2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania major

UniProt:

Q4QEY5_LEIMA

TriTrypDb:

LmjF.16.0350 , LMJLV39_160008800 , LMJSD75_160008800

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	2

Expansion

Sequence features

Q4QEY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006304	DNA modification	5	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	2
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0035510	DNA dealkylation	6	2
GO:0035511	obsolete oxidative DNA demethylation	4	2
GO:0035513	oxidative RNA demethylation	4	2
GO:0035552	oxidative single-stranded DNA demethylation	5	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044728	obsolete DNA methylation or demethylation	6	2
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0070988	demethylation	2	2
GO:0070989	oxidative demethylation	3	2
GO:0071704	organic substance metabolic process	2	12
GO:0080111	DNA demethylation	3	2
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	2
GO:0005506	iron ion binding	6	2
GO:0008198	ferrous iron binding	7	2
GO:0016491	oxidoreductase activity	2	12
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	2
GO:0016706	2-oxoglutarate-dependent dioxygenase activity	4	2
GO:0032451	demethylase activity	2	2
GO:0035514	DNA demethylase activity	3	2
GO:0035515	oxidative RNA demethylase activity	3	2
GO:0035516	oxidative DNA demethylase activity	4	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0051213	dioxygenase activity	3	12
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.468
CLV_NRD_NRD_1	13	15	PF00675	0.551
CLV_NRD_NRD_1	18	20	PF00675	0.563
CLV_NRD_NRD_1	53	55	PF00675	0.601
CLV_PCSK_KEX2_1	13	15	PF00082	0.523
CLV_PCSK_KEX2_1	17	19	PF00082	0.541
CLV_PCSK_KEX2_1	4	6	PF00082	0.399
CLV_PCSK_KEX2_1	44	46	PF00082	0.502
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.407
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.406
CLV_PCSK_PC7_1	13	19	PF00082	0.536
CLV_PCSK_SKI1_1	138	142	PF00082	0.211
CLV_PCSK_SKI1_1	263	267	PF00082	0.254
CLV_PCSK_SKI1_1	362	366	PF00082	0.680
CLV_PCSK_SKI1_1	49	53	PF00082	0.465
CLV_PCSK_SKI1_1	74	78	PF00082	0.480
DEG_SCF_FBW7_1	304	309	PF00400	0.379
DEG_SPOP_SBC_1	127	131	PF00917	0.448
DOC_CDC14_PxL_1	81	89	PF14671	0.305
DOC_MAPK_gen_1	166	175	PF00069	0.454
DOC_MAPK_gen_1	44	52	PF00069	0.521
DOC_PP2B_LxvP_1	280	283	PF13499	0.501
DOC_PP4_FxxP_1	258	261	PF00568	0.436
DOC_PP4_FxxP_1	352	355	PF00568	0.497
DOC_USP7_MATH_1	203	207	PF00917	0.470
DOC_USP7_MATH_1	222	226	PF00917	0.484
DOC_USP7_MATH_1	261	265	PF00917	0.465
DOC_USP7_MATH_1	306	310	PF00917	0.436
DOC_WW_Pin1_4	302	307	PF00397	0.379
LIG_14-3-3_CanoR_1	138	143	PF00244	0.411
LIG_14-3-3_CanoR_1	157	162	PF00244	0.470
LIG_14-3-3_CanoR_1	38	46	PF00244	0.438
LIG_BIR_II_1	1	5	PF00653	0.417
LIG_BRCT_BRCA1_1	230	234	PF00533	0.411
LIG_EH1_1	201	209	PF00400	0.440
LIG_FHA_1	147	153	PF00498	0.482
LIG_FHA_1	194	200	PF00498	0.411
LIG_FHA_1	26	32	PF00498	0.444
LIG_FHA_2	279	285	PF00498	0.469
LIG_FHA_2	286	292	PF00498	0.435
LIG_LIR_Apic_2	130	136	PF02991	0.422
LIG_LIR_Gen_1	156	165	PF02991	0.436
LIG_LIR_Gen_1	243	250	PF02991	0.523
LIG_LIR_Gen_1	264	273	PF02991	0.525
LIG_LIR_Gen_1	307	318	PF02991	0.474
