Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QEY4_LEIMA

TriTrypDb:

LmjF.16.0360 , LMJLV39_160008900 , LMJSD75_160008900

Length:

688

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QEY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QEY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.551
CLV_C14_Caspase3-7	535	539	PF00656	0.549
CLV_NRD_NRD_1	114	116	PF00675	0.634
CLV_NRD_NRD_1	247	249	PF00675	0.677
CLV_NRD_NRD_1	440	442	PF00675	0.676
CLV_NRD_NRD_1	576	578	PF00675	0.646
CLV_NRD_NRD_1	587	589	PF00675	0.618
CLV_NRD_NRD_1	625	627	PF00675	0.621
CLV_PCSK_FUR_1	573	577	PF00082	0.601
CLV_PCSK_KEX2_1	114	116	PF00082	0.634
CLV_PCSK_KEX2_1	247	249	PF00082	0.656
CLV_PCSK_KEX2_1	440	442	PF00082	0.676
CLV_PCSK_KEX2_1	575	577	PF00082	0.648
CLV_PCSK_KEX2_1	587	589	PF00082	0.615
CLV_PCSK_SKI1_1	202	206	PF00082	0.601
CLV_PCSK_SKI1_1	401	405	PF00082	0.690
CLV_PCSK_SKI1_1	420	424	PF00082	0.488
CLV_PCSK_SKI1_1	435	439	PF00082	0.563
CLV_PCSK_SKI1_1	44	48	PF00082	0.493
CLV_PCSK_SKI1_1	481	485	PF00082	0.709
CLV_PCSK_SKI1_1	544	548	PF00082	0.547
CLV_PCSK_SKI1_1	603	607	PF00082	0.581
CLV_Separin_Metazoa	398	402	PF03568	0.560
DEG_Nend_UBRbox_2	1	3	PF02207	0.596
DEG_SPOP_SBC_1	182	186	PF00917	0.562
DEG_SPOP_SBC_1	203	207	PF00917	0.671
DOC_CKS1_1	618	623	PF01111	0.587
DOC_MAPK_gen_1	94	103	PF00069	0.639
DOC_MAPK_MEF2A_6	269	276	PF00069	0.580
DOC_PP2B_LxvP_1	221	224	PF13499	0.595
DOC_SPAK_OSR1_1	8	12	PF12202	0.428
DOC_USP7_MATH_1	118	122	PF00917	0.653
DOC_USP7_MATH_1	147	151	PF00917	0.639
DOC_USP7_MATH_1	174	178	PF00917	0.583
DOC_USP7_MATH_1	203	207	PF00917	0.671
DOC_USP7_MATH_1	210	214	PF00917	0.604
DOC_USP7_MATH_1	367	371	PF00917	0.714
DOC_USP7_MATH_1	38	42	PF00917	0.456
DOC_USP7_MATH_1	456	460	PF00917	0.602
DOC_USP7_MATH_1	464	468	PF00917	0.658
DOC_USP7_MATH_2	386	392	PF00917	0.616
DOC_WW_Pin1_4	125	130	PF00397	0.622
DOC_WW_Pin1_4	240	245	PF00397	0.712
DOC_WW_Pin1_4	289	294	PF00397	0.697
DOC_WW_Pin1_4	435	440	PF00397	0.755
DOC_WW_Pin1_4	446	451	PF00397	0.632
DOC_WW_Pin1_4	494	499	PF00397	0.700
DOC_WW_Pin1_4	503	508	PF00397	0.628
DOC_WW_Pin1_4	513	518	PF00397	0.673
DOC_WW_Pin1_4	547	552	PF00397	0.632
DOC_WW_Pin1_4	575	580	PF00397	0.699
DOC_WW_Pin1_4	596	601	PF00397	0.596
DOC_WW_Pin1_4	617	622	PF00397	0.797
DOC_WW_Pin1_4	682	687	PF00397	0.665
DOC_WW_Pin1_4	88	93	PF00397	0.634
LIG_14-3-3_CanoR_1	202	211	PF00244	0.603
LIG_14-3-3_CanoR_1	26	35	PF00244	0.434
LIG_14-3-3_CanoR_1	269	275	PF00244	0.583
LIG_14-3-3_CanoR_1	277	285	PF00244	0.559
