FHA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FHA domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QEY8_LEIMA

TriTrypDb:

LmjF.16.0320 , LMJLV39_160008400 , LMJSD75_160008400

Length:

1270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0030870	Mre11 complex	3	6
GO:0032991	protein-containing complex	1	6
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	6

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Expansion

Sequence features

Q4QEY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY8

Function

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Biological processes
Term	Name	Level	Count
GO:0000075	cell cycle checkpoint signaling	4	6
GO:0000077	DNA damage checkpoint signaling	5	6
GO:0000724	double-strand break repair via homologous recombination	7	2
GO:0000725	recombinational repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006281	DNA repair	5	6
GO:0006302	double-strand break repair	6	6
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	6

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003684	damaged DNA binding	5	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1139	1143	PF00656	0.391
CLV_C14_Caspase3-7	121	125	PF00656	0.465
CLV_C14_Caspase3-7	286	290	PF00656	0.365
CLV_C14_Caspase3-7	394	398	PF00656	0.575
CLV_C14_Caspase3-7	689	693	PF00656	0.625
CLV_NRD_NRD_1	1072	1074	PF00675	0.654
CLV_NRD_NRD_1	1250	1252	PF00675	0.691
CLV_NRD_NRD_1	229	231	PF00675	0.414
CLV_NRD_NRD_1	27	29	PF00675	0.385
CLV_NRD_NRD_1	403	405	PF00675	0.571

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WTU2	Leishmania donovani	89%	100%
A4H8F8	Leishmania braziliensis	61%	100%
A4HWT1	Leishmania infantum	89%	100%
E9AQI9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%

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