APH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Phosphotransferase enzyme family, putative

Species:

Leishmania major

UniProt:

Q4QF09_LEIMA

TriTrypDb:

LmjF.16.0110 , LMJLV39_160006200 , LMJSD75_160006200

Length:

826

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QF09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF09

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	2
GO:0006629	lipid metabolic process	3	2
GO:0006631	fatty acid metabolic process	4	2
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	2
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	2
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase	7	2
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003995	acyl-CoA dehydrogenase activity	5	2
GO:0016491	oxidoreductase activity	2	2
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	2
GO:0052890	oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor	4	2
GO:0016740	transferase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	208	212	PF00656	0.668
CLV_NRD_NRD_1	164	166	PF00675	0.458
CLV_NRD_NRD_1	199	201	PF00675	0.644
CLV_NRD_NRD_1	24	26	PF00675	0.456
CLV_NRD_NRD_1	253	255	PF00675	0.544
CLV_NRD_NRD_1	491	493	PF00675	0.438
CLV_NRD_NRD_1	524	526	PF00675	0.372
CLV_NRD_NRD_1	529	531	PF00675	0.335
CLV_NRD_NRD_1	549	551	PF00675	0.150
CLV_NRD_NRD_1	555	557	PF00675	0.375
CLV_NRD_NRD_1	596	598	PF00675	0.447
CLV_NRD_NRD_1	762	764	PF00675	0.460
CLV_PCSK_FUR_1	547	551	PF00082	0.493
CLV_PCSK_FUR_1	597	601	PF00082	0.480
CLV_PCSK_FUR_1	760	764	PF00082	0.515
CLV_PCSK_KEX2_1	132	134	PF00082	0.481
CLV_PCSK_KEX2_1	199	201	PF00082	0.651
CLV_PCSK_KEX2_1	24	26	PF00082	0.456
CLV_PCSK_KEX2_1	253	255	PF00082	0.552
CLV_PCSK_KEX2_1	45	47	PF00082	0.619
CLV_PCSK_KEX2_1	491	493	PF00082	0.408
CLV_PCSK_KEX2_1	524	526	PF00082	0.372
CLV_PCSK_KEX2_1	529	531	PF00082	0.335
CLV_PCSK_KEX2_1	549	551	PF00082	0.150
CLV_PCSK_KEX2_1	555	557	PF00082	0.312
CLV_PCSK_KEX2_1	596	598	PF00082	0.447
CLV_PCSK_KEX2_1	599	601	PF00082	0.447
CLV_PCSK_KEX2_1	760	762	PF00082	0.457
CLV_PCSK_KEX2_1	796	798	PF00082	0.690
CLV_PCSK_KEX2_1	812	814	PF00082	0.278
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.481
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.552
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.650
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.449
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.690
CLV_PCSK_PC1ET2_1	812	814	PF00082	0.278
