Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF13_LEIMA

TriTrypDb:

LmjF.16.0070 , LMJLV39_160005700 , LMJSD75_160005700

Length:

399

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.573
CLV_C14_Caspase3-7	361	365	PF00656	0.682
CLV_NRD_NRD_1	287	289	PF00675	0.512
CLV_NRD_NRD_1	372	374	PF00675	0.695
CLV_NRD_NRD_1	41	43	PF00675	0.566
CLV_NRD_NRD_1	76	78	PF00675	0.713
CLV_PCSK_KEX2_1	287	289	PF00082	0.470
CLV_PCSK_KEX2_1	323	325	PF00082	0.627
CLV_PCSK_KEX2_1	372	374	PF00082	0.695
CLV_PCSK_KEX2_1	41	43	PF00082	0.674
CLV_PCSK_KEX2_1	75	77	PF00082	0.708
CLV_PCSK_KEX2_1	89	91	PF00082	0.658
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.627
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.658
CLV_PCSK_PC7_1	85	91	PF00082	0.767
CLV_PCSK_SKI1_1	29	33	PF00082	0.520
CLV_PCSK_SKI1_1	295	299	PF00082	0.657
CLV_PCSK_SKI1_1	77	81	PF00082	0.752
DEG_Nend_UBRbox_2	1	3	PF02207	0.766
DEG_SPOP_SBC_1	191	195	PF00917	0.619
DOC_MAPK_gen_1	261	270	PF00069	0.619
DOC_MAPK_gen_1	75	81	PF00069	0.796
DOC_MAPK_gen_1	89	97	PF00069	0.524
DOC_MAPK_MEF2A_6	261	270	PF00069	0.466
DOC_MAPK_MEF2A_6	46	54	PF00069	0.620
DOC_MAPK_NFAT4_5	263	271	PF00069	0.468
DOC_PP1_RVXF_1	110	117	PF00149	0.597
DOC_PP2B_LxvP_1	255	258	PF13499	0.729
DOC_PP2B_LxvP_1	268	271	PF13499	0.480
DOC_USP7_MATH_1	191	195	PF00917	0.619
DOC_USP7_MATH_1	207	211	PF00917	0.592
DOC_USP7_MATH_1	237	241	PF00917	0.602
DOC_USP7_MATH_1	59	63	PF00917	0.538
DOC_WW_Pin1_4	101	106	PF00397	0.734
DOC_WW_Pin1_4	11	16	PF00397	0.763
DOC_WW_Pin1_4	372	377	PF00397	0.745
DOC_WW_Pin1_4	391	396	PF00397	0.493
DOC_WW_Pin1_4	70	75	PF00397	0.689
LIG_14-3-3_CanoR_1	199	204	PF00244	0.601
LIG_14-3-3_CanoR_1	372	376	PF00244	0.692
LIG_14-3-3_CanoR_1	75	80	PF00244	0.817
LIG_AP2alpha_2	117	119	PF02296	0.667
LIG_APCC_ABBA_1	116	121	PF00400	0.678
LIG_CaM_NSCaTE_8	305	312	PF13499	0.722
LIG_CtBP_PxDLS_1	137	141	PF00389	0.770
LIG_eIF4E_1	273	279	PF01652	0.643
LIG_FHA_1	19	25	PF00498	0.721
LIG_FHA_1	281	287	PF00498	0.549
LIG_GBD_Chelix_1	238	246	PF00786	0.639
LIG_LIR_Apic_2	149	155	PF02991	0.732
LIG_LIR_Gen_1	156	165	PF02991	0.723
LIG_LIR_Gen_1	240	250	PF02991	0.643
LIG_LIR_Gen_1	329	338	PF02991	0.603
LIG_LIR_Nem_3	156	160	PF02991	0.631
LIG_LIR_Nem_3	240	246	PF02991	0.642
LIG_LIR_Nem_3	329	334	PF02991	0.598
LIG_LIR_Nem_3	94	100	PF02991	0.775
LIG_LYPXL_SIV_4	326	334	PF13949	0.520
LIG_SH2_CRK	331	335	PF00017	0.673
LIG_SH2_CRK	383	387	PF00017	0.545
LIG_SH2_NCK_1	100	104	PF00017	0.669
LIG_SH2_NCK_1	327	331	PF00017	0.509
LIG_SH2_NCK_1	383	387	PF00017	0.545
LIG_SH2_PTP2	152	155	PF00017	0.676
LIG_SH2_PTP2	157	160	PF00017	0.591
LIG_SH2_SRC	56	59	PF00017	0.618
LIG_SH2_STAP1	243	247	PF00017	0.538
LIG_SH2_STAP1	327	331	PF00017	0.632
LIG_SH2_STAT3	273	276	PF00017	0.650
LIG_SH2_STAT5	125	128	PF00017	0.595
