LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QEZ3_LEIMA
TriTrypDb:
LmjF.16.0270 , LMJLV39_160007900 * , LMJSD75_160007900
Length:
1045

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEZ3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 718 722 PF00656 0.357
CLV_NRD_NRD_1 252 254 PF00675 0.522
CLV_NRD_NRD_1 268 270 PF00675 0.470
CLV_NRD_NRD_1 331 333 PF00675 0.579
CLV_NRD_NRD_1 873 875 PF00675 0.335
CLV_NRD_NRD_1 910 912 PF00675 0.358
CLV_NRD_NRD_1 985 987 PF00675 0.543
CLV_NRD_NRD_1 997 999 PF00675 0.411
CLV_PCSK_KEX2_1 251 253 PF00082 0.506
CLV_PCSK_KEX2_1 268 270 PF00082 0.474
CLV_PCSK_KEX2_1 331 333 PF00082 0.579
CLV_PCSK_KEX2_1 393 395 PF00082 0.354
CLV_PCSK_KEX2_1 873 875 PF00082 0.420
CLV_PCSK_KEX2_1 910 912 PF00082 0.358
CLV_PCSK_KEX2_1 985 987 PF00082 0.543
CLV_PCSK_KEX2_1 997 999 PF00082 0.411
CLV_PCSK_PC1ET2_1 393 395 PF00082 0.355
CLV_PCSK_SKI1_1 1000 1004 PF00082 0.470
CLV_PCSK_SKI1_1 298 302 PF00082 0.413
CLV_PCSK_SKI1_1 669 673 PF00082 0.346
CLV_PCSK_SKI1_1 760 764 PF00082 0.441
CLV_PCSK_SKI1_1 873 877 PF00082 0.394
CLV_PCSK_SKI1_1 929 933 PF00082 0.451
CLV_PCSK_SKI1_1 959 963 PF00082 0.526
CLV_Separin_Metazoa 207 211 PF03568 0.410
DEG_APCC_DBOX_1 338 346 PF00400 0.526
DEG_APCC_DBOX_1 668 676 PF00400 0.347
DEG_Nend_Nbox_1 1 3 PF02207 0.609
DEG_SCF_FBW7_1 177 184 PF00400 0.663
DEG_SCF_FBW7_1 228 235 PF00400 0.577
DEG_SPOP_SBC_1 176 180 PF00917 0.662
DEG_SPOP_SBC_1 279 283 PF00917 0.529
DEG_SPOP_SBC_1 3 7 PF00917 0.564
DOC_CYCLIN_RxL_1 266 277 PF00134 0.466
DOC_CYCLIN_yClb1_LxF_4 927 932 PF00134 0.363
DOC_CYCLIN_yCln2_LP_2 479 485 PF00134 0.442
DOC_CYCLIN_yCln2_LP_2 924 930 PF00134 0.381
DOC_CYCLIN_yCln2_LP_2 989 995 PF00134 0.433
DOC_MAPK_DCC_7 751 761 PF00069 0.437
DOC_MAPK_gen_1 12 21 PF00069 0.520
DOC_MAPK_gen_1 251 259 PF00069 0.453
DOC_MAPK_gen_1 542 551 PF00069 0.582
DOC_MAPK_gen_1 785 795 PF00069 0.540
DOC_MAPK_gen_1 803 812 PF00069 0.566
DOC_MAPK_gen_1 985 993 PF00069 0.497
DOC_MAPK_MEF2A_6 15 23 PF00069 0.478
DOC_MAPK_MEF2A_6 545 553 PF00069 0.455
DOC_MAPK_MEF2A_6 592 601 PF00069 0.380
DOC_MAPK_MEF2A_6 705 714 PF00069 0.366
DOC_MAPK_MEF2A_6 788 795 PF00069 0.427
DOC_MAPK_MEF2A_6 985 993 PF00069 0.485
