	124	PF00069	0.525
MOD_Plk_1	42	48	PF00069	0.620
MOD_Plk_1	847	853	PF00069	0.475
MOD_Plk_2-3	591	597	PF00069	0.458
MOD_Plk_4	169	175	PF00069	0.538
MOD_Plk_4	205	211	PF00069	0.502
MOD_Plk_4	321	327	PF00069	0.646
MOD_Plk_4	416	422	PF00069	0.418
MOD_Plk_4	471	477	PF00069	0.530
MOD_Plk_4	490	496	PF00069	0.519
MOD_Plk_4	569	575	PF00069	0.483
MOD_Plk_4	591	597	PF00069	0.370
MOD_Plk_4	621	627	PF00069	0.357
MOD_Plk_4	633	639	PF00069	0.485
MOD_Plk_4	692	698	PF00069	0.315
MOD_Plk_4	79	85	PF00069	0.511
MOD_ProDKin_1	127	133	PF00069	0.651
MOD_ProDKin_1	161	167	PF00069	0.565
MOD_ProDKin_1	378	384	PF00069	0.550
MOD_ProDKin_1	407	413	PF00069	0.567
MOD_ProDKin_1	573	579	PF00069	0.567
MOD_ProDKin_1	737	743	PF00069	0.268
MOD_ProDKin_1	898	904	PF00069	0.645
MOD_SUMO_for_1	656	659	PF00179	0.356
MOD_SUMO_rev_2	914	920	PF00179	0.610
TRG_DiLeu_BaEn_2	853	859	PF01217	0.482
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.306
TRG_DiLeu_BaLyEn_6	555	560	PF01217	0.498
TRG_DiLeu_BaLyEn_6	727	732	PF01217	0.268
TRG_ENDOCYTIC_2	211	214	PF00928	0.522
TRG_ENDOCYTIC_2	23	26	PF00928	0.397
TRG_ENDOCYTIC_2	261	264	PF00928	0.443
TRG_ENDOCYTIC_2	398	401	PF00928	0.400
TRG_ENDOCYTIC_2	589	592	PF00928	0.471
TRG_ENDOCYTIC_2	59	62	PF00928	0.641
TRG_ENDOCYTIC_2	635	638	PF00928	0.480
TRG_ENDOCYTIC_2	7	10	PF00928	0.660
TRG_ENDOCYTIC_2	820	823	PF00928	0.380
TRG_ENDOCYTIC_2	946	949	PF00928	0.426
TRG_ER_diArg_1	405	407	PF00400	0.403
TRG_ER_diArg_1	928	931	PF00400	0.384
TRG_NES_CRM1_1	659	672	PF08389	0.517
TRG_NLS_MonoExtN_4	676	683	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	658	662	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z4	Leptomonas seymouri	67%	99%
A0A1X0NZ72	Trypanosomatidae	41%	100%
A0A3S5H6W4	Leishmania donovani	94%	100%
A0A422NAC8	Trypanosoma rangeli	47%	100%
A4H8D3	Leishmania braziliensis	81%	100%
A4HFM9	Leishmania braziliensis	36%	100%
A4HWQ5	Leishmania infantum	94%	100%
C9ZPS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9AQG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5ARC8	Trypanosoma cruzi	43%	100%