CLV_PCSK_PC7_1	525	531	PF00082	0.355
CLV_PCSK_SKI1_1	12	16	PF00082	0.538
CLV_PCSK_SKI1_1	147	151	PF00082	0.511
CLV_PCSK_SKI1_1	166	170	PF00082	0.407
CLV_PCSK_SKI1_1	200	204	PF00082	0.619
CLV_PCSK_SKI1_1	32	36	PF00082	0.324
CLV_PCSK_SKI1_1	327	331	PF00082	0.528
CLV_PCSK_SKI1_1	410	414	PF00082	0.486
CLV_PCSK_SKI1_1	524	528	PF00082	0.419
CLV_PCSK_SKI1_1	617	621	PF00082	0.447
CLV_PCSK_SKI1_1	634	638	PF00082	0.341
CLV_PCSK_SKI1_1	643	647	PF00082	0.377
CLV_PCSK_SKI1_1	74	78	PF00082	0.491
DEG_APCC_DBOX_1	81	89	PF00400	0.539
DEG_SPOP_SBC_1	14	18	PF00917	0.510
DOC_ANK_TNKS_1	183	190	PF00023	0.551
DOC_CKS1_1	509	514	PF01111	0.480
DOC_CYCLIN_RxL_1	144	153	PF00134	0.501
DOC_CYCLIN_yClb1_LxF_4	376	382	PF00134	0.635
DOC_CYCLIN_yClb1_LxF_4	88	93	PF00134	0.593
DOC_MAPK_FxFP_2	215	218	PF00069	0.625
DOC_MAPK_gen_1	165	171	PF00069	0.431
DOC_MAPK_gen_1	176	185	PF00069	0.447
DOC_MAPK_gen_1	555	563	PF00069	0.333
DOC_MAPK_HePTP_8	250	262	PF00069	0.607
DOC_MAPK_MEF2A_6	253	262	PF00069	0.555
DOC_MAPK_MEF2A_6	555	563	PF00069	0.355
DOC_MAPK_MEF2A_6	599	608	PF00069	0.411
DOC_MAPK_MEF2A_6	704	712	PF00069	0.447
DOC_PP1_RVXF_1	408	414	PF00149	0.467
DOC_PP1_RVXF_1	88	94	PF00149	0.517
DOC_PP2B_LxvP_1	425	428	PF13499	0.535
DOC_PP2B_LxvP_1	507	510	PF13499	0.408
DOC_PP4_FxxP_1	215	218	PF00568	0.625
DOC_PP4_FxxP_1	381	384	PF00568	0.617
DOC_PP4_FxxP_1	738	741	PF00568	0.393
DOC_SPAK_OSR1_1	628	632	PF12202	0.447
DOC_USP7_MATH_1	431	435	PF00917	0.493
DOC_USP7_MATH_1	484	488	PF00917	0.490
DOC_USP7_MATH_1	713	717	PF00917	0.402
DOC_USP7_MATH_1	739	743	PF00917	0.498
DOC_USP7_UBL2_3	566	570	PF12436	0.480
DOC_WW_Pin1_4	15	20	PF00397	0.522
DOC_WW_Pin1_4	160	165	PF00397	0.498
DOC_WW_Pin1_4	356	361	PF00397	0.654
DOC_WW_Pin1_4	388	393	PF00397	0.680
DOC_WW_Pin1_4	480	485	PF00397	0.408
DOC_WW_Pin1_4	501	506	PF00397	0.447
DOC_WW_Pin1_4	508	513	PF00397	0.447
DOC_WW_Pin1_4	579	584	PF00397	0.480
DOC_WW_Pin1_4	737	742	PF00397	0.405
DOC_WW_Pin1_4	789	794	PF00397	0.690
LIG_14-3-3_CanoR_1	176	185	PF00244	0.428
LIG_14-3-3_CanoR_1	199	209	PF00244	0.654
LIG_14-3-3_CanoR_1	363	368	PF00244	0.663
LIG_14-3-3_CanoR_1	37	44	PF00244	0.571
LIG_14-3-3_CanoR_1	430	436	PF00244	0.540
LIG_14-3-3_CanoR_1	465	469	PF00244	0.335
LIG_14-3-3_CanoR_1	549	555	PF00244	0.358
LIG_14-3-3_CanoR_1	634	639	PF00244	0.359
LIG_14-3-3_CanoR_1	797	804	PF00244	0.547
LIG_AP2alpha_2	336	338	PF02296	0.458
LIG_BRCT_BRCA1_1	16	20	PF00533	0.561
LIG_BRCT_BRCA1_1	211	215	PF00533	0.633
