Elongator complex protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Elongator-like Protein 3a, putative

Species:

Leishmania major

UniProt:

Q4QEZ6_LEIMA

TriTrypDb:

LmjF.16.0240 , LMJLV39_160007600 , LMJSD75_160007600

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005635	nuclear envelope	4	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	3
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0032991	protein-containing complex	1	3
GO:0033588	elongator holoenzyme complex	3	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0140535	intracellular protein-containing complex	2	3
GO:1902494	catalytic complex	2	3
GO:0016020	membrane	2	1
GO:0005819	spindle	5	1

Expansion

Sequence features

Q4QEZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ6

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	3
GO:0002098	tRNA wobble uridine modification	8	3
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation	9	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	2
GO:0006396	RNA processing	6	3
GO:0006399	tRNA metabolic process	7	3
GO:0006400	tRNA modification	6	3
GO:0006473	protein acetylation	6	2
GO:0006475	internal protein amino acid acetylation	7	2
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0006996	organelle organization	4	2
GO:0008033	tRNA processing	8	3
GO:0008152	metabolic process	1	3
GO:0009451	RNA modification	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	2
GO:0016070	RNA metabolic process	5	3
GO:0016570	histone modification	5	2
GO:0016573	histone acetylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0018393	internal peptidyl-lysine acetylation	8	2
GO:0018394	peptidyl-lysine acetylation	7	2
GO:0019538	protein metabolic process	3	2
GO:0034470	ncRNA processing	7	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034660	ncRNA metabolic process	6	3
GO:0036211	protein modification process	4	2
GO:0043007	maintenance of rDNA	6	2
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0043543	protein acylation	5	2
GO:0043570	maintenance of DNA repeat elements	5	2
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	3
GO:0051276	chromosome organization	5	2
GO:0071704	organic substance metabolic process	2	3
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	19
GO:0003676	nucleic acid binding	3	19
GO:0003723	RNA binding	4	19
GO:0003824	catalytic activity	1	19
GO:0005488	binding	1	19
GO:0016407	acetyltransferase activity	5	19
GO:0016740	transferase activity	2	19
GO:0016746	acyltransferase activity	3	19
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	19
GO:0043167	ion binding	2	19
GO:0043169	cation binding	3	19
GO:0046872	metal ion binding	4	19
GO:0051536	iron-sulfur cluster binding	3	19
GO:0051539	4 iron, 4 sulfur cluster binding	4	19
GO:0051540	metal cluster binding	2	19
GO:0097159	organic cyclic compound binding	2	19
GO:0106261	tRNA uridine(34) acetyltransferase activity	6	11
GO:1901363	heterocyclic compound binding	2	19

