MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania major

UniProt:

Q4QF10_LEIMA

TriTrypDb:

LmjF.16.0100 , LMJLV39_160006100 , LMJSD75_160006100

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	11
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QF10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.561
CLV_C14_Caspase3-7	392	396	PF00656	0.664
CLV_C14_Caspase3-7	95	99	PF00656	0.392
CLV_NRD_NRD_1	380	382	PF00675	0.419
CLV_NRD_NRD_1	618	620	PF00675	0.452
CLV_PCSK_KEX2_1	380	382	PF00082	0.419
CLV_PCSK_KEX2_1	618	620	PF00082	0.452
CLV_PCSK_SKI1_1	138	142	PF00082	0.629
CLV_PCSK_SKI1_1	162	166	PF00082	0.750
CLV_PCSK_SKI1_1	380	384	PF00082	0.419
CLV_PCSK_SKI1_1	421	425	PF00082	0.349
DEG_APCC_DBOX_1	331	339	PF00400	0.478
DEG_APCC_DBOX_1	420	428	PF00400	0.581
DEG_APCC_DBOX_1	487	495	PF00400	0.602
DEG_SCF_FBW7_1	382	387	PF00400	0.628
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	273	279	PF00134	0.475
DOC_MAPK_FxFP_2	268	271	PF00069	0.363
DOC_MAPK_FxFP_2	369	372	PF00069	0.680
DOC_MAPK_gen_1	416	425	PF00069	0.632
DOC_MAPK_gen_1	485	493	PF00069	0.666
DOC_MAPK_gen_1	551	559	PF00069	0.615
DOC_PP1_RVXF_1	419	426	PF00149	0.562
DOC_PP1_RVXF_1	556	562	PF00149	0.555
DOC_PP2B_LxvP_1	174	177	PF13499	0.547
DOC_PP2B_LxvP_1	273	276	PF13499	0.344
DOC_PP2B_LxvP_1	343	346	PF13499	0.454
DOC_PP4_FxxP_1	268	271	PF00568	0.335
DOC_PP4_FxxP_1	305	308	PF00568	0.620
DOC_PP4_FxxP_1	369	372	PF00568	0.661
DOC_PP4_FxxP_1	435	438	PF00568	0.269
DOC_USP7_MATH_1	218	222	PF00917	0.582
DOC_USP7_MATH_1	227	231	PF00917	0.486
DOC_USP7_MATH_1	27	31	PF00917	0.448
DOC_USP7_MATH_1	300	304	PF00917	0.719
DOC_USP7_MATH_1	396	400	PF00917	0.737
DOC_USP7_MATH_2	252	258	PF00917	0.468
DOC_WW_Pin1_4	165	170	PF00397	0.487
DOC_WW_Pin1_4	187	192	PF00397	0.545
DOC_WW_Pin1_4	237	242	PF00397	0.473
DOC_WW_Pin1_4	380	385	PF00397	0.631
DOC_WW_Pin1_4	504	509	PF00397	0.709
LIG_14-3-3_CanoR_1	15	20	PF00244	0.468
LIG_14-3-3_CanoR_1	217	223	PF00244	0.519
LIG_14-3-3_CanoR_1	260	264	PF00244	0.454
LIG_14-3-3_CanoR_1	284	289	PF00244	0.645
LIG_14-3-3_CanoR_1	551	560	PF00244	0.537
LIG_14-3-3_CanoR_1	587	597	PF00244	0.371
LIG_Actin_WH2_2	268	286	PF00022	0.449
LIG_Actin_WH2_2	466	481	PF00022	0.330
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	450	454	PF00533	0.469