LIG_SH2_STAT5	152	155	PF00017	0.676
LIG_SH2_STAT5	157	160	PF00017	0.591
LIG_SH2_STAT5	243	246	PF00017	0.538
LIG_SH2_STAT5	321	324	PF00017	0.555
LIG_SH2_STAT5	348	351	PF00017	0.564
LIG_SH2_STAT5	56	59	PF00017	0.662
LIG_SH3_3	78	84	PF00018	0.721
LIG_SUMO_SIM_anti_2	78	83	PF11976	0.663
LIG_SUMO_SIM_par_1	136	141	PF11976	0.771
LIG_SUMO_SIM_par_1	348	354	PF11976	0.669
LIG_TRAF2_1	91	94	PF00917	0.649
MOD_CDC14_SPxK_1	73	76	PF00782	0.738
MOD_CDK_SPK_2	101	106	PF00069	0.711
MOD_CDK_SPK_2	70	75	PF00069	0.676
MOD_CDK_SPxK_1	70	76	PF00069	0.733
MOD_CDK_SPxxK_3	101	108	PF00069	0.713
MOD_CDK_SPxxK_3	70	77	PF00069	0.735
MOD_CK1_1	13	19	PF00069	0.716
MOD_CK1_1	156	162	PF00069	0.595
MOD_CK1_1	193	199	PF00069	0.618
MOD_CK1_1	339	345	PF00069	0.604
MOD_CK1_1	70	76	PF00069	0.735
MOD_CK2_1	11	17	PF00069	0.793
MOD_CK2_1	138	144	PF00069	0.656
MOD_CK2_1	207	213	PF00069	0.535
MOD_CK2_1	88	94	PF00069	0.672
MOD_Cter_Amidation	87	90	PF01082	0.675
MOD_GlcNHglycan	195	198	PF01048	0.600
MOD_GlcNHglycan	310	313	PF01048	0.595
MOD_GlcNHglycan	61	64	PF01048	0.557
MOD_GSK3_1	20	27	PF00069	0.532
MOD_GSK3_1	237	244	PF00069	0.563
MOD_GSK3_1	336	343	PF00069	0.660
MOD_GSK3_1	59	66	PF00069	0.613
MOD_GSK3_1	7	14	PF00069	0.722
MOD_NEK2_1	124	129	PF00069	0.708
MOD_NEK2_1	176	181	PF00069	0.619
MOD_NEK2_1	190	195	PF00069	0.499
MOD_NEK2_1	279	284	PF00069	0.594
MOD_PIKK_1	248	254	PF00454	0.536
MOD_PIKK_1	313	319	PF00454	0.552
MOD_PIKK_1	329	335	PF00454	0.523
MOD_PK_1	199	205	PF00069	0.704
MOD_PK_1	75	81	PF00069	0.816
MOD_PKA_1	75	81	PF00069	0.804
MOD_PKA_2	228	234	PF00069	0.697
MOD_PKA_2	371	377	PF00069	0.733
MOD_PKA_2	75	81	PF00069	0.786
MOD_PKB_1	293	301	PF00069	0.653
MOD_PKB_1	75	83	PF00069	0.815
MOD_Plk_1	279	285	PF00069	0.680
MOD_Plk_1	298	304	PF00069	0.390
MOD_Plk_4	153	159	PF00069	0.669
MOD_Plk_4	77	83	PF00069	0.598
MOD_ProDKin_1	101	107	PF00069	0.734
MOD_ProDKin_1	11	17	PF00069	0.763
MOD_ProDKin_1	372	378	PF00069	0.747
MOD_ProDKin_1	391	397	PF00069	0.494
MOD_ProDKin_1	70	76	PF00069	0.693
MOD_SUMO_rev_2	139	146	PF00179	0.678
TRG_DiLeu_BaEn_1	28	33	PF01217	0.631
TRG_DiLeu_BaEn_2	92	98	PF01217	0.664
TRG_ENDOCYTIC_2	157	160	PF00928	0.628
TRG_ENDOCYTIC_2	243	246	PF00928	0.538
TRG_ENDOCYTIC_2	331	334	PF00928	0.591
TRG_ER_diArg_1	105	108	PF00400	0.780
TRG_ER_diArg_1	260	263	PF00400	0.637
TRG_ER_diArg_1	286	288	PF00400	0.468
TRG_ER_diArg_1	41	43	PF00400	0.591
TRG_ER_diArg_1	74	77	PF00400	0.715
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.607
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.722
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDJ0	Leishmania donovani	90%	100%
A4H8D4	Leishmania braziliensis	66%	100%
A4HWQ6	Leishmania infantum	90%	100%
E9AQG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q8IS09	Leptomonas seymouri	29%	100%