Protein kinase domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

STE/STE20 serine/threonine-protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QEZ0_LEIMA

TriTrypDb:

LmjF.16.0300 , LMJLV39_160008200 , LMJSD75_160008200

Length:

631

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEZ0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	8
GO:0009966	regulation of signal transduction	4	2
GO:0009987	cellular process	1	8
GO:0010646	regulation of cell communication	4	2
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0023051	regulation of signaling	3	2
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043408	regulation of MAPK cascade	6	2
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0048583	regulation of response to stimulus	3	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1902531	regulation of intracellular signal transduction	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.602
CLV_C14_Caspase3-7	484	488	PF00656	0.541
CLV_NRD_NRD_1	113	115	PF00675	0.365
CLV_NRD_NRD_1	175	177	PF00675	0.394
CLV_NRD_NRD_1	254	256	PF00675	0.365
CLV_NRD_NRD_1	298	300	PF00675	0.457
CLV_NRD_NRD_1	304	306	PF00675	0.545
CLV_NRD_NRD_1	362	364	PF00675	0.706
CLV_PCSK_KEX2_1	113	115	PF00082	0.365
CLV_PCSK_KEX2_1	175	177	PF00082	0.397
CLV_PCSK_KEX2_1	254	256	PF00082	0.365
CLV_PCSK_KEX2_1	297	299	PF00082	0.450
CLV_PCSK_KEX2_1	304	306	PF00082	0.539
CLV_PCSK_KEX2_1	362	364	PF00082	0.704
CLV_PCSK_SKI1_1	143	147	PF00082	0.353
CLV_PCSK_SKI1_1	18	22	PF00082	0.482
CLV_PCSK_SKI1_1	226	230	PF00082	0.317
CLV_PCSK_SKI1_1	254	258	PF00082	0.413
CLV_PCSK_SKI1_1	396	400	PF00082	0.658
CLV_PCSK_SKI1_1	418	422	PF00082	0.591
CLV_PCSK_SKI1_1	583	587	PF00082	0.553
DEG_APCC_DBOX_1	125	133	PF00400	0.413
DEG_APCC_DBOX_1	395	403	PF00400	0.652
DEG_SPOP_SBC_1	442	446	PF00917	0.565
DOC_CDC14_PxL_1	397	405	PF14671	0.643
DOC_CYCLIN_RxL_1	251	258	PF00134	0.413
DOC_CYCLIN_yCln2_LP_2	116	122	PF00134	0.371
DOC_MAPK_DCC_7	396	405	PF00069	0.650
DOC_MAPK_gen_1	143	152	PF00069	0.413
DOC_MAPK_HePTP_8	393	405	PF00069	0.652
DOC_MAPK_MEF2A_6	396	405	PF00069	0.650
DOC_MAPK_MEF2A_6	506	514	PF00069	0.592
DOC_PP1_RVXF_1	224	231	PF00149	0.371
DOC_PP2B_LxvP_1	512	515	PF13499	0.620
DOC_PP4_FxxP_1	229	232	PF00568	0.391
DOC_PP4_FxxP_1	275	278	PF00568	0.466
DOC_USP7_MATH_1	280	284	PF00917	0.579
DOC_USP7_MATH_1	429	433	PF00917	0.606
DOC_USP7_MATH_1	442	446	PF00917	0.669
DOC_USP7_MATH_1	524	528	PF00917	0.645
DOC_WW_Pin1_4	243	248	PF00397	0.365
DOC_WW_Pin1_4	362	367	PF00397	0.775
DOC_WW_Pin1_4	564	569	PF00397	0.524
LIG_14-3-3_CanoR_1	113	119	PF00244	0.384
LIG_14-3-3_CanoR_1	126	130	PF00244	0.452