LIG_BRCT_BRCA1_1	457	461	PF00533	0.582
LIG_BRCT_BRCA1_1	59	63	PF00533	0.375
LIG_BRCT_BRCA1_1	675	679	PF00533	0.408
LIG_Clathr_ClatBox_1	149	153	PF01394	0.541
LIG_EH_1	305	309	PF12763	0.494
LIG_eIF4E_1	375	381	PF01652	0.590
LIG_FHA_1	268	274	PF00498	0.623
LIG_FHA_1	307	313	PF00498	0.561
LIG_FHA_1	363	369	PF00498	0.569
LIG_FHA_1	509	515	PF00498	0.461
LIG_FHA_1	71	77	PF00498	0.447
LIG_FHA_1	778	784	PF00498	0.504
LIG_FHA_2	635	641	PF00498	0.419
LIG_LIR_Apic_2	212	218	PF02991	0.628
LIG_LIR_Gen_1	100	108	PF02991	0.469
LIG_LIR_Gen_1	336	346	PF02991	0.464
LIG_LIR_Gen_1	493	501	PF02991	0.328
LIG_LIR_Gen_1	716	724	PF02991	0.448
LIG_LIR_Nem_3	100	106	PF02991	0.453
LIG_LIR_Nem_3	239	245	PF02991	0.497
LIG_LIR_Nem_3	320	325	PF02991	0.490
LIG_LIR_Nem_3	336	342	PF02991	0.396
LIG_LIR_Nem_3	458	464	PF02991	0.548
LIG_LIR_Nem_3	60	66	PF02991	0.378
LIG_LIR_Nem_3	716	721	PF02991	0.448
LIG_LIR_Nem_3	764	770	PF02991	0.385
LIG_LYPXL_yS_3	217	220	PF13949	0.684
LIG_LYPXL_yS_3	257	260	PF13949	0.582
LIG_MLH1_MIPbox_1	457	461	PF16413	0.582
LIG_MLH1_MIPbox_1	59	63	PF16413	0.418
LIG_MYND_1	420	424	PF01753	0.468
LIG_MYND_2	691	695	PF01753	0.441
LIG_PCNA_yPIPBox_3	664	678	PF02747	0.480
LIG_Pex14_2	93	97	PF04695	0.462
LIG_PTB_Apo_2	58	65	PF02174	0.496
LIG_Rb_pABgroove_1	236	244	PF01858	0.454
LIG_REV1ctd_RIR_1	524	534	PF16727	0.447
LIG_SH2_GRB2like	232	235	PF00017	0.637
LIG_SH2_GRB2like	375	378	PF00017	0.634
LIG_SH2_GRB2like	59	62	PF00017	0.394
LIG_SH2_NCK_1	207	211	PF00017	0.478
LIG_SH2_SRC	232	235	PF00017	0.637
LIG_SH2_SRC	454	457	PF00017	0.599
LIG_SH2_STAP1	375	379	PF00017	0.639
LIG_SH2_STAP1	494	498	PF00017	0.447
LIG_SH2_STAP1	59	63	PF00017	0.374
LIG_SH2_STAT3	414	417	PF00017	0.399
LIG_SH2_STAT5	174	177	PF00017	0.408
LIG_SH2_STAT5	245	248	PF00017	0.470
LIG_SH2_STAT5	249	252	PF00017	0.547
LIG_SH2_STAT5	289	292	PF00017	0.513
LIG_SH2_STAT5	414	417	PF00017	0.391
LIG_SH2_STAT5	454	457	PF00017	0.607
LIG_SH2_STAT5	473	476	PF00017	0.173
LIG_SH2_STAT5	515	518	PF00017	0.389
LIG_SH2_STAT5	748	751	PF00017	0.391
LIG_SH2_STAT5	770	773	PF00017	0.370
LIG_SH3_1	301	307	PF00018	0.487
LIG_SH3_1	476	482	PF00018	0.355
LIG_SH3_3	216	222	PF00018	0.634
LIG_SH3_3	301	307	PF00018	0.487
LIG_SH3_3	379	385	PF00018	0.528
LIG_SH3_3	425	431	PF00018	0.601
LIG_SH3_3	476	482	PF00018	0.355
LIG_SH3_3	580	586	PF00018	0.410
LIG_SUMO_SIM_anti_2	3	10	PF11976	0.444
LIG_SUMO_SIM_anti_2	309	316	PF11976	0.510
LIG_SUMO_SIM_par_1	104	109	PF11976	0.494