DOC_MAPK_NFAT4_5 788 796 PF00069 0.416
DOC_PP1_RVXF_1 299 306 PF00149 0.380
DOC_PP1_RVXF_1 927 933 PF00149 0.365
DOC_PP2B_LxvP_1 597 600 PF13499 0.490
DOC_PP2B_LxvP_1 924 927 PF13499 0.398
DOC_PP2B_LxvP_1 989 992 PF13499 0.439
DOC_USP7_MATH_1 176 180 PF00917 0.672
DOC_USP7_MATH_1 188 192 PF00917 0.556
DOC_USP7_MATH_1 232 236 PF00917 0.655
DOC_USP7_MATH_1 324 328 PF00917 0.617
DOC_USP7_MATH_1 441 445 PF00917 0.594
DOC_USP7_MATH_1 50 54 PF00917 0.621
DOC_USP7_MATH_1 522 526 PF00917 0.615
DOC_USP7_MATH_1 564 568 PF00917 0.413
DOC_USP7_MATH_1 737 741 PF00917 0.451
DOC_USP7_MATH_1 783 787 PF00917 0.356
DOC_USP7_MATH_1 835 839 PF00917 0.365
DOC_USP7_MATH_1 87 91 PF00917 0.682
DOC_WW_Pin1_4 172 177 PF00397 0.769
DOC_WW_Pin1_4 228 233 PF00397 0.606
DOC_WW_Pin1_4 567 572 PF00397 0.354
DOC_WW_Pin1_4 735 740 PF00397 0.400
DOC_WW_Pin1_4 78 83 PF00397 0.693
DOC_WW_Pin1_4 810 815 PF00397 0.438
DOC_WW_Pin1_4 85 90 PF00397 0.625
DOC_WW_Pin1_4 862 867 PF00397 0.457
DOC_WW_Pin1_4 93 98 PF00397 0.475
DOC_WW_Pin1_4 953 958 PF00397 0.642
LIG_14-3-3_CanoR_1 15 19 PF00244 0.511
LIG_14-3-3_CanoR_1 210 216 PF00244 0.415
LIG_14-3-3_CanoR_1 331 340 PF00244 0.566
LIG_14-3-3_CanoR_1 4 13 PF00244 0.627
LIG_14-3-3_CanoR_1 521 531 PF00244 0.620
LIG_14-3-3_CanoR_1 657 663 PF00244 0.354
LIG_14-3-3_CanoR_1 682 691 PF00244 0.408
LIG_14-3-3_CanoR_1 785 795 PF00244 0.385
LIG_14-3-3_CanoR_1 803 812 PF00244 0.669
LIG_Actin_WH2_2 738 753 PF00022 0.355
LIG_APCC_ABBA_1 812 817 PF00400 0.383
LIG_Clathr_ClatBox_1 867 871 PF01394 0.478
LIG_CtBP_PxDLS_1 620 624 PF00389 0.522
LIG_eIF4E_1 1039 1045 PF01652 0.406
LIG_EVH1_1 144 148 PF00568 0.523
LIG_FHA_1 1021 1027 PF00498 0.574
LIG_FHA_1 1039 1045 PF00498 0.387
LIG_FHA_1 203 209 PF00498 0.496
LIG_FHA_1 55 61 PF00498 0.629
LIG_FHA_1 632 638 PF00498 0.437
LIG_FHA_1 683 689 PF00498 0.433
LIG_FHA_1 707 713 PF00498 0.413
LIG_FHA_1 817 823 PF00498 0.364
LIG_FHA_1 850 856 PF00498 0.634
LIG_FHA_2 272 278 PF00498 0.495
LIG_FHA_2 283 289 PF00498 0.580
LIG_FHA_2 368 374 PF00498 0.432
LIG_FHA_2 39 45 PF00498 0.502
LIG_FHA_2 491 497 PF00498 0.488
LIG_GBD_Chelix_1 605 613 PF00786 0.402
LIG_LIR_Apic_2 142 147 PF02991 0.478
LIG_LIR_Apic_2 430 436 PF02991 0.561