LIG_14-3-3_CanoR_1	175	180	PF00244	0.378
LIG_14-3-3_CanoR_1	297	302	PF00244	0.495
LIG_14-3-3_CanoR_1	322	327	PF00244	0.594
LIG_14-3-3_CanoR_1	39	49	PF00244	0.290
LIG_Actin_WH2_2	249	266	PF00022	0.371
LIG_Actin_WH2_2	605	620	PF00022	0.561
LIG_AP2alpha_2	273	275	PF02296	0.365
LIG_APCC_ABBA_1	272	277	PF00400	0.327
LIG_APCC_ABBAyCdc20_2	138	144	PF00400	0.365
LIG_BIR_III_4	437	441	PF00653	0.559
LIG_BRCT_BRCA1_1	446	450	PF00533	0.678
LIG_Clathr_ClatBox_1	402	406	PF01394	0.634
LIG_deltaCOP1_diTrp_1	243	252	PF00928	0.365
LIG_eIF4E_1	507	513	PF01652	0.581
LIG_FHA_1	207	213	PF00498	0.378
LIG_FHA_1	321	327	PF00498	0.644
LIG_FHA_1	41	47	PF00498	0.396
LIG_FHA_1	426	432	PF00498	0.628
LIG_FHA_1	434	440	PF00498	0.542
LIG_FHA_1	574	580	PF00498	0.551
LIG_FHA_1	593	599	PF00498	0.580
LIG_FHA_2	105	111	PF00498	0.327
LIG_FHA_2	190	196	PF00498	0.305
LIG_FHA_2	206	212	PF00498	0.339
LIG_FHA_2	482	488	PF00498	0.602
LIG_FHA_2	55	61	PF00498	0.365
LIG_FHA_2	579	585	PF00498	0.550
LIG_LIR_Apic_2	182	188	PF02991	0.413
LIG_LIR_Apic_2	273	278	PF02991	0.467
LIG_LIR_Gen_1	106	116	PF02991	0.362
LIG_LIR_Gen_1	19	29	PF02991	0.414
LIG_LIR_Nem_3	106	112	PF02991	0.424
LIG_LIR_Nem_3	19	24	PF02991	0.408
LIG_LIR_Nem_3	407	413	PF02991	0.644
LIG_LIR_Nem_3	527	532	PF02991	0.649
LIG_PCNA_yPIPBox_3	284	298	PF02747	0.477
LIG_Rb_LxCxE_1	567	584	PF01857	0.515
LIG_SH2_CRK	109	113	PF00017	0.365
LIG_SH2_CRK	533	537	PF00017	0.594
LIG_SH2_STAP1	196	200	PF00017	0.365
LIG_SH2_STAP1	594	598	PF00017	0.587
LIG_SH2_STAT5	123	126	PF00017	0.391
LIG_SH2_STAT5	134	137	PF00017	0.445
LIG_SH2_STAT5	490	493	PF00017	0.605
LIG_SH2_STAT5	507	510	PF00017	0.505
LIG_SH2_STAT5	570	573	PF00017	0.534
LIG_SH2_STAT5	591	594	PF00017	0.531
LIG_SH2_STAT5	99	102	PF00017	0.340
LIG_SH3_3	529	535	PF00018	0.627
LIG_SUMO_SIM_anti_2	68	74	PF11976	0.354
LIG_SUMO_SIM_par_1	208	214	PF11976	0.365
LIG_TRAF2_1	282	285	PF00917	0.606
LIG_TRAF2_1	333	336	PF00917	0.687
LIG_WW_1	530	533	PF00397	0.624
MOD_CK1_1	104	110	PF00069	0.327
MOD_CK1_1	266	272	PF00069	0.342
MOD_CK1_1	312	318	PF00069	0.642
MOD_CK1_1	497	503	PF00069	0.595
MOD_CK2_1	205	211	PF00069	0.365
MOD_CK2_1	280	286	PF00069	0.598
MOD_CK2_1	297	303	PF00069	0.525
MOD_CK2_1	54	60	PF00069	0.357
MOD_CK2_1	578	584	PF00069	0.531
MOD_CK2_1	596	602	PF00069	0.581
MOD_GlcNHglycan	265	268	PF01048	0.365
MOD_GlcNHglycan	314	317	PF01048	0.648
MOD_GlcNHglycan	4	7	PF01048	0.481
MOD_GlcNHglycan	413	416	PF01048	0.665
MOD_GlcNHglycan	431	434	PF01048	0.523
MOD_GlcNHglycan	446	449	PF01048	0.729
MOD_GlcNHglycan	461	464	PF01048	0.676
MOD_GlcNHglycan	478	481	PF01048	0.494
MOD_GlcNHglycan	502	505	PF01048	0.797
MOD_GlcNHglycan	516	519	PF01048	0.585
