Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF08_LEIMA

TriTrypDb:

LmjF.16.0120 , LMJLV39_160006300 , LMJSD75_160006300

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.460
CLV_C14_Caspase3-7	525	529	PF00656	0.411
CLV_NRD_NRD_1	195	197	PF00675	0.459
CLV_NRD_NRD_1	316	318	PF00675	0.510
CLV_NRD_NRD_1	496	498	PF00675	0.463
CLV_NRD_NRD_1	602	604	PF00675	0.494
CLV_PCSK_KEX2_1	195	197	PF00082	0.514
CLV_PCSK_KEX2_1	316	318	PF00082	0.510
CLV_PCSK_KEX2_1	376	378	PF00082	0.488
CLV_PCSK_KEX2_1	496	498	PF00082	0.478
CLV_PCSK_KEX2_1	602	604	PF00082	0.378
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.381
CLV_PCSK_SKI1_1	269	273	PF00082	0.406
CLV_PCSK_SKI1_1	287	291	PF00082	0.451
CLV_PCSK_SKI1_1	504	508	PF00082	0.417
CLV_PCSK_SKI1_1	558	562	PF00082	0.329
CLV_PCSK_SKI1_1	574	578	PF00082	0.270
CLV_PCSK_SKI1_1	579	583	PF00082	0.323
CLV_PCSK_SKI1_1	610	614	PF00082	0.399
CLV_PCSK_SKI1_1	720	724	PF00082	0.391
CLV_Separin_Metazoa	772	776	PF03568	0.460
DEG_APCC_DBOX_1	499	507	PF00400	0.272
DEG_APCC_DBOX_1	573	581	PF00400	0.379
DEG_APCC_DBOX_1	609	617	PF00400	0.454
DEG_COP1_1	126	136	PF00400	0.555
DEG_Nend_UBRbox_1	1	4	PF02207	0.589
DEG_SPOP_SBC_1	154	158	PF00917	0.601
DEG_SPOP_SBC_1	591	595	PF00917	0.467
DOC_ANK_TNKS_1	9	16	PF00023	0.629
DOC_CYCLIN_RxL_1	555	564	PF00134	0.346
DOC_CYCLIN_RxL_1	80	91	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	736	742	PF00134	0.402
DOC_MAPK_DCC_7	438	448	PF00069	0.595
DOC_MAPK_gen_1	215	225	PF00069	0.585
DOC_MAPK_gen_1	80	89	PF00069	0.483
DOC_PP2B_LxvP_1	363	366	PF13499	0.380
DOC_PP2B_LxvP_1	616	619	PF13499	0.424
DOC_PP2B_LxvP_1	776	779	PF13499	0.374
DOC_USP7_MATH_1	150	154	PF00917	0.709
DOC_USP7_MATH_1	18	22	PF00917	0.673
DOC_USP7_MATH_1	292	296	PF00917	0.434
DOC_USP7_MATH_1	37	41	PF00917	0.548
DOC_USP7_MATH_1	461	465	PF00917	0.481
DOC_USP7_MATH_1	485	489	PF00917	0.571
DOC_USP7_MATH_1	521	525	PF00917	0.357
DOC_USP7_MATH_1	549	553	PF00917	0.490
DOC_USP7_MATH_1	591	595	PF00917	0.541
DOC_USP7_MATH_1	669	673	PF00917	0.501
DOC_WW_Pin1_4	181	186	PF00397	0.446
DOC_WW_Pin1_4	33	38	PF00397	0.474
DOC_WW_Pin1_4	411	416	PF00397	0.483
DOC_WW_Pin1_4	481	486	PF00397	0.469
DOC_WW_Pin1_4	506	511	PF00397	0.408
DOC_WW_Pin1_4	674	679	PF00397	0.765
LIG_14-3-3_CanoR_1	177	182	PF00244	0.576
LIG_14-3-3_CanoR_1	2	8	PF00244	0.618