LIG_14-3-3_CanoR_1	389	397	PF00244	0.682
LIG_14-3-3_CanoR_1	420	425	PF00244	0.548
LIG_14-3-3_CanoR_1	441	450	PF00244	0.672
LIG_14-3-3_CanoR_1	502	507	PF00244	0.617
LIG_14-3-3_CanoR_1	596	600	PF00244	0.542
LIG_14-3-3_CanoR_1	641	645	PF00244	0.554
LIG_14-3-3_CanoR_1	657	665	PF00244	0.460
LIG_14-3-3_CanoR_1	670	677	PF00244	0.488
LIG_14-3-3_CanoR_1	96	104	PF00244	0.618
LIG_Actin_WH2_2	263	279	PF00022	0.564
LIG_BIR_III_2	453	457	PF00653	0.561
LIG_BIR_III_4	628	632	PF00653	0.696
LIG_BRCT_BRCA1_1	12	16	PF00533	0.482
LIG_BRCT_BRCA1_1	665	669	PF00533	0.652
LIG_Clathr_ClatBox_1	353	357	PF01394	0.534
LIG_CtBP_PxDLS_1	491	495	PF00389	0.573
LIG_deltaCOP1_diTrp_1	19	24	PF00928	0.480
LIG_FHA_1	131	137	PF00498	0.634
LIG_FHA_1	203	209	PF00498	0.673
LIG_FHA_1	216	222	PF00498	0.539
LIG_FHA_1	27	33	PF00498	0.459
LIG_FHA_1	271	277	PF00498	0.579
LIG_FHA_1	323	329	PF00498	0.630
LIG_FHA_1	460	466	PF00498	0.737
LIG_FHA_1	554	560	PF00498	0.669
LIG_FHA_1	97	103	PF00498	0.619
LIG_FHA_2	130	136	PF00498	0.582
LIG_FHA_2	25	31	PF00498	0.457
LIG_FHA_2	347	353	PF00498	0.580
LIG_FHA_2	443	449	PF00498	0.678
LIG_FHA_2	468	474	PF00498	0.653
LIG_FHA_2	521	527	PF00498	0.636
LIG_FHA_2	596	602	PF00498	0.656
LIG_FHA_2	60	66	PF00498	0.639
LIG_Integrin_RGD_1	137	139	PF01839	0.651
LIG_LIR_Gen_1	163	171	PF02991	0.611
LIG_LIR_Gen_1	27	35	PF02991	0.293
LIG_LIR_Gen_1	530	539	PF02991	0.554
LIG_LIR_Gen_1	540	549	PF02991	0.548
LIG_LIR_Gen_1	7	17	PF02991	0.489
LIG_LIR_LC3C_4	352	356	PF02991	0.523
LIG_LIR_LC3C_4	98	103	PF02991	0.645
LIG_LIR_Nem_3	163	167	PF02991	0.620
LIG_LIR_Nem_3	27	31	PF02991	0.298
LIG_LIR_Nem_3	41	46	PF02991	0.371
LIG_LIR_Nem_3	478	483	PF02991	0.810
LIG_LIR_Nem_3	530	536	PF02991	0.579
LIG_LIR_Nem_3	540	545	PF02991	0.574
LIG_LIR_Nem_3	7	12	PF02991	0.455
LIG_PCNA_PIPBox_1	374	383	PF02747	0.629
LIG_Pex14_1	24	28	PF04695	0.467
LIG_Pex14_1	39	43	PF04695	0.350
LIG_Pex14_2	43	47	PF04695	0.475
LIG_SH2_CRK	164	168	PF00017	0.616
LIG_SH2_CRK	480	484	PF00017	0.825
LIG_SH2_CRK	49	53	PF00017	0.539
LIG_SH2_CRK	542	546	PF00017	0.585
LIG_SH2_PTP2	321	324	PF00017	0.478
LIG_SH2_STAP1	28	32	PF00017	0.451
LIG_SH2_STAP1	381	385	PF00017	0.607
LIG_SH2_STAP1	542	546	PF00017	0.585
LIG_SH2_STAT5	119	122	PF00017	0.676
LIG_SH2_STAT5	28	31	PF00017	0.458
LIG_SH2_STAT5	321	324	PF00017	0.516
LIG_SH3_3	195	201	PF00018	0.705
LIG_SH3_3	311	317	PF00018	0.548
LIG_SH3_3	419	425	PF00018	0.587
LIG_SH3_3	436	442	PF00018	0.546
LIG_SH3_3	476	482	PF00018	0.787
LIG_SH3_3	485	491	PF00018	0.666