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.337
CLV_C14_Caspase3-7	656	660	PF00656	0.577
CLV_NRD_NRD_1	226	228	PF00675	0.226
CLV_NRD_NRD_1	295	297	PF00675	0.289
CLV_NRD_NRD_1	336	338	PF00675	0.257
CLV_NRD_NRD_1	524	526	PF00675	0.284
CLV_NRD_NRD_1	637	639	PF00675	0.289
CLV_NRD_NRD_1	735	737	PF00675	0.611
CLV_NRD_NRD_1	80	82	PF00675	0.459
CLV_NRD_NRD_1	84	86	PF00675	0.463
CLV_PCSK_KEX2_1	226	228	PF00082	0.219
CLV_PCSK_KEX2_1	295	297	PF00082	0.286
CLV_PCSK_KEX2_1	336	338	PF00082	0.257
CLV_PCSK_KEX2_1	524	526	PF00082	0.283
CLV_PCSK_KEX2_1	636	638	PF00082	0.268
CLV_PCSK_KEX2_1	737	739	PF00082	0.544
CLV_PCSK_KEX2_1	84	86	PF00082	0.587
CLV_PCSK_PC1ET2_1	636	638	PF00082	0.325
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.520
CLV_PCSK_PC7_1	632	638	PF00082	0.283
CLV_PCSK_SKI1_1	278	282	PF00082	0.226
CLV_PCSK_SKI1_1	372	376	PF00082	0.210
CLV_PCSK_SKI1_1	398	402	PF00082	0.320
CLV_PCSK_SKI1_1	484	488	PF00082	0.236
CLV_PCSK_SKI1_1	504	508	PF00082	0.217
CLV_PCSK_SKI1_1	517	521	PF00082	0.436
CLV_PCSK_SKI1_1	84	88	PF00082	0.418
CLV_PCSK_SKI1_1	89	93	PF00082	0.352
CLV_PCSK_SKI1_1	97	101	PF00082	0.400
DEG_APCC_DBOX_1	295	303	PF00400	0.469
DOC_CDC14_PxL_1	28	36	PF14671	0.420
DOC_CKS1_1	421	426	PF01111	0.426
DOC_CKS1_1	560	565	PF01111	0.274
DOC_CYCLIN_yClb1_LxF_4	228	233	PF00134	0.426
DOC_CYCLIN_yClb5_NLxxxL_5	478	487	PF00134	0.437
DOC_MAPK_gen_1	175	185	PF00069	0.433
DOC_MAPK_gen_1	226	233	PF00069	0.426
DOC_MAPK_gen_1	242	249	PF00069	0.426
DOC_MAPK_gen_1	292	301	PF00069	0.385
DOC_MAPK_gen_1	453	462	PF00069	0.426
DOC_MAPK_gen_1	84	93	PF00069	0.416
DOC_MAPK_HePTP_8	450	462	PF00069	0.426
DOC_MAPK_MEF2A_6	292	301	PF00069	0.385
DOC_MAPK_MEF2A_6	453	462	PF00069	0.421
DOC_PP1_RVXF_1	168	175	PF00149	0.534
DOC_PP1_RVXF_1	228	234	PF00149	0.426
DOC_PP2B_PxIxI_1	457	463	PF00149	0.525
DOC_PP4_FxxP_1	174	177	PF00568	0.562
DOC_PP4_FxxP_1	288	291	PF00568	0.525
DOC_USP7_MATH_1	155	159	PF00917	0.662
DOC_USP7_MATH_1	590	594	PF00917	0.404
DOC_USP7_MATH_1	598	602	PF00917	0.379
DOC_USP7_MATH_1	66	70	PF00917	0.489
DOC_WW_Pin1_4	141	146	PF00397	0.718
DOC_WW_Pin1_4	153	158	PF00397	0.698
DOC_WW_Pin1_4	390	395	PF00397	0.336
DOC_WW_Pin1_4	404	409	PF00397	0.377
DOC_WW_Pin1_4	420	425	PF00397	0.426
DOC_WW_Pin1_4	435	440	PF00397	0.426
DOC_WW_Pin1_4	517	522	PF00397	0.563
DOC_WW_Pin1_4	559	564	PF00397	0.271
DOC_WW_Pin1_4	592	597	PF00397	0.249
DOC_WW_Pin1_4	694	699	PF00397	0.694
LIG_14-3-3_CanoR_1	242	247	PF00244	0.426
