Mitochondrial ornithine transporter 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial ornithine transporter 1-like protein

Species:

Leishmania major

UniProt:

Q4QEZ9_LEIMA

TriTrypDb:

LmjF.16.0210 , LMJLV39_160007300 , LMJSD75_160007300

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QEZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ9

Function

Biological processes
Term	Name	Level	Count
GO:0003333	amino acid transmembrane transport	5	2
GO:0006810	transport	3	3
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006820	monoatomic anion transport	5	2
GO:0006865	amino acid transport	5	2
GO:0009987	cellular process	1	3
GO:0015711	organic anion transport	5	2
GO:0015807	L-amino acid transport	5	2
GO:0015822	ornithine transport	6	2
GO:0015849	organic acid transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0046942	carboxylic acid transport	6	2
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0055085	transmembrane transport	2	3
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0098655	monoatomic cation transmembrane transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1902475	L-alpha-amino acid transmembrane transport	6	2
GO:1903352	L-ornithine transmembrane transport	5	2
GO:1903825	organic acid transmembrane transport	3	2
GO:1905039	carboxylic acid transmembrane transport	4	2
GO:1990542	mitochondrial transmembrane transport	3	2
GO:1990575	mitochondrial L-ornithine transmembrane transport	4	2

Molecular functions
Term	Name	Level	Count
GO:0000064	L-ornithine transmembrane transporter activity	5	2
GO:0005215	transporter activity	1	2
GO:0005342	organic acid transmembrane transporter activity	3	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015171	amino acid transmembrane transporter activity	5	2
GO:0015179	L-amino acid transmembrane transporter activity	6	2
GO:0022857	transmembrane transporter activity	2	2
GO:0046943	carboxylic acid transmembrane transporter activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.511
CLV_NRD_NRD_1	109	111	PF00675	0.332
CLV_NRD_NRD_1	198	200	PF00675	0.339
CLV_NRD_NRD_1	42	44	PF00675	0.173
CLV_PCSK_KEX2_1	197	199	PF00082	0.400
CLV_PCSK_KEX2_1	42	44	PF00082	0.173
CLV_PCSK_PC7_1	193	199	PF00082	0.330
CLV_PCSK_SKI1_1	229	233	PF00082	0.388
CLV_PCSK_SKI1_1	329	333	PF00082	0.388
DEG_APCC_DBOX_1	228	236	PF00400	0.330
DOC_CKS1_1	176	181	PF01111	0.269
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.397
DOC_PP2B_LxvP_1	83	86	PF13499	0.397
DOC_USP7_MATH_1	152	156	PF00917	0.664
DOC_USP7_MATH_1	254	258	PF00917	0.505
DOC_USP7_MATH_1	359	363	PF00917	0.535
DOC_USP7_MATH_1	365	369	PF00917	0.591
DOC_USP7_MATH_1	51	55	PF00917	0.282
DOC_WW_Pin1_4	124	129	PF00397	0.484
DOC_WW_Pin1_4	156	161	PF00397	0.607
DOC_WW_Pin1_4	175	180	PF00397	0.135
DOC_WW_Pin1_4	42	47	PF00397	0.378
LIG_14-3-3_CanoR_1	197	206	PF00244	0.391
LIG_14-3-3_CanoR_1	305	311	PF00244	0.414