LIG_LIR_Nem_3	156	161	PF02991	0.422
LIG_LIR_Nem_3	243	249	PF02991	0.523
LIG_LIR_Nem_3	264	269	PF02991	0.449
LIG_LIR_Nem_3	3	9	PF02991	0.399
LIG_LIR_Nem_3	307	313	PF02991	0.516
LIG_LIR_Nem_3	324	329	PF02991	0.514
LIG_LIR_Nem_3	80	84	PF02991	0.350
LIG_LYPXL_yS_3	188	191	PF13949	0.501
LIG_PCNA_PIPBox_1	195	204	PF02747	0.411
LIG_SH2_CRK	133	137	PF00017	0.514
LIG_SH2_CRK	246	250	PF00017	0.431
LIG_SH2_SRC	110	113	PF00017	0.446
LIG_SH2_SRC	133	136	PF00017	0.454
LIG_SH2_STAP1	110	114	PF00017	0.375
LIG_SH2_STAP1	144	148	PF00017	0.509
LIG_SH2_STAP1	246	250	PF00017	0.437
LIG_SH2_STAT3	192	195	PF00017	0.411
LIG_SH2_STAT5	153	156	PF00017	0.478
LIG_SH2_STAT5	279	282	PF00017	0.436
LIG_SH2_STAT5	300	303	PF00017	0.431
LIG_SH2_STAT5	79	82	PF00017	0.389
LIG_SH3_1	17	23	PF00018	0.610
LIG_SH3_3	17	23	PF00018	0.599
LIG_SH3_3	188	194	PF00018	0.515
LIG_SH3_3	47	53	PF00018	0.524
LIG_SUMO_SIM_anti_2	171	177	PF11976	0.493
LIG_TYR_ITIM	199	204	PF00017	0.248
MOD_CK1_1	215	221	PF00069	0.352
MOD_CK2_1	278	284	PF00069	0.332
MOD_CK2_1	285	291	PF00069	0.277
MOD_CK2_1	308	314	PF00069	0.446
MOD_CK2_1	9	15	PF00069	0.627
MOD_CK2_1	92	98	PF00069	0.308
MOD_GlcNHglycan	112	115	PF01048	0.384
MOD_GlcNHglycan	162	165	PF01048	0.413
MOD_GlcNHglycan	230	233	PF01048	0.411
MOD_GlcNHglycan	251	254	PF01048	0.248
MOD_GlcNHglycan	263	266	PF01048	0.248
MOD_GlcNHglycan	64	67	PF01048	0.663
MOD_GSK3_1	138	145	PF00069	0.279
MOD_GSK3_1	156	163	PF00069	0.332
MOD_GSK3_1	224	231	PF00069	0.266
MOD_GSK3_1	261	268	PF00069	0.339
MOD_GSK3_1	302	309	PF00069	0.333
MOD_GSK3_1	9	16	PF00069	0.691
MOD_NEK2_1	224	229	PF00069	0.282
MOD_NEK2_1	235	240	PF00069	0.205
MOD_NEK2_1	77	82	PF00069	0.403
MOD_PIKK_1	146	152	PF00454	0.252
MOD_PIKK_1	235	241	PF00454	0.391
MOD_PKA_1	13	19	PF00069	0.605
MOD_PKA_2	13	19	PF00069	0.574
MOD_PKA_2	156	162	PF00069	0.336
MOD_PKA_2	37	43	PF00069	0.511
MOD_PKB_1	155	163	PF00069	0.300
MOD_Plk_1	215	221	PF00069	0.288
MOD_Plk_2-3	285	291	PF00069	0.295
MOD_Plk_2-3	37	43	PF00069	0.444
MOD_Plk_4	171	177	PF00069	0.319
MOD_Plk_4	203	209	PF00069	0.276
MOD_ProDKin_1	302	308	PF00069	0.203
MOD_SUMO_rev_2	37	46	PF00179	0.399
TRG_DiLeu_BaEn_1	42	47	PF01217	0.442
TRG_DiLeu_LyEn_5	42	47	PF01217	0.442
TRG_ENDOCYTIC_2	158	161	PF00928	0.308
TRG_ENDOCYTIC_2	188	191	PF00928	0.301
TRG_ENDOCYTIC_2	201	204	PF00928	0.206
TRG_ENDOCYTIC_2	246	249	PF00928	0.397
TRG_ENDOCYTIC_2	279	282	PF00928	0.340
TRG_ENDOCYTIC_2	326	329	PF00928	0.391
TRG_ER_diArg_1	165	168	PF00400	0.306
TRG_ER_diArg_1	17	19	PF00400	0.620
TRG_ER_diArg_1	292	295	PF00400	0.324
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	356	360	PF00026	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAG0	Leptomonas seymouri	72%	86%
A0A0S4IYK4	Bodo saltans	46%	95%
A0A1X0PAI9	Trypanosomatidae	49%	100%
A0A3Q8IAB8	Leishmania donovani	95%	100%
A0A3R7NC97	Trypanosoma rangeli	48%	90%
A4H8G0	Leishmania braziliensis	83%	100%
A4HWT4	Leishmania infantum	95%	100%
C9ZLP0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AQJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q13686	Homo sapiens	29%	95%
Q54N08	Dictyostelium discoideum	26%	94%
Q9SA98	Arabidopsis thaliana	28%	100%
V5BRD6	Trypanosoma cruzi	51%	98%