AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ankyrin repeats (many copies)/Alpha/beta hydrolase family, putative

Species:

Leishmania major

UniProt:

Q4QEZ4_LEIMA

TriTrypDb:

LmjF.16.0260 , LMJLV39_160007800 , LMJSD75_160007800

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QEZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	4
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0019538	protein metabolic process	3	4
GO:0043170	macromolecule metabolic process	3	4
GO:0044238	primary metabolic process	2	4
GO:0071704	organic substance metabolic process	2	4
GO:1901564	organonitrogen compound metabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0008233	peptidase activity	3	4
GO:0008236	serine-type peptidase activity	4	4
GO:0017171	serine hydrolase activity	3	4
GO:0140096	catalytic activity, acting on a protein	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.340
CLV_NRD_NRD_1	260	262	PF00675	0.288
CLV_NRD_NRD_1	385	387	PF00675	0.333
CLV_PCSK_FUR_1	258	262	PF00082	0.237
CLV_PCSK_KEX2_1	260	262	PF00082	0.257
CLV_PCSK_KEX2_1	29	31	PF00082	0.350
CLV_PCSK_KEX2_1	319	321	PF00082	0.334
CLV_PCSK_KEX2_1	385	387	PF00082	0.330
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.326
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.334
CLV_PCSK_SKI1_1	293	297	PF00082	0.248
CLV_PCSK_SKI1_1	386	390	PF00082	0.338
CLV_PCSK_SKI1_1	416	420	PF00082	0.278
CLV_PCSK_SKI1_1	76	80	PF00082	0.346
CLV_PCSK_SKI1_1	91	95	PF00082	0.219
DEG_APCC_DBOX_1	90	98	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.675
DEG_SCF_FBW7_1	79	86	PF00400	0.457
DEG_SPOP_SBC_1	351	355	PF00917	0.558
DOC_CKS1_1	80	85	PF01111	0.491
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.308
DOC_MAPK_DCC_7	412	420	PF00069	0.459
DOC_MAPK_gen_1	136	144	PF00069	0.436
DOC_MAPK_gen_1	244	253	PF00069	0.508
DOC_MAPK_gen_1	73	81	PF00069	0.496
DOC_MAPK_MEF2A_6	136	144	PF00069	0.440
DOC_MAPK_MEF2A_6	244	252	PF00069	0.535
DOC_MAPK_MEF2A_6	412	421	PF00069	0.469
DOC_MAPK_MEF2A_6	63	70	PF00069	0.457
DOC_MAPK_MEF2A_6	87	94	PF00069	0.481
DOC_MAPK_NFAT4_5	87	95	PF00069	0.504
DOC_MAPK_RevD_3	21	36	PF00069	0.553
DOC_PP2B_LxvP_1	142	145	PF13499	0.308
DOC_SPAK_OSR1_1	302	306	PF12202	0.437
DOC_USP7_MATH_1	191	195	PF00917	0.584
DOC_USP7_MATH_1	488	492	PF00917	0.694
DOC_USP7_MATH_1	83	87	PF00917	0.590
DOC_USP7_UBL2_3	25	29	PF12436	0.539
DOC_USP7_UBL2_3	315	319	PF12436	0.534
DOC_WW_Pin1_4	128	133	PF00397	0.694
DOC_WW_Pin1_4	411	416	PF00397	0.512
DOC_WW_Pin1_4	478	483	PF00397	0.676
DOC_WW_Pin1_4	484	489	PF00397	0.751
DOC_WW_Pin1_4	79	84	PF00397	0.539
LIG_14-3-3_CanoR_1	260	264	PF00244	0.539
LIG_14-3-3_CanoR_1	293	298	PF00244	0.463
LIG_14-3-3_CanoR_1	375	379	PF00244	0.537
LIG_14-3-3_CanoR_1	385	391	PF00244	0.512
LIG_14-3-3_CanoR_1	42	46	PF00244	0.531
LIG_14-3-3_CanoR_1	432	438	PF00244	0.504
LIG_BIR_III_4	38	42	PF00653	0.478
LIG_BRCT_BRCA1_1	367	371	PF00533	0.563
LIG_deltaCOP1_diTrp_1	203	208	PF00928	0.623
LIG_FHA_1	294	300	PF00498	0.478
LIG_FHA_1	387	393	PF00498	0.549
LIG_FHA_2	355	361	PF00498	0.525
LIG_FHA_2	438	444	PF00498	0.584
LIG_FHA_2	459	465	PF00498	0.514
LIG_Integrin_RGD_1	63	65	PF01839	0.339
LIG_LIR_Gen_1	219	225	PF02991	0.550
LIG_LIR_Gen_1	301	311	PF02991	0.462
LIG_LIR_Gen_1	44	55	PF02991	0.457
LIG_LIR_Nem_3	165	171	PF02991	0.312
LIG_LIR_Nem_3	219	223	PF02991	0.536
LIG_LIR_Nem_3	301	306	PF02991	0.462
LIG_LIR_Nem_3	379	384	PF02991	0.506
LIG_MAD2	137	145	PF02301	0.478
LIG_MLH1_MIPbox_1	367	371	PF16413	0.563
LIG_PCNA_yPIPBox_3	53	63	PF02747	0.504
LIG_Pex14_2	157	161	PF04695	0.310
LIG_Pex14_2	390	394	PF04695	0.541
LIG_PTB_Apo_2	269	276	PF02174	0.549
LIG_PTB_Phospho_1	269	275	PF10480	0.549
LIG_SH2_CRK	152	156	PF00017	0.447
LIG_SH2_CRK	275	279	PF00017	0.437
LIG_SH2_CRK	318	322	PF00017	0.504
LIG_SH2_NCK_1	220	224	PF00017	0.499
LIG_SH2_PTP2	237	240	PF00017	0.514
LIG_SH2_SRC	220	223	PF00017	0.495
LIG_SH2_SRC	237	240	PF00017	0.542
LIG_SH2_STAP1	376	380	PF00017	0.524
LIG_SH2_STAP1	466	470	PF00017	0.496
LIG_SH2_STAT3	370	373	PF00017	0.639
LIG_SH2_STAT5	170	173	PF00017	0.288
LIG_SH2_STAT5	175	178	PF00017	0.314
LIG_SH2_STAT5	237	240	PF00017	0.543
LIG_SH2_STAT5	370	373	PF00017	0.543
LIG_SH2_STAT5	448	451	PF00017	0.497
LIG_SH2_STAT5	59	62	PF00017	0.496
LIG_SH3_2	239	244	PF14604	0.556
LIG_SH3_3	235	241	PF00018	0.464
LIG_SH3_3	480	486	PF00018	0.719
LIG_SUMO_SIM_anti_2	342	347	PF11976	0.409
LIG_SUMO_SIM_par_1	362	368	PF11976	0.630
LIG_TRAF2_1	487	490	PF00917	0.660
LIG_TYR_ITIM	150	155	PF00017	0.411
LIG_TYR_ITIM	218	223	PF00017	0.354
LIG_UBA3_1	23	29	PF00899	0.422
LIG_WW_1	184	187	PF00397	0.360
LIG_WW_2	483	486	PF00397	0.476
MOD_CDK_SPK_2	411	416	PF00069	0.379
MOD_CK1_1	131	137	PF00069	0.593
MOD_CK1_1	15	21	PF00069	0.642
MOD_CK1_1	194	200	PF00069	0.467
MOD_CK2_1	3	9	PF00069	0.588
MOD_CK2_1	437	443	PF00069	0.453
MOD_CK2_1	484	490	PF00069	0.599
MOD_CMANNOS	205	208	PF00535	0.538
MOD_CMANNOS	391	394	PF00535	0.480
MOD_GlcNHglycan	107	110	PF01048	0.662
MOD_GlcNHglycan	193	196	PF01048	0.491
MOD_GlcNHglycan	288	291	PF01048	0.421
MOD_GlcNHglycan	354	357	PF01048	0.460
MOD_GlcNHglycan	367	370	PF01048	0.562
MOD_GSK3_1	124	131	PF00069	0.687
MOD_GSK3_1	15	22	PF00069	0.569
MOD_GSK3_1	324	331	PF00069	0.278
MOD_GSK3_1	350	357	PF00069	0.428
MOD_GSK3_1	484	491	PF00069	0.598
MOD_GSK3_1	55	62	PF00069	0.328
MOD_GSK3_1	79	86	PF00069	0.384
MOD_NEK2_1	311	316	PF00069	0.302
MOD_NEK2_1	324	329	PF00069	0.255
MOD_NEK2_1	365	370	PF00069	0.514
MOD_NEK2_1	424	429	PF00069	0.433
MOD_NEK2_1	437	442	PF00069	0.274
MOD_NEK2_1	458	463	PF00069	0.368
MOD_NEK2_1	92	97	PF00069	0.444
MOD_NEK2_2	41	46	PF00069	0.410
MOD_PKA_2	124	130	PF00069	0.677
MOD_PKA_2	259	265	PF00069	0.406
MOD_PKA_2	374	380	PF00069	0.455
MOD_PKA_2	41	47	PF00069	0.408
MOD_PKA_2	431	437	PF00069	0.374
MOD_PKB_1	10	18	PF00069	0.528
MOD_Plk_1	12	18	PF00069	0.593
MOD_Plk_1	339	345	PF00069	0.205
MOD_Plk_1	466	472	PF00069	0.472
MOD_Plk_2-3	259	265	PF00069	0.417
MOD_Plk_4	19	25	PF00069	0.412
MOD_Plk_4	329	335	PF00069	0.308
MOD_Plk_4	354	360	PF00069	0.407
MOD_Plk_4	386	392	PF00069	0.419
MOD_Plk_4	424	430	PF00069	0.517
MOD_Plk_4	466	472	PF00069	0.472
MOD_ProDKin_1	128	134	PF00069	0.627
MOD_ProDKin_1	411	417	PF00069	0.375
MOD_ProDKin_1	478	484	PF00069	0.622
MOD_ProDKin_1	79	85	PF00069	0.417
MOD_SUMO_rev_2	439	447	PF00179	0.346
MOD_SUMO_rev_2	69	78	PF00179	0.423
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.356
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.372
TRG_ENDOCYTIC_2	152	155	PF00928	0.355
TRG_ENDOCYTIC_2	170	173	PF00928	0.351
TRG_ENDOCYTIC_2	220	223	PF00928	0.386
TRG_ENDOCYTIC_2	275	278	PF00928	0.274
TRG_ENDOCYTIC_2	318	321	PF00928	0.294
TRG_ENDOCYTIC_2	47	50	PF00928	0.417
TRG_ER_diArg_1	384	386	PF00400	0.377
TRG_ER_diLys_1	492	495	PF00400	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G5	Leptomonas seymouri	76%	98%
A0A0S4IJD1	Bodo saltans	46%	98%
A0A1X0NHG0	Trypanosomatidae	57%	100%
A0A3S5H6W8	Leishmania donovani	96%	100%
A0A422N2H5	Trypanosoma rangeli	58%	100%
A4H8F2	Leishmania braziliensis	85%	100%
A4HWS5	Leishmania infantum	96%	100%
C9ZW49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5B955	Trypanosoma cruzi	58%	100%