LIG_14-3-3_CanoR_1	504	512	PF00244	0.486
LIG_14-3-3_CanoR_1	53	60	PF00244	0.426
LIG_14-3-3_CanoR_1	565	569	PF00244	0.394
LIG_14-3-3_CanoR_1	682	692	PF00244	0.592
LIG_14-3-3_CanoR_1	720	728	PF00244	0.475
LIG_14-3-3_CanoR_1	85	90	PF00244	0.454
LIG_14-3-3_CanoR_1	92	100	PF00244	0.434
LIG_Actin_WH2_2	200	217	PF00022	0.408
LIG_BIR_III_2	440	444	PF00653	0.510
LIG_BIR_III_2	777	781	PF00653	0.486
LIG_Clathr_ClatBox_1	532	536	PF01394	0.469
LIG_FHA_1	149	155	PF00498	0.748
LIG_FHA_1	220	226	PF00498	0.491
LIG_FHA_1	234	240	PF00498	0.468
LIG_FHA_1	275	281	PF00498	0.361
LIG_FHA_1	402	408	PF00498	0.363
LIG_FHA_1	473	479	PF00498	0.448
LIG_FHA_1	552	558	PF00498	0.294
LIG_FHA_1	632	638	PF00498	0.391
LIG_FHA_1	84	90	PF00498	0.503
LIG_FHA_2	107	113	PF00498	0.363
LIG_FHA_2	292	298	PF00498	0.410
LIG_FHA_2	633	639	PF00498	0.371
LIG_FHA_2	93	99	PF00498	0.350
LIG_GBD_Chelix_1	728	736	PF00786	0.386
LIG_LIR_Apic_2	361	365	PF02991	0.487
LIG_LIR_Apic_2	71	76	PF02991	0.370
LIG_LIR_Gen_1	160	171	PF02991	0.521
LIG_LIR_Gen_1	270	280	PF02991	0.405
LIG_LIR_Nem_3	160	166	PF02991	0.621
LIG_LIR_Nem_3	205	211	PF02991	0.344
LIG_LIR_Nem_3	270	275	PF02991	0.473
LIG_LIR_Nem_3	567	571	PF02991	0.446
LIG_LIR_Nem_3	598	604	PF02991	0.410
LIG_LIR_Nem_3	644	648	PF02991	0.400
LIG_LIR_Nem_3	660	665	PF02991	0.380
LIG_LIR_Nem_3	750	755	PF02991	0.497
LIG_MYND_3	618	622	PF01753	0.401
LIG_NRBOX	177	183	PF00104	0.370
LIG_NRBOX	556	562	PF00104	0.335
LIG_NRBOX	731	737	PF00104	0.289
LIG_PDZ_Class_2	781	786	PF00595	0.581
LIG_REV1ctd_RIR_1	135	145	PF16727	0.550
LIG_RPA_C_Fungi	136	148	PF08784	0.466
LIG_RPA_C_Fungi	721	733	PF08784	0.394
LIG_SH2_CRK	568	572	PF00017	0.419
LIG_SH2_CRK	645	649	PF00017	0.405
LIG_SH2_STAP1	332	336	PF00017	0.411
LIG_SH2_STAP1	41	45	PF00017	0.509
LIG_SH2_STAT3	402	405	PF00017	0.425
LIG_SH2_STAT5	106	109	PF00017	0.360
LIG_SH2_STAT5	136	139	PF00017	0.489
LIG_SH2_STAT5	187	190	PF00017	0.377
LIG_SH2_STAT5	402	405	PF00017	0.425
LIG_SH2_STAT5	539	542	PF00017	0.541
LIG_SH2_STAT5	705	708	PF00017	0.476
LIG_SH3_3	276	282	PF00018	0.364
LIG_SH3_3	454	460	PF00018	0.465
LIG_SH3_3	56	62	PF00018	0.457
LIG_SH3_3	675	681	PF00018	0.668
LIG_SH3_3	710	716	PF00018	0.472
LIG_SH3_3	736	742	PF00018	0.527
LIG_SUMO_SIM_anti_2	730	736	PF11976	0.365
LIG_SUMO_SIM_anti_2	86	91	PF11976	0.498
LIG_SUMO_SIM_par_1	150	161	PF11976	0.514