LIG_LIR_Apic_2 754 758 PF02991 0.369
LIG_LIR_Gen_1 17 23 PF02991 0.470
LIG_LIR_Gen_1 695 702 PF02991 0.417
LIG_LIR_Gen_1 813 823 PF02991 0.351
LIG_LIR_Nem_3 1005 1010 PF02991 0.431
LIG_LIR_Nem_3 17 21 PF02991 0.490
LIG_LIR_Nem_3 293 297 PF02991 0.425
LIG_LIR_Nem_3 471 476 PF02991 0.352
LIG_LIR_Nem_3 721 726 PF02991 0.353
LIG_LIR_Nem_3 771 776 PF02991 0.354
LIG_LIR_Nem_3 813 818 PF02991 0.368
LIG_NRBOX 475 481 PF00104 0.423
LIG_NRBOX 498 504 PF00104 0.375
LIG_NRBOX 914 920 PF00104 0.353
LIG_PCNA_PIPBox_1 66 75 PF02747 0.639
LIG_Pex14_1 719 723 PF04695 0.369
LIG_PTB_Apo_2 772 779 PF02174 0.334
LIG_PTB_Phospho_1 772 778 PF10480 0.336
LIG_REV1ctd_RIR_1 793 801 PF16727 0.433
LIG_SH2_NCK_1 830 834 PF00017 0.404
LIG_SH2_PTP2 990 993 PF00017 0.523
LIG_SH2_SRC 486 489 PF00017 0.453
LIG_SH2_SRC 728 731 PF00017 0.484
LIG_SH2_SRC 990 993 PF00017 0.497
LIG_SH2_STAP1 559 563 PF00017 0.410
LIG_SH2_STAT5 1039 1042 PF00017 0.484
LIG_SH2_STAT5 486 489 PF00017 0.453
LIG_SH2_STAT5 636 639 PF00017 0.479
LIG_SH2_STAT5 728 731 PF00017 0.550
LIG_SH2_STAT5 776 779 PF00017 0.335
LIG_SH2_STAT5 990 993 PF00017 0.523
LIG_SH3_2 306 311 PF14604 0.584
LIG_SH3_3 142 148 PF00018 0.535
LIG_SH3_3 300 306 PF00018 0.390
LIG_SH3_3 406 412 PF00018 0.691
LIG_SH3_3 479 485 PF00018 0.572
LIG_SH3_3 530 536 PF00018 0.576
LIG_SH3_3 565 571 PF00018 0.353
LIG_SH3_3 596 602 PF00018 0.374
LIG_SH3_3 614 620 PF00018 0.529
LIG_SH3_3 860 866 PF00018 0.478
LIG_SH3_3 944 950 PF00018 0.646
LIG_SUMO_SIM_anti_2 386 391 PF11976 0.436
LIG_SUMO_SIM_par_1 549 555 PF11976 0.502
LIG_SUMO_SIM_par_1 865 871 PF11976 0.493
LIG_TRFH_1 481 485 PF08558 0.458
LIG_TRFH_1 698 702 PF08558 0.411
LIG_UBA3_1 389 393 PF00899 0.332
LIG_UBA3_1 502 510 PF00899 0.421
LIG_UBA3_1 586 592 PF00899 0.461
LIG_WRC_WIRS_1 189 194 PF05994 0.619
LIG_WRC_WIRS_1 836 841 PF05994 0.342
LIG_WRC_WIRS_1 893 898 PF05994 0.410
LIG_WW_1 340 343 PF00397 0.461
MOD_CDC14_SPxK_1 956 959 PF00782 0.468
MOD_CDK_SPK_2 78 83 PF00069 0.621
MOD_CDK_SPxK_1 177 183 PF00069 0.663
MOD_CDK_SPxK_1 953 959 PF00069 0.493
MOD_CDK_SPxxK_3 93 100 PF00069 0.446
MOD_CK1_1 191 197 PF00069 0.621
MOD_CK1_1 286 292 PF00069 0.594
MOD_CK1_1 334 340 PF00069 0.556