LIG_14-3-3_CanoR_1	329	338	PF00244	0.365
LIG_BRCT_BRCA1_1	334	338	PF00533	0.378
LIG_BRCT_MDC1_1	379	383	PF00533	0.569
LIG_deltaCOP1_diTrp_1	246	252	PF00928	0.306
LIG_FHA_1	15	21	PF00498	0.323
LIG_FHA_1	226	232	PF00498	0.314
LIG_FHA_1	302	308	PF00498	0.378
LIG_FHA_2	176	182	PF00498	0.254
LIG_FHA_2	337	343	PF00498	0.397
LIG_LIR_Apic_2	155	160	PF02991	0.636
LIG_LIR_Gen_1	62	71	PF02991	0.185
LIG_LIR_Nem_3	352	358	PF02991	0.526
LIG_LIR_Nem_3	62	67	PF02991	0.296
LIG_LIR_Nem_3	78	83	PF02991	0.268
LIG_PCNA_yPIPBox_3	102	111	PF02747	0.330
LIG_Pex14_1	279	283	PF04695	0.298
LIG_PTB_Apo_2	231	238	PF02174	0.397
LIG_PTB_Phospho_1	231	237	PF10480	0.397
LIG_SH2_CRK	220	224	PF00017	0.306
LIG_SH2_CRK	355	359	PF00017	0.445
LIG_SH2_CRK	80	84	PF00017	0.283
LIG_SH2_STAT5	220	223	PF00017	0.427
LIG_SH2_STAT5	237	240	PF00017	0.262
LIG_SH2_STAT5	80	83	PF00017	0.438
LIG_WRC_WIRS_1	76	81	PF05994	0.314
MOD_CK1_1	155	161	PF00069	0.586
MOD_CK1_1	366	372	PF00069	0.602
MOD_CK1_1	53	59	PF00069	0.249
MOD_CK2_1	175	181	PF00069	0.294
MOD_CK2_1	254	260	PF00069	0.454
MOD_CK2_1	336	342	PF00069	0.348
MOD_GlcNHglycan	124	127	PF01048	0.631
MOD_GlcNHglycan	165	168	PF01048	0.435
MOD_GlcNHglycan	190	193	PF01048	0.379
MOD_GlcNHglycan	273	276	PF01048	0.258
MOD_GlcNHglycan	312	315	PF01048	0.456
MOD_GlcNHglycan	345	348	PF01048	0.379
MOD_GlcNHglycan	361	364	PF01048	0.468
MOD_GlcNHglycan	365	368	PF01048	0.537
MOD_GlcNHglycan	55	58	PF01048	0.306
MOD_GSK3_1	152	159	PF00069	0.611
MOD_GSK3_1	171	178	PF00069	0.246
MOD_GSK3_1	221	228	PF00069	0.377
MOD_GSK3_1	306	313	PF00069	0.390
MOD_GSK3_1	332	339	PF00069	0.397
MOD_GSK3_1	359	366	PF00069	0.526
MOD_N-GLC_1	101	106	PF02516	0.330
MOD_NEK2_1	171	176	PF00069	0.397
MOD_NEK2_1	210	215	PF00069	0.443
MOD_NEK2_1	303	308	PF00069	0.417
MOD_NEK2_1	310	315	PF00069	0.414
MOD_NEK2_1	32	37	PF00069	0.424
MOD_NEK2_1	331	336	PF00069	0.380
MOD_NEK2_1	50	55	PF00069	0.185
MOD_NEK2_2	24	29	PF00069	0.254
MOD_NEK2_2	75	80	PF00069	0.332
MOD_PIKK_1	210	216	PF00454	0.185
MOD_PIKK_1	65	71	PF00454	0.410
MOD_PKA_1	198	204	PF00069	0.282
MOD_PKA_2	122	128	PF00069	0.602
MOD_PKA_2	198	204	PF00069	0.424
MOD_PKA_2	359	365	PF00069	0.509
MOD_PKB_1	197	205	PF00069	0.402
MOD_Plk_1	101	107	PF00069	0.330
MOD_Plk_1	349	355	PF00069	0.503
MOD_Plk_4	152	158	PF00069	0.603
MOD_Plk_4	171	177	PF00069	0.274
MOD_Plk_4	264	270	PF00069	0.315
MOD_Plk_4	306	312	PF00069	0.420
MOD_Plk_4	323	329	PF00069	0.417
MOD_Plk_4	332	338	PF00069	0.382
MOD_Plk_4	350	356	PF00069	0.376
MOD_Plk_4	59	65	PF00069	0.424
MOD_ProDKin_1	124	130	PF00069	0.484
MOD_ProDKin_1	156	162	PF00069	0.594
MOD_ProDKin_1	175	181	PF00069	0.135
MOD_ProDKin_1	42	48	PF00069	0.378
MOD_SUMO_rev_2	125	133	PF00179	0.588
TRG_ENDOCYTIC_2	220	223	PF00928	0.363
TRG_ENDOCYTIC_2	278	281	PF00928	0.397
TRG_ENDOCYTIC_2	355	358	PF00928	0.448
TRG_ENDOCYTIC_2	80	83	PF00928	0.283
TRG_ER_diArg_1	121	124	PF00400	0.720
TRG_ER_diArg_1	196	199	PF00400	0.419