LIG_SUMO_SIM_par_1	148	153	PF11976	0.551
LIG_SUMO_SIM_par_1	309	316	PF11976	0.510
LIG_SUMO_SIM_par_1	707	714	PF11976	0.349
LIG_TRAF2_1	179	182	PF00917	0.448
LIG_TRAF2_1	264	267	PF00917	0.517
LIG_TRAF2_1	591	594	PF00917	0.421
LIG_TRAF2_1	637	640	PF00917	0.434
LIG_UBA3_1	104	110	PF00899	0.403
LIG_UBA3_1	171	178	PF00899	0.430
LIG_UBA3_1	422	426	PF00899	0.561
LIG_UBA3_1	7	12	PF00899	0.489
LIG_WW_3	427	431	PF00397	0.552
MOD_CDC14_SPxK_1	163	166	PF00782	0.512
MOD_CDK_SPK_2	160	165	PF00069	0.498
MOD_CDK_SPxK_1	160	166	PF00069	0.494
MOD_CDK_SPxxK_3	356	363	PF00069	0.661
MOD_CDK_SPxxK_3	789	796	PF00069	0.689
MOD_CK1_1	228	234	PF00069	0.625
MOD_CK1_1	248	254	PF00069	0.657
MOD_CK1_1	366	372	PF00069	0.659
MOD_CK1_1	391	397	PF00069	0.721
MOD_CK1_1	789	795	PF00069	0.578
MOD_CK2_1	176	182	PF00069	0.443
MOD_CK2_1	391	397	PF00069	0.647
MOD_CK2_1	634	640	PF00069	0.439
MOD_Cter_Amidation	522	525	PF01082	0.447
MOD_GlcNHglycan	227	230	PF01048	0.585
MOD_GlcNHglycan	445	448	PF01048	0.577
MOD_GlcNHglycan	486	489	PF01048	0.424
MOD_GlcNHglycan	622	625	PF01048	0.419
MOD_GlcNHglycan	634	637	PF01048	0.383
MOD_GlcNHglycan	713	716	PF01048	0.428
MOD_GlcNHglycan	749	752	PF01048	0.536
MOD_GSK3_1	205	212	PF00069	0.626
MOD_GSK3_1	228	235	PF00069	0.595
MOD_GSK3_1	268	275	PF00069	0.495
MOD_GSK3_1	362	369	PF00069	0.669
MOD_GSK3_1	388	395	PF00069	0.710
MOD_GSK3_1	460	467	PF00069	0.333
MOD_GSK3_1	480	487	PF00069	0.150
MOD_GSK3_1	618	625	PF00069	0.382
MOD_GSK3_1	673	680	PF00069	0.436
MOD_GSK3_1	777	784	PF00069	0.506
MOD_GSK3_1	785	792	PF00069	0.579
MOD_GSK3_1	796	803	PF00069	0.408
MOD_LATS_1	794	800	PF00433	0.685
MOD_N-GLC_1	373	378	PF02516	0.654
MOD_N-GLC_1	672	677	PF02516	0.454
MOD_NEK2_1	106	111	PF00069	0.463
MOD_NEK2_1	205	210	PF00069	0.591
MOD_NEK2_1	236	241	PF00069	0.521
MOD_NEK2_1	443	448	PF00069	0.538
MOD_NEK2_1	460	465	PF00069	0.324
MOD_NEK2_1	500	505	PF00069	0.357
MOD_NEK2_1	595	600	PF00069	0.420
MOD_NEK2_1	618	623	PF00069	0.405
MOD_NEK2_1	62	67	PF00069	0.447
MOD_NEK2_1	649	654	PF00069	0.373
MOD_NEK2_1	672	677	PF00069	0.360
MOD_NEK2_1	700	705	PF00069	0.373
MOD_NEK2_1	747	752	PF00069	0.483
MOD_NEK2_2	464	469	PF00069	0.335
MOD_NEK2_2	713	718	PF00069	0.480
MOD_PIKK_1	176	182	PF00454	0.462
MOD_PIKK_1	436	442	PF00454	0.606
MOD_PIKK_1	538	544	PF00454	0.430
MOD_PIKK_1	649	655	PF00454	0.392
MOD_PK_1	555	561	PF00069	0.448
MOD_PKA_1	555	561	PF00069	0.402
MOD_PKA_1	57	63	PF00069	0.466
MOD_PKA_1	796	802	PF00069	0.591