MOD_CK1_1 427 433 PF00069 0.662
MOD_CK1_1 5 11 PF00069 0.658
MOD_CK1_1 520 526 PF00069 0.605
MOD_CK1_1 567 573 PF00069 0.396
MOD_CK1_1 626 632 PF00069 0.661
MOD_CK1_1 76 82 PF00069 0.665
MOD_CK1_1 786 792 PF00069 0.385
MOD_CK2_1 1026 1032 PF00069 0.409
MOD_CK2_1 146 152 PF00069 0.437
MOD_CK2_1 271 277 PF00069 0.450
MOD_CK2_1 324 330 PF00069 0.557
MOD_CK2_1 490 496 PF00069 0.501
MOD_Cter_Amidation 871 874 PF01082 0.346
MOD_GlcNHglycan 113 116 PF01048 0.484
MOD_GlcNHglycan 285 288 PF01048 0.624
MOD_GlcNHglycan 318 321 PF01048 0.718
MOD_GlcNHglycan 326 329 PF01048 0.628
MOD_GlcNHglycan 335 339 PF01048 0.537
MOD_GlcNHglycan 426 429 PF01048 0.723
MOD_GlcNHglycan 443 446 PF01048 0.539
MOD_GlcNHglycan 499 502 PF01048 0.470
MOD_GlcNHglycan 52 55 PF01048 0.585
MOD_GlcNHglycan 524 527 PF01048 0.643
MOD_GlcNHglycan 658 661 PF01048 0.508
MOD_GlcNHglycan 663 666 PF01048 0.391
MOD_GlcNHglycan 672 675 PF01048 0.266
MOD_GlcNHglycan 685 688 PF01048 0.355
MOD_GlcNHglycan 785 788 PF01048 0.379
MOD_GlcNHglycan 806 809 PF01048 0.573
MOD_GlcNHglycan 839 842 PF01048 0.327
MOD_GlcNHglycan 85 88 PF01048 0.586
MOD_GlcNHglycan 89 92 PF01048 0.550
MOD_GSK3_1 127 134 PF00069 0.496
MOD_GSK3_1 172 179 PF00069 0.790
MOD_GSK3_1 228 235 PF00069 0.656
MOD_GSK3_1 278 285 PF00069 0.586
MOD_GSK3_1 286 293 PF00069 0.477
MOD_GSK3_1 330 337 PF00069 0.710
MOD_GSK3_1 38 45 PF00069 0.493
MOD_GSK3_1 4 11 PF00069 0.556
MOD_GSK3_1 424 431 PF00069 0.656
MOD_GSK3_1 451 458 PF00069 0.588
MOD_GSK3_1 50 57 PF00069 0.592
MOD_GSK3_1 517 524 PF00069 0.682
MOD_GSK3_1 567 574 PF00069 0.436
MOD_GSK3_1 60 67 PF00069 0.689
MOD_GSK3_1 619 626 PF00069 0.570
MOD_GSK3_1 627 634 PF00069 0.548
MOD_GSK3_1 635 642 PF00069 0.456
MOD_GSK3_1 670 677 PF00069 0.377
MOD_GSK3_1 678 685 PF00069 0.403
MOD_GSK3_1 72 79 PF00069 0.540
MOD_GSK3_1 804 811 PF00069 0.543
MOD_GSK3_1 81 88 PF00069 0.559
MOD_GSK3_1 862 869 PF00069 0.428
MOD_GSK3_1 89 96 PF00069 0.500
MOD_LATS_1 519 525 PF00433 0.602
MOD_N-GLC_1 163 168 PF02516 0.618
MOD_N-GLC_1 441 446 PF02516 0.536
MOD_NEK2_1 2 7 PF00069 0.651
MOD_NEK2_1 42 47 PF00069 0.556
MOD_NEK2_1 451 456 PF00069 0.716
MOD_NEK2_1 506 511 PF00069 0.393
MOD_NEK2_1 613 618 PF00069 0.462
MOD_NEK2_1 795 800 PF00069 0.375
