DUF4110 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Galactose oxidase, central domain/Domain of unknown function (DUF4110), putative

Species:

Leishmania major

UniProt:

Q4QF12_LEIMA

TriTrypDb:

LmjF.16.0080 , LMJLV39_160005800 , LMJSD75_160005800

Length:

736

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.382
CLV_C14_Caspase3-7	511	515	PF00656	0.592
CLV_C14_Caspase3-7	545	549	PF00656	0.700
CLV_NRD_NRD_1	32	34	PF00675	0.607
CLV_NRD_NRD_1	372	374	PF00675	0.483
CLV_NRD_NRD_1	400	402	PF00675	0.733
CLV_NRD_NRD_1	450	452	PF00675	0.421
CLV_NRD_NRD_1	552	554	PF00675	0.731
CLV_NRD_NRD_1	661	663	PF00675	0.293
CLV_NRD_NRD_1	7	9	PF00675	0.625
CLV_NRD_NRD_1	702	704	PF00675	0.315
CLV_NRD_NRD_1	718	720	PF00675	0.501
CLV_PCSK_FUR_1	5	9	PF00082	0.628
CLV_PCSK_FUR_1	700	704	PF00082	0.384
CLV_PCSK_KEX2_1	119	121	PF00082	0.333
CLV_PCSK_KEX2_1	19	21	PF00082	0.561
CLV_PCSK_KEX2_1	200	202	PF00082	0.376
CLV_PCSK_KEX2_1	330	332	PF00082	0.440
CLV_PCSK_KEX2_1	364	366	PF00082	0.381
CLV_PCSK_KEX2_1	372	374	PF00082	0.453
CLV_PCSK_KEX2_1	376	378	PF00082	0.549
CLV_PCSK_KEX2_1	383	385	PF00082	0.515
CLV_PCSK_KEX2_1	400	402	PF00082	0.682
CLV_PCSK_KEX2_1	450	452	PF00082	0.414
CLV_PCSK_KEX2_1	55	57	PF00082	0.539
CLV_PCSK_KEX2_1	552	554	PF00082	0.731
CLV_PCSK_KEX2_1	661	663	PF00082	0.280
CLV_PCSK_KEX2_1	7	9	PF00082	0.624
CLV_PCSK_KEX2_1	702	704	PF00082	0.315
CLV_PCSK_KEX2_1	718	720	PF00082	0.501
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.333
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.554
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.461
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.459
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.383
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.580
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.466
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.539
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.640
CLV_PCSK_PC7_1	372	378	PF00082	0.637
CLV_PCSK_PC7_1	657	663	PF00082	0.247
CLV_PCSK_SKI1_1	182	186	PF00082	0.333
CLV_PCSK_SKI1_1	195	199	PF00082	0.474
CLV_PCSK_SKI1_1	23	27	PF00082	0.579
CLV_PCSK_SKI1_1	373	377	PF00082	0.641
CLV_PCSK_SKI1_1	475	479	PF00082	0.381
CLV_PCSK_SKI1_1	607	611	PF00082	0.444
CLV_PCSK_SKI1_1	661	665	PF00082	0.385
CLV_PCSK_SKI1_1	679	683	PF00082	0.187
DEG_APCC_DBOX_1	383	391	PF00400	0.606
DEG_APCC_DBOX_1	678	686	PF00400	0.445
DEG_APCC_KENBOX_2	33	37	PF00400	0.674
DEG_SCF_FBW7_2	626	632	PF00400	0.419
DEG_SPOP_SBC_1	134	138	PF00917	0.314
DEG_SPOP_SBC_1	640	644	PF00917	0.445
DOC_ANK_TNKS_1	650	657	PF00023	0.445
DOC_CKS1_1	626	631	PF01111	0.298
DOC_CKS1_1	75	80	PF01111	0.477