LIG_14-3-3_CanoR_1	687	695	PF00244	0.720
LIG_14-3-3_CanoR_1	726	730	PF00244	0.495
LIG_APCC_ABBA_1	114	119	PF00400	0.463
LIG_BIR_II_1	1	5	PF00653	0.645
LIG_eIF4E_1	440	446	PF01652	0.445
LIG_FHA_1	159	165	PF00498	0.471
LIG_FHA_1	511	517	PF00498	0.599
LIG_FHA_1	714	720	PF00498	0.551
LIG_FHA_2	284	290	PF00498	0.467
LIG_FHA_2	320	326	PF00498	0.423
LIG_FHA_2	361	367	PF00498	0.451
LIG_FHA_2	5	11	PF00498	0.586
LIG_FHA_2	518	524	PF00498	0.367
LIG_FHA_2	583	589	PF00498	0.319
LIG_FHA_2	68	74	PF00498	0.539
LIG_LIR_Apic_2	266	271	PF02991	0.539
LIG_LIR_Apic_2	286	291	PF02991	0.525
LIG_LIR_Gen_1	169	177	PF02991	0.551
LIG_LIR_Gen_1	422	432	PF02991	0.447
LIG_LIR_Gen_1	532	541	PF02991	0.336
LIG_LIR_Gen_1	561	572	PF02991	0.270
LIG_LIR_Gen_1	617	626	PF02991	0.302
LIG_LIR_LC3C_4	181	186	PF02991	0.394
LIG_LIR_Nem_3	169	174	PF02991	0.528
LIG_LIR_Nem_3	200	206	PF02991	0.263
LIG_LIR_Nem_3	232	236	PF02991	0.438
LIG_LIR_Nem_3	264	268	PF02991	0.451
LIG_LIR_Nem_3	413	418	PF02991	0.436
LIG_LIR_Nem_3	422	428	PF02991	0.448
LIG_LIR_Nem_3	434	440	PF02991	0.436
LIG_LIR_Nem_3	532	538	PF02991	0.311
LIG_LIR_Nem_3	561	567	PF02991	0.380
LIG_LIR_Nem_3	617	623	PF02991	0.286
LIG_MYND_3	31	35	PF01753	0.431
LIG_NRBOX	482	488	PF00104	0.430
LIG_Pex14_1	203	207	PF04695	0.426
LIG_Pex14_1	560	564	PF04695	0.283
LIG_Pex14_2	199	203	PF04695	0.268
LIG_PTAP_UEV_1	147	152	PF05743	0.492
LIG_SH2_CRK	579	583	PF00017	0.324
LIG_SH2_CRK	620	624	PF00017	0.254
LIG_SH2_CRK	640	644	PF00017	0.495
LIG_SH2_CRK	722	726	PF00017	0.425
LIG_SH2_CRK	83	87	PF00017	0.453
LIG_SH2_NCK_1	620	624	PF00017	0.323
LIG_SH2_STAP1	620	624	PF00017	0.323
LIG_SH2_STAT3	418	421	PF00017	0.426
LIG_SH2_STAT5	171	174	PF00017	0.385
LIG_SH2_STAT5	207	210	PF00017	0.451
LIG_SH2_STAT5	218	221	PF00017	0.451
LIG_SH2_STAT5	409	412	PF00017	0.376
LIG_SH2_STAT5	437	440	PF00017	0.441
LIG_SH2_STAT5	473	476	PF00017	0.451
LIG_SH2_STAT5	586	589	PF00017	0.399
LIG_SH3_1	206	212	PF00018	0.426
LIG_SH3_1	692	698	PF00018	0.477
LIG_SH3_2	291	296	PF14604	0.525
LIG_SH3_3	140	146	PF00018	0.703
LIG_SH3_3	160	166	PF00018	0.414
LIG_SH3_3	206	212	PF00018	0.451
LIG_SH3_3	288	294	PF00018	0.493
LIG_SH3_3	384	390	PF00018	0.479
LIG_SH3_3	535	541	PF00018	0.361
LIG_SH3_3	692	698	PF00018	0.491
LIG_SH3_3	700	706	PF00018	0.463
LIG_Sin3_3	132	139	PF02671	0.454
LIG_SUMO_SIM_anti_2	181	187	PF11976	0.371
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.451
LIG_SUMO_SIM_anti_2	621	627	PF11976	0.323
LIG_SUMO_SIM_par_1	181	187	PF11976	0.381