MOD_PIKK_1 191 197 PF00454 0.568
MOD_PIKK_1 451 457 PF00454 0.634
MOD_PIKK_1 62 68 PF00454 0.642
MOD_PIKK_1 873 879 PF00454 0.443
MOD_PKA_1 331 337 PF00069 0.518
MOD_PKA_1 873 879 PF00069 0.306
MOD_PKA_2 14 20 PF00069 0.502
MOD_PKA_2 3 9 PF00069 0.640
MOD_PKA_2 330 336 PF00069 0.626
MOD_PKA_2 520 526 PF00069 0.759
MOD_PKA_2 656 662 PF00069 0.429
MOD_PKA_2 804 810 PF00069 0.690
MOD_PKA_2 873 879 PF00069 0.312
MOD_PKA_2 979 985 PF00069 0.567
MOD_Plk_1 367 373 PF00069 0.474
MOD_Plk_1 703 709 PF00069 0.381
MOD_Plk_1 816 822 PF00069 0.354
MOD_Plk_4 1026 1032 PF00069 0.409
MOD_Plk_4 14 20 PF00069 0.536
MOD_Plk_4 223 229 PF00069 0.656
MOD_Plk_4 632 638 PF00069 0.354
MOD_Plk_4 65 71 PF00069 0.639
MOD_Plk_4 706 712 PF00069 0.441
MOD_Plk_4 737 743 PF00069 0.454
MOD_Plk_4 751 757 PF00069 0.294
MOD_Plk_4 892 898 PF00069 0.439
MOD_Plk_4 937 943 PF00069 0.534
MOD_ProDKin_1 172 178 PF00069 0.769
MOD_ProDKin_1 228 234 PF00069 0.606
MOD_ProDKin_1 567 573 PF00069 0.358
MOD_ProDKin_1 735 741 PF00069 0.394
MOD_ProDKin_1 78 84 PF00069 0.694
MOD_ProDKin_1 810 816 PF00069 0.426
MOD_ProDKin_1 85 91 PF00069 0.619
MOD_ProDKin_1 862 868 PF00069 0.441
MOD_ProDKin_1 93 99 PF00069 0.466
MOD_ProDKin_1 953 959 PF00069 0.638
MOD_SUMO_for_1 239 242 PF00179 0.513
MOD_SUMO_rev_2 507 512 PF00179 0.421
TRG_DiLeu_BaEn_1 242 247 PF01217 0.374
TRG_DiLeu_BaEn_1 386 391 PF01217 0.358
TRG_DiLeu_BaLyEn_6 106 111 PF01217 0.386
TRG_DiLeu_BaLyEn_6 371 376 PF01217 0.440
TRG_DiLeu_BaLyEn_6 568 573 PF01217 0.360
TRG_DiLeu_BaLyEn_6 863 868 PF01217 0.509
TRG_ENDOCYTIC_2 698 701 PF00928 0.422
TRG_ENDOCYTIC_2 815 818 PF00928 0.467
TRG_ENDOCYTIC_2 990 993 PF00928 0.523
TRG_ER_diArg_1 250 253 PF00400 0.483
TRG_ER_diArg_1 873 875 PF00400 0.336
TRG_ER_diArg_1 909 911 PF00400 0.361
TRG_ER_diArg_1 985 988 PF00400 0.525
TRG_NES_CRM1_1 817 831 PF08389 0.496
TRG_Pf-PMV_PEXEL_1 109 113 PF00026 0.395
TRG_Pf-PMV_PEXEL_1 364 368 PF00026 0.417

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDQ5 Leptomonas seymouri 46% 100%
A0A3Q8IIY2 Leishmania donovani 90% 100%
A4H8F6 Leishmania braziliensis 70% 100%
A4HWS6 Leishmania infantum 90% 100%
E9AQI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS