Putative proteasome 26S non-ATPase subunit 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome 26S non-ATPase subunit 9, putative

Species:

Leishmania major

UniProt:

Q4QEZ1_LEIMA

TriTrypDb:

LmjF.16.0290 , LMJLV39_160008100 , LMJSD75_160008100

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	12
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1905368	peptidase complex	3	12
GO:1905369	endopeptidase complex	4	12

Expansion

Sequence features

Q4QEZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0043248	proteasome assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0070682	proteasome regulatory particle assembly	7	12
GO:0071840	cellular component organization or biogenesis	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.480
CLV_NRD_NRD_1	215	217	PF00675	0.405
CLV_NRD_NRD_1	37	39	PF00675	0.340
CLV_PCSK_KEX2_1	131	133	PF00082	0.483
CLV_PCSK_KEX2_1	140	142	PF00082	0.468
CLV_PCSK_KEX2_1	37	39	PF00082	0.338
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.536
CLV_PCSK_PC7_1	33	39	PF00082	0.386
CLV_PCSK_SKI1_1	29	33	PF00082	0.465
CLV_PCSK_SKI1_1	43	47	PF00082	0.295
DEG_APCC_DBOX_1	32	40	PF00400	0.284
DEG_APCC_DBOX_1	94	102	PF00400	0.309
DEG_Nend_UBRbox_3	1	3	PF02207	0.507
DOC_ANK_TNKS_1	233	240	PF00023	0.437
DOC_MAPK_gen_1	150	160	PF00069	0.368
DOC_MAPK_MEF2A_6	153	160	PF00069	0.394
DOC_USP7_MATH_1	19	23	PF00917	0.619
DOC_WW_Pin1_4	164	169	PF00397	0.344
DOC_WW_Pin1_4	57	62	PF00397	0.252
LIG_14-3-3_CanoR_1	114	122	PF00244	0.446
LIG_FHA_1	187	193	PF00498	0.573
LIG_FHA_1	49	55	PF00498	0.306
LIG_FHA_2	114	120	PF00498	0.501
LIG_FHA_2	185	191	PF00498	0.432
LIG_FHA_2	21	27	PF00498	0.593
LIG_FHA_2	92	98	PF00498	0.354
LIG_Integrin_isoDGR_2	2	4	PF01839	0.430
LIG_LIR_Apic_2	13	18	PF02991	0.481
LIG_LIR_Gen_1	103	112	PF02991	0.393
LIG_LIR_Nem_3	103	109	PF02991	0.393
LIG_PCNA_yPIPBox_3	95	109	PF02747	0.376
LIG_PDZ_Class_3	248	253	PF00595	0.466
LIG_SH2_CRK	106	110	PF00017	0.393
LIG_SH2_CRK	15	19	PF00017	0.476
LIG_SH2_CRK	183	187	PF00017	0.471
LIG_SH2_STAT5	56	59	PF00017	0.393
LIG_SH3_3	212	218	PF00018	0.457
LIG_SH3_3	226	232	PF00018	0.449
LIG_SUMO_SIM_anti_2	226	232	PF11976	0.459
LIG_SUMO_SIM_par_1	7	14	PF11976	0.670
LIG_TRAF2_1	116	119	PF00917	0.556
LIG_TRAF2_1	168	171	PF00917	0.495
LIG_TYR_ITIM	181	186	PF00017	0.335
MOD_CK2_1	113	119	PF00069	0.485
MOD_CK2_1	164	170	PF00069	0.492
MOD_CK2_1	184	190	PF00069	0.221
MOD_CK2_1	201	207	PF00069	0.304
MOD_GSK3_1	182	189	PF00069	0.508
MOD_GSK3_1	83	90	PF00069	0.456
MOD_N-GLC_2	77	79	PF02516	0.376
MOD_PIKK_1	113	119	PF00454	0.477
MOD_PIKK_1	184	190	PF00454	0.373
MOD_PKA_2	113	119	PF00069	0.440
MOD_PKA_2	149	155	PF00069	0.383
MOD_PKA_2	200	206	PF00069	0.396
MOD_PKA_2	87	93	PF00069	0.346
MOD_Plk_1	20	26	PF00069	0.563
MOD_Plk_4	104	110	PF00069	0.405
MOD_ProDKin_1	164	170	PF00069	0.348
MOD_ProDKin_1	57	63	PF00069	0.252
TRG_DiLeu_BaEn_4	34	40	PF01217	0.235
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.395
TRG_ENDOCYTIC_2	106	109	PF00928	0.393
TRG_ENDOCYTIC_2	183	186	PF00928	0.341
TRG_ER_diArg_1	131	134	PF00400	0.568
TRG_ER_diArg_1	36	38	PF00400	0.403
TRG_ER_diArg_1	64	67	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	37	42	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	4	8	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I787	Leptomonas seymouri	74%	96%
A0A0S4ITV9	Bodo saltans	40%	100%
A0A1X0NG23	Trypanosomatidae	38%	100%
A0A3R7M5T2	Trypanosoma rangeli	41%	100%
A0A3S5H6W9	Leishmania donovani	96%	98%
A4H8F4	Leishmania braziliensis	82%	100%
A4HWS8	Leishmania infantum	96%	98%
C9ZW47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AQI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O00233	Homo sapiens	30%	100%
O94393	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P40555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
Q10920	Caenorhabditis elegans	29%	100%
Q3SZ19	Bos taurus	32%	100%
Q552Y8	Dictyostelium discoideum	22%	97%
Q9CR00	Mus musculus	33%	100%
Q9VFS8	Drosophila melanogaster	34%	100%
Q9WTV5	Rattus norvegicus	34%	100%
V5AKS5	Trypanosoma cruzi	47%	100%