TRG_ER_diArg_1	41	43	PF00400	0.209
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K309	Rattus norvegicus	28%	100%
A0A0N0P7X0	Leptomonas seymouri	26%	100%
A0A0N0P7Y4	Leptomonas seymouri	30%	100%
A0A0N1HX25	Leptomonas seymouri	22%	100%
A0A0N1I8T5	Leptomonas seymouri	23%	100%
A0A0N1IMA2	Leptomonas seymouri	52%	100%
A0A0S4IMF4	Bodo saltans	22%	100%
A0A0S4IV98	Bodo saltans	26%	100%
A0A0S4IZG7	Bodo saltans	22%	100%
A0A0S4JIA4	Bodo saltans	24%	90%
A0A0S4JM95	Bodo saltans	32%	100%
A0A0S4JR63	Bodo saltans	23%	100%
A0A1X0NFT4	Trypanosomatidae	32%	100%
A0A1X0NIA3	Trypanosomatidae	23%	100%
A0A1X0NJD2	Trypanosomatidae	25%	100%
A0A1X0NLW7	Trypanosomatidae	24%	100%
A0A1X0NUT2	Trypanosomatidae	26%	100%
A0A1X0P4Q9	Trypanosomatidae	27%	100%
A0A3R7KGU8	Trypanosoma rangeli	28%	100%
A0A3R7N0M4	Trypanosoma rangeli	25%	100%
A0A3R7RT89	Trypanosoma rangeli	24%	100%
A0A3S5H6W7	Leishmania donovani	92%	100%
A0A3S7WTS6	Leishmania donovani	27%	100%
A0A3S7WYS1	Leishmania donovani	26%	100%
A0A422NF39	Trypanosoma rangeli	27%	100%
A0A422NVT9	Trypanosoma rangeli	21%	100%
A0JN87	Bos taurus	21%	100%
A1CIF6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	26%	100%
A1CWA4	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	25%	100%
A2Q9F0	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	25%	100%
A4H8E6	Leishmania braziliensis	26%	100%
A4H8E7	Leishmania braziliensis	76%	99%
A4HDW8	Leishmania braziliensis	24%	100%
A4HWR9	Leishmania infantum	27%	100%
A4HWS0	Leishmania infantum	92%	100%
A4I163	Leishmania infantum	26%	100%
A4QNX2	Danio rerio	28%	100%
A6RAY2	Ajellomyces capsulatus (strain NAm1 / WU24)	24%	100%
B0Y4J4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	25%	100%
C9ZW54	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
D0A5E9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A9N0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AMX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AQH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AQH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9AX97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O04619	Arabidopsis thaliana	23%	100%
O14281	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
O43772	Homo sapiens	26%	100%
O97562	Sus scrofa	24%	100%
O97649	Sus scrofa	22%	100%
P10566	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
P25874	Homo sapiens	23%	100%
P32331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P33303	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
P38087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
P38152	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P40464	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	20%	100%
P97521	Rattus norvegicus	25%	100%
Q01356	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
Q03028	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
Q08DK4	Bos taurus	25%	100%
Q08DK7	Bos taurus	23%	100%
Q0CT66	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	25%	100%
Q10248	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	100%
Q12289	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q12375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
Q17QI7	Bos taurus	24%	100%
Q1ECW7	Danio rerio	25%	100%
Q1LZB3	Bos taurus	22%	100%
Q27257	Caenorhabditis elegans	23%	100%
Q287T7	Danio rerio	22%	100%
Q2UU67	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	24%	100%
Q3MHI3	Bos taurus	25%	100%
Q3SZI5	Bos taurus	23%	100%
Q3TZX3	Mus musculus	23%	100%
Q498U3	Rattus norvegicus	21%	100%
Q4QA75	Leishmania major	27%	85%
Q4QF00	Leishmania major	27%	100%
Q4WQC5	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q54BM3	Dictyostelium discoideum	22%	100%
Q54FE6	Dictyostelium discoideum	26%	100%
Q54VS7	Dictyostelium discoideum	21%	100%
Q54W11	Dictyostelium discoideum	21%	100%
Q55DY8	Dictyostelium discoideum	24%	100%
Q55E85	Dictyostelium discoideum	24%	100%
Q5B717	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	23%	100%
Q5HZE0	Rattus norvegicus	23%	100%
Q5RFB7	Pongo abelii	23%	100%
Q5ZKP7	Gallus gallus	24%	100%
Q6DG32	Danio rerio	26%	100%
Q6DHS9	Danio rerio	23%	100%
Q6IS41	Mus musculus	26%	100%
Q6J329	Rattus norvegicus	25%	100%
Q6NYZ6	Danio rerio	22%	82%
Q6P036	Danio rerio	23%	100%
Q6Q0C1	Homo sapiens	25%	100%
Q6ZT89	Homo sapiens	26%	100%
Q7ZYD5	Xenopus laevis	23%	75%
Q84UC7	Arabidopsis thaliana	25%	100%
Q86AV5	Dictyostelium discoideum	23%	100%
Q86HN8	Dictyostelium discoideum	22%	88%
Q8BGP6	Mus musculus	20%	100%
Q8BL03	Mus musculus	22%	100%
Q8BW66	Mus musculus	27%	100%
Q8BZ09	Mus musculus	24%	100%
Q8CFJ7	Mus musculus	23%	100%
Q8HXY2	Macaca fascicularis	26%	100%
Q8N413	Homo sapiens	23%	100%
Q8N8R3	Homo sapiens	24%	100%
Q8RWA5	Arabidopsis thaliana	23%	100%
Q922G0	Mus musculus	23%	100%
Q93XM7	Arabidopsis thaliana	27%	100%
Q94AG6	Arabidopsis thaliana	25%	100%
Q96CQ1	Homo sapiens	24%	100%
Q99297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q99JD3	Rattus norvegicus	25%	100%
Q9BQT8	Homo sapiens	24%	100%
Q9BSK2	Homo sapiens	22%	100%
Q9BXI2	Homo sapiens	27%	100%
Q9BZJ4	Homo sapiens	25%	100%
Q9CA93	Arabidopsis thaliana	25%	100%
Q9D8K8	Mus musculus	24%	100%
Q9FI73	Arabidopsis thaliana	23%	100%
Q9P6L7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	21%	100%
Q9P7X9	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q9SB52	Arabidopsis thaliana	22%	100%
Q9VM51	Drosophila melanogaster	24%	100%
Q9VQ37	Drosophila melanogaster	23%	100%
Q9VQG4	Drosophila melanogaster	23%	100%
Q9W720	Danio rerio	23%	100%
Q9WVD5	Mus musculus	29%	100%
Q9Y619	Homo sapiens	28%	100%
Q9Z2Z6	Mus musculus	26%	100%
V5B5N3	Trypanosoma cruzi	22%	100%
V5BD15	Trypanosoma cruzi	24%	100%
V5BDR1	Trypanosoma cruzi	31%	100%
V5BI33	Trypanosoma cruzi	24%	100%
V5BP20	Trypanosoma cruzi	26%	100%
V5BSW1	Trypanosoma cruzi	27%	100%
V5BVW0	Trypanosoma cruzi	24%	100%