LIG_SH3_3	548	554	PF00018	0.600
LIG_SH3_3	615	621	PF00018	0.714
LIG_SH3_4	70	77	PF00018	0.625
LIG_SUMO_SIM_anti_2	352	357	PF11976	0.533
LIG_SUMO_SIM_anti_2	98	106	PF11976	0.612
LIG_SUMO_SIM_par_1	352	357	PF11976	0.533
LIG_SUMO_SIM_par_1	520	526	PF11976	0.595
LIG_SUMO_SIM_par_1	555	561	PF11976	0.646
LIG_SUMO_SIM_par_1	98	106	PF11976	0.635
LIG_TRAF2_1	150	153	PF00917	0.647
LIG_TRAF2_1	189	192	PF00917	0.652
LIG_TRAF2_1	523	526	PF00917	0.597
LIG_TRAF2_1	72	75	PF00917	0.644
MOD_CDK_SPK_2	435	440	PF00069	0.677
MOD_CDK_SPK_2	446	451	PF00069	0.587
MOD_CDK_SPxK_1	435	441	PF00069	0.715
MOD_CDK_SPxK_1	513	519	PF00069	0.672
MOD_CDK_SPxK_1	88	94	PF00069	0.631
MOD_CDK_SPxxK_3	240	247	PF00069	0.709
MOD_CDK_SPxxK_3	596	603	PF00069	0.587
MOD_CK1_1	231	237	PF00069	0.675
MOD_CK1_1	289	295	PF00069	0.717
MOD_CK1_1	361	367	PF00069	0.649
MOD_CK1_1	446	452	PF00069	0.749
MOD_CK1_1	459	465	PF00069	0.736
MOD_CK1_1	467	473	PF00069	0.635
MOD_CK1_1	493	499	PF00069	0.665
MOD_CK1_1	505	511	PF00069	0.590
MOD_CK1_1	512	518	PF00069	0.706
MOD_CK1_1	599	605	PF00069	0.546
MOD_CK1_1	640	646	PF00069	0.724
MOD_CK1_1	88	94	PF00069	0.654
MOD_CK2_1	147	153	PF00069	0.661
MOD_CK2_1	24	30	PF00069	0.468
MOD_CK2_1	346	352	PF00069	0.571
MOD_CK2_1	442	448	PF00069	0.597
MOD_CK2_1	467	473	PF00069	0.657
MOD_CK2_1	520	526	PF00069	0.609
MOD_CK2_1	560	566	PF00069	0.669
MOD_CK2_1	59	65	PF00069	0.642
MOD_CK2_1	595	601	PF00069	0.660
MOD_DYRK1A_RPxSP_1	435	439	PF00069	0.673
MOD_GlcNHglycan	12	15	PF01048	0.501
MOD_GlcNHglycan	120	123	PF01048	0.638
MOD_GlcNHglycan	149	152	PF01048	0.686
MOD_GlcNHglycan	175	179	PF01048	0.615
MOD_GlcNHglycan	212	215	PF01048	0.668
MOD_GlcNHglycan	231	234	PF01048	0.513
MOD_GlcNHglycan	278	281	PF01048	0.612
MOD_GlcNHglycan	293	296	PF01048	0.533
MOD_GlcNHglycan	360	363	PF01048	0.681
MOD_GlcNHglycan	365	368	PF01048	0.635
MOD_GlcNHglycan	369	372	PF01048	0.653
MOD_GlcNHglycan	432	435	PF01048	0.640
MOD_GlcNHglycan	560	563	PF01048	0.716
MOD_GlcNHglycan	672	675	PF01048	0.614
MOD_GlcNHglycan	677	680	PF01048	0.636
MOD_GlcNHglycan	87	90	PF01048	0.647
MOD_GSK3_1	125	132	PF00069	0.629
MOD_GSK3_1	166	173	PF00069	0.597
MOD_GSK3_1	174	181	PF00069	0.552
MOD_GSK3_1	210	217	PF00069	0.637
MOD_GSK3_1	228	235	PF00069	0.554
MOD_GSK3_1	287	294	PF00069	0.721
MOD_GSK3_1	322	329	PF00069	0.671
MOD_GSK3_1	34	41	PF00069	0.444
MOD_GSK3_1	363	370	PF00069	0.650
MOD_GSK3_1	442	449	PF00069	0.731
MOD_GSK3_1	467	474	PF00069	0.754
MOD_GSK3_1	490	497	PF00069	0.692
MOD_GSK3_1	502	509	PF00069	0.617
MOD_GSK3_1	595	602	PF00069	0.542
MOD_GSK3_1	603	610	PF00069	0.579
MOD_GSK3_1	88	95	PF00069	0.601
MOD_LATS_1	500	506	PF00433	0.580
MOD_LATS_1	655	661	PF00433	0.510
MOD_LATS_1	668	674	PF00433	0.478
MOD_N-GLC_1	228	233	PF02516	0.673
MOD_N-GLC_1	270	275	PF02516	0.539
MOD_NEK2_1	204	209	PF00069	0.674
MOD_NEK2_1	270	275	PF00069	0.580
MOD_NEK2_1	276	281	PF00069	0.553
MOD_NEK2_1	287	292	PF00069	0.530
MOD_NEK2_1	346	351	PF00069	0.591
MOD_NEK2_1	430	435	PF00069	0.742
MOD_NEK2_1	471	476	PF00069	0.688
MOD_NEK2_1	492	497	PF00069	0.704
MOD_NEK2_1	532	537	PF00069	0.597
MOD_NEK2_1	586	591	PF00069	0.675
MOD_NEK2_1	87	92	PF00069	0.659
MOD_PIKK_1	326	332	PF00454	0.568
MOD_PKA_1	440	446	PF00069	0.673
MOD_PKA_2	276	282	PF00069	0.617
MOD_PKA_2	346	352	PF00069	0.571
MOD_PKA_2	388	394	PF00069	0.611
MOD_PKA_2	440	446	PF00069	0.710
MOD_PKA_2	586	592	PF00069	0.593
MOD_PKA_2	595	601	PF00069	0.572
MOD_PKA_2	640	646	PF00069	0.552
MOD_PKA_2	95	101	PF00069	0.634
MOD_Plk_1	270	276	PF00069	0.537
MOD_Plk_2-3	473	479	PF00069	0.646
MOD_Plk_4	204	210	PF00069	0.675
MOD_Plk_4	270	276	PF00069	0.574
MOD_Plk_4	532	538	PF00069	0.609
MOD_ProDKin_1	125	131	PF00069	0.621
MOD_ProDKin_1	240	246	PF00069	0.710
MOD_ProDKin_1	289	295	PF00069	0.693
MOD_ProDKin_1	435	441	PF00069	0.756
MOD_ProDKin_1	446	452	PF00069	0.630
MOD_ProDKin_1	494	500	PF00069	0.702
MOD_ProDKin_1	503	509	PF00069	0.630
MOD_ProDKin_1	513	519	PF00069	0.672
MOD_ProDKin_1	547	553	PF00069	0.635
MOD_ProDKin_1	575	581	PF00069	0.699
MOD_ProDKin_1	596	602	PF00069	0.659
MOD_ProDKin_1	617	623	PF00069	0.796
MOD_ProDKin_1	682	688	PF00069	0.668
MOD_ProDKin_1	88	94	PF00069	0.631
MOD_SUMO_rev_2	398	406	PF00179	0.658
MOD_SUMO_rev_2	599	605	PF00179	0.646
MOD_SUMO_rev_2	65	72	PF00179	0.638
TRG_DiLeu_BaLyEn_6	479	484	PF01217	0.694
TRG_ENDOCYTIC_2	164	167	PF00928	0.622
TRG_ENDOCYTIC_2	28	31	PF00928	0.458
TRG_ENDOCYTIC_2	321	324	PF00928	0.628
TRG_ENDOCYTIC_2	480	483	PF00928	0.826
TRG_ENDOCYTIC_2	542	545	PF00928	0.622
TRG_ER_diArg_1	113	115	PF00400	0.634
TRG_ER_diArg_1	238	241	PF00400	0.711
TRG_ER_diArg_1	246	248	PF00400	0.623
TRG_ER_diArg_1	439	441	PF00400	0.674
TRG_ER_diArg_1	573	576	PF00400	0.661
TRG_ER_diArg_1	586	588	PF00400	0.712
TRG_ER_diArg_1	656	659	PF00400	0.644
TRG_Pf-PMV_PEXEL_1	481	486	PF00026	0.702

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA95	Leishmania donovani	91%	100%
A4H8G1	Leishmania braziliensis	57%	100%
A4HWT5	Leishmania infantum	90%	100%
E9AQJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%