DOC_MAPK_gen_1	19	28	PF00069	0.680
DOC_MAPK_gen_1	200	206	PF00069	0.328
DOC_MAPK_gen_1	364	371	PF00069	0.388
DOC_MAPK_gen_1	450	458	PF00069	0.403
DOC_MAPK_gen_1	603	611	PF00069	0.499
DOC_MAPK_gen_1	691	698	PF00069	0.333
DOC_PP1_RVXF_1	193	200	PF00149	0.338
DOC_PP1_RVXF_1	551	558	PF00149	0.728
DOC_USP7_MATH_1	134	138	PF00917	0.298
DOC_USP7_MATH_1	428	432	PF00917	0.756
DOC_USP7_MATH_1	640	644	PF00917	0.369
DOC_USP7_MATH_1	650	654	PF00917	0.254
DOC_USP7_UBL2_3	3	7	PF12436	0.666
DOC_USP7_UBL2_3	30	34	PF12436	0.617
DOC_USP7_UBL2_3	55	59	PF12436	0.441
DOC_USP7_UBL2_3	606	610	PF12436	0.455
DOC_WW_Pin1_4	232	237	PF00397	0.417
DOC_WW_Pin1_4	340	345	PF00397	0.411
DOC_WW_Pin1_4	585	590	PF00397	0.505
DOC_WW_Pin1_4	625	630	PF00397	0.298
DOC_WW_Pin1_4	74	79	PF00397	0.408
LIG_14-3-3_CanoR_1	125	134	PF00244	0.379
LIG_14-3-3_CanoR_1	135	143	PF00244	0.305
LIG_14-3-3_CanoR_1	174	181	PF00244	0.419
LIG_14-3-3_CanoR_1	249	255	PF00244	0.386
LIG_14-3-3_CanoR_1	274	282	PF00244	0.457
LIG_14-3-3_CanoR_1	641	646	PF00244	0.334
LIG_14-3-3_CanoR_1	657	663	PF00244	0.238
LIG_Actin_WH2_2	387	402	PF00022	0.553
LIG_APCC_ABBA_1	254	259	PF00400	0.408
LIG_APCC_ABBA_1	609	614	PF00400	0.422
LIG_APCC_ABBA_1	84	89	PF00400	0.370
LIG_BRCT_BRCA1_1	323	327	PF00533	0.402
LIG_BRCT_BRCA1_1	479	483	PF00533	0.397
LIG_deltaCOP1_diTrp_1	167	171	PF00928	0.285
LIG_DLG_GKlike_1	641	649	PF00625	0.351
LIG_eIF4E_1	676	682	PF01652	0.445
LIG_FHA_1	460	466	PF00498	0.388
LIG_FHA_1	482	488	PF00498	0.436
LIG_FHA_1	586	592	PF00498	0.540
LIG_FHA_1	75	81	PF00498	0.387
LIG_FHA_2	411	417	PF00498	0.763
LIG_FHA_2	476	482	PF00498	0.370
LIG_FHA_2	64	70	PF00498	0.448
LIG_FHA_2	647	653	PF00498	0.404
LIG_LIR_Gen_1	160	168	PF02991	0.291
LIG_LIR_Gen_1	175	184	PF02991	0.239
LIG_LIR_Gen_1	269	280	PF02991	0.458
LIG_LIR_Gen_1	350	361	PF02991	0.486
LIG_LIR_Gen_1	632	640	PF02991	0.373
LIG_LIR_Nem_3	112	118	PF02991	0.279
LIG_LIR_Nem_3	160	165	PF02991	0.304
LIG_LIR_Nem_3	175	181	PF02991	0.239
LIG_LIR_Nem_3	269	275	PF02991	0.465
LIG_LIR_Nem_3	350	356	PF02991	0.438
LIG_LIR_Nem_3	363	369	PF02991	0.263
LIG_LIR_Nem_3	491	496	PF02991	0.391
LIG_LIR_Nem_3	632	638	PF02991	0.400
LIG_LIR_Nem_3	707	713	PF02991	0.323
LIG_LYPXL_S_1	366	370	PF13949	0.363
LIG_LYPXL_yS_3	367	370	PF13949	0.370
LIG_MYND_1	564	568	PF01753	0.711
LIG_Pex14_2	150	154	PF04695	0.377
LIG_Pex14_2	165	169	PF04695	0.155
LIG_Pex14_2	219	223	PF04695	0.357
LIG_Pex14_2	635	639	PF04695	0.419
LIG_Pex14_2	97	101	PF04695	0.419
LIG_PTB_Apo_2	351	358	PF02174	0.380
LIG_PTB_Apo_2	458	465	PF02174	0.382
LIG_PTB_Phospho_1	351	357	PF10480	0.494
LIG_PTB_Phospho_1	458	464	PF10480	0.386
LIG_Rb_LxCxE_1	294	308	PF01857	0.366