MOD_GlcNHglycan	526	529	PF01048	0.561
MOD_GSK3_1	171	178	PF00069	0.365
MOD_GSK3_1	201	208	PF00069	0.365
MOD_GSK3_1	293	300	PF00069	0.455
MOD_GSK3_1	308	315	PF00069	0.561
MOD_GSK3_1	318	325	PF00069	0.603
MOD_GSK3_1	416	423	PF00069	0.697
MOD_GSK3_1	425	432	PF00069	0.665
MOD_GSK3_1	440	447	PF00069	0.553
MOD_GSK3_1	496	503	PF00069	0.686
MOD_GSK3_1	574	581	PF00069	0.545
MOD_GSK3_1	592	599	PF00069	0.577
MOD_GSK3_1	621	628	PF00069	0.543
MOD_N-GLC_1	312	317	PF02516	0.665
MOD_N-GLC_1	494	499	PF02516	0.663
MOD_NEK2_1	150	155	PF00069	0.486
MOD_NEK2_1	169	174	PF00069	0.390
MOD_NEK2_1	179	184	PF00069	0.365
MOD_NEK2_1	205	210	PF00069	0.334
MOD_NEK2_1	420	425	PF00069	0.693
MOD_NEK2_1	574	579	PF00069	0.493
MOD_NEK2_1	612	617	PF00069	0.535
MOD_NEK2_1	83	88	PF00069	0.383
MOD_NEK2_2	416	421	PF00069	0.609
MOD_PIKK_1	280	286	PF00454	0.432
MOD_PK_1	322	328	PF00069	0.642
MOD_PKA_1	175	181	PF00069	0.365
MOD_PKA_1	297	303	PF00069	0.467
MOD_PKA_2	125	131	PF00069	0.342
MOD_PKA_2	175	181	PF00069	0.412
MOD_PKA_2	263	269	PF00069	0.365
MOD_PKA_2	297	303	PF00069	0.467
MOD_PKA_2	321	327	PF00069	0.607
MOD_PKA_2	40	46	PF00069	0.365
MOD_Plk_1	312	318	PF00069	0.662
MOD_Plk_1	406	412	PF00069	0.659
MOD_Plk_1	574	580	PF00069	0.545
MOD_Plk_2-3	101	107	PF00069	0.365
MOD_Plk_2-3	189	195	PF00069	0.305
MOD_Plk_2-3	406	412	PF00069	0.641
MOD_Plk_4	125	131	PF00069	0.360
MOD_Plk_4	175	181	PF00069	0.353
MOD_Plk_4	266	272	PF00069	0.328
MOD_Plk_4	315	321	PF00069	0.630
MOD_Plk_4	322	328	PF00069	0.637
MOD_Plk_4	508	514	PF00069	0.695
MOD_Plk_4	61	67	PF00069	0.316
MOD_Plk_4	612	618	PF00069	0.532
MOD_Plk_4	83	89	PF00069	0.340
MOD_ProDKin_1	243	249	PF00069	0.365
MOD_ProDKin_1	362	368	PF00069	0.775
MOD_ProDKin_1	564	570	PF00069	0.525
MOD_SUMO_rev_2	14	20	PF00179	0.467
MOD_SUMO_rev_2	162	172	PF00179	0.396
MOD_SUMO_rev_2	599	606	PF00179	0.569
TRG_DiLeu_BaEn_1	554	559	PF01217	0.552
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.519
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.357
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.643
TRG_ENDOCYTIC_2	109	112	PF00928	0.340
TRG_ENDOCYTIC_2	87	90	PF00928	0.376
TRG_ER_diArg_1	112	114	PF00400	0.365
TRG_ER_diArg_1	253	255	PF00400	0.365
TRG_ER_diArg_1	297	299	PF00400	0.514
TRG_NES_CRM1_1	44	58	PF08389	0.364
TRG_NES_CRM1_1	60	74	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.365
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEW4	Leptomonas seymouri	59%	100%
A0A3S7WTT7	Leishmania donovani	91%	100%
A4H459	Leishmania braziliensis	27%	100%
A4H8F5	Leishmania braziliensis	82%	100%
A4HWS9	Leishmania infantum	91%	100%
E9AQI7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%