Las1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Las1 family protein

Gene product:

Las1-like, putative

Species:

Leishmania major

UniProt:

Q4QF01_LEIMA

TriTrypDb:

LmjF.16.0190 , LMJLV39_160007000 , LMJSD75_160007000

Length:

365

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0030684	preribosome	3	2
GO:0030687	preribosome, large subunit precursor	4	2
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	11
GO:0090730	Las1 complex	4	11
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1902555	endoribonuclease complex	4	11
GO:1902911	protein kinase complex	5	11
GO:1905348	endonuclease complex	3	11
GO:1905354	exoribonuclease complex	3	11
GO:1990234	transferase complex	3	11
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QF01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QF01

Function

Biological processes
Term	Name	Level	Count
GO:0000460	maturation of 5.8S rRNA	9	2
GO:0000470	maturation of LSU-rRNA	9	2
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006364	rRNA processing	8	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0016072	rRNA metabolic process	7	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.720
CLV_C14_Caspase3-7	43	47	PF00656	0.566
CLV_C14_Caspase3-7	53	57	PF00656	0.504
CLV_NRD_NRD_1	11	13	PF00675	0.518
CLV_NRD_NRD_1	130	132	PF00675	0.369
CLV_NRD_NRD_1	18	20	PF00675	0.480
CLV_NRD_NRD_1	190	192	PF00675	0.297
CLV_NRD_NRD_1	2	4	PF00675	0.596
CLV_NRD_NRD_1	26	28	PF00675	0.491
CLV_NRD_NRD_1	261	263	PF00675	0.704
CLV_NRD_NRD_1	347	349	PF00675	0.745
CLV_NRD_NRD_1	40	42	PF00675	0.648
CLV_PCSK_FUR_1	24	28	PF00082	0.562
CLV_PCSK_KEX2_1	103	105	PF00082	0.364
CLV_PCSK_KEX2_1	11	13	PF00082	0.497
CLV_PCSK_KEX2_1	116	118	PF00082	0.150
CLV_PCSK_KEX2_1	18	20	PF00082	0.495
CLV_PCSK_KEX2_1	192	194	PF00082	0.297
CLV_PCSK_KEX2_1	2	4	PF00082	0.552
CLV_PCSK_KEX2_1	26	28	PF00082	0.473
CLV_PCSK_KEX2_1	347	349	PF00082	0.750
CLV_PCSK_KEX2_1	40	42	PF00082	0.583
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.364
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.150
CLV_PCSK_PC1ET2_1	192	194	PF00082	0.297
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.694
CLV_PCSK_SKI1_1	104	108	PF00082	0.309
CLV_PCSK_SKI1_1	117	121	PF00082	0.280
CLV_PCSK_SKI1_1	12	16	PF00082	0.631
CLV_PCSK_SKI1_1	299	303	PF00082	0.514
DEG_APCC_DBOX_1	116	124	PF00400	0.297
DEG_APCC_DBOX_1	25	33	PF00400	0.664
DEG_Nend_UBRbox_1	1	4	PF02207	0.594
DOC_MAPK_gen_1	191	199	PF00069	0.297
DOC_MAPK_MEF2A_6	222	231	PF00069	0.297
DOC_PP1_RVXF_1	101	108	PF00149	0.311
DOC_PP2B_LxvP_1	288	291	PF13499	0.636
DOC_PP2B_LxvP_1	35	38	PF13499	0.693
DOC_USP7_MATH_1	216	220	PF00917	0.369
DOC_USP7_MATH_1	270	274	PF00917	0.690
DOC_WW_Pin1_4	331	336	PF00397	0.787
DOC_WW_Pin1_4	55	60	PF00397	0.744
DOC_WW_Pin1_4	81	86	PF00397	0.568
LIG_14-3-3_CanoR_1	191	200	PF00244	0.404
LIG_14-3-3_CanoR_1	271	279	PF00244	0.553
LIG_14-3-3_CanoR_1	62	69	PF00244	0.664
LIG_14-3-3_CterR_2	363	365	PF00244	0.692
LIG_Actin_WH2_2	143	161	PF00022	0.355
LIG_BIR_III_2	56	60	PF00653	0.510
LIG_BIR_III_4	308	312	PF00653	0.571