LIG_SUMO_SIM_par_1	221	226	PF11976	0.463
LIG_SUMO_SIM_par_1	301	308	PF11976	0.418
LIG_SUMO_SIM_par_1	559	564	PF11976	0.306
LIG_SUMO_SIM_par_1	84	91	PF11976	0.502
LIG_TRAF2_1	167	170	PF00917	0.460
LIG_TRAF2_1	358	361	PF00917	0.536
LIG_TRAF2_1	490	493	PF00917	0.365
LIG_TRAF2_1	629	632	PF00917	0.550
LIG_TRAF2_1	76	79	PF00917	0.449
LIG_TRFH_1	512	516	PF08558	0.415
LIG_TYR_ITIM	566	571	PF00017	0.410
LIG_WW_3	679	683	PF00397	0.600
LIG_WW_3	7	11	PF00397	0.524
MOD_CDC14_SPxK_1	36	39	PF00782	0.441
MOD_CDC14_SPxK_1	679	682	PF00782	0.728
MOD_CDK_SPK_2	181	186	PF00069	0.489
MOD_CDK_SPxK_1	33	39	PF00069	0.452
MOD_CDK_SPxK_1	676	682	PF00069	0.741
MOD_CK1_1	153	159	PF00069	0.615
MOD_CK1_1	161	167	PF00069	0.467
MOD_CK1_1	258	264	PF00069	0.532
MOD_CK1_1	308	314	PF00069	0.391
MOD_CK1_1	481	487	PF00069	0.612
MOD_CK1_1	564	570	PF00069	0.426
MOD_CK1_1	595	601	PF00069	0.428
MOD_CK1_1	630	636	PF00069	0.484
MOD_CK1_1	674	680	PF00069	0.665
MOD_CK1_1	685	691	PF00069	0.492
MOD_CK1_1	721	727	PF00069	0.422
MOD_CK2_1	164	170	PF00069	0.494
MOD_CK2_1	258	264	PF00069	0.550
MOD_CK2_1	291	297	PF00069	0.503
MOD_CK2_1	387	393	PF00069	0.446
MOD_CK2_1	591	597	PF00069	0.485
MOD_CK2_1	632	638	PF00069	0.389
MOD_CK2_1	755	761	PF00069	0.455
MOD_CK2_1	85	91	PF00069	0.438
MOD_CK2_1	92	98	PF00069	0.433
MOD_GlcNHglycan	160	163	PF01048	0.573
MOD_GlcNHglycan	20	23	PF01048	0.594
MOD_GlcNHglycan	294	297	PF01048	0.460
MOD_GlcNHglycan	336	339	PF01048	0.403
MOD_GlcNHglycan	389	392	PF01048	0.393
MOD_GlcNHglycan	463	466	PF01048	0.470
MOD_GlcNHglycan	54	57	PF01048	0.509
MOD_GlcNHglycan	551	554	PF01048	0.485
MOD_GlcNHglycan	673	676	PF01048	0.687
MOD_GlcNHglycan	685	688	PF01048	0.603
MOD_GlcNHglycan	713	716	PF01048	0.506
MOD_GlcNHglycan	747	750	PF01048	0.445
MOD_GSK3_1	13	20	PF00069	0.624
MOD_GSK3_1	150	157	PF00069	0.723
MOD_GSK3_1	177	184	PF00069	0.508
MOD_GSK3_1	185	192	PF00069	0.484
MOD_GSK3_1	255	262	PF00069	0.693
MOD_GSK3_1	292	299	PF00069	0.475
MOD_GSK3_1	33	40	PF00069	0.473
MOD_GSK3_1	481	488	PF00069	0.495
MOD_GSK3_1	545	552	PF00069	0.660
MOD_GSK3_1	591	598	PF00069	0.527
MOD_GSK3_1	627	634	PF00069	0.541
MOD_GSK3_1	64	71	PF00069	0.406
MOD_GSK3_1	669	676	PF00069	0.587
MOD_GSK3_1	755	762	PF00069	0.567
MOD_GSK3_1	81	88	PF00069	0.419
MOD_N-GLC_1	154	159	PF02516	0.579
MOD_N-GLC_1	189	194	PF02516	0.563