LIG_REV1ctd_RIR_1	113	124	PF16727	0.419
LIG_REV1ctd_RIR_1	636	645	PF16727	0.314
LIG_REV1ctd_RIR_1	696	707	PF16727	0.298
LIG_SH2_CRK	493	497	PF00017	0.424
LIG_SH2_GRB2like	210	213	PF00017	0.379
LIG_SH2_NCK_1	210	214	PF00017	0.391
LIG_SH2_NCK_1	713	717	PF00017	0.598
LIG_SH2_SRC	210	213	PF00017	0.379
LIG_SH2_SRC	464	467	PF00017	0.464
LIG_SH2_SRC	713	716	PF00017	0.596
LIG_SH2_STAT3	267	270	PF00017	0.462
LIG_SH2_STAT3	466	469	PF00017	0.472
LIG_SH2_STAT5	114	117	PF00017	0.314
LIG_SH2_STAT5	146	149	PF00017	0.384
LIG_SH2_STAT5	162	165	PF00017	0.384
LIG_SH2_STAT5	218	221	PF00017	0.345
LIG_SH2_STAT5	333	336	PF00017	0.338
LIG_SH2_STAT5	357	360	PF00017	0.465
LIG_SH2_STAT5	464	467	PF00017	0.359
LIG_SH3_3	558	564	PF00018	0.679
LIG_SH3_3	623	629	PF00018	0.298
LIG_SH3_3	70	76	PF00018	0.421
LIG_SH3_3	80	86	PF00018	0.295
LIG_SUMO_SIM_par_1	337	343	PF11976	0.374
LIG_TRAF2_1	405	408	PF00917	0.727
LIG_TRAF2_1	414	417	PF00917	0.532
LIG_TRAF2_1	430	433	PF00917	0.699
LIG_TRAF2_1	66	69	PF00917	0.535
LIG_UBA3_1	288	295	PF00899	0.502
LIG_UBA3_1	482	489	PF00899	0.528
LIG_WRC_WIRS_1	349	354	PF05994	0.369
MOD_CDC14_SPxK_1	235	238	PF00782	0.327
MOD_CDK_SPK_2	74	79	PF00069	0.402
MOD_CDK_SPxK_1	232	238	PF00069	0.312
MOD_CDK_SPxK_1	625	631	PF00069	0.315
MOD_CDK_SPxxK_3	340	347	PF00069	0.432
MOD_CK1_1	189	195	PF00069	0.360
MOD_CK1_1	250	256	PF00069	0.372
MOD_CK1_1	278	284	PF00069	0.405
MOD_CK1_1	410	416	PF00069	0.670
MOD_CK1_1	437	443	PF00069	0.564
MOD_CK1_1	517	523	PF00069	0.533
MOD_CK2_1	173	179	PF00069	0.419
MOD_CK2_1	402	408	PF00069	0.676
MOD_CK2_1	410	416	PF00069	0.638
MOD_CK2_1	470	476	PF00069	0.535
MOD_CK2_1	63	69	PF00069	0.434
MOD_CK2_1	646	652	PF00069	0.400
MOD_CK2_1	721	727	PF00069	0.496
MOD_Cter_Amidation	381	384	PF01082	0.577
MOD_Cter_Amidation	550	553	PF01082	0.739
MOD_Cter_Amidation	604	607	PF01082	0.506
MOD_GlcNHglycan	127	130	PF01048	0.509
MOD_GlcNHglycan	191	194	PF01048	0.346
MOD_GlcNHglycan	249	252	PF01048	0.366
MOD_GlcNHglycan	394	397	PF01048	0.568
MOD_GlcNHglycan	453	456	PF01048	0.470
MOD_GlcNHglycan	500	504	PF01048	0.523
MOD_GlcNHglycan	519	522	PF01048	0.543
MOD_GlcNHglycan	525	528	PF01048	0.532
MOD_GlcNHglycan	623	626	PF01048	0.322
MOD_GSK3_1	153	160	PF00069	0.312
MOD_GSK3_1	232	239	PF00069	0.413
MOD_GSK3_1	403	410	PF00069	0.644
MOD_GSK3_1	424	431	PF00069	0.665
MOD_GSK3_1	477	484	PF00069	0.392
MOD_GSK3_1	495	502	PF00069	0.340
MOD_GSK3_1	510	517	PF00069	0.524
MOD_GSK3_1	519	526	PF00069	0.493
MOD_GSK3_1	621	628	PF00069	0.338
MOD_GSK3_1	641	648	PF00069	0.230
MOD_GSK3_1	661	668	PF00069	0.320
MOD_LATS_1	449	455	PF00433	0.497
MOD_N-GLC_1	110	115	PF02516	0.419
MOD_NEK2_1	28	33	PF00069	0.515