LIG_SxIP_EBH_1	692	705	PF03271	0.525
LIG_TRAF2_1	116	119	PF00917	0.564
LIG_TRAF2_1	520	523	PF00917	0.249
LIG_TRAF2_1	615	618	PF00917	0.249
LIG_TRAF2_1	750	753	PF00917	0.439
LIG_UBA3_1	445	453	PF00899	0.283
LIG_WW_3	289	293	PF00397	0.210
MOD_CDK_SPxxK_3	153	160	PF00069	0.580
MOD_CDK_SPxxK_3	517	524	PF00069	0.162
MOD_CK1_1	120	126	PF00069	0.469
MOD_CK1_1	158	164	PF00069	0.603
MOD_CK1_1	2	8	PF00069	0.688
MOD_CK1_1	510	516	PF00069	0.559
MOD_CK1_1	529	535	PF00069	0.315
MOD_CK2_1	2	8	PF00069	0.645
MOD_CK2_1	359	365	PF00069	0.284
MOD_CK2_1	423	429	PF00069	0.262
MOD_CK2_1	517	523	PF00069	0.302
MOD_CK2_1	582	588	PF00069	0.324
MOD_CK2_1	67	73	PF00069	0.570
MOD_CK2_1	747	753	PF00069	0.546
MOD_DYRK1A_RPxSP_1	592	596	PF00069	0.191
MOD_GlcNHglycan	12	15	PF01048	0.712
MOD_GlcNHglycan	122	126	PF01048	0.742
MOD_GlcNHglycan	148	151	PF01048	0.708
MOD_GlcNHglycan	180	183	PF01048	0.414
MOD_GlcNHglycan	190	193	PF01048	0.335
MOD_GlcNHglycan	309	312	PF01048	0.323
MOD_GlcNHglycan	47	50	PF01048	0.517
MOD_GlcNHglycan	509	512	PF01048	0.537
MOD_GlcNHglycan	517	520	PF01048	0.494
MOD_GlcNHglycan	600	603	PF01048	0.348
MOD_GlcNHglycan	626	629	PF01048	0.268
MOD_GlcNHglycan	733	736	PF01048	0.582
MOD_GSK3_1	10	17	PF00069	0.740
MOD_GSK3_1	117	124	PF00069	0.531
MOD_GSK3_1	146	153	PF00069	0.724
MOD_GSK3_1	155	162	PF00069	0.603
MOD_GSK3_1	184	191	PF00069	0.330
MOD_GSK3_1	319	326	PF00069	0.280
MOD_GSK3_1	360	367	PF00069	0.426
MOD_GSK3_1	419	426	PF00069	0.303
MOD_GSK3_1	539	546	PF00069	0.465
MOD_GSK3_1	659	666	PF00069	0.660
MOD_GSK3_1	686	693	PF00069	0.693
MOD_N-GLC_1	197	202	PF02516	0.358
MOD_N-GLC_1	307	312	PF02516	0.268
MOD_N-GLC_1	690	695	PF02516	0.712
MOD_NEK2_1	100	105	PF00069	0.548
MOD_NEK2_1	159	164	PF00069	0.391
MOD_NEK2_1	184	189	PF00069	0.353
MOD_NEK2_1	307	312	PF00069	0.277
MOD_NEK2_1	338	343	PF00069	0.315
MOD_NEK2_1	374	379	PF00069	0.268
MOD_NEK2_1	725	730	PF00069	0.568
MOD_NEK2_1	87	92	PF00069	0.471
MOD_NEK2_2	283	288	PF00069	0.303
MOD_PIKK_1	12	18	PF00454	0.508
MOD_PIKK_1	176	182	PF00454	0.414
MOD_PIKK_1	618	624	PF00454	0.439
MOD_PIKK_1	713	719	PF00454	0.599
MOD_PKA_2	100	106	PF00069	0.549
MOD_PKA_2	359	365	PF00069	0.283
MOD_PKA_2	686	692	PF00069	0.444
MOD_PKA_2	725	731	PF00069	0.499
MOD_Plk_1	52	58	PF00069	0.351
MOD_Plk_1	543	549	PF00069	0.378
MOD_Plk_1	674	680	PF00069	0.762
MOD_Plk_2-3	4	10	PF00069	0.590
MOD_Plk_2-3	539	545	PF00069	0.399
MOD_Plk_4	109	115	PF00069	0.653
MOD_Plk_4	159	165	PF00069	0.593
MOD_Plk_4	184	190	PF00069	0.357