MOD_NEK2_1	203	208	PF00069	0.534
MOD_NEK2_1	233	238	PF00069	0.317
MOD_NEK2_1	406	411	PF00069	0.501
MOD_NEK2_1	448	453	PF00069	0.538
MOD_NEK2_1	478	483	PF00069	0.402
MOD_NEK2_1	52	57	PF00069	0.547
MOD_NEK2_1	561	566	PF00069	0.317
MOD_NEK2_1	755	760	PF00069	0.488
MOD_NEK2_2	371	376	PF00069	0.413
MOD_NEK2_2	657	662	PF00069	0.537
MOD_PIKK_1	323	329	PF00454	0.369
MOD_PIKK_1	39	45	PF00454	0.554
MOD_PIKK_1	401	407	PF00454	0.518
MOD_PIKK_1	427	433	PF00454	0.636
MOD_PKA_2	116	122	PF00069	0.496
MOD_PKA_2	185	191	PF00069	0.363
MOD_PKA_2	52	58	PF00069	0.486
MOD_PKA_2	564	570	PF00069	0.403
MOD_Plk_1	189	195	PF00069	0.559
MOD_Plk_1	296	302	PF00069	0.389
MOD_Plk_1	37	43	PF00069	0.566
MOD_Plk_1	631	637	PF00069	0.523
MOD_Plk_2-3	126	132	PF00069	0.573
MOD_Plk_2-3	221	227	PF00069	0.375
MOD_Plk_2-3	632	638	PF00069	0.461
MOD_Plk_4	177	183	PF00069	0.509
MOD_Plk_4	203	209	PF00069	0.416
MOD_Plk_4	325	331	PF00069	0.528
MOD_Plk_4	567	573	PF00069	0.404
MOD_Plk_4	632	638	PF00069	0.448
MOD_Plk_4	649	655	PF00069	0.390
MOD_Plk_4	657	663	PF00069	0.463
MOD_Plk_4	85	91	PF00069	0.429
MOD_ProDKin_1	181	187	PF00069	0.449
MOD_ProDKin_1	33	39	PF00069	0.469
MOD_ProDKin_1	411	417	PF00069	0.484
MOD_ProDKin_1	481	487	PF00069	0.474
MOD_ProDKin_1	506	512	PF00069	0.413
MOD_ProDKin_1	674	680	PF00069	0.766
MOD_SUMO_rev_2	72	81	PF00179	0.445
TRG_DiLeu_BaEn_1	325	330	PF01217	0.482
TRG_DiLeu_BaEn_4	173	179	PF01217	0.457
TRG_DiLeu_BaEn_4	693	699	PF01217	0.360
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.437
TRG_ENDOCYTIC_2	211	214	PF00928	0.444
TRG_ENDOCYTIC_2	568	571	PF00928	0.408
TRG_ENDOCYTIC_2	645	648	PF00928	0.411
TRG_ER_diArg_1	195	198	PF00400	0.506
TRG_ER_diArg_1	315	317	PF00400	0.452
TRG_ER_diArg_1	496	498	PF00400	0.478
TRG_ER_diArg_1	601	603	PF00400	0.503
TRG_ER_diArg_1	689	692	PF00400	0.430
TRG_NLS_MonoExtN_4	80	86	PF00514	0.516
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.410

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y7	Leptomonas seymouri	45%	99%
A0A1X0NZ28	Trypanosomatidae	28%	100%
A0A3R7M3M3	Trypanosoma rangeli	29%	100%
A0A3S7WTS3	Leishmania donovani	91%	100%
A4H8D9	Leishmania braziliensis	72%	91%
A4HWR1	Leishmania infantum	91%	100%
C9ZPS0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AQG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%