LIG_BRCT_BRCA1_1	512	516	PF00533	0.691
LIG_BRCT_BRCA1_1	593	597	PF00533	0.353
LIG_BRCT_BRCA1_1	92	96	PF00533	0.383
LIG_BRCT_BRCA1_2	450	456	PF00533	0.355
LIG_CSL_BTD_1	276	279	PF09270	0.475
LIG_EH1_1	321	329	PF00400	0.376
LIG_eIF4E_1	418	424	PF01652	0.601
LIG_eIF4E_1	535	541	PF01652	0.633
LIG_eIF4E_1	670	676	PF01652	0.429
LIG_FHA_1	159	165	PF00498	0.556
LIG_FHA_1	381	387	PF00498	0.624
LIG_FHA_1	455	461	PF00498	0.360
LIG_FHA_1	472	478	PF00498	0.449
LIG_FHA_1	675	681	PF00498	0.441
LIG_FHA_2	342	348	PF00498	0.377
LIG_FHA_2	402	408	PF00498	0.621
LIG_FHA_2	615	621	PF00498	0.537
LIG_FHA_2	658	664	PF00498	0.628
LIG_LIR_Apic_2	236	241	PF02991	0.526
LIG_LIR_Apic_2	303	308	PF02991	0.636
LIG_LIR_Apic_2	367	372	PF02991	0.600
LIG_LIR_Apic_2	434	438	PF02991	0.296
LIG_LIR_Gen_1	210	218	PF02991	0.556
LIG_LIR_Gen_1	22	29	PF02991	0.526
LIG_LIR_Gen_1	364	372	PF02991	0.455
LIG_LIR_Gen_1	472	483	PF02991	0.499
LIG_LIR_Gen_1	594	602	PF02991	0.301
LIG_LIR_Gen_1	671	680	PF02991	0.394
LIG_LIR_Nem_3	210	214	PF02991	0.506
LIG_LIR_Nem_3	22	26	PF02991	0.510
LIG_LIR_Nem_3	274	280	PF02991	0.459
LIG_LIR_Nem_3	309	313	PF02991	0.452
LIG_LIR_Nem_3	364	368	PF02991	0.369
LIG_LIR_Nem_3	472	478	PF02991	0.384
LIG_LIR_Nem_3	525	531	PF02991	0.599
LIG_LIR_Nem_3	594	600	PF02991	0.292
LIG_LIR_Nem_3	671	675	PF02991	0.421
LIG_LIR_Nem_3	99	105	PF02991	0.432
LIG_Pex14_2	266	270	PF04695	0.349
LIG_Pex14_2	463	467	PF04695	0.413
LIG_Pex14_2	598	602	PF04695	0.475
LIG_Pex14_2	69	73	PF04695	0.324
LIG_Pex14_2	92	96	PF04695	0.344
LIG_PTAP_UEV_1	190	195	PF05743	0.472
LIG_PTB_Apo_2	412	419	PF02174	0.606
LIG_PTB_Apo_2	493	500	PF02174	0.653
LIG_PTB_Phospho_1	412	418	PF10480	0.608
LIG_REV1ctd_RIR_1	366	371	PF16727	0.572
LIG_SH2_CRK	102	106	PF00017	0.434
LIG_SH2_CRK	238	242	PF00017	0.535
LIG_SH2_CRK	634	638	PF00017	0.624
LIG_SH2_CRK	670	674	PF00017	0.475
LIG_SH2_GRB2like	40	43	PF00017	0.468
LIG_SH2_PTP2	612	615	PF00017	0.465
LIG_SH2_SRC	313	316	PF00017	0.309
LIG_SH2_SRC	610	613	PF00017	0.399
LIG_SH2_STAP1	670	674	PF00017	0.281
LIG_SH2_STAT3	106	109	PF00017	0.412
LIG_SH2_STAT5	152	155	PF00017	0.485
LIG_SH2_STAT5	313	316	PF00017	0.287
LIG_SH2_STAT5	365	368	PF00017	0.399
LIG_SH2_STAT5	37	40	PF00017	0.422
LIG_SH2_STAT5	610	613	PF00017	0.330
LIG_SH2_STAT5	626	629	PF00017	0.547