MOD_NEK2_1	348	353	PF00069	0.441
MOD_NEK2_1	470	475	PF00069	0.531
MOD_NEK2_1	620	625	PF00069	0.381
MOD_NEK2_1	639	644	PF00069	0.152
MOD_NEK2_1	645	650	PF00069	0.316
MOD_NEK2_2	287	292	PF00069	0.436
MOD_PIKK_1	135	141	PF00454	0.312
MOD_PIKK_1	153	159	PF00454	0.188
MOD_PIKK_1	266	272	PF00454	0.438
MOD_PIKK_1	428	434	PF00454	0.709
MOD_PIKK_1	495	501	PF00454	0.433
MOD_PKA_1	661	667	PF00069	0.371
MOD_PKA_2	124	130	PF00069	0.340
MOD_PKA_2	134	140	PF00069	0.228
MOD_PKA_2	173	179	PF00069	0.385
MOD_PKA_2	640	646	PF00069	0.324
MOD_PKA_2	650	656	PF00069	0.300
MOD_PKA_2	661	667	PF00069	0.318
MOD_PKA_2	89	95	PF00069	0.383
MOD_Plk_1	110	116	PF00069	0.353
MOD_Plk_1	278	284	PF00069	0.446
MOD_Plk_1	475	481	PF00069	0.378
MOD_Plk_1	50	56	PF00069	0.417
MOD_Plk_1	631	637	PF00069	0.417
MOD_Plk_2-3	403	409	PF00069	0.720
MOD_Plk_2-3	514	520	PF00069	0.584
MOD_Plk_2-3	721	727	PF00069	0.496
MOD_Plk_4	110	116	PF00069	0.393
MOD_Plk_4	252	258	PF00069	0.385
MOD_Plk_4	348	354	PF00069	0.526
MOD_Plk_4	459	465	PF00069	0.396
MOD_Plk_4	520	526	PF00069	0.508
MOD_Plk_4	641	647	PF00069	0.400
MOD_ProDKin_1	232	238	PF00069	0.427
MOD_ProDKin_1	340	346	PF00069	0.418
MOD_ProDKin_1	585	591	PF00069	0.500
MOD_ProDKin_1	625	631	PF00069	0.298
MOD_ProDKin_1	74	80	PF00069	0.405
MOD_SUMO_rev_2	431	437	PF00179	0.544
MOD_SUMO_rev_2	689	699	PF00179	0.419
TRG_DiLeu_BaEn_1	677	682	PF01217	0.298
TRG_DiLeu_BaEn_4	179	185	PF01217	0.333
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.511
TRG_ENDOCYTIC_2	146	149	PF00928	0.307
TRG_ENDOCYTIC_2	162	165	PF00928	0.384
TRG_ENDOCYTIC_2	353	356	PF00928	0.453
TRG_ENDOCYTIC_2	367	370	PF00928	0.270
TRG_ENDOCYTIC_2	493	496	PF00928	0.424
TRG_ER_diArg_1	371	373	PF00400	0.457
TRG_ER_diArg_1	399	401	PF00400	0.649
TRG_ER_diArg_1	450	452	PF00400	0.403
TRG_ER_diArg_1	661	663	PF00400	0.291
TRG_ER_diArg_1	702	705	PF00400	0.384
TRG_ER_diArg_1	718	720	PF00400	0.574
TRG_NES_CRM1_1	388	403	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	679	684	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	702	707	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R8	Leptomonas seymouri	75%	100%
A0A0S4JR73	Bodo saltans	49%	94%
A0A1X0NZQ9	Trypanosomatidae	59%	100%
A0A3Q8I9A1	Leishmania donovani	95%	100%
A0A422NAE1	Trypanosoma rangeli	59%	100%
A4H8D5	Leishmania braziliensis	84%	100%
A4HWQ7	Leishmania infantum	95%	100%
C9ZPS3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	99%
E9AQG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q08979	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q5R8W1	Pongo abelii	32%	100%
Q8TBB5	Homo sapiens	33%	100%
Q921I2	Mus musculus	32%	100%
V5BBA4	Trypanosoma cruzi	60%	100%