MOD_Plk_4	283	289	PF00069	0.333
MOD_Plk_4	353	359	PF00069	0.362
MOD_Plk_4	543	549	PF00069	0.267
MOD_Plk_4	582	588	PF00069	0.368
MOD_Plk_4	87	93	PF00069	0.356
MOD_ProDKin_1	141	147	PF00069	0.721
MOD_ProDKin_1	153	159	PF00069	0.694
MOD_ProDKin_1	390	396	PF00069	0.335
MOD_ProDKin_1	404	410	PF00069	0.372
MOD_ProDKin_1	420	426	PF00069	0.268
MOD_ProDKin_1	435	441	PF00069	0.268
MOD_ProDKin_1	517	523	PF00069	0.402
MOD_ProDKin_1	559	565	PF00069	0.271
MOD_ProDKin_1	592	598	PF00069	0.249
MOD_ProDKin_1	694	700	PF00069	0.696
MOD_SUMO_rev_2	429	438	PF00179	0.278
TRG_DiLeu_BaEn_3	52	58	PF01217	0.351
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.361
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.368
TRG_ENDOCYTIC_2	171	174	PF00928	0.520
TRG_ENDOCYTIC_2	236	239	PF00928	0.283
TRG_ENDOCYTIC_2	579	582	PF00928	0.300
TRG_ENDOCYTIC_2	620	623	PF00928	0.327
TRG_ENDOCYTIC_2	640	643	PF00928	0.388
TRG_ENDOCYTIC_2	722	725	PF00928	0.564
TRG_ENDOCYTIC_2	83	86	PF00928	0.459
TRG_ENDOCYTIC_2	96	99	PF00928	0.416
TRG_ER_diArg_1	225	227	PF00400	0.268
TRG_ER_diArg_1	294	296	PF00400	0.361
TRG_ER_diArg_1	335	337	PF00400	0.311
TRG_ER_diArg_1	501	504	PF00400	0.348
TRG_ER_diArg_1	524	526	PF00400	0.303
TRG_ER_diArg_1	551	554	PF00400	0.303
TRG_ER_diArg_1	83	85	PF00400	0.570
TRG_NLS_MonoExtC_3	735	740	PF00514	0.626
TRG_NLS_MonoExtC_3	80	85	PF00514	0.477
TRG_NLS_MonoExtN_4	736	741	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFU7	Leptomonas seymouri	70%	100%
A0A0S4KPU1	Bodo saltans	60%	100%
A0A1X0NG94	Trypanosomatidae	59%	100%
A0A1X0NX69	Trypanosomatidae	45%	100%
A0A3Q8ICG0	Leishmania donovani	94%	100%
A0A3S7WXV4	Leishmania donovani	45%	100%
A0A422NDG5	Trypanosoma rangeli	60%	100%
A4H8F0	Leishmania braziliensis	83%	100%
A4HD08	Leishmania braziliensis	45%	100%
A4HWS3	Leishmania infantum	94%	100%
A4I0J4	Leishmania infantum	45%	100%
C9ZVC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZW50	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AQI1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	99%
E9AWF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
O14023	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q1ZXC6	Dictyostelium discoideum	32%	100%
Q2KJ61	Bos taurus	33%	100%
Q4QB17	Leishmania major	45%	100%
Q5HZM6	Xenopus laevis	34%	100%
Q5RIC0	Danio rerio	34%	100%
Q5ZHS1	Gallus gallus	33%	100%
Q6NVL5	Xenopus tropicalis	32%	100%
Q9CZX0	Mus musculus	33%	100%
Q9H9T3	Homo sapiens	32%	100%
V5B5L2	Trypanosoma cruzi	58%	100%