Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEY7_LEIMA

TriTrypDb:

LmjF.16.0330 , LMJLV39_160008500 , LMJSD75_160008500

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QEY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.553
CLV_NRD_NRD_1	216	218	PF00675	0.351
CLV_NRD_NRD_1	313	315	PF00675	0.540
CLV_NRD_NRD_1	348	350	PF00675	0.376
CLV_PCSK_KEX2_1	189	191	PF00082	0.613
CLV_PCSK_KEX2_1	216	218	PF00082	0.351
CLV_PCSK_KEX2_1	348	350	PF00082	0.375
CLV_PCSK_KEX2_1	84	86	PF00082	0.477
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.529
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.423
CLV_PCSK_SKI1_1	182	186	PF00082	0.619
CLV_PCSK_SKI1_1	197	201	PF00082	0.515
CLV_PCSK_SKI1_1	314	318	PF00082	0.385
CLV_PCSK_SKI1_1	340	344	PF00082	0.395
CLV_PCSK_SKI1_1	349	353	PF00082	0.302
DEG_APCC_DBOX_1	216	224	PF00400	0.349
DEG_SIAH_1	46	54	PF03145	0.488
DOC_CKS1_1	178	183	PF01111	0.656
DOC_CYCLIN_RxL_1	345	353	PF00134	0.418
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.486
DOC_MAPK_gen_1	348	356	PF00069	0.404
DOC_PP1_RVXF_1	318	325	PF00149	0.338
DOC_PP1_RVXF_1	346	353	PF00149	0.414
DOC_PP2B_LxvP_1	266	269	PF13499	0.485
DOC_USP7_MATH_1	156	160	PF00917	0.687
DOC_USP7_MATH_1	170	174	PF00917	0.573
DOC_USP7_MATH_1	308	312	PF00917	0.461
DOC_USP7_MATH_1	37	41	PF00917	0.646
DOC_USP7_MATH_1	47	51	PF00917	0.708
DOC_USP7_MATH_1	53	57	PF00917	0.683
DOC_WW_Pin1_4	17	22	PF00397	0.594
DOC_WW_Pin1_4	177	182	PF00397	0.626
DOC_WW_Pin1_4	240	245	PF00397	0.493
DOC_WW_Pin1_4	372	377	PF00397	0.480
LIG_14-3-3_CanoR_1	203	211	PF00244	0.554
LIG_BRCT_BRCA1_1	108	112	PF00533	0.487
LIG_Clathr_ClatBox_1	326	330	PF01394	0.427
LIG_eIF4E_1	120	126	PF01652	0.537
LIG_FAT_LD_1	220	228	PF03623	0.442
LIG_FHA_1	106	112	PF00498	0.435
LIG_FHA_1	203	209	PF00498	0.624
LIG_FHA_2	132	138	PF00498	0.650
LIG_FHA_2	284	290	PF00498	0.503
LIG_LIR_Gen_1	289	300	PF02991	0.333
LIG_LIR_Gen_1	86	95	PF02991	0.328
LIG_LIR_Nem_3	109	115	PF02991	0.500
LIG_LIR_Nem_3	191	195	PF02991	0.586
LIG_LIR_Nem_3	20	26	PF02991	0.377
LIG_LIR_Nem_3	289	295	PF02991	0.335
LIG_LIR_Nem_3	86	90	PF02991	0.328
LIG_LYPXL_S_1	266	270	PF13949	0.436
LIG_LYPXL_yS_3	267	270	PF13949	0.434
LIG_MAD2	261	269	PF02301	0.438
LIG_NRBOX	110	116	PF00104	0.400
LIG_NRBOX	219	225	PF00104	0.476
LIG_Pex14_2	192	196	PF04695	0.547
LIG_Pex14_2	352	356	PF04695	0.371
LIG_Rb_LxCxE_1	325	344	PF01857	0.426
LIG_REV1ctd_RIR_1	315	324	PF16727	0.383
LIG_SH2_CRK	23	27	PF00017	0.435
LIG_SH2_CRK	292	296	PF00017	0.399
LIG_SH2_STAT3	89	92	PF00017	0.254
LIG_SH2_STAT5	117	120	PF00017	0.435
LIG_SH2_STAT5	226	229	PF00017	0.438
LIG_SH2_STAT5	89	92	PF00017	0.376
LIG_SH3_3	10	16	PF00018	0.693
LIG_Sin3_3	112	119	PF02671	0.413
LIG_TRAF2_1	377	380	PF00917	0.460
MOD_CDK_SPK_2	177	182	PF00069	0.659
MOD_CDK_SPxxK_3	17	24	PF00069	0.604