LIG_BRCT_BRCA1_1	88	92	PF00533	0.552
LIG_deltaCOP1_diTrp_1	95	99	PF00928	0.358
LIG_FHA_1	120	126	PF00498	0.391
LIG_FHA_1	141	147	PF00498	0.279
LIG_FHA_1	216	222	PF00498	0.406
LIG_FHA_1	272	278	PF00498	0.709
LIG_FHA_1	354	360	PF00498	0.587
LIG_FHA_1	82	88	PF00498	0.695
LIG_FHA_2	110	116	PF00498	0.398
LIG_FHA_2	292	298	PF00498	0.503
LIG_FHA_2	65	71	PF00498	0.692
LIG_LIR_Gen_1	98	107	PF02991	0.360
LIG_LIR_Nem_3	98	102	PF02991	0.282
LIG_Pex14_2	233	237	PF04695	0.279
LIG_Pex14_2	88	92	PF04695	0.497
LIG_SH2_SRC	139	142	PF00017	0.279
LIG_SH2_STAT3	245	248	PF00017	0.501
LIG_SH2_STAT5	139	142	PF00017	0.297
LIG_SH2_STAT5	245	248	PF00017	0.524
LIG_SH3_3	332	338	PF00018	0.582
LIG_SUMO_SIM_par_1	273	282	PF11976	0.482
LIG_SUMO_SIM_par_1	329	334	PF11976	0.610
MOD_CDK_SPxxK_3	55	62	PF00069	0.520
MOD_CK1_1	181	187	PF00069	0.410
MOD_CK1_1	256	262	PF00069	0.529
MOD_CK1_1	273	279	PF00069	0.517
MOD_CK1_1	284	290	PF00069	0.510
MOD_CK1_1	352	358	PF00069	0.649
MOD_CK2_1	109	115	PF00069	0.272
MOD_CK2_1	251	257	PF00069	0.585
MOD_CK2_1	55	61	PF00069	0.568
MOD_CMANNOS	96	99	PF00535	0.279
MOD_GlcNHglycan	117	120	PF01048	0.375
MOD_GlcNHglycan	183	186	PF01048	0.404
MOD_GlcNHglycan	257	261	PF01048	0.633
MOD_GlcNHglycan	283	286	PF01048	0.634
MOD_GlcNHglycan	351	354	PF01048	0.721
MOD_GlcNHglycan	75	78	PF01048	0.680
MOD_GSK3_1	115	122	PF00069	0.463
MOD_GSK3_1	348	355	PF00069	0.767
MOD_GSK3_1	51	58	PF00069	0.665
MOD_GSK3_1	71	78	PF00069	0.715
MOD_N-GLC_1	109	114	PF02516	0.399
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	109	114	PF00069	0.351
MOD_NEK2_1	178	183	PF00069	0.418
MOD_NEK2_1	231	236	PF00069	0.382
MOD_NEK2_2	119	124	PF00069	0.306
MOD_PIKK_1	231	237	PF00454	0.355
MOD_PKA_1	192	198	PF00069	0.355
MOD_PKA_1	347	353	PF00069	0.601
MOD_PKA_2	1	7	PF00069	0.595
MOD_PKA_2	192	198	PF00069	0.477
MOD_PKA_2	270	276	PF00069	0.551
MOD_PKA_2	347	353	PF00069	0.625
MOD_PKA_2	61	67	PF00069	0.761
MOD_Plk_1	256	262	PF00069	0.583
MOD_Plk_1	279	285	PF00069	0.623
MOD_Plk_2-3	304	310	PF00069	0.618
MOD_Plk_4	87	93	PF00069	0.423
MOD_ProDKin_1	331	337	PF00069	0.788
MOD_ProDKin_1	55	61	PF00069	0.743
MOD_ProDKin_1	81	87	PF00069	0.563
MOD_SUMO_rev_2	292	301	PF00179	0.567
MOD_SUMO_rev_2	95	105	PF00179	0.356
TRG_DiLeu_BaEn_4	30	36	PF01217	0.574
TRG_ER_diArg_1	1	3	PF00400	0.656
TRG_ER_diArg_1	126	129	PF00400	0.417
TRG_ER_diArg_1	18	20	PF00400	0.507
TRG_ER_diArg_1	190	193	PF00400	0.279
TRG_ER_diArg_1	206	209	PF00400	0.279
TRG_ER_diArg_1	24	27	PF00400	0.574
TRG_ER_diArg_1	264	267	PF00400	0.683
TRG_NES_CRM1_1	220	230	PF08389	0.279
TRG_NLS_MonoCore_2	261	266	PF00514	0.579
TRG_NLS_MonoExtC_3	190	196	PF00514	0.322
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG6	Leptomonas seymouri	57%	100%
A0A0S4JJ56	Bodo saltans	36%	100%
A0A1X0NFY0	Trypanosomatidae	44%	100%
A0A3Q8IA87	Leishmania donovani	86%	100%
A0A3R7K8F7	Trypanosoma rangeli	44%	100%
A4H8E5	Leishmania braziliensis	76%	100%
A4HWR8	Leishmania infantum	86%	100%
C9ZW55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	97%
E9AQH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%