LIG_SH3_2	279	284	PF14604	0.498
LIG_SH3_3	188	194	PF00018	0.593
LIG_SH3_3	273	279	PF00018	0.330
LIG_SUMO_SIM_anti_2	671	677	PF11976	0.329
LIG_SUMO_SIM_par_1	176	185	PF11976	0.555
LIG_SUMO_SIM_par_1	325	331	PF11976	0.451
LIG_SUMO_SIM_par_1	665	671	PF11976	0.643
LIG_SUMO_SIM_par_1	672	677	PF11976	0.370
LIG_TYR_ITSM	98	105	PF00017	0.399
LIG_UBA3_1	141	147	PF00899	0.332
LIG_UBA3_1	356	362	PF00899	0.359
LIG_WRC_WIRS_1	201	206	PF05994	0.506
LIG_WRC_WIRS_1	365	370	PF05994	0.582
LIG_WRC_WIRS_1	432	437	PF05994	0.283
LIG_WRC_WIRS_1	464	469	PF05994	0.432
LIG_WRC_WIRS_1	597	602	PF05994	0.449
LIG_WRC_WIRS_1	669	674	PF05994	0.281
MOD_CDC14_SPxK_1	507	510	PF00782	0.729
MOD_CDK_SPK_2	380	385	PF00069	0.647
MOD_CDK_SPxK_1	504	510	PF00069	0.728
MOD_CK1_1	158	164	PF00069	0.547
MOD_CK1_1	182	188	PF00069	0.531
MOD_CK1_1	2	8	PF00069	0.565
MOD_CK1_1	210	216	PF00069	0.514
MOD_CK1_1	240	246	PF00069	0.481
MOD_CK1_1	30	36	PF00069	0.467
MOD_CK1_1	364	370	PF00069	0.475
MOD_CK1_1	536	542	PF00069	0.624
MOD_CK1_1	657	663	PF00069	0.578
MOD_CK2_1	284	290	PF00069	0.633
MOD_CK2_1	341	347	PF00069	0.399
MOD_CK2_1	614	620	PF00069	0.535
MOD_CK2_1	637	643	PF00069	0.676
MOD_CK2_1	657	663	PF00069	0.633
MOD_GlcNHglycan	165	168	PF01048	0.712
MOD_GlcNHglycan	229	232	PF01048	0.697
MOD_GlcNHglycan	296	299	PF01048	0.423
MOD_GlcNHglycan	386	389	PF01048	0.404
MOD_GlcNHglycan	4	7	PF01048	0.733
MOD_GlcNHglycan	435	438	PF01048	0.421
MOD_GlcNHglycan	528	531	PF01048	0.468
MOD_GlcNHglycan	544	547	PF01048	0.254
MOD_GlcNHglycan	64	67	PF01048	0.481
MOD_GlcNHglycan	74	77	PF01048	0.486
MOD_GlcNHglycan	92	95	PF01048	0.579
MOD_GSK3_1	121	128	PF00069	0.502
MOD_GSK3_1	196	203	PF00069	0.558
MOD_GSK3_1	233	240	PF00069	0.520
MOD_GSK3_1	380	387	PF00069	0.624
MOD_GSK3_1	433	440	PF00069	0.439
MOD_GSK3_1	469	476	PF00069	0.447
MOD_GSK3_1	5	12	PF00069	0.507
MOD_GSK3_1	506	513	PF00069	0.740
MOD_GSK3_1	587	594	PF00069	0.414
MOD_N-GLC_1	187	192	PF02516	0.710
MOD_N-GLC_1	207	212	PF02516	0.727
MOD_N-GLC_1	218	223	PF02516	0.787
MOD_N-GLC_1	657	662	PF02516	0.321
MOD_NEK2_1	141	146	PF00069	0.477
MOD_NEK2_1	163	168	PF00069	0.504
MOD_NEK2_1	181	186	PF00069	0.429
MOD_NEK2_1	283	288	PF00069	0.603
MOD_NEK2_1	294	299	PF00069	0.574
MOD_NEK2_1	328	333	PF00069	0.538
MOD_NEK2_1	38	43	PF00069	0.445