MOD_CK1_1	147	153	PF00069	0.719
MOD_CK1_1	57	63	PF00069	0.537
MOD_CK1_1	83	89	PF00069	0.499
MOD_CK2_1	131	137	PF00069	0.620
MOD_CK2_1	283	289	PF00069	0.375
MOD_CK2_1	374	380	PF00069	0.465
MOD_CK2_1	53	59	PF00069	0.633
MOD_GlcNHglycan	154	157	PF01048	0.630
MOD_GlcNHglycan	168	171	PF01048	0.663
MOD_GlcNHglycan	185	188	PF01048	0.449
MOD_GlcNHglycan	270	273	PF01048	0.411
MOD_GlcNHglycan	7	10	PF01048	0.596
MOD_GSK3_1	1	8	PF00069	0.589
MOD_GSK3_1	152	159	PF00069	0.733
MOD_GSK3_1	166	173	PF00069	0.618
MOD_GSK3_1	197	204	PF00069	0.568
MOD_GSK3_1	26	33	PF00069	0.490
MOD_GSK3_1	38	45	PF00069	0.623
MOD_GSK3_1	53	60	PF00069	0.562
MOD_GSK3_1	96	103	PF00069	0.457
MOD_N-GLC_1	276	281	PF02516	0.437
MOD_N-GLC_1	38	43	PF02516	0.629
MOD_N-GLC_1	96	101	PF02516	0.591
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	115	120	PF00069	0.449
MOD_NEK2_1	168	173	PF00069	0.544
MOD_NEK2_1	26	31	PF00069	0.482
MOD_NEK2_1	341	346	PF00069	0.447
MOD_NEK2_1	63	68	PF00069	0.604
MOD_NEK2_2	96	101	PF00069	0.407
MOD_PIKK_1	147	153	PF00454	0.567
MOD_PIKK_1	276	282	PF00454	0.406
MOD_PKA_2	202	208	PF00069	0.549
MOD_PKA_2	26	32	PF00069	0.599
MOD_Plk_1	105	111	PF00069	0.309
MOD_Plk_1	96	102	PF00069	0.585
MOD_Plk_2-3	333	339	PF00069	0.443
MOD_Plk_4	1	7	PF00069	0.735
MOD_Plk_4	106	112	PF00069	0.499
MOD_Plk_4	191	197	PF00069	0.597
MOD_Plk_4	30	36	PF00069	0.580
MOD_Plk_4	47	53	PF00069	0.676
MOD_ProDKin_1	17	23	PF00069	0.593
MOD_ProDKin_1	177	183	PF00069	0.620
MOD_ProDKin_1	240	246	PF00069	0.493
MOD_ProDKin_1	372	378	PF00069	0.479
MOD_SUMO_rev_2	310	317	PF00179	0.432
MOD_SUMO_rev_2	333	342	PF00179	0.519
MOD_SUMO_rev_2	375	384	PF00179	0.479
TRG_DiLeu_BaEn_1	219	224	PF01217	0.423
TRG_DiLeu_BaEn_1	337	342	PF01217	0.429
TRG_DiLeu_BaEn_1	59	64	PF01217	0.682
TRG_DiLeu_BaEn_4	337	343	PF01217	0.426
TRG_DiLeu_BaEn_4	379	385	PF01217	0.433
TRG_ENDOCYTIC_2	23	26	PF00928	0.427
TRG_ENDOCYTIC_2	267	270	PF00928	0.434
TRG_ENDOCYTIC_2	292	295	PF00928	0.382
TRG_ER_diArg_1	215	217	PF00400	0.366
TRG_ER_diArg_1	347	349	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	320	325	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Y6	Leptomonas seymouri	49%	90%
A0A0S4JDY7	Bodo saltans	43%	100%
A0A1X0NZ18	Trypanosomatidae	47%	100%
A0A1X0NZ32	Trypanosomatidae	27%	91%
A0A3Q8IAF9	Leishmania donovani	94%	100%
A0A3R7KLW2	Trypanosoma rangeli	28%	87%
A0A422N3A0	Trypanosoma rangeli	46%	100%
A4H8F9	Leishmania braziliensis	81%	98%
A4HWT2	Leishmania infantum	94%	100%
C9ZW42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZW43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	97%
C9ZXL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	90%
E9AQJ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AX32	Trypanosoma cruzi	28%	73%
V5D513	Trypanosoma cruzi	29%	100%