Putative eukaryotic translation initiation factor 1A

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 1A, putative

Species:

Leishmania major

UniProt:

Q4QF06_LEIMA

TriTrypDb:

LmjF.16.0140 , LMJLV39_160006500 , LMJSD75_160006500

Length:

168

Annotations

Annotations by Jardim et al.

Translation, eukaryotic translation initiation factor 1A

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 12
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

Q4QF06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF06

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0003743	translation initiation factor activity	4	11
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.491
CLV_NRD_NRD_1	70	72	PF00675	0.201
CLV_PCSK_KEX2_1	25	27	PF00082	0.461
CLV_PCSK_KEX2_1	85	87	PF00082	0.215
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.443
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.229
CLV_PCSK_SKI1_1	10	14	PF00082	0.483
CLV_PCSK_SKI1_1	26	30	PF00082	0.320
CLV_PCSK_SKI1_1	43	47	PF00082	0.174
DEG_APCC_KENBOX_2	109	113	PF00400	0.500
DOC_MAPK_gen_1	43	51	PF00069	0.401
DOC_MAPK_MEF2A_6	44	53	PF00069	0.415
DOC_USP7_MATH_1	14	18	PF00917	0.626
DOC_USP7_MATH_1	56	60	PF00917	0.428
DOC_USP7_UBL2_3	3	7	PF12436	0.505
DOC_WW_Pin1_4	98	103	PF00397	0.492
LIG_FHA_1	128	134	PF00498	0.568
LIG_FHA_2	99	105	PF00498	0.361
LIG_LIR_Apic_2	27	33	PF02991	0.474
LIG_LIR_Gen_1	130	139	PF02991	0.499
LIG_LIR_Gen_1	37	46	PF02991	0.402
LIG_LIR_Nem_3	130	135	PF02991	0.499
LIG_LIR_Nem_3	37	42	PF02991	0.402
LIG_PDZ_Class_3	163	168	PF00595	0.456
LIG_SH2_CRK	39	43	PF00017	0.401
LIG_SH2_GRB2like	30	33	PF00017	0.463
LIG_SH2_NCK_1	30	34	PF00017	0.474
LIG_SH2_PTP2	132	135	PF00017	0.522
LIG_SH2_SRC	30	33	PF00017	0.466
LIG_SH2_STAT5	132	135	PF00017	0.522
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.401
LIG_SUMO_SIM_anti_2	92	98	PF11976	0.401
LIG_TRAF2_1	120	123	PF00917	0.569
LIG_TYR_ITSM	128	135	PF00017	0.570
MOD_CK2_1	117	123	PF00069	0.323
MOD_CK2_1	98	104	PF00069	0.504
MOD_GlcNHglycan	119	122	PF01048	0.515
MOD_NEK2_2	8	13	PF00069	0.471
MOD_Plk_1	26	32	PF00069	0.525
MOD_Plk_4	57	63	PF00069	0.486
MOD_ProDKin_1	98	104	PF00069	0.489
MOD_SUMO_for_1	84	87	PF00179	0.456
TRG_DiLeu_BaEn_1	104	109	PF01217	0.324
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.403
TRG_ENDOCYTIC_2	132	135	PF00928	0.522
TRG_ENDOCYTIC_2	39	42	PF00928	0.401
TRG_Pf-PMV_PEXEL_1	106	111	PF00026	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z1	Leptomonas seymouri	88%	100%
A0A0S4JME0	Bodo saltans	57%	94%
A0A1X0NFW8	Trypanosomatidae	72%	99%
A0A3S5H6W6	Leishmania donovani	100%	100%
A0A422NDF4	Trypanosoma rangeli	71%	100%
A4H8E1	Leishmania braziliensis	99%	100%
A4HWR3	Leishmania infantum	100%	100%
C9ZW61	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	98%
E9AQH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O14602	Homo sapiens	37%	100%
P38912	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
P47813	Homo sapiens	37%	100%
P47814	Oryctolagus cuniculus	42%	100%
P47815	Triticum aestivum	40%	100%
P55877	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	46%	100%
P56331	Onobrychis viciifolia	38%	100%
Q54YJ6	Dictyostelium discoideum	40%	100%
Q5RA42	Pongo abelii	37%	100%
Q60872	Mus musculus	39%	100%
Q6GVM3	Pan troglodytes	37%	100%
Q6VV72	Rattus norvegicus	39%	100%
Q8BMJ3	Mus musculus	37%	100%