MOD_PKA_2	268	274	PF00069	0.584
MOD_PKA_2	354	360	PF00069	0.687
MOD_PKA_2	36	42	PF00069	0.589
MOD_PKA_2	362	368	PF00069	0.590
MOD_PKA_2	464	470	PF00069	0.335
MOD_PKA_2	555	561	PF00069	0.480
MOD_PKA_2	595	601	PF00069	0.428
MOD_PKA_2	796	802	PF00069	0.681
MOD_Plk_1	649	655	PF00069	0.355
MOD_Plk_1	672	678	PF00069	0.415
MOD_Plk_4	245	251	PF00069	0.546
MOD_Plk_4	363	369	PF00069	0.553
MOD_Plk_4	469	475	PF00069	0.326
MOD_Plk_4	574	580	PF00069	0.402
MOD_Plk_4	673	679	PF00069	0.447
MOD_Plk_4	713	719	PF00069	0.421
MOD_Plk_4	777	783	PF00069	0.493
MOD_ProDKin_1	15	21	PF00069	0.524
MOD_ProDKin_1	160	166	PF00069	0.494
MOD_ProDKin_1	356	362	PF00069	0.652
MOD_ProDKin_1	388	394	PF00069	0.681
MOD_ProDKin_1	480	486	PF00069	0.408
MOD_ProDKin_1	501	507	PF00069	0.447
MOD_ProDKin_1	508	514	PF00069	0.447
MOD_ProDKin_1	579	585	PF00069	0.480
MOD_ProDKin_1	737	743	PF00069	0.406
MOD_ProDKin_1	789	795	PF00069	0.695
MOD_SUMO_rev_2	277	285	PF00179	0.495
MOD_SUMO_rev_2	4	14	PF00179	0.485
TRG_DiLeu_BaEn_1	3	8	PF01217	0.464
TRG_DiLeu_BaEn_2	98	104	PF01217	0.538
TRG_DiLeu_BaEn_3	3	9	PF01217	0.464
TRG_DiLeu_BaEn_3	99	105	PF01217	0.523
TRG_DiLeu_BaLyEn_6	132	137	PF01217	0.446
TRG_DiLeu_BaLyEn_6	509	514	PF01217	0.480
TRG_DiLeu_BaLyEn_6	601	606	PF01217	0.408
TRG_ENDOCYTIC_2	198	201	PF00928	0.559
TRG_ENDOCYTIC_2	217	220	PF00928	0.684
TRG_ENDOCYTIC_2	257	260	PF00928	0.582
TRG_ENDOCYTIC_2	322	325	PF00928	0.424
TRG_ENDOCYTIC_2	494	497	PF00928	0.350
TRG_ENDOCYTIC_2	59	62	PF00928	0.375
TRG_ER_diArg_1	198	200	PF00400	0.650
TRG_ER_diArg_1	24	26	PF00400	0.458
TRG_ER_diArg_1	490	492	PF00400	0.447
TRG_ER_diArg_1	524	526	PF00400	0.368
TRG_ER_diArg_1	528	530	PF00400	0.340
TRG_ER_diArg_1	546	549	PF00400	0.355
TRG_ER_diArg_1	554	556	PF00400	0.383
TRG_ER_diArg_1	595	597	PF00400	0.417
TRG_ER_diArg_1	760	763	PF00400	0.502
TRG_ER_FFAT_2	87	99	PF00635	0.602
TRG_NLS_MonoExtC_3	130	135	PF00514	0.482
TRG_NLS_MonoExtN_4	596	603	PF00514	0.447
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	802	806	PF00026	0.575
TRG_PTS1	823	826	PF00515	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM33	Leptomonas seymouri	77%	100%
A0A0S4JJA9	Bodo saltans	36%	94%
A0A1X0NZ43	Trypanosomatidae	48%	100%
A0A3S5H6W5	Leishmania donovani	98%	100%
A0A422MZZ3	Trypanosoma rangeli	49%	100%
A4H8D8	Leishmania braziliensis	88%	100%
A4HWR0	Leishmania infantum	98%	100%
E9AQG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BFW1	Trypanosoma cruzi	48%	100%