Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QF02_LEIMA

TriTrypDb:

LmjF.16.0180 , LMJLV39_160006900 , LMJSD75_160006900

Length:

158

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QF02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.657
CLV_NRD_NRD_1	96	98	PF00675	0.607
CLV_PCSK_KEX2_1	122	124	PF00082	0.683
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.683
CLV_PCSK_SKI1_1	106	110	PF00082	0.562
CLV_PCSK_SKI1_1	125	129	PF00082	0.684
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DOC_CKS1_1	12	17	PF01111	0.698
DOC_MAPK_gen_1	104	111	PF00069	0.658
DOC_USP7_MATH_1	150	154	PF00917	0.495
DOC_WW_Pin1_4	11	16	PF00397	0.577
DOC_WW_Pin1_4	128	133	PF00397	0.761
LIG_14-3-3_CanoR_1	6	15	PF00244	0.749
LIG_14-3-3_CterR_2	156	158	PF00244	0.601
LIG_BRCT_BRCA1_1	41	45	PF00533	0.730
LIG_FHA_2	12	18	PF00498	0.710
LIG_FHA_2	147	153	PF00498	0.497
LIG_FHA_2	55	61	PF00498	0.557
LIG_LIR_Apic_2	10	15	PF02991	0.698
LIG_LIR_Gen_1	62	72	PF02991	0.684
LIG_LIR_Nem_3	62	67	PF02991	0.657
LIG_SH2_CRK	64	68	PF00017	0.669
LIG_SH2_PTP2	12	15	PF00017	0.695
LIG_SH2_STAT5	12	15	PF00017	0.672
MOD_CK1_1	11	17	PF00069	0.734
MOD_CK1_1	121	127	PF00069	0.678
MOD_CK1_1	133	139	PF00069	0.519
MOD_CK1_1	33	39	PF00069	0.627
MOD_CK1_1	88	94	PF00069	0.709
MOD_CK2_1	128	134	PF00069	0.762
MOD_CK2_1	146	152	PF00069	0.481
MOD_CK2_1	33	39	PF00069	0.740
MOD_CK2_1	54	60	PF00069	0.550
MOD_GlcNHglycan	134	138	PF01048	0.582
MOD_GlcNHglycan	32	35	PF01048	0.617
MOD_GlcNHglycan	87	90	PF01048	0.741
MOD_GSK3_1	109	116	PF00069	0.524
MOD_GSK3_1	146	153	PF00069	0.497
MOD_GSK3_1	26	33	PF00069	0.647
MOD_GSK3_1	35	42	PF00069	0.645
MOD_GSK3_1	4	11	PF00069	0.712
MOD_GSK3_1	56	63	PF00069	0.544
MOD_N-GLC_1	150	155	PF02516	0.496
MOD_NEK2_1	109	114	PF00069	0.642
MOD_NEK2_1	45	50	PF00069	0.537
MOD_NEK2_1	67	72	PF00069	0.569
MOD_PIKK_1	109	115	PF00454	0.586
MOD_PKA_2	60	66	PF00069	0.670
MOD_Plk_2-3	130	136	PF00069	0.727
MOD_Plk_4	26	32	PF00069	0.466
MOD_Plk_4	8	14	PF00069	0.733
MOD_ProDKin_1	11	17	PF00069	0.578
MOD_ProDKin_1	128	134	PF00069	0.762
TRG_ENDOCYTIC_2	64	67	PF00928	0.661
TRG_ENDOCYTIC_2	99	102	PF00928	0.655
TRG_ER_diArg_1	123	126	PF00400	0.718

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NG26	Trypanosomatidae	32%	85%
A0A3S7WTR1	Leishmania donovani	86%	100%
A0A422NDE0	Trypanosoma rangeli	36%	84%
A4HWR7	Leishmania infantum	85%	100%
C9ZW57	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	80%
E9AI52	Leishmania braziliensis	89%	86%
E9AQH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5AP83	Trypanosoma cruzi	36%	84%