MOD_NEK2_1	389	394	PF00069	0.634
MOD_NEK2_1	431	436	PF00069	0.384
MOD_NEK2_1	448	453	PF00069	0.309
MOD_NEK2_1	454	459	PF00069	0.374
MOD_NEK2_1	463	468	PF00069	0.342
MOD_NEK2_1	469	474	PF00069	0.314
MOD_NEK2_1	518	523	PF00069	0.708
MOD_NEK2_1	542	547	PF00069	0.567
MOD_NEK2_1	668	673	PF00069	0.484
MOD_NEK2_1	96	101	PF00069	0.370
MOD_NEK2_2	259	264	PF00069	0.385
MOD_NEK2_2	308	313	PF00069	0.507
MOD_NEK2_2	533	538	PF00069	0.632
MOD_PIKK_1	233	239	PF00454	0.532
MOD_PKA_2	121	127	PF00069	0.452
MOD_PKA_2	259	265	PF00069	0.450
MOD_PKA_2	283	289	PF00069	0.668
MOD_PKA_2	96	102	PF00069	0.364
MOD_PKB_1	585	593	PF00069	0.316
MOD_Plk_1	207	213	PF00069	0.526
MOD_Plk_1	218	224	PF00069	0.588
MOD_Plk_1	518	524	PF00069	0.751
MOD_Plk_1	97	103	PF00069	0.430
MOD_Plk_4	141	147	PF00069	0.470
MOD_Plk_4	15	21	PF00069	0.494
MOD_Plk_4	196	202	PF00069	0.579
MOD_Plk_4	240	246	PF00069	0.503
MOD_Plk_4	361	367	PF00069	0.355
MOD_Plk_4	389	395	PF00069	0.672
MOD_Plk_4	463	469	PF00069	0.355
MOD_Plk_4	572	578	PF00069	0.418
MOD_Plk_4	668	674	PF00069	0.526
MOD_Plk_4	80	86	PF00069	0.317
MOD_Plk_4	97	103	PF00069	0.464
MOD_ProDKin_1	165	171	PF00069	0.485
MOD_ProDKin_1	187	193	PF00069	0.545
MOD_ProDKin_1	237	243	PF00069	0.471
MOD_ProDKin_1	380	386	PF00069	0.627
MOD_ProDKin_1	504	510	PF00069	0.710
MOD_SUMO_rev_2	221	230	PF00179	0.527
MOD_SUMO_rev_2	392	399	PF00179	0.689
TRG_DiLeu_BaEn_1	501	506	PF01217	0.677
TRG_DiLeu_BaEn_2	289	295	PF01217	0.691
TRG_ENDOCYTIC_2	102	105	PF00928	0.439
TRG_ENDOCYTIC_2	365	368	PF00928	0.340
TRG_ENDOCYTIC_2	420	423	PF00928	0.544
TRG_ENDOCYTIC_2	595	598	PF00928	0.350
TRG_ENDOCYTIC_2	610	613	PF00928	0.344
TRG_ENDOCYTIC_2	634	637	PF00928	0.589
TRG_ENDOCYTIC_2	670	673	PF00928	0.434
TRG_ER_diArg_1	380	382	PF00400	0.619
TRG_NES_CRM1_1	629	643	PF08389	0.662
TRG_Pf-PMV_PEXEL_1	652	656	PF00026	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD79	Leptomonas seymouri	64%	98%
A0A0S4JPR5	Bodo saltans	38%	75%
A0A1X0NZJ8	Trypanosomatidae	38%	99%
A0A3S7WTR7	Leishmania donovani	94%	100%
A0A422N036	Trypanosoma rangeli	36%	96%
A4H8D7	Leishmania braziliensis	75%	100%
A4HWQ9	Leishmania infantum	94%	100%
C9ZPS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	94%
E9AQG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5D792	Trypanosoma cruzi	38%	97%